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ISSNL (Roberts) 16-NOV-2018 INTERNATIONAL SPACE STATION U.S. NATIONAL LAB Michael Roberts Deputy Chief Scientist, ISS-NL 16 November 2018 CASIS IS A NOT FOR PROFIT, NON GOVERNMENTAL ORGANIZATION THAT MANAGES THE ISS US NATIONAL LAB NASA provides: • Funding: $15M per year • Transportation: Commercial Resupply Services to/from ISS • Payload integration services • Resource Allocation: Not less than 50% of the U.S.O.S research capacity on ISS to ISS National Lab sponsored projects CASIS creates (as part of 50% allocation): • Access to the ISS U.S. National Lab for Academic and Non-Profit Institutions, Government Agencies, and Commercial Companies to conduct R&D • Non-traditional partnerships, cost-sharing agreements, and other arrangements to leverage funding for R&D activities on the ISS National Lab that benefit from space OA-9 Launch May 20 2018 Cygnus Capsule Payload Integration Quad locker stowed on Cygnus CAL is installed on station and in commissioning phase. OA-9 Launch May 20 2018 Title PI Facilities ZBLAN Additive Manufacturing Operations / Made in Space MMCG CP-09538 NIH NCATS Continuous Liquid-Liquid Separation in Zaiput Flow Microgravity / CP-09432 Technologies Enhanced Biological Production of University of Alaska- Isobutene / CP-09923 Anchorage Cygnus Capsule Payload Integration Quad locker stowed on Cygnus SpX-15 Launch June 29 2018 Title PI Facilities Domesticating Algae for Sustainable Production in Space / U. Florida ZBLAN CP-09739 MMCG NIH NCATS Endothelial Cells in Microgravity for Evaluation of Cancer Angiex Therapy Toxicity / CP-09719 Orbital Sidekick ISS Hyperspectral Earth Imaging System Trial Orbital Sidekick / CP-09890 Quantifying Cohesive Sediment Dynamics for Advanced UCSB Environmental Monitoring CP-09664 Microgravity Crystal Growth for Improvement in Neutron U. Toledo Diffraction / CP-09714 Bone Densitometer / CP-00461 TechShot CygnusEffects Capsule of Microgravity Payload onIntegration Production of Fluoride-basedQuad lockerMade stowed in Space on Cygnus Optical Fibers / CP-09595 STaARS-1 Research Facility / CP-09695 STaARS Facilities ZBLAN NG-10 Launch Nov 17 2018 MMCG NIH NCATS Title PI Utilizing the MISSE Platform Materials Science In Space / CP-00828 Made in Space Metal Additive Manufacturing Aluminum Alloy Satellite Antennas / CP-00825 Optisys A SiC UV Sensor for Reliable Operation in Low Earth Orbit / CP-00829 Ozark ICs Materials International Space Station Experiment (MISSE) Flight Facility / CP- Alpha Space 09717 Design of Scalable Gas Separation Membranes via Synthesis under Cemsica Microgravity / CP-09857 Crystallization of LRRK2 under Microgravity Conditions (Reflight) / CP-09707 MJFF Effects of Microgravity on Production of Fluoride-Based Optical Fibers / CP- Made in Space 09595 MicrofluidicCygnus Capsule Lab-on Payload-a Chip toIntegration Track Biomarkers in SkeletalQuad Muscle locker Cells stowed/ CP- onMicro Cygnus-gRx 09570 SpX-16 Launch - I Dec 4 2018 Title PI Facilities BioServe Support to Rodent Research Reference Mission- U. Colorado ZBLAN 1 / CP-00861 MMCG NIH NCATS SlingShot – MACE / CP-09977 SEOPS Space-Based Ubiquitous Cellular Phone Connectivity / UbiquitiLink CP-00845 Biofilm Thickness/Viability and Elevated Microbial Nalco Champion Corrosion Risk / CP-09853 Tympanogen - Wound Healing / CP-09521 Tympanogen Crystallization of RAS in Space / CP-00847 NIH NCI (Frederick NL) Bone Densitometer / CP-00461 TechShot Cygnus Capsule Payload Integration Quad locker stowed on Cygnus Barley Germination and Malting in Microgravity Budweiser Objective 3 (1 & 2 complete) / CP-09850 SpX-16 Launch - II Dec 4 2018 Title PI Facilities ZBLAN Enhancement of Performance and Longevity of a LambdaVision MMCG Protein-Based Retinal Implant / CP-09723 NIH NCATS Spaceflight Effects on Vascular Endothelial and U. Florida Smooth Muscle Cell Processes / CP-09735 Microgravity Model for Immunological Senescence UCSF on Tissue Stem Cells / CP-09833 Furphy-Residual Momentum and Tank Dynamics / Orb Fab CP-00841 Cygnus Capsule Payload Integration Quad locker stowed on Cygnus Facilities SpX-17 Launch - I NET Feb 17 2019 ZBLAN MMCG NIH NCATS Title PI Structure of Proximal and Distal Tubule Microphysiological Systems / CP-09808 U. Washington Preparation of PLGA Nanoparticles Based on Precipitation Technique / CP- Medimmune 09852 Droplet Formation Studies in Microgravity / CP-09691 Delta Faucet Capillary-Driven Microfluidics in Space / CP-07544 1Drop Diagnostics Cartilage-Bone-Synovium Microphysiological System / CP-09806 MIT Space Development Acceleration Capability (SDAC) / CP-09276 Craig Technologies An ISS Experiment on Electrodeposition / CP-09741 U. Florida EffectsCygnus of Capsule Microgravity Payload on Human Integration Physiology: Blood-BrainQuad Barrier locker Chip /stowed onEmulate Cygnus CP09809 SpX-17 Launch - II NET Feb 17 2019 Title PI Facilities ZBLAN Microgravity Crystal Growth for Improvement in U. Toledo MMCG Neutron Diffraction / CP-09714 NIH NCATS Fiber Optics Manufacturing in Space (FOMS) / CP- FOMS 09518 National Cancer Institute NExT Space Crystallization NCI Program / CP-09893 Cygnus Capsule Payload Integration Quad locker stowed on Cygnus NIH AND NSF PROGRAMS ON ISS- NL TISSUE ENGINEERING AND ADVANCED MATERIALS IN ORBIT PRODUCTION REGENERATIVE MEDICINE NIH/NCATS – NIBIB NSF Fluid Dynamics Chips in Space 2.0 NSF 19-### TBD RFA-TR-18-001 $11M NSF 18-521 $2.0M Chips in Space 1.0 NSF 16-518 $1.5M RFA-TR-16-019 $12M NSF Tissue Engineering NSF Combustion NSF 20-### TBD NSF 17-517 $1.8M NSF 19-509 $2.0M NSF 18-514 $1.8M TISSUE ENGINEERING AND REGENERATIVE MEDICINE “The main advantage of an organoid is structural sophistication of multiple lineages with an architecture resembling that of the original tissue via self-organization, albeit at a much smaller scale compared to the size of adult human organs (Figure 1).” Takebe, Zhang, and Radisic (2017) Cell Stem Cell 21: 297- 300. TISSUE ENGINEERING AND REGENERATIVE MEDICINE IN SPACE BioMed-ISS Flight Projects Flight Projects Wu (Stanford U) Heart Cells SpX-9 Malany (micro-gRx) muscle MPS model Vascular Zubair (Mayo Clinic) SpX-10 Tuan (U of Pittsburgh) bone MPS model Tissue Kearns-Jonker (Loma Linda U) SpX-11 Challenge Ground Projects Gregory (TAMU) Bone tumor cells Tissue Hare (U Miami) Cardiac stem cells Engineering Schwartz (U Houston) Cardiac progenitor cells Xu (Emory U) Cardiomyocytes hiPSC http://casistissuechip.blogspot.com/ STEM CELLS TISSUE CHIPS TISSUE CHIPS CHIPS IN SPACE NIH grant awards (~$23M) 2 ISS-NL flight opportunities Chips in Space 1.0 (NCATS): 5 projects awarded July 2017 Photo courtesy of U Penn Chips in Space 2.0 (NCATS & NIBIB): 4 projects awarded October 2018 CHIPS IN SPACE 1.0 Lung Host Defense Blood Brain Barrier Kidney Function WHY SPACE? Immune Function Musculoskeletal Disease ISS National Lab CiS 1.0 SpX-17 (Dec 2018) SpX-18 (Feb 2019) NG-11 (Apr 2019) CHIPS IN SPACE 2.0 Sarcopenia Intestine-Chip Microbiome WHY SPACE? Engineered Heart Tissues Cardiac Dysfunction NIBIB/NCATS NSF 18- 514: NSF/CASIS COLLABORATION ON TISSUE ENGINEERING ON THE ISS TO BENEFIT LIFE ON EARTH NSF CBET (Chemical, Bioengineering, Environmental & Transport Systems Division) and CASIS awarded two projects in August-2018. ISS: Liver Tissue Engineering in Space (Tammy Chang - UCSF) This research hypothesizes that the uniquely favorable conditions for three- dimensional cellular self-organization in microgravity onboard the ISS National Lab will allow formation of a microvascular network within self- assembled liver parenchyma that feeds into a central macro blood vessel. Tissue Engineered Muscle in Microgravity as a Novel Platform to Study Sarcopenia (Ngan Huang – Palo Alto Veterans Institute) The overarching hypothesis is that engineered skeletal muscle in microgravity mimics salient features of sarcopenia on Earth and is a robust platform for testing of drugs to treat sarcopenia. NSF 19- 509: NSF/CASIS COLLABORATION ON TISSUE ENGINEERING AND MECHANOBIOLOGY ON THE ISS TO BENEFIT LIFE ON EARTH NSF CBET (Chemical, Bioengineering, Environmental & Transport Systems Division) and and Civil, Mechanical, and Manufacturing Infrastructure (CMMI). Up to $2M to support PI research with $400k per project NASA to support Implementation Partner Webinar Nov 5th 1pm ET Step 1 proposals due Jan 2nd 2019 Full proposals due Feb 15th 2019 https://www.iss-casis.org/nsf-cbet-cmmi/ or look up NSF 19-509 3D BIOPRINTING IN MICROGRAVITY techshot 3D BioFabrication techshot Inc. Facility (launching to ISS-NL on SpaceX-18, May 2019) Made in Space partners with Allevi ZeroG to develop the bio extruder Allevi THANK YOU! Uluru, or Ayers Rock, a sandstone monolith in the heart of Australia’s Northern Territory’s https://www.iss-casis.org arid "Red Centre” as seen from the ISS. https://projects.iss-casis.org https://www.spacestationexplorers.org ISSCASIS ISS_CASIS CASIS ISS_CASIS The ISS National Lab is managed by the Center for the Advancement of Science in Space (CASIS). All images courtesy of NASA or CASIS unless otherwise stated. .
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