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Chronic Venous Insufficiency and Varicose Veins of the Lower Extremities

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Chronic Venous Insufficiency and Varicose Veins of the Lower Extremities REVIEW Korean J Intern Med 2019;34:269-283 https://doi.org/10.3904/kjim.2018.230 Chronic venous insufficiency and varicose veins of the lower extremities Young Jin Youn1,2 and Juyong Lee2 1Division of Cardiology, Department Chronic venous insufficiency (CVI) of the lower extremities manifests itself in of Internal Medicine, Yonsei various clinical spectrums, ranging from asymptomatic but cosmetic problems University Wonju College of Medicine, Wonju, Korea; 2Division of to severe symptoms, such as venous ulcer. CVI is a relatively common medical Interventional Cardiology, Calhoun problem but is often overlooked by healthcare providers because of an underap- Cardiology Center, UConn Health, preciation of the magnitude and impact of the problem, as well as incomplete University of Connecticut School of Medicine, Farmington, CT, USA recognition of the various presenting manifestations of primary and secondary venous disorders. The prevalence of CVI in South Korea is expected to increase, Received : June 27, 2018 given the possible underdiagnoses of CVI, the increase in obesity and an aging Accepted : September 8, 2018 population. This article reviews the pathophysiology of CVI of the lower extrem- Correspondence to ities and highlights the role of duplex ultrasound in its diagnosis and radiofre- Juyong Lee, M.D. quency ablation, and iliac vein stenting in its management. Division of Interventional Cardiology, Calhoun Cardiology Keywords: Diagnosis; Review; Therapeutics; Venous insufficiency Center, UConn Health, University of Connecticut School of Medicine, 263 Farmington Av, Farmington, CT 06030, USA Tel: +1-860-679-2058 Fax: +1 860 679 3346. E-mail: [email protected] INTRODUCTION dividuals, albeit the estimated prevalence of CVI varies depending on the population studies [5-7]. Chronic venous insufficiency (CVI) of the lower ex- Advancing age, family history, prolonged standing, tremities is associated with a wide clinical spectrum, obesity, smoking, sedentary lifestyle, lower extremity ranging from asymptomatic but cosmetic problems to trauma, prior venous thrombosis, the presence of an severe symptoms [1-4]. This includes telangiectases (or arteriovenous shunt, high estrogen states, and preg- spider veins), reticular veins, varicose veins, edema, pig- nancy are all considered risk factors for CVI [5,8-13]. mentation and/or eczema, lipodermatosclerosis, atro- Although the prevalence of CVI in the Asian population phie blanche, and venous ulceration. is significantly lower compared with non-Hispanic CVI is a relatively common medical problem but is whites according to a multiethnic cross-sectional study often overlooked by healthcare providers because of [14], the prevalence of CVI in South Korea is expected to an underappreciation of the magnitude and impact of increase due to the possible underdiagnosis of CVI, the the problem, as well as incomplete recognition of the increase in obesity, and an aging population. This arti- various presenting manifestations of primary and sec- cle reviews the pathophysiology of CVI of the lower ex- ondary venous disorders [2]. Abnormal venous flows of tremities and highlights the role of duplex ultrasound the lower extremities are observed in up to 50% of in- (DUS) in its diagnosis, and radiofrequency ablation Copyright © 2019 The Korean Association of Internal Medicine pISSN 1226-3303 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ eISSN 2005-6648 by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited4 http://www.kjim.org The Korean Journal of Internal Medicine Vol. 34, No. 2, March 2019 SEV CFV Variation at the SFJ CFV SCI EPV SFJ GSV AASV FV PASV Hunterian perforator(s) GSV Dodd perforator(s) CE CE PV To GSV To GSV To GSV PV PV PV SPJ SPJ SPJ Boyd's perforator(s) Cockett’s perforators A B C Figure 1. Venous system of the lower limb. (A) Great saphenous vein and its tributaries. (B) Small saphenous vein and its varia- tions. (C) Perforating veins. SEV, superficial epigastric vein; SCI, superficial circumflex iliac vein; CFV, common femoral vein; EPV, external pudendal vein; SFJ, saphenofemoral junction; AASV, anterior accessory of the great saphenous vein; PASV, pos- terior accessory of the great saphenous vein; GSV, great saphenous vein; CE, cranial extension of the small saphenous vein; PV, popliteal vein; SPJ, saphenopopliteal junction; FV, femoral vein. (RFA) and iliac vein stenting in its management. hypertension due to the remaining obstruction of the venous flow and valvular reflux due to valve damage [16]. PATHOPHYSIOLOGY VENOUS ANATOMY AND ITS VARIATIONS The main pathophysiological cause of the clinical man- ifestation of CVI of the lower extremities is ambulatory To understand the pathophysiology of CVI or vari- venous hypertension, which is caused by venous valve cose veins as well as their therapeutic options, such as reflux, venous flow obstruction, or both [2]. The venous endovenous ablations, one should know the anatomy pressure of the foot vein in the standstill position with- and variations of the veins. The consensus on the no- out skeletal muscle contraction is as high as 80 to 90 menclature of anatomic terminology was established by mmHg. In a subject with competent venous valves, this an International Interdisciplinary Committee in 2001 pressure decreases to less than 30 mmHg during ambu- and 2005 [17,18]. The venous system can be divided into lation [15]. However, in a patient with CVI, the decrease three major components: the superficial venous system, in venous pressure with leg movements is attenuated. If the deep venous system, and perforating veins. valves in the perforator veins are incompetent, the high pressures generated in the deep veins by calf-muscle Superficial venous system contraction can be transmitted to the superficial system The superficial venous system drains the blood flow and to the microcirculation in skin. This is called ambu- from the skin and the subcutaneous tissues (Fig. 1). latory venous hypertension. Postthrombotic syndrome Historically, any veins located above the deep mus- after deep vein thrombosis (DVT) also causes venous cular fascia, which are not deep veins, are considered 270 www.kjim.org https://doi.org/10.3904/kjim.2018.230 Youn YJ and Lee J. Chronic venous insufficiency xx SFJSFJ GSV GSV CFACFA CFVCFV x x AWithoutWithout compression compression WithWith compression compression B R RCFV CFV SFJ SFJ Figure 2. Sonographic landmark of superficial femoral veins. (A) The ‘Egyptian eye’: a transverse ultrasound image of the great saphenous vein in the thigh with/without compression showing the fascial components that constitute the saphenous compartment. (B) Transverse view of the common femoral vein (CFV) and artery in the right groin: ‘Mickey mouse’ view. GSV, great saphenous vein; CFA, common femoral artery; SFJ, saphenofemoral junction. superficial veins. The superficial venous system can The saphenofemoral junction (SFJ or saphenous be divided into thick-walled truncal veins, such as the junction or saphenous arch) is a critical area in terms great saphenous vein (GSV) and the small saphenous of understanding flow patterns, treatment approach- vein (SSV), which lie between the saphenous sheath and es, and the recurrence of varicosities. Using DUS, the the muscular fascia, and the thin-walled superficial or “Mickey mouse” sign (Fig. 2B) can be used as a land- epifascial tributaries, which lie between the skin and mark consisting of the common femoral artery, CFV, saphenous fascia [19,20]. This relationship between and GSV. The SFJ includes the area between the termi- veins and sheath or fascia looks like an Egyptian eye on nal and preterminal valves of the CFV and three major the ultrasound (Fig. 2A). It is used as a key marker to tributaries draining in the GSV: the external pudendal, identify the saphenous veins. However, only 50% of pa- inferior epigastric, and external circumflex iliac veins. tients have the saphenous trunk located throughout the Regarding endovenous ablation, leaving the superfi- entire saphenous compartment from the ankle to the cial inferior epigastric vein intact is believed to reduce groin [19,21]. the incidence of endovenous heat-induced thrombus The GSV is the longest vein in the body (Fig. 1A). It (EHIT) extension into the femoral vein. The anatomic originates on the medial side of the foot and ascends an- variation of the SFJ is significant [3]. A major distal trib- terior to the medial malleolus and then along the medial utary of the SFJ is the AASV. Approximately half of pa- side of the calf and thigh and drains into the common tients have the AASV. Because the AASV can be a source femoral vein (CFV) [18,22]. In the tibial part, the GSV is of recurrent varicose veins, it is important in diagnosis joined by two tributaries: the posterior accessory of the and treatment [23]. great saphenous vein (PASV; previously called the vein The SSV originates on the dorsolateral aspect of the of Leonardo) and the anterior accessory of the great sa- foot, ascends posterior to the lateral malleolus and phenous vein (AASV). Clinically, the PASV is important along the posterolateral aspect of the calf, and drains in patients with venous ulceration because the posterior into the popliteal vein (Fig. 1B). The saphenopopliteal tibial perforators (previously called Cockett) connect the junction (SPJ), where the SSV joins the popliteal vein, posterior tibial veins and the PASV, but not the distal GSV. shows variability. Cranial extension (CE) of the SSV is https://doi.org/10.3904/kjim.2018.230 www.kjim.org 271 The Korean Journal of Internal Medicine Vol. 34, No. 2, March 2019 present in 95% of limbs and is the continuation of the Perforating vein SSV. However, in approximately 25% of limbs, the SSV Perforators are bridging channels between the super- does not have a connection to the deep vein but con- ficial and deep venous systems (Fig. 1C). These veins tinues up the posterior thigh as the CE.
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