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Endocrinology ENDOCRINOLOGY Neuro-Biogenic Amine Profiles l Evaluation of neuro-biogenic amines and metabolites l Functional assessment of neurotransmitter enzyme function l Supports treatment monitoring and identification of metabolism imbalance Science + Insight Neuro-Biogenic Amine Profiles Urinary neuro-biogenic amines provide insight into a patient’s overall ability to synthesize and metabolize neurotransmitters. Doctor’s Data’s Neuro-Biogenic Amine Profiles help identify alterations in urinary neurotransmitter status which may be associated with a variety of conditions from metabolic to behavioral disorders. Value in Clinical Practice Analysis of urinary neuro-biogenic amines and their metabolites provides a non-invasive assessment of neurotransmitter metabolism. A review of current scientific literature indicates that neuro-biogenic amine testing may be useful in a variety of areas: Doctor’s Data offers • Functional testing—Neuro-biogenic amine metabolism may be mediated by catechol-O- Urinary Neuro-Biogenic methyltransferase (COMT), monoamine oxidase (MAO), and other enzymes. Test results may provide functional information about these important enzymes. Amine Profiles as a non- • Imbalance identification—Research indicates that urinary neuro-biogenic amine levels invasive way to assess may correlate with conditions such as depression and PTSD. the neurotransmitters • Response to therapy—Certain neuro-biogenic amines such as serotonin may be altered by essential for normal the addition of neurotransmitter precursors such as 5-hydroxytryptophan (5-HTP). These function. Our profiles changes may be apparent in the urine. are designed to help • Toxicology risk assessment—Changes in urinary serotonin, dopamine, and glutamate you identify therapeutic levels have been suggested as biomarkers for neurobehavioral toxicology resulting from opportunities to support chemical or environmental exposures. your patients’ health. Neuro-Biogenic Amines in the Body Neuro-biogenic amines are produced from essential aromatic amino acids and secreted from pre-synaptic neurons into the synapse between nerve cells to stimulate receptors on post- synaptic neurons. While circulating levels of neuro-biogenic amines and metabolites may have a variety of sources, urinary levels primarily reflect activity of the peripheral and enteric nervous systems. In fact, up to 20 percent of urinary neurotransmitters are estimated to originate in the central nervous system. By measuring urinary neuro-biogenic amines, we can learn a great deal about a patient’s ability to synthesize and metabolize neurotransmitters in the peripheral nervous system and behind the blood-brain barrier. Neuro-biogenic amine levels may be influenced by diet, age, gender, body mass, kidney function, environmental exposures, infection, and tobacco use, as well as conditions such as metabolic disorders, mood or behavioral disorders, or in rare cases the presence of certain tumors. As a result, evaluating urinary neuro-biogenic amines may offer increased clarity about a patient’s health and functional status. Neuro-Biogenic Amine Profiles and Test Components Comprehensive Neuro-Biogenic Neuro-Biogenic Amines Amines Catecholamine Fractionation, free: 4 4 Epinephrine, Norepinephrine, Dopamine Serotonin 4 4 Histamine 4 4 GABA 4 4 Glutamate 4 4 Glycine 4 4 Phenethylamine (PEA) 4 4 Taurine 4 Tryptamine 4 Tyramine 4 Tyrosine 4 5-Hydroxyindolacetic acid (5-HIAA) 4 3,4-Dihydroxyphenylacetic acid (DOPAC) 4 3-Methoxytyramine (3-MT) 4 Metanephrine Fractionation: 4 Metanephrine, Normetanephrine Creatinine 4 4 Which profile to order? The Comprehensive Profile includes additional catecholamine metabolites and metanephrines which provide expanded functional enzyme assessment. For more information about all available tests, clinical information and sample reports, visit doctorsdata.com. Results are presented in a clear, easy-to-understand report which details target ranges and graphically illustrates areas of elevated risk. Result-specific commentary is also provided. Science + Insight 3755 Illinois Avenue St. Charles, IL 60174-2420 800.323.2784 (US AND CANADA) 0871.218.0052 (UK) +1.630.377.8139 (GLOBAL) doctorsdata.com ©2015 Doctor’s Data, Inc. All rights reserved..
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