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F Drug Forecasts Europe Drug Forecasts:f Evaluate"' Europe Drug Forecasts to 2026: Real-world, country level historic product sales and consensus based forecasts. Conduct European market sizing, R&D horizon scanning and price comparison utilising real world government and company reported sales data with country level, consensus based product forecasts to 2026. Model Government European Future Pipeline and Company Market Sizing Impact Reported Forecasts for key Forecasts for full Drug Sales branded products R&D pipeline Compare with audit based systems European Pricing Generic Market Launch Dates Perform Analysis Launch dates comparative Generic sales, for products pricing analysis volume & pricing in European countries Single solution for business development and licensing, commercial and corporate strategy, consultants and investment banks Europe Product Forecasts (€m): Top 5 Brands in 2022 Anti-TNF Products European Market Sizing Humira Enbrel Simponi Remicade Cimzia Other Tecentriq (atezolizumab) Durvalumab (durvalumab) Margetuximab (margetuximab) 8,000 Olaratumab (olaratumab) PF-05280014 (trastuzumab) Other 3,000 Forecasts for key branded drugs at a European country level – 7,000 market value of over €100bn in 2026 6,000 2,500 5,000 2,000 • Conduct future market assessment 4,000 1,500 Sales (€m) Sales (€m) 3,000 • Map future trends of key marketed drugs 1,000 2,000 500 • Profile in line products 1,000 0 0 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2016 2017 2018 2019 2020 2021 2022 Humira Enbrel Simponi Remicade Cimzia Other Tecentriq (atezolizumab) Durvalumab (durvalumab) Margetuximab (margetuximab) Europe8,000 R&D Product Forecasts: Olaratumab (olaratumab) PF-05280014 (trastuzumab) Other Monoclonal Antibody Antineoplastics 3,000 7,000 Model Future Pipeline Impact Humira Enbrel Simponi Remicade Cimzia Other Tecentriq (atezolizumab) Durvalumab (durvalumab) Margetuximab (margetuximab) 6,000 2,500 8,000 Olaratumab (olaratumab) PF-05280014 (trastuzumab) Other 5,0003,000 Full forecast pipeline for R&D products7,000 launching in Europe – 2,000 4,0002,500 Avastin Keytruda Herceptin Perjeta Opdivo 6,000 1,500 YERVOY market value €30bn Sales (€m) 100% Sales (€m) 95%3,000 5mg/ml Perf FL 40ml 14,000 5,000 2,000 (Unassigned Company) 90% 1,000 85%2,000 • Map key pipeline assets that are likely4,000 to launch by 2026 80% YERVOY 1,500 75% 5mg/ml500 Perf FL 10ml 3,500 Sales (€m) Sales (€m) 70%1,000 3,000 (Unassigned Company) 65% and measure impact 1,000 60% 0 0 ADCETRIS 2,000 55% 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 50mg Perf2016 FL 20173,150 2018 2019 2020 2021 2022 50% (Unassigned Company) 45%500 1,000 • Identify new medicines and how they impact therapy areas 40% 35% PERJETA 0 30% 0 420mg Perf FL 14ml 2,861 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 25% 2016 2017 2018 2019 2020 2021 2022 (Unassigned Company) 20% 15% KADCYLA 10% 100mg Perf FL Humira Enbrel Simponi Remicade Cimzia Other Tecentriq (atezolizumab) Durvalumab (durvalumab) Margetuximab (margetuximab) 1,798 5% (Unassigned Company) 8,000 Sales0 OlaratumabMarket (olaratumab) Share within PF-05280014 Key (trastuzumab) Brands: Other 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2,000 4,000 6,000 8,000 10,000 12,000 14,000 Monoclonal3,000 Antibody Antineoplastics 7,000 Competitive Landscaping 2,500 Avastin Keytruda Herceptin Perjeta Opdivo 6,000 100% YERVOY 95% 5mg/ml Perf FL 40ml 14,000 5,000 2,000 Historical government and company reported sales data 90% (Unassigned Company) 85% 4,000 80% YERVOY Avastin Keytruda Herceptin Perjeta Opdivo 1,500 75% YERVOY 5mg/ml Perf FL 10ml 3,500 Sales (€m) 100% Sales (€m) (EU 5 and other key markets) 70% (Unassigned Company) 95%3,000 5mg/ml Perf FL 40ml 14,000 (Unassigned65% Company) 90% 60%1,000 85%2,000 ADCETRIS 55% 50mg Perf FL 3,150 • Compare product performance across80% key European markets 50% YERVOY 75% 5mg/ml500 Perf FL 10ml 3,500 (Unassigned Company) 1,000 45% 70% (Unassigned40% Company) 65% 35% PERJETA • Map uptake trends and drivers across60% 0European countries 30% 0 ADCETRIS 420mg Perf FL 14ml 2,861 55% 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 25% 50mg Perf2016 FL 20173,150 2018 2019 2020 2021 2022 (Unassigned Company) 50% (Unassigned20% Company) 45% 15% KADCYLA • 40% 10% 100mg Perf FL 1,798 Understand drug launch timelines across35% 20 countries PERJETA 5% (Unassigned Company) 30% 420mg Perf FL 14ml 2,861 (Unassigned0 Company) 25% 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2,000 4,000 6,000 8,000 10,000 12,000 14,000 20% 15% KADCYLA 10% 100mg Perf FL 1,798 5% (Unassigned Company) 0 Manufacturer Price (France) € - Latest 0 2,000 4,000 6,000 8,000 10,000 12,000 14,000 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 (€) Monoclonal Antibody Antineoplastics Pricing Comparison Analysis AcrossAvastin Keytruda Countries Herceptin Perjeta Opdivo 100% YERVOY 95% 5mg/ml Perf FL 40ml 14,000 90% (Unassigned Company) Ex-factory pricing data for Germany, France,85% Italy, England, Poland, 80% YERVOY 75% 5mg/ml Perf FL 10ml 3,500 70% (Unassigned Company) Spain and other key markets 65% 60% ADCETRIS 55% 50mg Perf FL 3,150 50% (Unassigned Company) • Perform comparative analysis across45% EU 6 countries for key products 40% 35% PERJETA 30% 420mg Perf FL 14ml 2,861 • Use price/DDD benchmark to inform25% quick assessment of new assets (Unassigned Company) 20% 15% KADCYLA 10% 100mg Perf FL 1,798 5% (Unassigned Company) 0 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2,000 4,000 6,000 8,000 10,000 12,000 14,000 A pioneering methodology for European country level drug forecasts Powered by Evaluate’s industry standard consensus forecasts and broken out on a European country level using: • European historical data – government and company reported • Coupled with Evaluate’s proprietary methodology inputs: – Estimated European launch timelines of R&D products – Analogue methodology to model forecast for R&D products – European uptake patterns and country launch timings – Expected European generic entry Copyright © 2021 Evaluate Ltd. All rights reserved. Evaluate provides trusted commercial intelligence for the pharmaceutical industry. We help our clients to refine and transform their understanding of the past, present and future of the global pharmaceutical market to drive better decisions. When you partner with Evaluate, our constantly expanding solutions and our transparent methodologies and datasets are instantly at your disposal, along with personalized, expert support. Evaluate gives you the time and confidence to turn understanding into insight, and insight into action. provides a complete, dynamic view of development risk and commercial return across the full clinical lifecycle, delivering game-changing insight into pharma asset potential. offers a global view of the pharmaceutical market’s past, present and future performance with consensus forecasts to 2026, company financials, pipelines and deals. tracks, benchmarks, and forecasts global performance for the medical device and diagnostic industry with consensus forecasts to 2026, company financials and more. improves your strategic decision-making with customized solutions and deep insights that draw on our industry expertise and trusted commercial intelligence. provides award-winning, thought-provoking news and insights into current and future developments in the industry, and is the only pharmaceutical news service underpinned by Evaluate’s commercial intelligence. www.evaluate.com | @EvaluatePharma @EvaluateVantage Evaluate Headquarters Evaluate Americas Evaluate Asia Pacific Evaluate Ltd. 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