Author Manuscript Published OnlineFirst on July 25, 2016; DOI: 10.1158/1078-0432.CCR-16-0122 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Antitumor effect of programmed death-1 (PD-1) blockade in humanized the NOG-major histocompatibility complex (MHC) double knockout mouse Tadashi Ashizawa1, Akira Iizuka1, Chizu Nonomura1, Ryota Kondo1, Chie Maeda1, Haruo Miyata1, Takashi Sugino4, Koichi Mitsuya3, Nakamasa Hayashi3, Yoko Nakasu3, Kouji Maruyama2, Ken Yamaguchi5, Ikumi Katano6, Mamoru Ito6, Yasuto Akiyama1, 3* 1Immunotherapy Division, 2Experimental Animal Facility, Shizuoka Cancer Center Research Institute, 3Division of Neurosurgery, 4Division of Pathology, 5Office of the President, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan 6Central Institute for Experimental Animals, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan Running title; Antitumor effect of anti-PD-1 antibody in NOG-MHC dKO mice Keywords; Immune checkpoint antibody, anti-PD-1 antibody, humanized NOG mouse, NOG-MHC dKO mouse, autologous immunotherapy model Financial support; This work was supported by a grant to Akira Iizuka from JSPS KAKENHI (Grant Number 26430178), Japan. Address correspondence to: Yasuto Akiyama, M.D., Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, 1 Downloaded from clincancerres.aacrjournals.org on September 30, 2021. © 2016 American Association for Cancer Research. Author Manuscript Published OnlineFirst on July 25, 2016; DOI: 10.1158/1078-0432.CCR-16-0122 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Sunto-gun, Shizuoka 411-8777, Japan. Tel: (+81) 559895222 (Ext. 5330), Fax: (+81) 559896085, e-mail;
[email protected] Conflict of interest The authors declare that they have no conflict of interest.