Pyometra and Pregnancy with Herlyn-Werner- Wunderlich Syndrome Piometria E Gravidez Com Síndrome De Herlyn-Werner- Wunderlich

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Pyometra and Pregnancy with Herlyn-Werner- Wunderlich Syndrome Piometria E Gravidez Com Síndrome De Herlyn-Werner- Wunderlich THIEME Case Report 623 Pyometra and Pregnancy with Herlyn-Werner- Wunderlich Syndrome Piometria e gravidez com síndrome de Herlyn-Werner- Wunderlich Maria Inês Reis1 Ana Patrícia Vicente1 Joana Cominho1 Andrea Sousa Gomes1 Luísa Martins1 Filomena Nunes1 1 Department of Obstetrics and Gynecology and Department of Address for correspondence Maria Inês Reis, Medical Resident, Maternal Fetal Medicine, Hospital Dr. José de Almeida, Department of Obstetrics and Gynecology and Department of Lisbon, Portugal Maternal Fetal Medicine Hospital Dr. José de Almeida, Rua Dr. Henrique Martins Gomes, 1600-396 Lisbon, Portugal Rev Bras Ginecol Obstet 2016;38:623–628. (e-mail: [email protected]). Abstract We describe a Herlyn-Werner-Wunderlich syndrome (HWWS) patient with previous history of infertility who got pregnant without treatment and presented a pyometra in Keywords the contralateral uterus throughout the gestational period, despite multiple antibiotic ► Herlyn-Werner- treatments. Due to the uterus’ congenital anomaly and the possibility of ascending Wunderlich infection with subsequent abortion, this pregnancy was classified as high-risk. We syndrome believe that the partial horizontal septum in the vagina may have contributed to the ► pyometra closure of the gravid uterus cervix, thus ensuring that the pregnancy came to term, ► pregnancy with an uneventful vaginal delivery. ► magnetic resonance imaging and ultrasonography Resumo Os autores descrevem uma paciente com síndrome de Herlyn-Werner-Wunderlich Palavras-Chave (SHWW) e história prévia de infertilidade, que engravidou espontaneamente. Durante ► síndrome de Herlyn- todo o período gestacional apresentou, apesar da instituição de antibioticoterapia, um Werner-Wunderlich piometra localizado ao útero não gravídico. Devido à anomalia congênita uterina e ao ► piometra risco de infeção ascendente, com possível desfecho obstétrico desfavorável, esta ► gravidez gravidez foi classificada de alto risco. O septo vaginal horizontal e parcial poderá ter ► ultrasonografiae contribuído para ausência de disseminação da infecção, permitindo que a gravidez ressonância tenha chegado a termo, com um parto vaginal, sem intercorrências. magnética Introduction tal anomalies, resulting from failure of development, defective fusion or defects in regression of the septum Mullerian duct anomalies (MDAs) are congenital defects during fetal development. A review of the prevalence of of the female genital system that arise from the abnormal different types of uterine malformations revealed that embryological development of the Mullerian ducts.1,2 uterus didelphys was found to be the second least com- These abnormalities include a wide range of developmen- mon of all MDAs.3 received DOI http://dx.doi.org/ Copyright © 2016 by Thieme-Revinter June 29, 2016 10.1055/s-0036-1594304. Publicações Ltda, Rio de Janeiro, Brazil accepted ISSN 0100-7203. October 3, 2016 published online December 21, 2016 624 Pyometra and Pregnancy with Herlyn-Werner-Wunderlich Syndrome Reis et al. Herlyn-Werner-Wunderlich syndrome (HWWS), also known pregnancy, but carried her pregnancy to term and delivered as obstructed hemivagina and ipsilateral renal anomaly (OH- vaginally without complications. VIRA) syndrome was first described in 1971–1976.4,5 It is a rare congenital anomaly of the female genital tract characterized by Case Report uterus didelphys, ipsilateral renal agenesis and blind hemivagina. Itsprevalenceisdifficulttoascertain,butitisestimatedtobe A 27-year-old nulliparous woman, with menarche at age 12 0.1–3.8%.1 In the literature, the syndrome often appears as a and normal menses. The patient did not report having – single case report or as a small series.3,6 9 Patients with this dysmenorrhea; however, intermittent dyspareunia, chronic disorder usually present, shortly after menarche, with intermit- pelvic pain and abundant vaginal purulent discharge epi- tent dysmenorrhea, irregular vaginal hemorrhage, mucopuru- sodes were present in the past. Her medical history was lent discharge, acute pelvic pain or palpable mass due to the significant for a congenitally absent right kidney, diagnosed associated hematocolpos or hematometra, which result from at age 15, and infertility history for over 6 years. The retained long standing menstrual flow in the obstructed infertility causes of the couple were investigated, and the hemivagina. magnetic resonance imaging (MRI) identified a uterus didel- The rarity of this condition may contribute to diagnostic phys with partial longitudinal vaginal septum, moderated delay. Early diagnosis with appropriate surgical intervention hematocolpos in the right hemi-uterus, ipsilateral renal with vaginoplasty and vaginal septostomy decreases the agenesis and right ureteral ectasia with ectopic vesical long-term morbidity of these women.10,11 The surgical out- insertion, suggestive of renal scar regression (►Fig. 1). The come is excellent, and it is associated with a successful patient had not had any treatment at that point, as she ceased reproductive performance in the future. to attend infertility appointments. In this case report we discuss a rare case of a HWWS She achieved a spontaneous pregnancy and was referred patient who kept a chronic purulent discharge throughout all to our prenatal care department, in first trimester, due to the Fig. 1 Coronal abdomino-pelvic MRI – uterus didelphys, ipsilateral renal agenesis, and right ureteral ectasia with ectopic vesical insertion. Rev Bras Ginecol Obstet Vol. 38 No. 12/2016 Pyometra and Pregnancy with Herlyn-Werner-Wunderlich Syndrome Reis et al. 625 uterine anomaly and its associated risks, as well as com- The patient experienced spontaneous labor at 39 weeks. plaints of pelvic pain and vaginal purulent discharge. The partial septum was not an impediment to the vaginal The general physical examination was unremarkable. birth, and a healthy female newborn weighing 2,645 g was Copious quantities of yellowish discharge from the left-side delivered. The postpartum period progressed uneventfully. cervix were found on the speculum exam. A vaginal swab was She was discharged within 48 hours postpartum (►Fig. 4). collected, and cultures of Streptococcus oralis and mitis stains In the absence of any signs and symptoms, the routine were isolated. The laboratory evaluations, including leukogram assessment of the maternal health was undertaken six weeks and c-reactive protein (CRP), were within normal limits. The after delivery, and the partial vaginal septum was not found. patient was started on cefuroxime according to an antibiotic susceptibility test, and continued daily antibiotic prophylaxis Discussion with 1 g Amoxicillin throughout pregnancy. The pelvic ultrasound scan revealed a single fetus on the Herlyn-Werner-Wunderlich syndrome is extremely rare. To left hemi-uterus, and the right hemi-uterus was filled with our knowledge, there are five cases of pregnancies associated – – fluid with altered echogenicity. Two separate cervices were to HWWS,12 15 seven cases of HWWS with pyocolpos,16 22 documented, the left anterior and right posterior (►Figs. 2 one case of pregnancy in HWWS with pyocolpos,23 and two and 3). cases of pregnancy with pyocolpos in a uterus didelphys.24,25 The patient attended a Maternal-Fetal Medicine consulta- According to the European Society of Human Reproduc- tion, and serial evaluations of inflammatory parameters and tion and Embryology (ESHRE) and the European Society for cervical length were performed throughout the pregnancy, and Gynecological Endoscopy (ESGE)26 consensus on the Classi- they remained within normal limits. The fetus showed appro- fication of Female Genital tract congenital anomalies, HWWS priate growth monitored in a serial ultrasound every four appears to be included in Class U3B uterine anomaly, class C2 weeks. cervix anomaly, and class V3 vaginal anomaly. Ã Fig. 2 Pelvic ultrasound scan – fetus on the left hemi-uterus and right hemi-uterus with altered echogenicity fluid ( ). Rev Bras Ginecol Obstet Vol. 38 No. 12/2016 626 Pyometra and Pregnancy with Herlyn-Werner-Wunderlich Syndrome Reis et al. – Fig. 3 Pelvic ultrasound two separate cervices, left anterior (32.3 mm) and right posterior (29 mm). Fig. 4 Postpartum pelvic ultrasound. Rev Bras Ginecol Obstet Vol. 38 No. 12/2016 Pyometra and Pregnancy with Herlyn-Werner-Wunderlich Syndrome Reis et al. 627 Herlyn-Werner-Wunderlich syndrome is commonly diag- We presume that a partial vaginal septum might have nosed at the time of menarche. The vaginal septum is gen- been critical to the success of the pregnancy, preventing the erally longitudinal, and can have a variable thickness. Delay in ascending infection of the pregnant uterus. diagnosis is common especially due to: the communication A uterus didelphys is not an indication for cesarean between the two cavities, from the incomplete hemivaginal delivery, and thus vaginal delivery should be considered – obstruction; septum elasticity; and the use of drugs, such as first, if there is no obstruction of the birth canal.34 36 oral contraceptives and non-steroidal anti-inflammatory The absence of similar cases in the literature proved to be drugs, which might minimize symptoms and, therefore, a challenge in the management of this clinical case. Careful further delay the recognition of the condition. A high index attention is necessary for early recognition and appropriate of suspicion is required to diagnose these cases at an early management of this condition for a successful outcome. stage, avoiding complications, such
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