August l, 1995 Vol. XLVII No. 16 "Still U.S. Department of Health The Second and Human Services Best Thing About Payd4y" National Institutes of Health IH Recori More Than a Place to Sleep NCl's Stephen Katz Children's Inn Celebrates Fifth Anniversary To Direct NIAMS By Rich McManus r. Stephen I. Karz, an internation he Children's Inn at NIH D ally known dermatologist and marked its fifth birthday July 11 immunologist, has been appointed T with a daylong outdoor gala on director of the National Institute of the hoedown/rodeo theme; kids, hope Arthritis and Musculoskeletal and Skin and home were the featured values and Diseases, effective Aug. 1. He succeeds Merck & Co. Inc., as usual, brought the Dr. Michael D. Lockshin, acting direc grandest gift-its second $500,000 tor, and Dr. Lawrence E. Shulman, the challenge grant, chis atop a construction first and founding director of the gift of $3. 7 million char built rhe institute, which marks its 10th anniver structure in the first place. sary in 1996. Taking advantage of the inn's woodsy In making the seclusion on campus, the party-divided announcement, into a breakfast thank-you feast for NIH NIH director Dr. employees, a lunchtime cookout/carnival NCI Pediatric Branch chiefDr. Philip Harold Varmus for pediatric patients and ocher young Pizzo oversees a child's attempt to blow out said, "Dr. Katz's sters, and an evening hoedown/barbecue, the candles on the inn's fifth birthday cake. outstanding hosted by ABC-TV's Cokie Roberts (an tremendously to the warmth we can scientific and inn board member) for corporate provide children participating in clinical credentials givers-took place under a large cent pediatric research." Thanking the and effeccive erected on a hillside overlooking the 36- children, families, scaff and volunteers leadership skills room mn. who make the inn a special place, he make him a clear Dr. Stephen Katz Reps. Richard Gephardt (D-Mo.) and singled our the contributions of the choice for chis Connie Morella (R-Md.) dropped in at many NIH'ers who volunteer there: important post. He has demonstrated a noon ro offer congratulations, as did "They complete the circle of compassion commitment to building strong scientific NIH director Dr. Harold Varmus, who, chat forms che core of the inn." programs at che NIH. He will provide quipping char the scene "looks like the Gephardt, whose wife Jane is on the excellent leadership at rhe NlAMS." set of Bonanza," said the inn "adds (See INN ANNIVERSARY, Page 6) (See NIAMS DIRECTOR, Page 5) New Pertussis Vaccines NIDDK's Rall, Robbins Recall 40-Year Careers Shown Effective, Safe By Jane DeMouy n two large clinical trials supported en Jack Robbins first set foot on the Clinical Center's Eight North in Iby NIAID, researchers in Italy and 954, he laid claim to one cf only two working labs on rhe floor. T he Sweden have shown char three new hospital was only a year old, and the soft-spoken young researcher had left vaccines are highly effective in protecting Memorial Hospital and Sloan-Kettering Institute in New York ro help establish the infants against pertussis (whooping Clinical Endocrinology Brarrch (CEB) for the fledgling National Institute of Arthritis cough) and have fewer side effects than and Metabolic Diseases, now NIDDK. the currently used vaccine. Pertussis is His friend Ed Rall, who had shared his scudies of thyroid function and thyroid an extremely contagious respiratory cancer in Rulon Rawson's lab at Sloan-Kettering, joined him a year later to head the disease that worldwide afflicts more than CEB. Rall recalls char his present office- a divided space che size of two walk-in 50 million people and causes about closers-was rhen the library, conference room and lunch room. Eight North also 350,000 deaths each year. was home to two animal rooms, "marvelously new at the time," Rall remembers. The new vaccines are known as "acellu The CEB would come to be known as "one of rhe most extraordinary labs in the lar" vaccines because they contain only world." Bue at the time, neither Rall nor Robbins suspecced they were standing on the specific parts of the pertussis bacce the brink of an era. rium thought to be importanc for "Ir was really just rhe beginning of the grand rise of American biomedical science," immunity, in contrast to "whole-cell" recalls NIH alumnus Jesse Roth, now director of geriatric medicine at Johns Hopkins vaccines rhat employ whole, killed Medical School. "The science was simpler, che rimes were simpler. There was a pertussis organisms. continuous flow of young minds coming through, and a growing NIH research In the rwo randomized, double-blind budget," he adds. The two thyroid experts had already done groundbreaking work trials char coincided with severe pertussis characterizing thyroxine-binding proteins and treating thyroid cancer with radioactive epidemics in both countries, three iodine by calculating a whole body radiation dose. Each enjoyed cremendous respect acellular vaccines demonstrated efficacies for his encyclopedic knowledge of his field. Each had an open, inquiring mind fed by of 84 percent, 84 percent and 85 percent, Bach, Brahms, and books outside the realm of science. (See PERTUSSIS, Page 10) (See RALL AND ROBBINS, Page 4) page2
The Record August I, 1995 Program Trains Minority Students, Professors By Bob Kuska On college campuses across America, ate, to join them in the session. The summer is usually reserved for rest and idea is that two work better than one in relaxation. Bur 29 college srudencs and exporting the science. professors recently put their vacation Although the majority of participants plans on hold to visit the NIH campus are African American, the program also and immerse themselves in curring-edge reaches out co Native Americans, science. Hispanics, and other minorities. Their recent stay in Bethesda was part One of the themes of this year's spring of an ongoing course called "Minority session was the Human Genome Project Faculty-Studenc Partnerships in Biotech and the burgeoning field of molecular nology." Held twice each year, the genetics. Participants met with program trains students and professors NCH GR director Dr. Francis Collins mainly from historically Black colleges in and other NCHGR staff during their the latest topics and techniques in stay, toured NCHGR intramural biotechnology. research laboratories in Bldg. 49, and Dr. Lee Van Lenten has retired after 24 W ith this intensive training seminar, learned the dos and don'ts of performing years with the Public Health Service, 19 of program organizers say they hope to experiments using recombinant DNA them with NIGMS. At the time ofhis create "a ripple effect" when participants technologies. retirement, he was serving as acting chiefof head back to campus in the fall. "Many Although most srudents said they had the Pharmacological and Physiological historically Black colleges don't have the heard previously about the Human Sciences Branch, NIGMS, where he financial resources to keep up with all of Genome Project, they said coming to administered a portfolio ofresearch grants the advances in biotechnology," said in the area ofphysiology and trauma and Freddie Brown, a retired NIH research bztrn injury. He also administered the chemist who coordinates the program "Coming to NIH for just 1 NIGMS Medical Scientist Training through the Foundation for Advanced week opens the door to a Program grants. Van Lenten received his Education in the Sciences. "What we're A.B. from Colgate University and his M.D. hoping is parcicipants will learn a world most would have never from Yale University School ofMedicine. technique, go home and share their seen or heard about. .. " During his career, he was awarded two knowledge with others, establish labora Commendation Medals and an Outstand tories, or just know where to go to NIH helped chem better understand the ing Service Medal. collaborate with those who do have the scientific and ethical issues arising from resources." che project. "Most of what I knew about Launched in 1989, the Minority the Human Genome Project came from Faculty-Student Partnership already has reading Time and Newsweek, where they The NIH Record brought l 65 students and faculty co just talked about it in general terms," Published biweekly at Bethesda, Md., by the Editorial NIH from 70 different colleges. said Augustus Billy of Florida Memorial Operations Branch, Division of Public Information, for rhe information ofemployees of the National lnsrirures of According to Brown, roughly one-third College. "Hearing about the Human Health, Department of Health and Human Services. The of the students return to NTH for Genome Project here has really opened content is rcprinrablc without permission. Pictures may be available on request. Use of funds for printing this internships and seven have moved on to my eyes a !or. Hearing the talks has periodical has been approved by the director of the Office of medical school. Yet, two-thirds of the simplified it and helped me get an idea of Managcmenr and Budget through Sep The Record August I, 1995 Conference Call Addresses Perinatal HIV Transmission r. James Balsley, chief of the including minimal toxicity in both D Pediatric Medicine Branch in the groups and a mild anemia in infants NIAID Division of AIDS, recently was a receiving the drug, which subsided after panelist on the I I th Incernational Srate 6 weeks of age. He also described the of-the-Arc HIV Clinical Conference Call followup studies chat will evaluate any series. This series, directed by Dr. Abe long-term effects on either the babies or Macher, a PHS officer with the Health their mothers. Resources and Services Administration, is Following the program, participants designed to reach a wide audience of evaluating che conference call offered primary care providers with cutting edge words of congratulations and encourage clinical information about HIV. ment. Karen Edge, an HIV/AIDS The subject matter of the recent epidemiologist with che New Mexico telephone conference, perinatal transmis department of heal th, remarked, "This sion of HIV and intervention strategies, was one of the best teleconference gave Balsley and ocher expert consultants seminars chat I have sac in on." Reginald an opportunity to discuss and answer Finger of the Kentucky department of NIH deputy director Dr. Ruth Kirschstein questions about the findings of rhe health services wrote, "Very interesting recently received the Georgeanna Seeger NIAID-sponsored AIDS Clinical Trials information, helpful for lecture presenta Jones Women's Health Lifetime Achieve Group (ACTG) protocol 076. This tions char I and our staff may be giving." ment Award. Sponsored by the Society for scudy, completed lase year, showed the And Nilson Toledo, a dental consultant the Advancement ofWomen '.r Health effectiveness of zidovudine (AZT) in wirh rhe Puerto Rico AIDS Education Research and Warner WeLlcome Consumer reducing the risk of transmission of HIV and Training Center, described che Healthcare in cooperation with the from infected pregnant women to their content of the conference as "very National Health Council, the award was offspring by approximately two-thirds. presented to Kirschstein on June 27 at the According to updated analysis of the Third Annual Congress on Women '.r study data, transmission rates were 7.9 "This was one ofthe best Health held in Washington, D. C. Jones, a percent for the AZT group and 27.7 teleconference seminars that johns Hopkins University School of percent for the placebo group. . ,, Medicine professor-physician and first Primary care providers participated in Ihave sat in on. woman president ofthe American Fertility the conference via telephone from all 50 Society, pioneered in the area of infertility states, the District of Columbia, Puerto informative, state-of-the-art and and helped establish it internationally as a Rico, Sr. Croix and Sr. Thomas, while usable ... borh for clinicians, primary credible field. She is credited with Voice of America broadcast worldwide healrh care providers and educators in founding the first in vitro fertilization via satellite and shore-wave radio to an HIV issues." facility in the United States and in 15)81 audience of more chan 1 million people. Other guest experts featured on the was responsible for delivering the first !VF Macher's office conducts a needs conference call panel included: Dr. baby in this country. The first woman assessment 3 months in advance of each Arlene Bardeguez of the University of director ofan NIH institute (NIGMS in conference call to gather questions from Medicine and Dentistry of New Jersey in 15)74) who also helped establish NJH'.r the primary care community on the Newark; Mary Boland of rhe National Office ofResearch on Women '.r Health in discussion topic. A summary of chose Pediatric and Family HIV Resource 15)5)1 , Kirschstein has been a scientist and compiled questions is then mailed back Center in Newark; Dr. Eric Goosby of administrator in the Public Health Service to providers before the conference call so the HIV Policy Office, Office of the for more than 40 years. they know what will be discussed. They Assistant Secretary for Health; Dr. can also ask additional questions ac the Cheryl Healton of rhe Columbia Brown Heads NCI Office rime of the call. University School of Public Health in Dr. Patricia Ann Brown has been After finishing the conference call, New York City; and Dr. Martha Rogers named director ofNCI's Office of Balsley praised the valuable service that of the Centers for D isease Control and Laboratory Animal Science (OLAS). Macher and his fellow panelists provide Prevention in Aclanta. She earned her V.M.D. from the health care professionals. "I found the To produce these programs, Macher University of Pennsylvania School of questions to be very practical questions collaborates with universities and Veterinary Medicine in 1978 and has that they [practitioners] find important medical centers, as well as with other held a number of positions from director in a real world setting." He noted che federal agencies, including the Depart of che Laboratory of Animal Medicine to importance of transferring research ments ofJusrice, Defense and Stare, the deputy director and acting director of the findings into clinical practice and Indian Health Service and the Veterans Office of Laboratory Animal Science. underscored that role "as one we should Administration. Her outstanding service has earned her play. It is our responsibility to the The next HIV Clinical Conference Call the PHS Achievement Medal, and che public." will focus on HIV viral load and will PHS Commendation Medal. In addition to discussing rhe clinical rake place Sept. 28 at 1 p.m. ET. For "The OLAS occupies a critical position application of rhe 076 regimen by health more information about how to register, in NCI research and the institute is most care practitioners, Balsley addressed the send a request via fax to Macher, 3- fortunate to have Dr. Brown at its helm," common side effects experienced by 1719 .- Jack Hilovsky D said NCI acting director Dr. Edward women and infants who take AZT, Sondik. D page4 The Record August I, 1995 RALL AND ROBBINS (Continued from Page 1) When Rall became the institute's scientific director in 1962, Robbins became chief of the CEB, a role he would play for nearly 30 years. They made a dynamic team that would help establish and nurture the scientific prowess of NIDDK for most of its 45-year history. Rall and Robbins were known firsc for cheir scientific expertise. Building on earlier work, they formulated the free thyroxine hypothesis, which proposed thac che concentration of free hormone in the blood is directly related to the hormone's action on cells and metabo lism. Ir is "a basic concept that has stood the test of rime," Robbins says modestly. NIDDK director Dr. Phillip Gorden (second from r) and NIDDK alumnus Dr. Jesse Roth Known also for cheir expertise in (l) join with honorees Dr. Jack Robbins (second from l) and Dr. Ed Rall at the symposium radiation carcinogenesis, Rall and entitled 'The Global Village ofj.E. Rall and Jacob Robbins." Robbins joined scientists from Brookhaven Laboratory to follow scientific infancy, really parental figures," was kinecic, and sparks flew. Marshall Islands inhabitants exposed to says Phil Gorden, NIDDK director and "People were more formal everywhere radioactive fallout from hydrogen bomb hose, with Nino Salvatore, of the sympo- else," Roth adds, "bur in that branch, tests in the Pacific. They were later sium. "To me, those were the defining everybody was equal. You said some- consulted during the crisis at Three Mile years of my career," added Benoit de thing, you had to be prepared to be Island in Pennsylvania, and they have Crombugghe, professor and chair of challenged. Jack and Ed would get continuously studied rhe fallout effects molecular generics at the University of challenged, openly, quickly. Data on the people of Nagasaki and Texas. counted, not who said it." Hiroshima as well as on thousands of "Ed thought his only job was tO select Robbins was quieter, a man with an children exposed to radiation during the excellent people, to encourage them and acute sense of humor, who loved puns. Chernobyl disaster, projects still yielding criticize them in ~------~ Rall was more given information about thyroid cancer. positive ways, and Rall, Robbins' 'Global Village' to repartee, the Their alter egos were no less significant: !er chem go," says "quick hand gre- Rall and Robbins recruited, encouraged, Jesse Roch. Re- Below is a partial list of scientists nade," says Roth. challenged, and delighted a steady stream search dollars were who were part of the Clinical Endocri- They set a high of brilliant young investigators and readily available in nology Branch: scientific standard clinical associates who would themselves the late 1950's and From Belgium, Phillippe de Nayer but criticized lend polish to NIDDK's reputation. 1%O's, and bright and Daniel Glinoer; constructively. Among their prize recruits were Nobelist young investigators From Australia, Sam Rose; "They had opinions, Harold Varmus, Dan Federman, Mitchell coming out of From South Africa, Andreis Van Zyl; thoughts, creative Rabkin, Ira Pastan, Sheuwann Cheng, graduate programs From France, Pierre Freychet and things to say," Harold Edelhoch, Bob Lefkowitz, Jan often faced the Jacques Nunez; remembers Gorden, Wolff, Jesse Roth, Phillip Gorden, Saul choice of being From England, Rosalind Pitt-Rivers and were comfort- Rosen, Ron Kahn, Henry Merzger, Vera drafted for military and Jamshed Tata; able raising ques- Nikodem, Hans Cahnmann, Reed service in Korea or From Finland, Panu Vilkki; tions outside rheir Larsen, Marvin Gershengorn, and Bruce Vietnam or doing From Germany, Dankwart Reinwein; own field. "They Weintraub. Gaetano Salvatore and postdoctoral work From Japan, Nobuo Ui and Yoichi were always inter- Mario Andreoli and many others came at NIH. With few Kondo; esred, excited, and from Italy, along with notable fully developed From the Czech Republic, Zdenek pleased by rhings," thyroidologisrs from a host of other biomedical research Kosrrouch and Marta Kostrouchova. adds Roth. countries, to create an international centers in the Gorden remembers consortium that further enriched their country at the rime, rhe best and bright a tremendous cross-fertilization among a energetic circle (see sidebar). est came to Bethesda. "We were drawing mixed and uninhibited group of highly Many of them reunited at NIH in June from the rop 5 percent of the graduate intellectual people, where core ideas to celebrate their mentors, each now programs at the best schools in. the abounded. Each person brought what he scientist emeritus, at a symposium citied country," recounts Earl Laurence, acting had to the group, and rook away some "The Global Village of J.E. Rall and deputy director ofNIDDK. thing new from the synergy that hap Jacob Robbins." The day's sciencific NIH was growing, but it was still small, pened there. "Somebody would throw focus was tinged with reminiscences char informal, and free-wheeling. In journal out something they had just read in made the event "touching" in Robbins' clubs, biochemists rubbed shoulders with PNAS [Proceedings ofthe National words. organic chemists and incipient molecular Academy ofSciences] and all of a sudden, "They were a part of everyone's biologists; in the CEB, the atmosphere something would click. Jack and Ed page 5 The Record August I, 1995 created a community where that sort of synergism could exist," says Gorden. NIAID s Dr. Albert Z. Kapikian has been As vital as the scientific circle was, elected president ofthe American Epide members of the CEB enjoyed as much miological Society. He is assistant chiefof becoming part of the Rall-Robbins the Laboratory ofInfectious Diseases and social circle when Bethesda was scill a heads the epidemiology section. He joins small cown. There were annual CEB other NIH'ers who have held the society's picnics, Christmas day gatherings, and presidency, including Dr. Rollo E. Dyer weekend trips to Antietam Meadows, (1948), Dr. J.A. Bell (1952) and Dr. J.E. the cattle farm near Sharpsburg, Md., Smadel (1963). Kapikian 's pioneering owned jointly by Ed, Jack, Barry studies using immune electron microscopy Blumberg, and Wil Rall. "They have led to the discovery, detection and charac the coldest shower you ever took; I terization ofimportant viruses ofhuman think they have the water piped in fresh disease such as the Norwalk virus, which from below the polar cap," quips Roth. causes epidemic gastroenteritis, and the Postdocs from Italy, France, and hepatitis A virus. He and his colleagues elsewhere especially appreciated their also developed and patented an experimen welcome. "I always felt the CEB ought tal vaccine to protect infants against severe diarrhea caused by rotavirnses. to be supported by the State Depart ment," jokes Robbins, alluding to the international relations he and Rall NIAMS DIRECTOR STEPHEN KATZ TAKES REINS ON AUG. 1 carried on through the years. (Continued from Page 1) Jean Robbins, Jack's wife and a professional cellist who played with the "I view chis appointment as a tremen dermatologic societies, and 1992 election Washington Opera, the National Bailee, dous challenge and an opportunity to into the Institute of Medicine of che and the National Gallery Orchestra, participate in setting health research Narional Academy of Sciences. loved to host musicales for CEB friends. policy and priorities chat address the Karz has served many scientific organi The Robbins' New Year's Eve party, chronic and often disabling diseases with zations in leadership positions, such as with four different quartets playing in which the institute is concerned," said president of the Society for Investigative different parts of the house, became a Karz. "Many of these diseases are those Dermatology (SID), membership on the tradition. "There were enough people," char I have been interested in for most of board of directors of SID and of the recalls Jack with a smile, "to have octets my professional life." Association of Professors of Dermatol and nonets. " Karz was most recenrly chief of the ogy, secretary-general of the I 8th World From 1981 to 1991, Rall served as Dermatology Branch, NCI, a position he Congress of Dermatology in New York NIH deputy director for intramural will maintain. H e was also Marion B. in 1992, and secretary-treasurer of the research, where he continued to cham Sulzberger professor of dermatology at Clinical Immunology Society. He has pion the freedom of the individual the Uniformed Services University of the also served on the editorial boards of scientist. As an emeritus, he works now Health Sciences, a position he relin most clinical and investigative dermatol on thyroid/steroid hormone receptors quished last month. ogy journals and of many immunology and is excited by the insights provided Katz' studies of Langerhans cells and journals. He has authored or coauthored by molecular biology. epidermally derived cyrokines have more than 180 scientific articles and 50 He thinks NIH will continue to thrive. demonstrated chat skin is a critical book chapters and edited several confer "Cross fertilization is one of the great component of the immune system both ence proceedings. strengths of rhe NIH," he asserts. He in its normal function and as a target in Katz was born in New York City in calls the juxtaposition of patient care immunologically mediated diseases. He 194 I and grew up in the Washington, . units, clinical investigators and basic has also made seminal discoveries in the D.C., and Bethesda areas. He earned a science labs "one of the geniuses" of the field of inherited and acquired blistering B.A. degree wm Laude in history from Clinical Center. skin diseases. the University of Maryland; an M.D. Robbins continues his work in thyroid Ac NCI, he has led a prngram of degree cum Laude from Tulane University cancer in children. Both men concede invesrigations in fundamencal biological Medical School; and a Ph.D. degree in that scientific life today is much more and clinical problems in neoplastic and immunology from the University of complex. nonneoplastic diseases of the skin. He London. He completed a medical In the beginning, "if we needed to do has trained a large number of outstand internship at Los Angeles County electrophoresis, we designed an instru ing immunodermacologists in and Hospital, a residency in dermatology at ment and built it over in the shop," outside of the U nited States. the University of Miami School of Robbins says quietly. Today, they agree, He has received many government and Medicine, military service at Walter Reed kits for various procedures are conve private sector awards, including the General Hospital in Washington, D.C., nient if pricey, and make many processes Presidential Executive Meritorious Rank and postdoctoral work ar the Royal simple and efficient. Automation has Award, the PHS Superior Service Award, College of Surgeons of England. He accelerated the pace of discovery. the NIH Director's Award, the joined NIH in 197 4 as a senior investiga Characteristically, Rall says, "It's Sulzberger Lecture Award of the Ameri tor in the Dermatology Branch, becom certainly the most exciting time in the can Academy of Dermatology, honorary ing acting chief in 1977, and chief in world to be alive, if you' re in science. "O membership in many international 1980. D page6 The Record August l, 1995 INN ANNIVERSARY GALA EMPHASIZES KIDS, HOPE AND HOME (Continued from Page 1) inn board, recalled a dark moment in live, to love, and to laugh. 1972 when their son Matt, then an It's a place to grow up. I infant, was diagnosed with terminal found our at the inn that I !" cancer in their home city of St. Louis. didn't have just two "Mace is now 24," Gephardt beamed, parents. I had 10 parents, "and will be attending law and business 100 parents." school in the fall." Scanding well over 6 feet Also bearing cancer was lunch-hour tall and sporting a Hugh emcee Craig Kline, 26, of Freehold, N.J., Grant hair-do, Kline was who came to che inn in October 1990 upstaged by little Brian suffering from Burkicc's lymphoma. A Scholl, age 13, whom recent graduate of the University of Kline described as his Virginia law school now headed for "roommate, friend and practice in Manhattan, he underwent 4 mentor." ,,;,r.v-~~-r..·,· months of treatment at NIH and has "When I first met Craig, d .._. he was in pretty bad NIH irector Dr. Harold Varmus (l) escorts Rep. Richard recently been in remission. shape," confided Scholl, Gephafirdt _(D-Mo.} and his wife Jane (~n inn board member) "Words alone can't express how • I d II d to the estzval tent at the noon celebration July J J. wonderful it is ... just co be here on this bearing a arge o an most precious day," he said. "I came speaking with such crowd-pleasing here 5 years ago a tired, weak, frightened assurance chat Gephardt later hoped person, and I met some of the finesc never co face him in a political race. "I people I have ever known. You under figured I'm just not going to lee this guy stand the minute you come rhrough char die." Scholl was similarly blunt on the front door chat you're at home." value of che inn: "Ir's like love, basically, He called the inn "a place co learn, co everywhere. Everything you need is donated. It's just wonderful here." Love was nowhere more palpable than in the bearing of Naomi Thornton of Baltimore, who sat at the far edge of the festival tent eating a hamburger with her foster child Kweisi Woods, 8, who was born borh HIV-positive and with cerebral palsy. Naomi Thornton ofBaltimore and her Having lose both a son and a cousin to foster child Kweisi Woods, 8, enjoy a light AIDS, Thornton, a nursing assistant who moment during lunch. has cared for both geriatric patients and children, arranged through Baltimore's both literal and metaphoric. 1 Kennedy-Krieger Institute to take in "He's gone from a size 2 / 2 to a size 4'/z little Kweisi, a big-eyed, gentle child who shoe. And he's gained quire a bit of ..... weight, which is good. He's been very Cancer survivor Craig Kline, 26, of demonstrated personable fluency with healthy. Never sick once during the Freehold, N.j., greets Rep. Connie Morella his foster mother but would venture not winter." (R-Md.) during the noon hour festivities. a syllable to an interviewer. "He likes coming out Having grandchildren who span ages 2- here," said Thornton, 22, Thornton says Kweisi firs right in. who had co take classes to "We're just family. He's part of the become a foster parent family. Our whole family has grown and who now attends from having him around-my sisters, my twice-weekly counseling mother, aunts, church people. He has a sessions at NIH co help big brother at our church (Pleasant Zion parents of ailing young Baptist Church). And he sings in the sters cope. "Right now, choir. Got a pretty voice." he's my job." Though his legs are in braces and he A scoic woman with eyes occasionally uses a walker when he can undimmed by pain, manage to bridle his natural enthusiasm, Thornton observed, "A Kweisi is quite active. "Anything his legs lot of people don't want will allow, he'll do," says Thornton. "He to take children [Kweisi's) likes to ride his Big Wheel; he can't ride ' age. He's grown quite a a bike. He loves to read." Bob Gray, executive director of the inn, greets NJH'ers who bit since he's been with Finally, Kweisi abandons his silence turned out for the breakfast, which was the inns way of me. " when asked his favorite activities: "Play thanking its many generous patrons among employees. The growth has been anything," he blurts pleasantly before page 7 The Record August l, 1995 unless you've been through it- not even your family ac home. Everyone looks out for everyone else's child-ic's like Craig (Kline) said- chere's nor one mom, there's 10." The hope, good wishes and support of parencs help rhe Moores gee through each day, one day at a time. M ike puts in a special word for Clinical Cencer caregivers: "They provide so much love, so much safety and security. Face-painting, games and other activities were available for kids at the noon celebration. Casey didn't want co go home, she of leukemia was made. became so attached to them. We Casey recalls a first day of unending couldn't possibly give back what we've rests at the Clinical Cenrer, culminating gocten from chem." in the relief of a warm welcome at the He said che 2 years chat have-elapsed mn. since that fateful morning of diagnosis "Ir was just incredible," enthuses have passed "like 2 weeks. We feel like Casey. "They gave me a big welcome, these anniversary parties they throw in we got a tour of the inn, and they made July are parcies for our being here." sure we were comfortable. They make Concludes Linda Moore, "The most you feel totally at home." importanc thing to remember is that the Now in the maintenance phase of her inn is not a place rn sleep. It's much, prococol, which requires only two nights much more than chat, and chose are the Casey Moore (c) says the inn has helped a month at che inn, Casey recalls with chings that make the inn special. " immeasurably in her fight against cancer. pleasure an ice storm char once kept the Helping preserve and nourish chat sense Here she sits with parents Linda and Mike. Moores inn-bound for a week: "A loc of of caring is Dolores Dalomba, che inn's ambling off to spend his allotment of che kids couldn't fly our, so we all ran resident manager for the pasc year and a around together, playing Nintendo, carnival tickets. half. She came to the inn having held a watching TV, doing whatever we More willing to schmooze was Casey similar post in a high-rise luxury building wanced. It was great." Moore, 14, of Harrisburg, Pa., a rising with many elderly residencs. Asked what's best about che inn, she 9th grader who has been coming to NIH "I didn't know whac to expect when I declares, "All the other kids that are and the inn since July 1993. "It's like goc here," she admits. "In my previous there. The kids have been through job, I had to deal with disabilities such as my dad and I say, it's my home away treatment, they know how I'm feeling. from home," she said of the inn. Alzheimer's disease and broken hips," she It's just the greatest thing." Moore and her parents, Linda and said. "Bue with older people, you know Her parents concur that it's the Mike, had never heard of NIH and the end result. Here, you know some camaraderie of families facing similar will get well, which balances the knowl Bethesda on that summer morning 2 crises that gives the inn its special edge that some you will lose. it were years ago when they visited cheir surgeon If character. for a IO o'clock appointment. "By 3 only constant loss, it would be very, very "T hat is an undervalued part of the difficult. I've seen many recover." o'clock, we were ac NJH," says Linda, whole process of dealing with childhood DaLornba says che strength of the kids marveling at the speed with which cheir illness," said Mike Moore. "Ir's very is most impressive co her. "The kids are lives were transformed once a diagnosis important to fight chis thing mentally as great- they have a great deal of courage well as physically, and the inn provides and fortitude. You learn a lot from chis help. It's a whole new subculture, them." with a new vocabulary that you have to Parents, too, she said, need all the learn, and a new environment. The inn strength they can muster. "They cope serves as a link between your old way of with burdens differently. Some cake it living and the new one chat is very real, real hard. Some are sick themselves. important." But we all pull together and support the "We have made many friends here," kids and each other. The kids make adds wife Linda. "And it doesn't stop friends wich each ocher and the parents when you leave here. There are constant make friends wich each other." calls to other patients, keeping in touch. What parents most provide one another The support continues." is hope, she observes. "You see parencs Boch credit the inn staff with strong with kids at different stages of illness. support, and with brokering relation Ir's important for the ones just starting ships between parents in similar binds. out to realize [from more experienced "Sometimes they'll just direct you to a parents] chat there is hope, there is B1·ian Scholl, shown here with his toy doll, parent in che same circumstance," said another side ac che end of this ordeal." paid tribute to his roommate, Craig Kline, Linda. "And thac's important because no Since April, Dalomba reports, the inn who has fought cancer successfully. one really knows how you' re feeling (Continued on Page 8) Photos: Ernie Branson page 8 The Record August I, 1995 (Continued from Page 7) has experienced a surge of requests for rooms that it is not always able co accommodate. "The hardest parr of the job is saying there's no room at rhe inn," she said. "Ar least another IO rooms would be nice. Bue anything that helps make the family more comfortable would be high on my list of priorities." The emotional costs of chis kind of work are high, she allows, but such stakes ~-"'-- attract a very caring sort of staff. "The The Kapitol K!owns visited during lunch and bestowed hugs and humor on party guests. inn attracts wonderful people," she said. "If we can help ease (families'] pain, it on interest income alone. Russell said an founding fathers, NCI Pediatric Branch helps, whether it's a happy ending or endowment of $12 million is needed. chief Dr. Phil Pizzo: "I believe that the not. " Conflicting trends have made the inn's greatest success has been in provid DaLomba, who is off duty on Fridays future hard to map, she suggested: not ing a family-centered environment that and Saturdays, has a retreat co which she long ago, patient census was high and the has supported children and fam ilies repairs in the mountains of West Vir inn was "turning away two and three facing the challenge of serious illness, ginia, near Martinsburg. "It's very quiet, families a day, which put us in a crisis empowering chem to participate in the peaceful and rural. I come back re mode." Plans were drafted co add 18 clinical research mission of the NIH. freshed." rooms to rhe existing facility, which had Without the inn, it is hard to believe chat The inn has grown from four full-rime been built with eventual expansion in we could conduct intensive outpatient staff to six in the past 5 years, and a cadre mind. Bur then came federal downsizing based research protocols in childhood of some 275 volunteers- many of them and, now, "NIH pediatric programs are cancer, AIDS and ocher important areas NIH'ers- pirches in as well. Still, shrinking, and the census is coming of pediatric research. In my opinion, the holiday weekends, particularly religious down. But che inn is generally full these Children's Inn serves as a partner in the holidays such as Easter, can be hard co days. If pediatric programs continue to clinical research mission of the NIH. Ir staff, said Dalomba. shrink, expansion won't be necessary." provides comfort for children and their "The D .C. metro area has a constancly But maintenance and operation coses parents, helps keep siblings and ocher changing population," she acknowledged, will continue, and one day rhe inn will family members together, and provides a "so we have a lot of volunteer turnover. need physical improvements such as a beacon of hope for the future. The Life circumstances change-jobs change, new roof or ocher replacements, she Children's Inn continues co serve as a people go back to school. Some come reported. symbol to the NIH and its community back to us after being away for a while." In other words, rhe inn is like most 5- chat improving the lives of children is "We are truly blessed co have the year-olds: it has weathered growth pains, important and that the NIH is dedicated continued support of a wonderful staff," developed a personality and is maturing to comforting the spirit while seeking said Kathy Russell, past president of the despite a menu of obstacles. And, like new ways to heal the body." inn, present board member, and chair of the patients, it has so many "parents" in The Children's Inn at NIH the inn governance committee. "We the form of dreamers, benefactors, and CFC# I 007-is a private, nonprofit have also been blessed by the support of caring people that future milestone charitable organization dependent on Merck," which has pledged almost $5 birthdays seem all but assured. private contributions for its operating million in support of the inn since 1990. Concluded another of che inn's needs. 0 The challenge in the next decade, she said, "will be to sustain the mission of the inn in the face of cutbacks in N IH The NIH Life Sciences funding and in the economy, which is Education Connection not as successful as when we builc the IIATIONAI. INSTI~ T\l~ TE!!!S1110F!'l,H.;:EAL,-,ITH.,.., inn.,, c:e, /;& ~ Come to Poster Day 1995 on Aug. 4 to find out what She viewed the birthday gala as an ~"'-4 ION"S \~ young scientists at NIH are learning and discovering. This opportunity "to draw artention to the year, 370 high school, college, and medical students will be fact that we can only survive with presenting their summer's work. Stop by and show your support. The poster continued financial support. CFC and session will be held in the Bldg. 10 lobby area and Visitor Information Center NIH support is just critical," she empha from 10 a.en. to l p.m. For more information, call Deborah Cohen, 2-2176. sized. "We need the insricucional ~ The Speakers Bureau, sponsored by the Office of Research on Women's support of NIH-the in-kind services Health, needs volunreers. This is a great opportunity to increase your visibility in such as landscaping and interior and the community by speaking to students, government employees, or civic groups. exterior maintenance. Ir's an exciting Speakers typically discuss their research specialty. Popular topics requested are time. It keeps us focused on being able breast cancer, Alzheimer's disease, cardiovascular disease, fitness, nutrition, and to sustain che dream." osteoporosis. The bureau also needs speakers on careers in science, women in The inn's goal has always been co science, and rhe scientific process. Requests for speakers are screened and facili acquire so generous an endowment that tated through the NIH Office of Science Education. If you are interested in it could sustain itself from year to year becoming a member of the Speakers Bureau, call Gloria Seel man, 6-0608. page 9 The Record August l , 1995 N/AMS' Stephen Gordon Retires After 30 Years By Barbara Weldon ~ ---.- .__ _,_, - ...... , Medical and Biological Engineering. Gordon has coauthored numerous r. Stephen L. Gordon, rhe first articles and books on bone fo rmation, D chief of the M usculoskeletal low back pain, total hip replacement, Diseases Branch, NIAMS, recently effects of space crave] on the musculosk retired after 30 years of government eletal system, and effects of exercise. His service. "Dr. Gordon is che definition of lacesc endeavor is a book in progress on the best in public service. No one has Repetitive Disorders ofthe Upper Extrem had a warmer, more producrive associa ity. tion with the grantee community. He "Unlike many retirees who are eager co developed fields of research in the hang out a sign 'Gone Fishing,' I would musculoskeleral arena char didn't exist rather continue my efforts on making before," said Dr. Michael D. Lockshin, people better. I am looking forward co a NIAMS acting director. second career in the private sector, Gordon came to NIH in 1978 as a Then NIAMS acting director Dr. Michael working in the biomedical fields of grants associate co gain insight into Lockshin (1) presents a special recognition injury prevention and orthopaedic funding, management, and public policy treatments," Gordon said. 0 award to Dr. Stephen Gordon "in recogni issues in biomedical research. In 1979, tion ofhis years ofdedicated, exemplary he joined what was known as the service to the NIAMS, to the NIH, and to Lunch Hour Dance Class National Institute of Arthritis, Metabo the academic research community as Still haven't figured our the Electric lism, and Digestive Diseases, as the first director ofthe Mmculoskeletal Diseases Slide? How about the Booe Skootin' director of research on orthopaedics. Program." Boogie or che Achy Breaky Heart? Now When NIAMS was created in 1986, he you can learn these popular country became the first chief of its M usculoskel western line dances and many more ecal Diseases Branch. In chat capacity, Council on Physical Fitness and Sports, here at NIH during your lunch hour. he is credited with spurring biomedical a panelist on the surgeon general's Every Tuesday, from noon to 1 p.m., in research and interventions in low back workshop on health promotion and the 14th floor gymnasium of the Clinical pain, osteoporosis, osreoarthricis, spores aging, an advisor to the FDA on os Center, the R&W Country Western medicine, and repetitive motion disor teoporosis and to the World Health Dance Club holds open-to-all classes to ders. He was responsible for more than Organization committee on osteoporo learn and practice the latest line dances. 150 grants and contracts with a budget sis, and a consultant to NASA on No experience needed. No "pardners" in excess of $26 million. biorobotics and space station programs. needed. A few more men would be nice. Gordon says chat NIH is an exciting, A native of Philadelphia, Gordon Written instructions are available. Wear invigorating environment and there are received a B.S. in mechanical engineer soft-soled shoes co protect the floor. many opportunities to have an impact ing in 1967, an M.S. in biomedical Voluntary donations to the club of $1-$2 on a national level. "One of my greatest engineering in 1970, and a Ph.D. in per class are accepted. Dennis Askwith, accomplishments has been to play a key biomedical engineering in 1973, all from 6-5031, has more information. 0 role in biomedical research and interven Drexel University in Philadelphia. tions in osteoporosis," he said. He During his graduate years, he was an 'Science of Business' Session added that, years ago, most women independent research investigator for the thought chat osteoporosis was a general Naval Air Development Center in NIH will be presenting a poster session consequence of old age and the disease Pennsylvania. His research centered on entitled, "The Science of Business," on was nor well understood. The 1984 mathematical and computer analyses of Thursday, 0cc. 12, in the Visitor Consensus Development Conference on large crash simulation studies. From Information Center, Bldg. 10. The Osteoporosis encouraged research into 1973 through 1977, he was chief of a purpose is to publicize reinvention and the disease and brought co the attention biomedical engineering group analyzing reengineering efforts throughout NIH. of the American public chat medication, simulated car crashes for the Safety If you wish to participate as an exhibitor, diet, and exercise could alcer the course Research Laboratory, National Highway call Carl Lucas, 6-6752, Elmer Sembly of the disease. Traffic Safety Administration. III, 4-4935, or Bob Schaller, 4-4923. Dr. Lawrence E. Shulman, former Gordon is che recipient of many Participation will be limited to 30 NIAMS director, said, "We have awards and honors, including the NIH posters, and deadline for registration is accomplished much together over the D irector's Award and special recognition Aug. 15. D years, consensus conferences on os awards from NIAMS, rhe Academic teoporosis and on total hip replacement, Orthopaedic Society, and the Os Performance Study Recruits scientific workshops on back pain, teoporosis Foundation. He is a member The USUHS department of medical initiati ves in space research on bone and of many scientific, professional, and and clinical psychology needs healthy muscle with NASA, and successful public organizations including the male, nonsmoking volunteers, ages 29- initiatives in spores (and baller) medicine Orthopedic Research Society, che 45, for a 2½-hour study of the effects of both here and in the USSR." American Society of Bone and Mineral noise on performance. A $30 payment is Gordon has served on several congres Research, and the American Running provided. Call Laura or Martha, (301) sionally mandated task forces. He has and Fitness Association. He is a found 295-3263. D been an advisor to the President's ing fellow of the American Institute of page 1 O The Record August I , 1995 PERTUSSIS chose normally found in the U.S., where (Continued from Page 1) NIDR's Harding Mourned, pertussis is much less common. Spent 47 Years at NIH respectively, in protecting vaccinated National surveillance data and observa Mel Harding, 71, who managed children against pertussis, and caused tional studies clearly indicate that the NIDR's Animal Care Unit until his significantly fewer side effects than did a pertussis vaccines currently licensed in retirement in 1992, died on June 6 at whole-cell vaccine currently used in the the U.S. are safe and effective. These his home in Rockville, Md., following United Stares. A fourth acellular vaccine vaccines have reduced the annual number a massive heart attack. also had fewer side effects chan the of reported cases in the U.S. by more Harding was born in Gaithersburg, whole-cell vaccine, bur was less effective than 95 percent. In addition, the few Md., and was a long-rime Montgomery (58 percent efficacy). In both the Italian vaccinated persons who develop pertussis County resident. and Swedish studies, the whole-cell generally have milder disease than He first joined vaccine was less protective than the unvaccinated persons who have pertussis. the government acellular vaccines, with efficacy rates of Children in the U.S. generally receive a in 1945 as a 36 percent and 48 percent, respectively. whole-cell pertussis vaccine as part of a laboratory The two large-scale efficacy trials began diphtheria-cetanus-pertussis (DTP) technician with in 1992 and together enrolled more than formulacion at 2, 4 and 6 months of age, what was then 25,000 children. The four acellular with additional shoes at 12 to 18 months the National vaccines previously underwent extensive and before entering school. The whole Institute of safety and immunogenicity resting in cell pertussis vaccine, or one of two Health. His infants in the U.S. in NIAID's Vaccine licensed acellular pertussis vaccines, can love of animals and Treatment Evaluation Units. be used for the fourth and fifth doses. and concern for "While whole-cell pertussis vaccines No booster doses were given in the trials their well-being Mel Harding have saved tens of thousands of lives and in Italy and Sweden. led him to a job have long been the cornerstone of "Until the new vaccines are available," with a forerunner ofNCRR's Veteri childhood immunization programs in the noted Fauci, "the Public Health Service nary Resources Program. U.S., acellular vaccines promise to recommends that parents continue co In 1953, Harding came to NIDR as become the new gold standard in have their infants immunized against an animal care technician and went on pertussis immunization," said NIAID pertussis wich the current vaccine, which co help establish the institute's germ director Dr. Anthony Fauci. "These for many years has safely and effectively free animal unit. This group produced results mark important progress toward controlled this disease in the United one of the most exciting discoveries in the eventual NIAID goal of developing States." dental research by proving chat rooth acellular combination vaccines that can Whole-cell pertussis vaccines are decay is an infectious disease. In 1968, protect children against numerous composed of killed Bordetella pertussis he was appointed manager of NIDR's diseases with a minimum of vaccine shoes bacteria. Acellular pertussis vaccines animal care unit. and a minimum of side effects." consist of purified components extracted Harding was credited by the investi "These trials, the culmination of more from the organism. All of the acellular gators who worked with him for than 15 years of N IAID efforts in the vaccines in rhe two trials contained an changing the institute's perception of development of acellular pertussis inactivated form of pertussis toxin, either animal care and for helping guide vaccines, represent a critical step toward native or recombinant. 0 NIDR inco the modern era of labora licensure of these vaccines for young tory animal science. infants in the U .S.," added Dr. John La Training Classes Even after 47 years of federal service, Montagne, director of NIAID's Division DQD" he remained active in NIDR's CFC of M icrobiology and Infectious Diseases, Introduction rn Computer Securiry 817 campaign. He was also active in crafts; which supported the two trials. "NIAID Gerring Starred wi rh Windows 8/8 many of his seasonal decorations can be is working closely with the Food and C URE -PC Network Group 8/8 QMF Access to Human Resource seen at the Children's Inn at NIH. He Drug Administration and the vaccine Data for Personnel 819-10 was a tireless worker who will be manufacturers to ensure that these PC Topic Session 8/10 missed by those who knew and worked acellular pertussis vaccines become Managing & Oprimizing D82 Tables Workshop 8/11 lnrroduction to HT ML 8/ 14 with him over his long career here. available as soon as possible." To Getting Starred with Windows 8/ 14 He is survived by two brothers, expedite approval of new acellular NIH SQL Proccssor Wo rkshop 8114 Albert Harding, Jr., and Charles B. pertussis vaccines, NIAID is making Netscape for the Macintosh 8/ 15 Harding, and six sisters, Hazel available the testing facilities of its W indows NT and NTS H ands-on W orkshop 8/ 16 ENTER MAIL 8/17 Emerson, Ruth Kidwell, Hanna Vaccine and Treatment Evaluation Units Learn rhc Power of PUB NET Using Windows 8/17 Harding, Doris Smith, Elizabeth to assist manufacturers in collecting any Learn rhe Power of PUBN ET Usi ng rhe Mac 8/17 Webb, and Delores Bell. He is also addicional necessary data. Da raba.se T echnology Seminar 8/18 Clienr/Server Database Connec The Record August I, 1995 Christian B. Anfinsen, NIH Nobel Laureate, Dies the Sciences (FAES), designed to provide By Alan N. Schechter university-level courses for the NIH hristian B. Anfinsen, winner of the community. In the early 1960's he C Nobel Prize for chemistry, died of introduced intensive participacory an apparent heart attack on May 14, at seminars to che Research Associate the age of 79. In 1972 he shared, with Program for young physicians coming to Stanford Moore and William H. Stein of NIH in the Commissioned Corps. Rockefeller University, the Nobel Prize These seminars markedly broadened che for studies conducted in the NIH program as a research training experi ence, and spread recognition of it intramural research program. The nationally and internationally. Swedish Royal Academy of Sciences cited Born in Monessen, Pa., on Mar. 26, him for his "studies on ribonuclease, in 1916, Anfinsen received a B.A. from panicular the relationship berween rhe Swarthmore College in 1937 and an amino acid sequence and the biologically M.S. in organic chemistry from the active conformation." University of Pennsylvania in 1939. He At the time of his death, Anfinsen was received his Ph.D. in biological chemis professor of biophysical chemistry at try from Harvard Medical School in Johns Hopkins University. Originally 1943. recruited to NIH in 1950 by James He subsequently caught at Harvard Shannon to the newly created intramural Medical School and the Weizmann research program of the then National Institute of Science in Rehovot, Israel. Heart Institute, Anfinsen was chief of the He held visiting professorships at the Laboratory of Cellular Physiology there Carlsberg Laboratory, che Nobel Medical until 1962. He went tO Harvard for a Dr. Christian B. Anfinsen Institute, and Oxford University. year, but was recruited back co NIH by]. At the time of his death, he was Edward Rall, scientific director of the the time it was proposed, this elegant overseeing a project funded by the then National Institute of Arthritis and principle has become part of the funda National Science Foundation to develop Metabolic Diseases, now NIDDK. mental paradigm of molecular biology as thermostable enzymes for remediation of Anfinsen was chief of that inscitute's well as the basis of vast biotechnology environmental contamination. 0 Laboratory of Chemical Biology from efforts. 1963 to I 981, when he "retired" to In subsequent work, Anfinsen and his Hopkins. colleagues identified and isolated che first TPAININr TIID: In 1956, while working with Fred protein of the group now called chaper The Division of Workforce White and Michael Sela to determine the ones, the protein-disulfide isomerase. Development, OHRM, offers entire amino acid sequence of ribonu They helped develop the technique of the following courses: clease (RNase), Anfinsen noted chat the affinity chromatography in biochemistry. disulfide crosslinks in bovine pancreatic Their protein folding studies, done Courses and Programs Staning Dates RNase could reform, with restored largely with staphylococcal nuclease, Management and Supervisory, 6-6211 enzymatic activity, after chemical determined the mechanism of folding for Attirudcs: How They Affect Productivity in disruption. this protein, and their use of chemical the Workplace: 8/3 Lacer, he demonstrated that che synthesis allowed the investigation of che Successful Middle Managem The Record August I, 1995 NC/'s Fraumeni Receives Cancer Research Award Sign Up for AIDS Walk The Washington AIDS Walk is his year's General Motors Cancer counseling. The doctors realized, scheduled co take place Saturday, Sept. T Research Foundation award however, that generic data might expose 23, sponsored by the Whitman/Walker winners included NCI's Dr. Joseph F. carriers to psychological stress, social Clinic. The R&W and NIH Gay & Fraumeni, Jr., director of the Epidemiol stigmatization, and barriers to employ Lesbian Employee's Forum are working ogy and Biostatistics Program, Division ment and health and life insurance. A co organize all NTH groups co march of Cancer Etiology. He and Dr. p53 predisposition resting program was together. Each group is encouraged co Frederick P. Li of the Dana-Farber delayed until a research program to assess wear NIH logo shirts, lab coats, or Cancer Institute, Boston, and a former risks and benefits could be established. something unique co their institute. NCI employee In 1991, at two international work NIH walkers are being asked to specify himself, shared shops, the doctors and their colleagues Whitman/Walker of Suburban Maryland GM's Charles S. authored a set of recommendations for on their pledge registration form. A Mott prize for predictive generic testing. A testing grant has been applied for through outstanding program was then developed and is now Suburban Maryland so chat a portion of research in cancer available for families with Li-Fraumeni the proceeds are donated co Camp causation and syndrome and is used ro identify carriers Funshine, Special Love Inc.'s weekend prevention. for early intervention. family camp for children diagnosed The two Fraumeni gave a lecture describing the HIV-positive. scientists are evolution of research and discovery about Registration forms are available at all recognized for the the family cancer syndrome recently at R&W locations. Needed are team discovery of Li- the annual GM Awards program at N IH. leaders and walkers from last year who F raumeni Dr. Joseph Fraumeni Jr. The GM prizes are considered by many would like co help or participate in this syndrome, a family co have the mosr rigorous jury selection year's event. In previous years, there has cancer syndrome that involves at least six process of any major biomedical research been great participation from NIH'ers in types of cancer affecting children and prize. The award includes a cash prize the walk. R&W is looking forward to young adults, and for their pioneering and a medal. having the groups join together with research on genetic testing that i-dentifies In addition co his position at NCI, first-time walkers to make a statement on gene carriers for early intervention. Over Fraumeni is also an adjunct professor of behalf of"the world's premier center for three decades of research, they helped epidemiology at the Harvard School of AIDS research." create the field of molecular epidemiol Public Health and the Uniformed For more information or co volunteer, ogy for the study of cancer causation and Services University of the Health call Jodi DeOms at R&W, 6-6061. D further classified rhe importance of genes Sciences. He received his undergraduate as risk factors for cancer. degree from Harvard College and his In l 969, the doctors published their medical degree from Duke University. PC Topic Session, Aug. 10 first description of a familial disorder of He completed his residency at Johns DCRT's Discributed Systems Branch diverse and apparently inherired cancers. Hopkins Hospital and Memorial Sloan holds regular PC Topic Sessions de At the time, mosr forms of cancer were Kettering Cancer Center. He also has a signed to keep NIH'ers up to date on thought to have distinct causes, and master's degree in epidemiology from rapidly advancing PC rechnology. genetic and familial susceptibilities were Harvard School of Public Health. D Featured Thursday, Aug. 10, 9:30-11 not believed ro play an important role in a.m. in Bldg. l0's Lipsett Amphitheater cancer causation. The doctors helped co Sailing Lessons Offered will be Systems Compatibility Corp.'s "break the mold" and bring new think Join the fun with the NIH Sailing Outside In for Windows. ing about genetic susceptibility in cancer. Association. Basic training classes start Windows users today have an incred "Our work seemed like a hopeful sign. Wednesday evening, Aug. 23. Cost is ibly wide assortment of software applica We used to believe that every cancer had $110 plus $35 membership dues. tions co choose from. The downside of a separate pathway. However, if differ Course includes six evening classroom this blessing is the profusion of incom ent cancers share pathways, as they seem sessions, a Saturday morning orienta patible file formats. What do you do to do, then prevention could be simpli tion at the marina and three or four when someone sends you a file created fied," said Fraumeni. weekday afternoons on South River with an application you don' t own? If Their work subsequently led to near Annapolis, with two students and you're smart, you reach for Outside Tn, collaborative molecular studies that one instructor in the club's Flying Scots rhe premier file viewer. Outside In not related Li-Fraumeni syndrome to an (19-foot sloop-rigged centerboard only lets you view and print-with inherited alteration in p53, a tumor daysailers). Students successfully original formatting intact-files in suppressor gene chat in a mutated form is completing the training qualify ro dozens of word processor, spreadsheet, now recognized co be associated with a charter these boars at low races. darabase, and graphics formats, but it wide variety of sporadic as well as Students must be NIH or NOAA also integrates with Microsoft Mail and heri cable cancers. employees, patients, or contractors, as Windows File Manager for one-click The discovery of p53 mutations in well as R&W members. Application access co its features. Come see for many families with Li-Fraumeni syn forms (class and membership) and more yourself the closest thing co an indis drome provided an opportunity co information on the Sailing Association pensable Windows utility we know of, identify unaffected carriers of rhe gene are available at the R&W activities desk and find out what SCC has in score for for early cancer detection, treatment, and in Bldg. 31, Rm. BIW30. Windows 95. D