Puberty and Fertility in CF

Total Page:16

File Type:pdf, Size:1020Kb

Puberty and Fertility in CF Managing Nutrition & Digestive Problems — Puberty and Fertility in CF PUBERTY AND FERTILITY IN CF Puberty * is the period of time GROWTH AND DEVELOPMENT IN PUBERTY Your son or daughter may find it when a person’s body changes and Young people with CF go through hard to start puberty later than becomes sexually mature. Puberty puberty and develop into men friends and classmates. Your child occurs when certain hormones * and women just as other people may be self-conscious about being (special chemicals in the body), without CF do. Adolescents with one of the shortest kids in his or such as estrogen ,* testosterone ,* CF, however, may start puberty her class or being less developed and growth hormone ,* are made later than other adolescents. Some than the other kids in the locker by the body. This “surge” or in - of the physical signs of growth and room. If your child is struggling crease of hormones sends signals development that may be delayed with feelings about puberty or how to the body and leads to dramatic include: he or she looks, talking with a CF physical and emotional changes. health care team member may • Getting taller or reaching close Adolescence * is the stage of help your child figure out ways to to adult height development when puberty takes improve nutrition or general place. At no other time in a • Underarm hair, pubic hair, and health to speed up the start of person’s life is there such intense facial hair (in boys) puberty. The CF health care team growth and development, except • Boys’ voices getting deeper and can also help reassure your child during infancy. Although we talk their genitals * growing larger that the time will come for him about “reaching puberty,” it • Girls developing breasts and or her to go through puberty—it doesn’t happen overnight— beginning to have menstrual will happen. puberty is actually a process that periods * or menses * takes three to five years. No two When puberty starts may depend MALE FERTILITY adolescents * go through puberty on the overall health of a person. During puberty, boys with CF exactly the same way nor do they A person with CF who is under - develop normal physical sexual reach puberty at the same age. weight, for example, or who has features. They produce sex Although changes in the body are severe lung disease may go hormones and have normal sexual most noticeable, an adolescent’s through puberty later than other drives. More than 90 percent brain is maturing during puberty adolescents with CF. Severely of men with CF, however, are as well, and will continue to underweight girls may begin their infertile * and cannot make a mature after the body is fully periods even later, or their periods female pregnant. Being infertile developed. With these brain may not follow a regular cycle. does not mean that a man is and body changes in puberty, Having enough body fat helps impotent (unable to have sexual adolescents’ interests change and puberty start on time. Adolescents intercourse *). Men with CF can most become more focused on with CF who have good nutrition have sexual intercourse and dating, relationships, appearance, will usually have a normal growth produce sperm * like other young and sexuality. spurt. However, some children men. But in CF the tube that carries the sperm from the testes A person normally becomes with CF, even when well-nourished, tend to start puberty late. A reason to the seminal vesicles * (called fertile * during puberty. Fertility * the vas deferens *) is blocked or is a woman’s ability to conceive * for this may be how a person with CF makes and uses growth absent. When the vas deferens is (become pregnant) or a man’s absent, it is called congenital ability to bring about conception * hormones. If your child does not show any signs of puberty by age bilateral absence of the vas (getting someone pregnant). deferens * (CBAVD). If a man Sometimes certain conditions 14 for boys (an increase in size of the testes * is the first sign) and age has CBAVD, his semen * (the fluid or diseases can affect the onset of ejaculated * from the penis * when puberty. Cystic fibrosis * (CF *) can 13 for girls (breast development is the first sign), talk with your sexually stimulated) contains no affect the timing of puberty and sperm. For pregnancy to occur, a fertility in both males and females. doctor. Your child may need to see a pediatric endocrinologist ,* man’s sperm cell * must meet a a doctor who specializes in hormone problems. *See CF Words to Know Glossary . Cystic Fibrosis Family Education Program … 1 Managing Nutrition & Digestive Problems — Puberty and Fertility in CF woman’s egg cell. To know abnormally thick. Very thick severe lung disease may not have whether a man is infertile, the mucus makes it hard for a male’s enough lung function to have a doctor can do a “sperm count” on sperm to get through the cervix to healthy pregnancy. In this case, semen ejaculated from the penis. meet the egg. Also, women with CF pregnancy could put both the A man with CF can talk with his who are very underweight can woman and her baby at risk. doctor about having this test. Up have less frequent and less regular Some women with CF develop to 5 percent of men with CF do ovulation, making it more difficult diabetes * (blood sugar * have sperm in their semen and to get pregnant. problems) during pregnancy and can father children naturally. PREGNANCY need to control it for their health New medical techniques allow and their babies’ health. If a Getting Ready for Pregnancy some men with CBAVD to father woman with CF is pregnant, she When a woman with CF is children. There is now a way to needs to get medical care from an considering having a baby, she get the sperm from the testes and obstetrician * (OB) who specializes fertilize * the egg from a female. should talk with her CF doctor in high-risk pregnancies. A high- A fertility specialist * can give about the risks, and look at her risk obstetrician can help treat lung function * and weight men with CF more information current diabetes in pregnancy and can to see if she can have a healthy about how it is done and the help prevent or treat other pregnancy. Ideally, a woman with success rate. health problems related to CF should be at or close to her the pregnancy. FEMALE FERTILITY ideal body weight before getting In puberty, females begin to pregnant. A woman with CF has to Besides seeing the obstetrician, * menstruate * (monthly flow of take in an extra 300 calories pregnant women with CF should every day and gain about 20 blood). Menstrual cycles * usually continue to see their CF health last 28 to 31 days, but they can pounds during a pregnancy to care team for regular CF care. vary from woman to woman and ensure normal growth of the baby. PASSING ON THE CF GENE from month to month. During the Being at one’s ideal body weight Along with planning a pregnancy first half of the cycle, the uterus * reduces the risk of having a prepares itself for pregnancy by premature baby or needing a like other parents, people with CF cesarean section * (surgery) to building up extra tissue. If the have other things to think about, deliver the baby. woman does not get pregnant such as: What is the possibility I could pass the CF gene * on to my during this time, the uterus Certain medications could put child? And, what are the chances releases or sheds this extra tissue the developing baby at risk; my child will have CF? When a and some blood. This release is therefore, the CF health care team person with CF has a child, the called having a menstrual period may need to change some of the baby will get a CF gene from the or menses. After the menses is woman’s CF medicines she before parent with CF. The child will over (usually in 4 to 7 days), the gets pregnant. either be a carrier * of the CF gene menstrual cycle begins again. Health Risks with Pregnancy or will have CF. Whether the child Once they have had their first Pregnancy can be more risky in is a carrier or has CF depends on period (menses), many females women with CF who have lung the other parent. Remember, a with CF are able to get pregnant. problems. Pregnancy can some - person has to inherit * two CF Some women with CF do have times lead to more lung problems. genes to have the disease. children of their own. Others, When a woman with CF is Here are the possibilities: however, have problems getting pregnant, it is important for pregnant. Although ovulation * her to watch for signs of infection * • When the other parent is a CF (release of eggs from the ovary *) and to take action to prevent carrier (has one CF gene), the occurs normally in CF, the mucus * lung problems with treatments child has one chance in two in the woman’s cervix * can be (airway clearance * and breathing (50%) of having CF. treatments *). A woman who has 2 … Cystic Fibrosis Family Education Program *See CF Words to Know Glossary . Managing Nutrition & Digestive Problems — Puberty and Fertility in CF INHERITING CF: PARENT WITH CF AND PARENT CARRYING CF GENE exam * before starting birth control and talk with her doctor about the risks of each type of birth control method. For example, birth control pills may cause an increase in blood sugar levels if a woman has CF-related diabetes (CFRD) .* Birth control pills may also have drug interactions with certain antibiotics * or other Has CF Carrier medicines.
Recommended publications
  • Puberty in Girls: Discussing Masturbation
    PUBERTY IN GIRLS: DISCUSSING MASTURBATION Discussing masturbation is an anxiety-provoking moment for any parent. It is important to address the topic with your daughter in a manner that is consistent with your family’s belief system and to set rules that are both age appropriate and comfortable for you to follow through with. This includes acknowledging that it is normal for your daughter to have sexual urges and interest. A good way to open the conversation is through books that discuss puberty and sexual topics in a frank and straightforward manner. Find out what your daughter already knows. Make sure she knows the different parts of her body and their functions. Consider using picture books or a body puzzle to make a simple game such as “find the body part” to see if your daughter understands what the body parts are and their functions; give her a healthy reward or praise to show her that she has done well. Read books together about puberty/adolescence, OR if your daughter doesn’t want to read with you, make them available to her by placing them in places where she plays. When it comes to discussing masturbation, you will need to be explicit. Because many individuals on the autism spectrum tend to self-stimulate in various ways, boundaries must be set around masturbation. Teach rules for appropriate time and place, and tell your daughter that sometimes masturbation is not an option. Provide her with private time where she will be undisturbed. Establish an open dialogue with your daughter about sexuality, which includes being safe and socially appropriate.
    [Show full text]
  • Original Article HISTOLOGICAL CHARACTERISTICS of FOLLICULOGENESIS in MURRAH WATER BUFFALOES DURING the EARLY POSTPUBERTAL PERIOD
    Bulgarian Journal of Veterinary Medicine, 2020, 23, No 1, 8088 ISSN 1311-1477; DOI: 10.15547/bjvm.2156 Original article HISTOLOGICAL CHARACTERISTICS OF FOLLICULOGENESIS IN MURRAH WATER BUFFALOES DURING THE EARLY POSTPUBERTAL PERIOD V. MANOV, V. PLANSKI & G. S. POPOV Faculty of Veterinary Medicine, University of Forestry, Sofia, Bulgaria Summary Manov, V., V. Planski & G. S. Popov, 2020. Histological characteristics of folliculogenesis in Murrah water buffaloes during the early postpubertal period. Bulg. J. Vet. Med., 23, No 1, 8088. A characteristic feature of water buffalo heifers is that they approach breeding maturity later than bovine heifers. From a physiological and endocrinological view, this is related to a later puberty, which affects the overall reproductive performance of water buffalo. The aim of this study was to highlight some morphological characteristics of the water buffalo (Bubalus bubalis) ovaries in the early postpubertal period. The results showed active ovaries of the examined specimens. Some of the follicles had no oocyte, but were with normal structure and physiological activity. Histology is a de- finitive method for examination of ovarian activity in water buffaloes. In some of the ovulating folli- cles the oocyte was absent during early puberty. The presence of corpora lutea confirmed the endo- crine maturity of the hypothalamus-pituitary-gonadal endocrine axis in 11–14 months old heifers despite the absence of oocytes. Key words: corpus luteum, estrus, follicle, ovary, ovulation, postpubertal period, water buffalo heifer INTRODUCTION Water buffalo heifers attain breeding ma- variable and is influenced by a wide vari- turity later than bovine heifers which is ety of factors, including climate, geo- attributed to later onset of puberty, affect- graphic area, breed, season of birth, and ing the overall reproductive performance.
    [Show full text]
  • Puberty—Ready Or Not Expect Some Big Changes
    puberty—ready or not expect some big changes Puberty is the time in your life when your Zits! body starts changing from that of a child to that of an Girls & Boys. adult. At times you may feel like your body is totally Another change that out of control! Your arms, legs, hands, and feet happens during puberty is that your skin gets oilier and you may may grow faster than the rest of your body. You may feel a little start to sweat more. This is because your glands are growing too. clumsier than usual. It’s important to wash every day to keep your skin Compared to your friends you may feel too tall, too short, too clean. Most people use a deodorant or antiperspirant to keep odor fat, or too skinny. You may feel self-conscious about and wetness under control. Don’t be surprised, even if you wash these changes, but many of your friends probably do too. your face every day, that you still get pimples. This is called acne, and it’s normal during this time when your hormone levels are Everyone goes through puberty, but not always at high. Almost all teens get acne at one time or another. the same time or exactly in the same way. In general, here’s Whether your case is mild or severe, there are things you can do what you can expect. to keep it under control. For more information on controlling acne, talk with your pediatrician. When? There’s no “right” time for puberty to begin.
    [Show full text]
  • Knowledge About Human Reproduction and Experience of Puberty 4
    KNOWLEDGE ABOUT HUMAN REPRODUCTION AND EXPERIENCE OF PUBERTY 4 4.1 KNOWLEDGE AND EXPERIENCE OF PUBERTY Knowledge of the physiology of human reproduction and the means to protect oneself against sexual or reproductive problems and diseases should be available to adolescents. Better knowledge of these subjects among young adults will lead to correct attitudes and responsible reproductive health behavior. 4.1.1 Knowledge of Physical Changes In the 2002-2003 Indonesia Young Adult Reproductive Health Survey (IYARHS), respondents were asked several questions to measure their knowledge about human reproduction and the experience of puberty. They were asked to name any physical changes that a boy or a girl goes through during the transition from childhood to adolescence. The responses were spontaneous, without any prompting from the interviewer. The findings are presented in Table 4.1. It is interesting to note that while the respondents may have experienced some of the physical changes listed in the questionnaire, some may not have recognized them as part of the process of growing up into adulthood; others may not report them to the interviewer. Table 4.1 Knowledge of physical changes at puberty Percentage of unmarried women and men age 15-24 who know of specific physical changes in a boy and a girl at puberty, by age, IYARHS 2002-2003 Women Men Indicators of physical changes 15-19 20-24 Total 15-19 20-24 Total In a boy Develop muscles 26.3 27.7 26.8 33.1 30.4 32.0 Change in voice 52.2 65.6 56.7 35.5 44.6 39.2 Growth of facial hair, pubic hair,
    [Show full text]
  • Puberty in Boys: from Physical Changes to Masturbation
    PUBERTY IN BOYS: FROM PHYSICAL CHANGES TO MASTURBATION Boys grow and develop (both mentally and physically) at different rates and ages. It is important to know when the “right” time is to begin talking with your son about his development. Ideally, you should begin introducing your son to his body, including his genitals, at an early age. Then, when it is time to talk about the sexual function of his body, it may not be as difficult. Use your judgment in determining when your son is ready for a conversation about puberty and sexuality. For many boys, this may be around age 9 to 11. Keep in mind that it may be earlier or later, depending on your child’s development. Whatever the age, it is important to think about where to begin. Find out what your son knows. Does he already know the body parts? Does he know what it means to have an erection? Use visuals such as drawings and pictures, or use a hand held mirror to help find out if he can name his body parts and genitals and tell you the function of each part. When talking with your son about his body, use the proper or real names of each body part, instead of just saying “down there.” Also teach your son the slang terms for male and female body parts; he is likely to hear them at school or elsewhere. Keep it SIMPLE. For example: “This is your penis: this is where the urine/pee comes out when you use the toilet.” “This is your anus: this is where the stool/poop comes out after your food has been digested.” “This is your penis: this is where semen comes out when you ejaculate.” Be POSITIVE and tell him that his body will grow taller, his testicles and penis will grow bigger, and hair will grow under his arms and in his groin area and that it is NORMAL.
    [Show full text]
  • Female Tanner Stages (Sexual Maturity Rating)
    Strength of Recommendations Preventive Care Visits – 6 to 17 years Bold = Good Greig Health Record Update 2016 Italics = Fair Plain Text = consensus or Selected Guidelines and Resources – Page 3 inconclusive evidence The CRAFFT Screening Interview Begin: “I’m going to ask you a few questions that I ask all my patients. Please be honest. I will keep your Screening for Major Depressive Disorder -USPSTF answers confidential.” Age 12 years to 18 years 7 to 11 yrs No Yes Part A During the past 12 months did you: Screen (when systems in place for diagnosis, treatment and Insufficient 1. Drink any alcohol (more than a few sips)? □ □ follow-up) evidence 2. Smoked any marijuana or hashish? □ □ Risk factors- parental depression, co-morbid mental health or chronic medical 3. Used anything else to get high? (“anything else” includes illegal conditions, having experienced a major negative life event drugs, over the counter and prescription drugs and things that you sniff or “huff”) □ □ Tools-Patient Health Questionnaire for Adolescent(PHQ9-A) Tools For clinic use only: Did the patient answer “yes” to any questions in Part A? &Beck Depression Inventory-Primary Care version (BDI-PC) perform less No □ Yes □ well Ask CAR question only, then stop. Ask all 6 CRAFFT questions Treatment-Pharmacotherapy – fluoxetine (a SSRI) is Part B Have you ever ridden in a CAR driven by someone □ □ efficacious but SSRIs have a risk of suicidality – consider only (including yourself) who was ‘‘high’’ or had been using if clinical monitoring is possible. Psychotherapy alone or alcohol or drugs? combined with pharmacotherapy can be efficacious.
    [Show full text]
  • Precocious Puberty Children with Spina BiDa and Hydrocephalus May Start Puberty Earlier Than Their Peers
    SBA National Resource Center: 800-621-3141 Precocious Puberty Children with Spina Bida and hydrocephalus may start puberty earlier than their peers. What is Puberty? If major breast development starts before age 8, it is considered early. (Sometimes girls will have some Puberty refers to normal body changes that lead to breast development, with no other signs of puberty. maturity and the ability to have children. Normal puberty This isolated change may be normal.) begins between ages 8 and 12 in girls and between 9 and 14 in boys. Hormones made in the brain control the timing and sequence of puberty. These hormones What are the stages of normal puberty in boys? stimulate other parts of the body to make sex hormones. The usual sequence in boys is: The sex hormones, especially estrogen in girls and testosterone in boys, cause sexual maturation. • The testicles grow larger. • The penis grows larger. What are the stages of normal puberty in girls? • Pubic hair grows. The physical changes seen in puberty are labeled by “Tanner staging.” Stage 1 is child-like (before puberty) • There is a growth spurt.rt. and stage 5 is full maturity. The usual sequence in girls is: • Other body hair grows.s. • Breasts start to develop. If boys show major developmentelopment • Hips widen and a there is a growth spurt that usually before age 9, it is considereddered lasts about three to four years. early. Early puberty in girls or boys is called • Pubic hair grows (three-to-six months after breasts “Precocious Puberty.” develop). • Other body hair grows.
    [Show full text]
  • The Hairlessness Norm Extended: Reasons for and Predictors of Women’S Body Hair Removal at Different Body Sites
    Sex Roles (2008) 59:889–897 DOI 10.1007/s11199-008-9494-3 ORIGINAL ARTICLE The Hairlessness Norm Extended: Reasons for and Predictors of Women’s Body Hair Removal at Different Body Sites Marika Tiggemann & Suzanna Hodgson Published online: 18 June 2008 # Springer Science + Business Media, LLC 2008 Abstract The study aimed to explore the motivations prescription renders many women not only perpetually behind and predictors of the practice of body hair removal dissatisfied with their bodies (Rodin et al. 1985), but also among women. A sample of 235 Australian female highly motivated to alter their bodies to match the ideal, as undergraduate students completed questionnaires asking illustrated by the existence of multi-million dollar diet, about the frequency and reasons for body hair removal, as exercise, cosmetic and cosmetic surgery industries. well as measures of media exposure. It was confirmed that One particular aspect of the ideal that has received the vast majority (approximately 96%) regularly remove relatively little research attention or theorizing is the their leg and underarm hair, most frequently by shaving, prescription for smooth hairless skin. This is most likely and attribute this to femininity and attractiveness reasons. A because the practice of removing unwanted body hair is so sizeable proportion (60%) also removed at least some of normative in Western cultures as to go unremarked. By far their pubic hair, with 48% removing most or all of it. Here the majority of women in the USA (Basow 1991), UK the attributions were relatively more to sexual attractiveness (Toerien et al. 2005) and Australia (Tiggemann and Kenyon and self-enhancement.
    [Show full text]
  • Post-Orgasmic Illness Syndrome: a Closer Look
    Indonesian Andrology and Biomedical Journal Vol. 1 No. 2 December 2020 Post-orgasmic Illness Syndrome: A Closer Look William1,2, Cennikon Pakpahan2,3, Raditya Ibrahim2 1 Department of Medical Biology, Faculty of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia 2 Andrology Specialist Program, Department of Medical Biology, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo Hospital, Surabaya, Indonesia 3 Ferina Hospital – Center for Reproductive Medicine, Surabaya, Indonesia Received date: Sep 19, 2020; Revised date: Oct 6, 2020; Accepted date: Oct 7, 2020 ABSTRACT Background: Post-orgasmic illness syndrome (POIS) is a rare condition in which someone experiences flu- like symptoms, such as feverish, myalgia, fatigue, irritabilty and/or allergic manifestation after having an orgasm. POIS can occur either after intercourse or masturbation, starting seconds to hours after having an orgasm, and can be lasted to 2 - 7 days. The prevalence and incidence of POIS itself are not certainly known. Reviews: Waldinger and colleagues were the first to report cases of POIS and later in establishing the diagnosis, they proposed 5 preliminary diagnostic criteria, also known as Waldinger's Preliminary Diagnostic Criteria (WPDC). Symptoms can vary from somatic to psychological complaints. The mechanism underlying this disease are not clear. Immune modulated mechanism is one of the hypothesis that is widely believed to be the cause of this syndrome apart from opioid withdrawal and disordered cytokine or neuroendocrine responses. POIS treatment is also not standardized. Treatments includeintra lymphatic hyposensitization of autologous semen, non-steroid anti-inflamation drugs (NSAIDs), steroids such as Prednisone, antihistamines, benzodiazepines, hormones (hCG and Testosterone), alpha-blockers, and other adjuvant medications.
    [Show full text]
  • Trends and Patterns in Menarche in the United States: 1995 Through 2013–2017 by Gladys M
    National Health Statistics Reports Number 146 September 10, 2020 Trends and Patterns in Menarche in the United States: 1995 through 2013–2017 By Gladys M. Martinez, Ph.D. Abstract older, have older friends, and be more likely to engage in negative behaviors Objective—This report presents national estimates of age at first menstrual period such as missing school, smoking, and for women aged 15–44 in the United States in 2013–2017 based on data from the drinking (8–11). The younger the age at National Survey of Family Growth (NSFG). Estimates for 2013–2017 are compared first menstrual period and first sexual with those from previous NSFG survey periods (1995, 2002, and 2006–2010). intercourse, the longer the interval Methods—Data for all survey periods analyzed are based on in-person interviews young women will potentially spend at with nationally representative samples of women in the household population aged risk of pregnancy. Differences in age at 15–44 in the United States. For the 2013–2017 survey period, interviews were menarche across population subgroups conducted with 10,590 female respondents aged 15–44. In 2015–2017, the age range may help explain differences in timing of the NSFG included women aged 15–49, but only those aged 15–44 were included of first sexual intercourse and timing of in this analysis. The response rate for the 2013–2017 NSFG was 67.4% for women. first births. The relationship between age Measures of menarche in this report include average age at first menstrual period, at menarche and the timing of first sexual probability of first menstrual period at each age, and the relationship between age at intercourse in the United States has menarche and age at first sexual intercourse.
    [Show full text]
  • Eruptive Cherry Hemangiomatosis Associated with Multicentric Castleman Disease a Case Report and Diagnostic Clue
    OBSERVATION Eruptive Cherry Hemangiomatosis Associated With Multicentric Castleman Disease A Case Report and Diagnostic Clue David C. Fajgenbaum, MSc; Misha Rosenbach, MD; Frits van Rhee, MD, PhD; Adnan Nasir, MD; Jason Reutter, MD Background: Eruptive cherry hemangiomatosis, which the cutaneous proliferations improved in association involves the sudden onset of multiple small vascular pro- with the systemic disease. liferations, has been rarely reported as a heralding sign of multicentric Castleman disease (MCD) and other lym- Conclusions: There is a scarcity of literature describ- phoproliferative diseases. We report a case wherein the ing the association between eruptive cherry hemangio- rapid appearance of cherry hemangiomata is the present- matosis and MCD. The likely underlying mechanism is ing sign of MCD. hypersecretion of vascular endothelial growth factor sec- ondary to an elevated interleukin 6 level. Failure to rec- ognize this association may have led to diagnostic de- Observations: A 25-year-old man with a 10-year his- lays. The authors suggest careful evaluation and follow-up tory of benign vascular growths developed 23 cutane- of all patients presenting with the sudden onset of cherry ous vascular proliferations and systemic symptoms 5 hemangiomata, particularly with systemic symptoms, days prior to presentation. Biopsy of the cutaneous lymphadenopathy, or other benign vascular endothelial lesions revealed a polypoidal proliferation of vessels growths, for the potential development of MCD and other consistent with cherry hemangiomata. Laboratory lymphoproliferative diseases. studies disclosed systemic abnormalities, and the find- ings of a subsequent lymph node biopsy confirmed MCD. Combination chemotherapy was initiated, and JAMA Dermatol. 2013;149(2):204-208 HYSICIANS HAVE REPORTED (ECH) in the setting of systemic symp- cases of eruptive cutaneous toms should be fully evaluated for the po- lesions as manifestations of tential development of MCD and other lym- underlying hemato-onco- phoproliferative diseases.
    [Show full text]
  • Review Article Physiologic Course of Female Reproductive Function: a Molecular Look Into the Prologue of Life
    Hindawi Publishing Corporation Journal of Pregnancy Volume 2015, Article ID 715735, 21 pages http://dx.doi.org/10.1155/2015/715735 Review Article Physiologic Course of Female Reproductive Function: A Molecular Look into the Prologue of Life Joselyn Rojas, Mervin Chávez-Castillo, Luis Carlos Olivar, María Calvo, José Mejías, Milagros Rojas, Jessenia Morillo, and Valmore Bermúdez Endocrine-Metabolic Research Center, “Dr. Felix´ Gomez”,´ Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela Correspondence should be addressed to Joselyn Rojas; [email protected] Received 6 September 2015; Accepted 29 October 2015 Academic Editor: Sam Mesiano Copyright © 2015 Joselyn Rojas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The genetic, endocrine, and metabolic mechanisms underlying female reproduction are numerous and sophisticated, displaying complex functional evolution throughout a woman’s lifetime. This vital course may be systematized in three subsequent stages: prenatal development of ovaries and germ cells up until in utero arrest of follicular growth and the ensuing interim suspension of gonadal function; onset of reproductive maturity through puberty, with reinitiation of both gonadal and adrenal activity; and adult functionality of the ovarian cycle which permits ovulation, a key event in female fertility, and dictates concurrent modifications in the endometrium and other ovarian hormone-sensitive tissues. Indeed, the ultimate goal of this physiologic progression is to achieve ovulation and offer an adequate environment for the installation of gestation, the consummation of female fertility. Strict regulation of these processes is important, as disruptions at any point in this evolution may equate a myriad of endocrine- metabolic disturbances for women and adverse consequences on offspring both during pregnancy and postpartum.
    [Show full text]