Muscle Spasms and Stiffness
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Hemimasticatory Spasm Treated with Botulinum Toxin
Arq Neuropsiquiatr 2002;60(2-A):288-289 HEMIMASTICATORY SPASM TREATED WITH BOTULINUM TOXIN Case report Hélio A.G. Teive1, Élcio J. Piovesan2, Francisco M.B. Germiniani3, Carlos Henrique A. Camargo3, Daniel Sá3, Rosana H. Scola4, Lineu C. Werneck5 ABSTRACT - We describe a female patient with hemimasticatory spasm, a rare movement disorder due to dysfunction of the motor trigeminal nerve of unknown origin. This patient had an excellent response to botulinum toxin therapy. KEY WORDS: hemimasticatory spasm, paroxysmal spasms, botulinum toxin. Espasmo hemimastigatório tratado com toxina botulínica: relato de caso RESUMO - Relatamos o caso de paciente feminina com espasmo hemimastigatório, distúrbio do movimento raro decorrente de disfunção da porção motora do nervo trigeminal, de etiologia desconhecida. A paciente teve excelente resposta clínica ao tratamento com toxina botulínica. PALAVRAS-CHAVE: espasmo hemimastigatório, espasmos paroxísticos, toxina botulínica. Hemimasticatory spasm (HMS) represents a rare spontaneously. She also complained of difficulty in talk- movement disorder due to a dysfunction of the mo- ing and swallowing when she had the spasms. tor trigeminal nerve of unknown origin. It is frequen- Neurological examination was normal except for in- tly misdiagnosed as hemifacial spasm, which is a tense contraction of the masseter and temporal muscles disorder due to dysfunction of the facial nerve1-3. on the right with severe facial pain when the patient had the spasms. Routine laboratory tests (WBC, biochemistry, The most striking features of HMS are the excruciat- VDRL, ERS) and ceruloplasmine were all normal. ing pain that accompanies the spasm itself and the The patient also had a previous history of irregular fact that initially masticatory movements act as a menstrual cycles and even amenorrhea for more than 1-3 trigger for the spasm . -
Perioral Twitching During Smiling - a Rare Form of Essential Tremor
Clinical Video Neurological Case Reports Published: 02 Dec, 2020 Perioral Twitching during Smiling - A Rare form of Essential Tremor Lea Pollak* Department of Neurology, Neurological Clinic, Kupat Cholim Macabi, Israel Abstract Involuntary movements of facial muscles such as jaw tremor, oromandibular dyskinesia, dystonia, facial myoclonus or hemifacial spasm are common in clinical practice. A 52-year old woman with a 15 year history of upper limb tremor complained of recent spread of the tremor to her face. On examination a moderate kinetic and action, mildly asymmetric tremor of the arms was present. On voluntary and spontaneous smiling bilateral twitching of the buccal muscles was observed. Keywords: Periorbital twitching; Essential tremor; Tardive dyskinesia Introduction Involuntary movements of facial muscles such as jaw tremor, oromandibular dyskinesia, dystonia, facial myoclonus or hemifacial spasm are common in clinical practice. Isolated tremor induced by mild contraction of smiling muscles smiling tremor is extremely rare and was reported by some authors to be associated with Parkinson disease while others related this condition to essential tremor [1-3]. Clinical Video A 52-year old woman with a 15 year history of upper limb tremor complained of recent spread of the tremor to her face. Her medical history comprised Crohn's disease treated with adalimumab and depression treated with sertraline and perphenazine during the last ten years. On examination a moderate kinetic and action, mildly asymmetric tremor of the arms was present. On voluntary and spontaneous smiling bilateral twitching of the buccal muscles was observed (video 1). The twitching disappeared on rest and forced smiling. There were no extra pyramidal signs or involuntary OPEN ACCESS movements of the jaw, lips or tongue (Figure 1). -
Isolated Corpus Callosal Infarction Secondary to Pericallosal Artery Disease Presenting As Alien Hand Syndrome N C Suwanwela, N Leelacheavasit
533 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.72.4.536 on 1 April 2002. Downloaded from SHORT REPORT Isolated corpus callosal infarction secondary to pericallosal artery disease presenting as alien hand syndrome N C Suwanwela, N Leelacheavasit ............................................................................................................................. J Neurol Neurosurg Psychiatry 2002;72:533–536 held a paper with both hands, the left hand would try to pull Two patients are described with the callosal type of alien the paper against the right. Some actions indicating mirror hand syndrome. Both presented with abnormal feelings in movement were also seen. For example, when he moved his the left upper limb and intermanual conflict without clinical right hand backwards, he felt that the left hand was pulled evidence of callosal apraxia or frontal lobe dysfunction back in the same manner. On examination, he was alert. such as motor deficit or reflexive grasping. Imaging studies Motor power of the arms and legs was full. There was no pin- disclosed subacute infarction in the body and splenium of prick sensory loss or inattention, on double simultaneous the corpus callosum due to pericallosal artery disease. stimulation test. Proprioceptive sense was normal. He could These patients were unique in their presentation as a not identify his left hand fingers or objects placed in his left callosal type of alien hand syndrome secondary to ischae- hand with his eyes closed, but was able to do so under visual mic stroke. observation. There was no apraxia of the left hand on verbal command, in imitation, and in actual object use. Frontal lobe releasing signs such as reflexive grasping, palmomental reflex, and snout reflex were absent. -
The Medical Management of Fibrodysplasia Ossificans Progressiva: Current Treatment Considerations
THE MEDICAL MANAGEMENT OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA: CURRENT TREATMENT CONSIDERATIONS The International Clinical Consortium on Fibrodysplasia Ossificans Progressiva1 May 2011 From The Center for Research in FOP and Related Disorders, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104 Corresponding Editor: Frederick S. Kaplan, M.D. Isaac and Rose Nassau Professor of Orthopaedic Molecular Medicine Director, Center for Research in FOP & Related Disorders The Perelman School of Medicine - The University of Pennsylvania Department of Orthopaedic Surgery 3737 Market Street – Sixth Floor Philadelphia, PA 19104, USA Tel: (office) 215-294-9145 Fax: 215-222-8854 Email: [email protected] Reprint Requests: [email protected] Associate Editors: Eileen M. Shore, Ph.D. Robert J. Pignolo, M.D., Ph.D. [Kaplan FS, Shore EM, Pignolo RJ (eds), name of individual consortium member, and The International Clinical Consortium on FOP. The medical management of fibrodysplasia ossificans progressiva: current treatment considerations. Clin Proc Intl Clin Consort FOP 4:1-100, 2011] 1See Section X (pages 84-100) for Complete Author Listing. ` 1 ABSTRACT…………………………………………………………………………………………… 5 I. THE CLINICAL AND BASIC SCIENCE BACKGROUND OF FOP……………..…………….. 6 A. Introduction………………………………………………………………..…..…..…………………. 6 B. Classic Clinical Features of FOP……………………………………………………..……………. 6 C. Other Skeletal Anomalies in FOP…………………………………………………………… 6 D. Radiographic Features of FOP……………………………………………………….…….... 7 E. Histopathology of FOP Lesions………………………………………………………………. 7 F. Laboratory Findings in FOP………………………………………………………………… 8 G. The Immune System & FOP…………………………………………………………………. 8 H. Misdiagnosis of FOP………………………………………………………………………………… 8 I. Epidemiologic, Genetic & Environmental Factors in FOP……………………..…………. 9 J. FOP & the BMP Signaling Pathway………………………………………………………… 9 K. The FOP Gene………………………………………………………………..………………. 9 L. Structural and Functional Consequences of the FOP Mutation…………………………… 10 M. -
Spinal and Bulbar Muscular Atrophy
Spinal and bulbar muscular atrophy Description Spinal and bulbar muscular atrophy, also known as Kennedy disease, is a disorder of specialized nerve cells that control muscle movement (motor neurons). These nerve cells originate in the spinal cord and the part of the brain that is connected to the spinal cord (the brainstem). Spinal and bulbar muscular atrophy mainly affects males and is characterized by muscle weakness and wasting (atrophy) that usually begins in adulthood and worsens slowly over time. Muscle wasting in the arms and legs results in cramping; leg muscle weakness can also lead to difficulty walking and a tendency to fall. Certain muscles in the face and throat (bulbar muscles) are also affected, which causes progressive problems with swallowing and speech. Additionally, muscle twitches (fasciculations) are common. Some males with the disorder experience unusual breast development ( gynecomastia) and may be unable to father a child (infertile). Frequency This condition affects fewer than 1 in 150,000 males and is very rare in females. Causes Spinal and bulbar muscular atrophy results from a particular type of mutation in the AR gene. This gene provides instructions for making a protein called an androgen receptor. This receptor attaches (binds) to a class of hormones called androgens, which are involved in male sexual development. Androgens and androgen receptors also have other important functions in both males and females, such as regulating hair growth and sex drive. The AR gene mutation that causes spinal and bulbar muscular atrophy is the abnormal expansion of a DNA segment called a CAG triplet repeat. Normally, this DNA segment is repeated up to about 36 times. -
Spinal Muscular Atrophy
FACT SHEET SPINAL MUSCULAR ATROPHY Spinal Muscular Atrophy (SMA) is a Motor Neuron Disease. It is caused by the mutation of the Survival of SYMPTOMS IN INFANTS • Muscle weakness. Motor Neuron (SMN) gene. It occurs due to the loss of • Muscle atrophy (wasting). motor neurons within the spinal cord and brain. It results • Poor muscle tone. in the progressive wasting away of muscles (atrophy) and • Areflexia (delayed reflexes). muscle weakness. SMA can affect people of all ages, races • Weak cry. or genders; however, the majority of cases occur in infancy • Difficulty sucking or swallowing. or childhood. There are four types of SMA. • Feeding difficulties. FORMS OF SMA • Weak cough. • Lack of developmental milestones (inability to lift head TYPE I (ACUTE INFANTILE) or sit up). • Also called Wernig-Hoffman Disease. • Limpness or a tendency to flop. • Most severe form of SMA. • Accumulations of secretions in the lungs or throat. • Usually diagnosed before six months of age. • Those affected cannot sit without support, lungs may SYMPTOMS IN ADULTS not fully develop, swallowing and breathing may be • Muscle weakness. difficult and there is weakness of the intercostal muscles • Muscle atrophy (wasting). (muscles between the ribs). • Weak tongue. • 95 per cent fatal by 18 • Stiffness. • Cramps. TYPE II (CHRONIC INFANTILE) • Fasciculation (twitching). • Usually diagnosed before the age of two, with the • Clumsiness. majority of cases diagnosed by 15 months. • Dyspnea (shortness of breath). • May be able to sit without assistance or even stand with support. DIAGNOSIS • Increased risk for complications from respiratory • A diagnosis can be made by an SMN gene test which infections. -
Essential Tremor of the Voice Vs. Spasmodic Dysphonia by Michael M
Essential Tremor (ET) Essential Tremor of the Voice vs. Spasmodic Dysphonia By Michael M. Johns, MD (pictured below)- Director at Emory Voice Center, Emory University, Atlanta, GA and member of the IETF Medical Advisory Board, and Madeleine Pethan, MS, CCC-SLP - Speech Pathologist at Emory Voice Center Introduction box, is not the only structure which can cause essential tremor of the voice. Tremor of the voice can be caused Certain neurologic conditions can cause people to have when any of the structures in the speech system is problems with their voice. These voice problems can affected. Essential tremor of the voice may be caused often lead to more difficulty communicating throughout by tremor in the soft palate, tongue, pharynx, or even daily life. It is important that patients with neurological muscles of respiration. Extralaryngeal tremor (i.e., out- voice disorders are evaluated by an otolaryngologist, or side the voice box) has been reported in up to as many ENT doctor, in addition to their neurologist to determine as 93% of patients with diagnosed essential tremor of the diagnosis and discuss treatment options. Many the voice. Similarly, most patients with essential tremor patients with essential tremor also experience essential of the voice also have tremor affecting their hands, leg, tremor of the voice. Essential tremor of the voice can chin, or trunk. often be confused with another neurologic voice disor- der known as spasmodic dysphonia. Essential tremor seems to be associated with aging, al- though the reasons are still inconclusive. Most studies What is Essential Tremor? report average age of onset from the late 40s to early 50s. -
Review of Systems Reason for Visit Past Gynecologic
REVIEW OF SYSTEMS Patient Name Date DOB Height Weight REASON FOR VISIT Why are you seeing the doctor today? ________________________________________________________________________________________ Have you been treated for this problem in the past? Yes No If yes, please explain ______________________________________________________________________________________________________ Have you had any recent radiology or laboratory studies? Yes No If yes, please indicate where, when, and type of study __________________________________________________________________________ PAST GYNECOLOGIC HISTORY Please indicate if you have received treatment for the conditions below, or if you are currently receiving treatment. Yes No Yes No Abnormal Pap HPV (Human Papillomavirus) Other Gynecologic Problems _______________________________________________________________________________________________ Are there any other medical problems that we should be aware of? ______________________________________________________________ _________________________________________________________________________________________________________________________ Are you currently pregnant or could you possibly be pregnant? Yes No Date of Last Menstrual Period ____________________/ / Do you/have you taken female hormones? Yes No Oral contraceptives? Yes No Type of contraception: _____________________________ Total number of: Pregnancies ________ Term Births ________ Pre-Term Births ________ Elective Abortions ________ Miscarriages ________ C-sections ________ REVIEW OF -
History-Of-Movement-Disorders.Pdf
Comp. by: NJayamalathiProof0000876237 Date:20/11/08 Time:10:08:14 Stage:First Proof File Path://spiina1001z/Womat/Production/PRODENV/0000000001/0000011393/0000000016/ 0000876237.3D Proof by: QC by: ProjectAcronym:BS:FINGER Volume:02133 Handbook of Clinical Neurology, Vol. 95 (3rd series) History of Neurology S. Finger, F. Boller, K.L. Tyler, Editors # 2009 Elsevier B.V. All rights reserved Chapter 33 The history of movement disorders DOUGLAS J. LANSKA* Veterans Affairs Medical Center, Tomah, WI, USA, and University of Wisconsin School of Medicine and Public Health, Madison, WI, USA THE BASAL GANGLIA AND DISORDERS Eduard Hitzig (1838–1907) on the cerebral cortex of dogs OF MOVEMENT (Fritsch and Hitzig, 1870/1960), British physiologist Distinction between cortex, white matter, David Ferrier’s (1843–1928) stimulation and ablation and subcortical nuclei experiments on rabbits, cats, dogs and primates begun in 1873 (Ferrier, 1876), and Jackson’s careful clinical The distinction between cortex, white matter, and sub- and clinical-pathologic studies in people (late 1860s cortical nuclei was appreciated by Andreas Vesalius and early 1870s) that the role of the motor cortex was (1514–1564) and Francisco Piccolomini (1520–1604) in appreciated, so that by 1876 Jackson could consider the the 16th century (Vesalius, 1542; Piccolomini, 1630; “motor centers in Hitzig and Ferrier’s region ...higher Goetz et al., 2001a), and a century later British physician in degree of evolution that the corpus striatum” Thomas Willis (1621–1675) implicated the corpus -
Myalgia As the Revealing Symptom of Multicore Disease and Fibre Type Disproportion Myopathy C Sobreira*, W Marques Jr, a a Barreira
1317 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.74.9.1317 on 21 August 2003. Downloaded from SHORT REPORT Myalgia as the revealing symptom of multicore disease and fibre type disproportion myopathy C Sobreira*, W Marques Jr, A A Barreira ............................................................................................................................. J Neurol Neurosurg Psychiatry 2003;74:1317–1319 toms of CFTDM are more uniform. However, some patients Background: Multicore disease and congenital fibre type exhibit unusual phenotypes such as rigid spine syndrome,10 11 disproportion myopathy are diseases assigned to the significant dysmorphic features,12 or very mild symptoms.13 heterogeneous group of congenital myopathies. Although Cramps are uncommon complaints in patients with multi- hypotonia and muscle weakness appearing in early life core disease or CFTDM and exercise related muscle pain has are the commonest manifestations of these diseases, not been associated with multicore disease. Aimed at contrib- distinct phenotypes and late onset cases have been uting to better delineating the phenotypic expression of these described. myopathies, we present the clinical cases of patients suffering Objective: To report the occurrence of myalgia as the late onset, generalised muscle pain, whose muscle biopsies revealing symptom of multicore disease and fibre type dis- revealed the distinguishing features of either multicore proportion myopathy. disease or CFTDM. Methods: The clinical cases of three patients with fibre type disproportion myopathy and one with multicore CASE REPORTS disease are described. Skeletal muscle biopsies were Patient 1 processed for routine histological and histochemical A 24 year old man was referred to a neurologist owing to studies. exercise related myalgia involving both the upper and lower Results: The clinical picture was unusual in that the symp- limbs. -
The Clinical Approach to Movement Disorders Wilson F
REVIEWS The clinical approach to movement disorders Wilson F. Abdo, Bart P. C. van de Warrenburg, David J. Burn, Niall P. Quinn and Bastiaan R. Bloem Abstract | Movement disorders are commonly encountered in the clinic. In this Review, aimed at trainees and general neurologists, we provide a practical step-by-step approach to help clinicians in their ‘pattern recognition’ of movement disorders, as part of a process that ultimately leads to the diagnosis. The key to success is establishing the phenomenology of the clinical syndrome, which is determined from the specific combination of the dominant movement disorder, other abnormal movements in patients presenting with a mixed movement disorder, and a set of associated neurological and non-neurological abnormalities. Definition of the clinical syndrome in this manner should, in turn, result in a differential diagnosis. Sometimes, simple pattern recognition will suffice and lead directly to the diagnosis, but often ancillary investigations, guided by the dominant movement disorder, are required. We illustrate this diagnostic process for the most common types of movement disorder, namely, akinetic –rigid syndromes and the various types of hyperkinetic disorders (myoclonus, chorea, tics, dystonia and tremor). Abdo, W. F. et al. Nat. Rev. Neurol. 6, 29–37 (2010); doi:10.1038/nrneurol.2009.196 1 Continuing Medical Education online 85 years. The prevalence of essential tremor—the most common form of tremor—is 4% in people aged over This activity has been planned and implemented in accordance 40 years, increasing to 14% in people over 65 years of with the Essential Areas and policies of the Accreditation Council age.2,3 The prevalence of tics in school-age children and for Continuing Medical Education through the joint sponsorship of 4 MedscapeCME and Nature Publishing Group. -
Porro NEWORK NEWS
International Polio Network SAINT LOUIS, MISSOURIUSA Winter 2003 .Vol. 19, No. 1 Porro NEWORKNEWS Straight Answers to Your "Cramped" Questions Holly H. Wise, P7; PhD, and Kerri A. Kolehma, MS, MD, Coastal Post-Polio Clinic, Charleston, South Carolina Tired in the morning? Is it diffi- Cramps can occur throughout origins anywhere in the central cult to get comfortable for a good the day but more often occur at and peripheral nervous systems night of sleep? A complaint often night or when a person is resting. and may explain the wide range reported at the Coastal Post-Polio Although it is not known exactly of conditions in which the Clinic in Charleston, South why cramps happen mostly at cramping occurs (Bentley, 1996). Carolina, is the inability to get these times, it is thought that to sleep at night due to leg pain, the resting muscle is not being Seeking Answers twitching, or cramping. stretched and is therefore more A thorough history and possibly easily excited. Muscle cramping is a relatively a referral for screening labs will common, painful, and bother- The basis for the theory that help determine the causes for some complaint among generally I cramps occur more at rest, due to I leg pain and cramping. Polio healthy adults, and is more com- I the muscle not being stretched, I survivors can provide a descrip- mon in women than men. Some I is that passive stretching can I tion of their muscle cramps, studies estimate as many as 50- 1 relieve muscle cramping. Pain I identification of the time and 70% of older adults may experi- I associated with cramping is likely I place when they occur, and an ence nocturnal leg and foot I caused by the demand of the I activity log of the 24-48 hours cramps (Abdulla, et.