Patient Allergic to Codeine?

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5t29t2014 UIC College of Pharmacy rytryry w "ryrycry ffi::w,,,$&'. F.-tE{t+J--.*.,-# ; llrlFORltATlOH GROUP i-"#,pRUG I'AQ Dnrg lulbrnratiorr Gl'ou1'l Departllent of Pharmacy What analgesics can be given to a patient allergic to codeine? Pr:actico For a patient with a true allergy to codeine, the risk of cross-reactiMty with another opioid can be reduced if an analgesic from a different About Us chemical class is used. Chemically, there are three classes of opioid analgesics:phenanthrenes, phenylpiperidine, and phenylheptanones. Pcople Morphine and its related opioids, including codeine, are in the phenanthrene class. The mixed agonist-antagonist agents (buprenorphine, nalbuphine, butorphanol, pentazocine, and dezocine) Potential Partncls h ips are also included in the phenanthrenes. Use of anyof these agents in a patientwith a true allergy to codeine may result in an allergic reaction. Meperidine and its related congeners are Thc ILxPrcss phenylpiperidines, while methadone and propoxlphene are phenylheptanones. Selecting agents from a different chem ical class s hould m inim ize the risk of cross-sensitivity. However, I{csidenc:y Prograni it is importantto note that use of an opioid from a different chemical class does not eliminate the risk of an allergic reaction. For patients with severe or life-threatening reactions, nonnarcotic Frccluently Askecl Questbns analgesics, such as nonsteroidal anti-inllammatoryagents or acetaminophen, should be Contact t..ls considered. Feedbac l< Phenylheptanones nery,,,,,,,,,,,,,,,,1trr1919s Phenylpiperidines Stuileullixteln f (diphenylheptanes) lVlorphine jMeperidine iMethadone tt" Hydromorphone Search Drug Info Group . lFentanVl lpropoxyphene Oxymorphone Sufentanit lL"""r"ir,"JU Le\Levcrphanol c.lplangl lAlfentanit I 99q."it-" --'*{--I *-' I I Oxycodone Buprenorphine Butorphanol |:l9rphil: Pentazocine Dezocine References Bau m ann T. Analges s ic election when the patient is allergic to codeine. Clin pharm 1 991 :1 0:65g. Hebel sK. Drug Facts and comparisons. st. Louis:Facts and comparisons.2000 Koo P. Pain. In:Young YE, Koda-Kimble MA editors. Applied Therapeutics:the clinical use of drugs. Vancouver (WA): Applied Therapeutics. ' ,\,,.,r. ,i , i.,r,t 1 ,,, .. i.,i i ir|,, .r.ritr|r t .i ilri isealch ;o llcPh?rmacy l, tii:,:..rllt i rt..:.,irrj ii|.i |t .rl,,i http://wv\iv/.ui c.edu/pharmacy/serVces/di/faq /codei ne.php.

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2.0 Synopsis
Hydrocodone/Acetaminophen Extended Release Tablets M12-807 Abbreviated Clinical Study Report R&D/11/661 2.0 Synopsis Abbott Laboratories Individual Study Table Referring (For National Authority to Part of Dossier: Use Only) Name of Study Drug: Volume: Hydrocodone/Acetaminophen Extended Release Page: Name of Active Ingredient: Hydrocodone 10 mg/ Acetaminophen 650 mg Extended Release Title of Study: A Phase 2, Randomized Withdrawal Study of the Analgesic Efficacy and Safety of Hydrocodone/Acetaminophen Extended Release Compared to Placebo in Subjects with Chronic Low Back Pain Coordinating Investigator: Study Sites: Seventeen investigative sites in the United States Publications: None Studied Period (Years): Phase of Development: 2 First Subject First Visit: 22 June 2011 Last Subject Last Visit: 28 October 2011 Objectives: The primary objective of this study was to compare the analgesic efficacy and safety of 1 tablet of hydrocodone/acetaminophen extended release 10 mg/650 mg administered twice daily over 2 weeks to placebo in subjects with moderate to moderately severe chronic low back pain (CLBP). A secondary objective of this study was to explore the population pharmacokinetics of hydrocodone and acetaminophen resulting from administration of hydrocodone/acetaminophen extended release 10 mg/650 mg tablets. Methodology: This Phase 2, multicenter, double-blind (DB), placebo-controlled, randomized withdrawal study compared the analgesic efficacy and safety of 1 tablet hydrocodone/acetaminophen extended release 10 mg/650 mg to placebo in subjects with moderate to moderately severe CLBP. Subjects met pre-defined criteria at the conclusion of the Open-Label (OL) Titration Period to proceed to randomization into the DB Maintenance Period of the study.
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Information to Users
The direct and modulatory antinociceptive actions of endogenous and exogenous opioid delta agonists Item Type text; Dissertation-Reproduction (electronic) Authors Vanderah, Todd William. Publisher The University of Arizona. Rights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. Download date 04/10/2021 00:14:57 Link to Item http://hdl.handle.net/10150/187190 INFORMATION TO USERS This ~uscript }las been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely. event that the author did not send UMI a complete mannscript and there are missing pages, these will be noted Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginnjng at the upper left-hand comer and contimJing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book. Photographs included in the original manuscript have been reproduced xerographically in this copy.
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