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Cellular and Molecular Immunology in Health and Disease

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Cellular and Molecular Immunology in Health and Disease A Symposium to Celebrate the 60th Birthday of Dr. Ranjan Sen Ranjan Sen, Ph.D., Chief, Laboratory of Molecular and Cell Biology and Immunology, National Institute on Aging CELLULAR AND MOLECULAR IMMUNOLOGY IN HEALTH AND DISEASE Frederick Alt, Ph.D. Harvard Medical School, USA Dipanjan ChowdHury, Ph.D. Harvard Medical School, USA David ScHatz, Ph.D. Date: January 30, 2016 Yale School of Medicine, USA Time: 8:30a.m. – 6:00p.m. StepHen Desiderio, M.D., Ph.D. John Hopkins Medicine, USA Place: Gerstenzang 121 Sankar GhosH, Ph.D. Brandeis University Columbia University, USA 415 SoutH Street Barbara Nikolajczyk, Ph.D. Boston University, USA WaltHam, MA 02453 StepHen Smale, Ph.D. University of California Los Angeles, USA Joel Pomerantz, Ph.D. Johns Hopkins University School of Medicine, USA Rudolf GrosscHedl, Ph.D. Max Planck Institute, Germany Batu Erman, Ph.D. Sabanci University, Turkey Christina Jamieson, Ph.D. University of California San Diego School of Medicine, USA YeHudit Bergman, Ph.D. The Hebrew University of Jerusalem, Israel Columbia University Whitehead, MIT Brandeis University National Institute of Health Ranjan Sen, Ph.D. Dr. Ranjan Sen, received his Ph.D. in chemistry from Columbia University in 1982. He made the transition to molecular biology as a postdoctoral fellow in David Baltimore's laboratory at M.I.T. and the Whitehead Institute, where he identified the transcription factor NF-κB. The NF-κB transcription factor family plays critical roles in many normal physiological processes and pathological conditions such as cancers, inflammation and autoimmune diseases. In 1987, Dr. Sen was appointed Assistant Professor in the Department of Biology and Rosenstiel Research Center at Brandeis University. He earned tenure in 1991 and was promoted to Professor of Biology in 1998. He moved to his present position as Chief, Laboratory of Cellular and Molecular Biology and Immunology at the National Institute on Aging in 2003. In 2014, Dr. Sen was elected as an American Association for the Advancement of Science (AAAS) fellow for his distinguished contributions to the fields of transcription factor biology and molecular immunology, specifically related to immune system development. Celebrating the 60th Birthday of Ranjan Sen, Ph.D. Symposium: Cellular and Molecular Immunology in Health and Disease Place: Gerstenzang 121, Brandeis University 8:30 – 9:30 a.m. Continental Breakfast (Carl J. SHapiro Science Center Atrium) 9:30 – 9:45 a.m. Introductory Remarks – Joan Press, Ph.D. Session I: DNA Recombination/Repair Chair: Weihong Wang, Ph.D.* 9:45 – 10:15 a.m. Frederick Alt, Ph.D. Recurrent DSB cluster genes in neural stem & progenitor cells may contribute to brain diversity & disease 10:15 – 10:35 a.m. Dipanjan Chowdhury, Ph.D.* Modulating the DNA DSB repair machinery is critical for genomic stability 10:35 – 10:45 a.m. Coffee Break 10:45 – 11:15 a.m. David Schatz, Ph.D. Evolution & regulation of the V(D)J recombinase 11:15 – 11:45 a.m. Stephen Desiderio, M.D., Ph.D. Allosteric control of V(D)J recombination: How RAG reads epigenetic marks 11:45 – 12:45 p.m. LuncH (Carl J. SHapiro Science Center Atrium) Session II: Inflammation/NF-κB Chair: Irvith Carvajal, Ph.D.* 12:45 – 1:15 p.m. Sankar Ghosh, Ph.D. Regulation of Immune homeostasis by NF-κB 1:15 – 1:35 p.m. Barbara Nikolajczyk, Ph.D.* T cell inflammatory signatures link human obesity to type 2 diabetes 1:35 – 2:05 p.m. Stephen Smale, Ph.D. Gene-specific regulatory strategies for NF-κB 2:05 – 2:25 p.m. Joel Pomerantz, Ph.D.* Mechanisms of normal & oncogenic signaling to NF-κB 2:25 – 2:40 p.m. Coffee Break Session III: Immunity/Gene Expression Chair: Winnie Tam, Ph.D.* 2:40 – 3:10 p.m. Rudolf Grosschedl, Ph.D. Transcriptional networks in B lymphopoiesis 3:10 – 3:30 p.m. Batu Erman, Ph.D.* Regulation of p53 by DNA damage 3:30 – 3:50 p.m. Christina Jamieson, Ph.D.* Inducible transcription: from T cells to bone metastatic prostate cancer – and back again? 3:50 – 4:20 p.m. Yehudit Bergman, Ph.D. Programming asynchronous replication in development Conclusion: 4:20 – 4:35 p.m. Barbara Nelsen, Ph.D.* 4:35 – 4:45 p.m. Video Presentation – Winnie Tam, Ph.D.* & Jaimy Joy 4:45 – 4:50 p.m. Aditi Priyadarshini Sen, Ph.D. 4:50 – 5:00 p.m. Closing Remarks – Ranjan Sen, Ph.D. 5:00 – 6:00 p.m. Social Hour (Carl J. Shapiro Science Center Atrium) * Sen lab alumni Maps / Directions: http://www.brandeis.edu/about/visiting/directions.html Lower Science Lot Upper Science Lot Gerstenzang P P Rosenstiel Basic Med ical Scien ce Main Entrance Athletics Lot P Contacts: Winnie Tam (781)504-9816 Weihong Wong (617)970-4189 Irvith Carvajal (857)919-2490 Dipanjan Chowdhury (781)266-7907 Barbara Nikolajczyk (617) 930-8249 Special Thanks to Our Sponsors: Biology Department, Brandeis University R A N J A N.
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