antioxidants Article Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats Anna Maria Giudetti 1,*,† , Daniele Vergara 1,† , Serena Longo 1 , Marzia Friuli 2, Barbara Eramo 2, Stefano Tacconi 1 , Marco Fidaleo 3,4 , Luciana Dini 3,4 , Adele Romano 2,‡ and Silvana Gaetani 2,*,‡ 1 Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Prov.le Lecce-Monteroni, 73100 Lecce, Italy;
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[email protected] (S.T.) 2 Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy;
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[email protected] (A.R.) 3 Department of Biology and Biotechnology “C. Darwin”, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy; marco.fi
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[email protected] (L.D.) 4 Research Center for Nanotechnology for Engineering of Sapienza (CNIS), Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy * Correspondence:
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[email protected] (S.G.) † Co-first authors. ‡ Co-last authors. Abstract: Long-term high-fat diet (HFD) consumption can cause weight gain and obesity, two condi- Citation: Giudetti, A.M.; Vergara, D.; tions often associated with hepatic non-alcoholic fatty liver and oxidative stress. Oleoylethanolamide Longo, S.; Friuli, M.; Eramo, B.; (OEA), a lipid compound produced by the intestine from oleic acid, has been associated with different Tacconi, S.; Fidaleo, M.; Dini, L.; beneficial effects in diet-induced obesity and hepatic steatosis.