Age Related Vision Loss
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ICO Guidelines for Glaucoma Eye Care
ICO Guidelines for Glaucoma Eye Care International Council of Ophthalmology Guidelines for Glaucoma Eye Care The International Council of Ophthalmology (ICO) Guidelines for Glaucoma Eye Care have been developed as a supportive and educational resource for ophthalmologists and eye care providers worldwide. The goal is to improve the quality of eye care for patients and to reduce the risk of vision loss from the most common forms of open and closed angle glaucoma around the world. Core requirements for the appropriate care of open and closed angle glaucoma have been summarized, and consider low and intermediate to high resource settings. This is the first edition of the ICO Guidelines for Glaucoma Eye Care (February 2016). They are designed to be a working document to be adapted for local use, and we hope that the Guidelines are easy to read and translate. 2015 Task Force for Glaucoma Eye Care Neeru Gupta, MD, PhD, MBA, Chairman Tin Aung, MBBS, PhD Nathan Congdon, MD Tanuj Dada, MD Fabian Lerner, MD Sola Olawoye, MD Serge Resnikoff, MD, PhD Ningli Wang, MD, PhD Richard Wormald, MD Acknowledgements We gratefully acknowledge Dr. Ivo Kocur, Medical Officer, Prevention of Blindness, World Health Organization (WHO), Geneva, Switzerland, for his invaluable input and participation in the discussions of the Task Force. We sincerely thank Professor Hugh Taylor, ICO President, Melbourne, Australia, for many helpful insights during the development of these Guidelines. International Council of Ophthalmology | Guidelines for Glaucoma Eye Care International -
Treat Cataracts and Astigmatism with One
TREAT CATARACTS Cataract patients have a choice Eye with cataract See life through the AcrySof® IQ Toric IOL. of treatments, including the As the eye ages, the lens becomes AND ASTIGMATISM WITH breakthrough AcrySof® IQ Toric cloudier, allowing less light to pass Ask your doctor about your options. intraocular lens (IOL) that treats through. The light that doesn’t make ONE PROCEDURE pre-existing corneal astigmatism at the it to the retina is diffused or scattered, same time that it corrects cataracts. leaving vision defocused and blurry. With a single procedure, you have the potential to enjoy freedom from glasses or contacts for distance vision with enhanced image quality – and see life through a new lens. 1. Independent third party research; Data on File, December 2011. Cataracts and astigmatism defined. Important Product Information A cataract is like a cloud over the eye’s lens, Eye with astigmatism CAUTION: Restricted by law to sale by or on the order of a physician. DESCRIPTION: interfering with quality of vision and making The AcrySof® IQ Toric Intraocular Lenses (IOLs) are artificial lenses implanted in the normal activities, such as driving a car, reading When the surface of the cornea has eye of adult patients following cataract surgery. These lenses are designed to correct pre-existing corneal astigmatism, which is the inability of the eye to focus clearly at a newspaper or seeing people’s faces, an uneven curvature, shaped more any distance because of difference curvatures on the cornea, and provide distance vision. WARNINGS / PRECAUTIONS: You may experience and need to contact your increasingly difficult. -
Presbyopia and Glaucoma: Two Diseases, One Pathophysiology? the 2017 Friedenwald Lecture
Lecture Presbyopia and Glaucoma: Two Diseases, One Pathophysiology? The 2017 Friedenwald Lecture Paul L. Kaufman,1 Elke Lutjen¨ Drecoll,2 and Mary Ann Croft1 1Department of Ophthalmology and Visual Sciences, Wisconsin National Primate Research Center, McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, Wisconsin, United States 2Institute of Anatomy II, Erlangen, Germany Correspondence: Paul L. Kaufman, Department of Ophthalmology and Visual Sciences, University of Wisconsin Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792-3220, USA; [email protected]. Citation: Kaufman PL, Lutjen¨ Drecoll E, Croft MA. Presbyopia and glaucoma: two diseases, one pathophysiology? The 2017 Friedenwald Lecture. Invest Ophthalmol Vis Sci. 2019;60:1801–1812. https://doi.org/10.1167/iovs.19-26899 resbyopia, the progressive loss of near focus as we age, is choroid and the retina stretch in parallel with each other during P the world’s most prevalent ocular affliction. Accommoda- the accommodative response. The question remains how far tive amplitude is at its maximum (~15 diopters) in the teen back the accommodative choroid/retina movement goes. years and declines fairly linearly thereafter (Fig. 1).1 By age 25 By ‘‘marking’’ points on retinal photographs (e.g., vascular about half the maximum accommodative amplitude has been bifurcations) in aphakic (to avoid lens magnification artifacts lost, by age 35 two-thirds are gone, and by the mid-40s all is during accommodation) monkey eyes, movement of the retina gone. Clinical symptoms usually begin at age ~40. The during accommodation can be quantified in terms of both accommodative apparatus of the rhesus monkey is very similar direction and magnitude (Fig. -
Cataract Surgery & Glaucoma
worldclasslasik.com http://www.worldclasslasik.com/cataract-surgery-new-jersey/cataract-surgery-glaucoma/ Cataract Surgery & Glaucoma The lens of your eye is responsible for focusing light on the objects you see. If the lens is clouded, then you can’t see things clearly, and this is known as a cataract. It can form gradually over many years or you can be born with a cataract. For some people, cataracts are not even noticeable. They just find themselves turning on more lights to read or having trouble with glares while driving at night. Most cataracts are problematic later in life. It is estimated that more than half of all Americans over the age of 80 will have cataracts or have had them corrected with surgery. Another common eye problem for seniors is glaucoma. Glaucoma is actually a group of eye diseases that affect the optic nerve by causing various types of damage due to high pressure. The optic nerve carries images from the retina to the brain, so advanced glaucoma can actually impair vision to the point of blindness. It is actually the leading cause of blindness in the world. However, glaucoma can be remedied in a number of ways. Early detection and treatment by your eye surgeon are critical in achieving optimal results. Resolve Cataracts and Glaucoma with Surgery While many adults over the age of 65 suffer from both cataracts and glaucoma, it is important to note that the two are not related. Glaucoma does not cause cataracts and cataracts do not cause glaucoma. That being said, cataract surgery involves creating a small incision in the lens of the eye to remove the affected, or “cloudy” area of the lens. -
Proposed International Clinical Diabetic Retinopathy and Diabetic Macular Edema Disease Severity Scales
Proposed International Clinical Diabetic Retinopathy and Diabetic Macular Edema Disease Severity Scales C. P. Wilkinson, MD,1 Frederick L. Ferris, III, MD,2 Ronald E. Klein, MD, MPH,3 Paul P. Lee, MD, JD,4 Carl David Agardh, MD,5 Matthew Davis, MD,3 Diana Dills, MD,6 Anselm Kampik, MD,7 R. Pararajasegaram, MD,8 Juan T. Verdaguer, MD,9 representing the Global Diabetic Retinopathy Project Group Purpose: To develop consensus regarding clinical disease severity classification systems for diabetic retinopathy and diabetic macular edema that can be used around the world, and to improve communication and coordination of care among physicians who care for patients with diabetes. Design: Report regarding the development of clinical diabetic retinopathy disease severity scales. Participants: A group of 31 individuals from 16 countries, representing comprehensive ophthalmology, retina subspecialties, endocrinology, and epidemiology. Methods: An initial clinical classification system, based on the Early Treatment Diabetic Retinopathy Study and the Wisconsin Epidemiologic Study of Diabetic Retinopathy publications, was circulated to the group in advance of a workshop. Each member reviewed this using e-mail, and a modified Delphi system was used to stratify responses. At a later workshop, separate systems for diabetic retinopathy and macular edema were developed. These were then reevaluated by group members, and the modified Delphi system was again used to measure degrees of agreement. Main Outcome Measures: Consensus regarding specific classification systems was achieved. Results: A five-stage disease severity classification for diabetic retinopathy includes three stages of low risk, afourthstageofseverenonproliferativeretinopathy,andafifthstageofproliferativeretinopathy.Diabeticmacular edema is classified as apparently present or apparently absent. If training and equipment allow the screener to make a valid decision, macular edema is further categorized as a function of its distance from the central macula. -
Miotics in Closed-Angle Glaucoma
Brit. J. Ophthal. (I975) 59, 205 Br J Ophthalmol: first published as 10.1136/bjo.59.4.205 on 1 April 1975. Downloaded from Miotics in closed-angle glaucoma F. GANIAS AND R. MAPSTONE St. Paul's Eye Hospital, Liverpool The initial treatment of acute primary closed-angle Table i Dosage in Groups I, 2, and 3 glaucoma (CAG) is directed towards lowering intraocular pressure (IOP) to normal levels as Group Case no. Duration IOP Time rapidly as possible. To this end, aqueous inflow is (days) (mm. Hg) (hrs) reduced by a drug such as acetazolamide (Diamox), and aqueous outflow is increased via the trabecular I I 2 8 5 meshwork by opening the closed angle with miotics. 3 7 21 3 The use of miotics is of respectable lineage and hal- 5 '4 48 7 lowed by usage, but regimes vary from "intensive" 7 8 I4 5 9 I0 I8 6 (i.e. frequent) to "occasional" (i.e. infrequent) instilla- I I 2 12 6 tions. Finally, osmotic agents are used after a variable '3 5 20 6 interval of time if the IOP remains raised. Tlle pur- I5 '4 I8 6 pose of this paper is to investigate the value of '7 '4 i6 6 miotics in the initial treatment of CAG. I9 6 02 2 2 2 8 2I 5 Material and methods 4 20t 20 6 Twenty patients with acute primary closed-angle glau- 6 I i8 5 http://bjo.bmj.com/ coma were treated, alternately, in one of two ways 8 4 i8 5 detailed below: I0 6 I8 6 I2 I0 20 6 (I) Intravenous Diamox 500 mg. -
Drug Class Review Ophthalmic Cholinergic Agonists
Drug Class Review Ophthalmic Cholinergic Agonists 52:40.20 Miotics Acetylcholine (Miochol-E) Carbachol (Isopto Carbachol; Miostat) Pilocarpine (Isopto Carpine; Pilopine HS) Final Report November 2015 Review prepared by: Melissa Archer, PharmD, Clinical Pharmacist Carin Steinvoort, PharmD, Clinical Pharmacist Gary Oderda, PharmD, MPH, Professor University of Utah College of Pharmacy Copyright © 2015 by University of Utah College of Pharmacy Salt Lake City, Utah. All rights reserved. Table of Contents Executive Summary ......................................................................................................................... 3 Introduction .................................................................................................................................... 4 Table 1. Glaucoma Therapies ................................................................................................. 5 Table 2. Summary of Agents .................................................................................................. 6 Disease Overview ........................................................................................................................ 8 Table 3. Summary of Current Glaucoma Clinical Practice Guidelines ................................... 9 Pharmacology ............................................................................................................................... 10 Methods ....................................................................................................................................... -
Association Between Visual Field Damage and Corneal Structural
www.nature.com/scientificreports OPEN Association between visual feld damage and corneal structural parameters Alexandru Lavric1*, Valentin Popa1, Hidenori Takahashi2, Rossen M. Hazarbassanov3 & Siamak Yousef4,5 The main goal of this study is to identify the association between corneal shape, elevation, and thickness parameters and visual feld damage using machine learning. A total of 676 eyes from 568 patients from the Jichi Medical University in Japan were included in this study. Corneal topography, pachymetry, and elevation images were obtained using anterior segment optical coherence tomography (OCT) and visual feld tests were collected using standard automated perimetry with 24-2 Swedish Interactive Threshold Algorithm. The association between corneal structural parameters and visual feld damage was investigated using machine learning and evaluated through tenfold cross-validation of the area under the receiver operating characteristic curves (AUC). The average mean deviation was − 8.0 dB and the average central corneal thickness (CCT) was 513.1 µm. Using ensemble machine learning bagged trees classifers, we detected visual feld abnormality from corneal parameters with an AUC of 0.83. Using a tree-based machine learning classifer, we detected four visual feld severity levels from corneal parameters with an AUC of 0.74. Although CCT and corneal hysteresis have long been accepted as predictors of glaucoma development and future visual feld loss, corneal shape and elevation parameters may also predict glaucoma-induced visual functional loss. While intraocular pressure (IOP), age, disc hemorrhage, and optic cup characteristics have been long identifed as classic risk factors for development of primary open-angle glaucoma (POAG)1,2, the Ocular Hypertension Treatment Study (OHTS) suggested central corneal thickness (CCT) as a new risk factor for development of POAG3. -
Flammer Syndrome, a Potential Risk Factor for Central Serous Chorioretinopathy?
Review Article ISSN: 2574 -1241 DOI: 10.26717/BJSTR.2020.24.004026 Flammer Syndrome, A Potential Risk Factor for Central Serous Chorioretinopathy? Tatjana Josifova 1*, Franz Fankhauser1 and Katarzyna Konieczka1,2 1Augenzentrum Prof Fankhauser, Bern, Switzerland 2Universitätspital Basel, Augenklinik, Basel, Switzerland *Corresponding author: Tatjana Josifova, Augenzentrum Prof Fankhauser, Bern, Switzerland ARTICLE INFO Abstract Received: December 16, 2019 Central serous chorioretinopathy (CSCR) is forth most common retinal disease, Published: January 06, 2020 mostly affecting men in their third and fourth life decade. Changes most often involve the macula and are associated with pigment epithelial and neurosensory retinal detachment. The literature highlights an involvement of the choroidal veins and pigment Citation: Tatjana Josifova, Franz Fankhaus- epithelium in the pathogenesis of CSCR. Nevertheless, both the risk factors and the molecular mechanisms of CSCR remain uncertain. The Flammer syndrome refers to a er, Katarzyna Konieczka. Flammer Syn- phenotype characterized by the combination of primary vascular dysregulation with drome, A Potential Risk Factor for Central a cluster of additional symptoms and signs. Subjects affected by the syndrome have Serous Chorioretinopathy?. Biomed J Sci & a predisposition to react differently to a number of stimuli, such as cold, physical or Tech Res 24(2)-2020. BJSTR. MS.ID.004026. emotional stress, or high altitude. We postulate that Flammer syndrome might be one of the risk factors for CSCR. This -
Retinal Detachment with Subretinal and Vitreous Hemorrhages Causing Secondary Angle Closure Glaucoma Diagnosed with Ultrasound
Henry Ford Health System Henry Ford Health System Scholarly Commons Emergency Medicine Articles Emergency Medicine 5-22-2020 Retinal detachment with subretinal and vitreous hemorrhages causing secondary angle closure glaucoma diagnosed with ultrasound Michael B. Holbrook Daniel Kaitis Lily Van Laere Jeffrey Van Laere Christopher R. Clark Follow this and additional works at: https://scholarlycommons.henryford.com/ emergencymedicine_articles YAJEM-159017; No of Pages 2 American Journal of Emergency Medicine xxx (xxxx) xxx Contents lists available at ScienceDirect American Journal of Emergency Medicine journal homepage: www.elsevier.com/locate/ajem Retinal detachment with subretinal and vitreous hemorrhages causing secondary angle closure glaucoma diagnosed with ultrasound Michael B. Holbrook, MD, MBA a,⁎, Daniel Kaitis, MD b, Lily Van Laere, MD b, Jeffrey Van Laere, MD, MPH a, Chris Clark, MD a a Henry Ford Hospital, Department of Emergency Medicine, Detroit, MI, United States of America b Henry Ford Hospital, Department of Ophthalmology, Detroit, MI, United States of America A 90-year-old female with a past medical history of trigeminal neu- choroid/retina consistent with a retinal detachment. Her pain was con- ralgia and age-related macular degeneration (AMD) presented with a trolled with oral hydrocodone/acetaminophen. Ultimately her vision four-day history of a left-sided headache, nausea, and vomiting. Regard- was deemed unsalvageable given her age, length of symptoms, and ing her left eye, she reported intermittent flashes of light over the past lack of light perception. At time of discharge, her left eye's IOP was month and complete vision loss for four days. She denied a history of di- 49 mmHg. -
Diabetic Retinopathy
RETINA HEALTH SERIES | Facts from the ASRS The Foundation American Society of Retina Specialists Committed to improving the quality of life of all people with retinal disease. Diabetic Retinopathy: Diabetic retinopathy (pronounced ret in OP uh thee) is a complication of diabetes that causes damage to the blood vessels of the retina— the light-sensitive tissue that lines the back part of the eye, allowing you to see fine detail. Diabetic retinopathy is the most common cause of irreversible blindness in working-age Americans. As many people with type 1 diabetes suffer blindness SYMPTOMS as those with the more common type 2 disease. Diabetic retinopathy occurs in more than half of the people who develop diabetes. It is possible to have diabetic retinopathy for a long time Causes: The primary cause of diabetic retinopathy is diabetes—a condition in without noticing symptoms until which the levels of glucose (sugar) in the blood are too high. Elevated sugar substantial damage has occurred. levels from diabetes can damage the small blood vessels that nourish the Symptoms of diabetic retinopathy retina and may, in some cases, block them completely. may occur in one or both eyes. When damaged blood vessels leak fluid into the retina it results in a Symptoms may include: condition known as diabetic macular edema which causes swelling in the • Blurred or double vision center part of the eye (macula) that provides the sharp vision needed for • Difficulty reading reading and recognizing faces. • The appearance of spots— Prolonged damage to the small blood vessels in the retina results in poor commonly called “floaters”— circulation to the retina and macula prompting the development of growth in your vision factors that cause new abnormal blood vessels (neovascularization) and scar • A shadow across the field of vision tissue to grow on the surface of the retina. -
Fact Sheet About Diabetic Macular Edema (Dme)
FACT SHEET ABOUT DIABETIC MACULAR EDEMA (DME) WHAT IS DME? Diabetic Macular Edema (DME) or "swelling of the macula" is a common complication in the eyes of patients with diabetes. It is a frequent cause of vision loss in patients with diabetes, and can eventually lead to blindness.1,2 The macula is the part of the retina responsible for central or fine vision. In DME, blood vessels in the retina are damaged by chronic high blood sugar levels. A breakdown in the blood-retinal barrier and increased vascular permeability allows fluid from blood vessels to leak into the retina, causing macular swelling.2 Fluid in the macula can cause severe vision loss or blindness.2 Vascular endothelial growth factor (VEGF), a naturally occurring family of growth factors in the body, appears to play a critical role in the development of DME.3 Increased VEGF production contributes to the vascular disruptions and leakage that characterize DME, as well as the formation of new blood vessels (a process known as angiogenesis) seen in more advanced forms of diabetic retinopathy (DR).2 DME STATISTICS According to the Centers for Disease Control and Prevention, approximately 29.1 million adults are living with diabetes (types I & II) in the U.S. 4 Of those, approximately 1.5 million people are diagnosed with DME.5 o The prevalence of DME is especially high among racial and ethnic minorities, particularly in African Americans.6 DME is the leading cause of blindness in young adults in developed countries.7 The increasing number of individuals with diabetes worldwide suggests that DME will continue to be a major contributor to vision loss and associated functional impairment.