Tao, Xin; Landis, Jessica N; Krisher, Rebecca L; Duncan, Francesca E; Silva, Elena; Lonczak, Agnieszka; Scott, Richard T 3rd; Zhan, Yiping; Chu, Tinchun; Scott, Richard T Jr; Treff, Nathan R. Mitochondrial DNA content is associated with ploidy status, maternal age, and oocyte maturation methods in mouse blastocysts.. J Assist Reprod Genet. 2017 Dec;34(12):1587-1594. doi: 10.1007/s10815-017-1070-8. Epub 2017 Oct 24. PubMed PMID: 29063991. Capalbo, Antonio; Treff, Nathan; Cimadomo, Danilo; Tao, Xin; Ferrero, Susanna; Vaiarelli, Alberto; Colamaria, Silvia; Maggiulli, Roberta; Orlando, Giovanna; Scarica, Catello; Scott, Richard; Ubaldi, Filippo Maria; Rienzi, Laura. Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles.. Fertil Steril. 2017 Dec;108(6):1007-1015.e3. doi: 10.1016/ j.fertnstert.2017.08.004. Epub 2017 Sep 15. PubMed PMID: 28923286. Treff, Nathan R; Zimmerman, Rebekah S. Advances in Preimplantation Genetic Testing for Monogenic Disease and Aneuploidy.. Annu Rev Genomics Hum Genet. 2017 Aug 31;18:189-200. doi: 10.1146/annurev-genom-091416-035508. Epub 2017 May 12. PubMed PMID: 28498723. Goodrich, David; Xing, Tongji; Tao, Xin; Lonczak, Agnieszka; Zhan, Yiping; Landis, Jessica; Zimmerman, Rebekah; Scott, Richard T Jr; Treff, Nathan R. Evaluation of comprehensive chromosome screening platforms for the detection of mosaic segmental aneuploidy.. J Assist Reprod Genet. 2017 Aug;34(8):975-981. doi: 10.1007/s10815-017-0924-4. Epub 2017 Jun 2. PubMed PMID: 28577183. Marin, Diego; Scott, Richard T Jr; Treff, Nathan R. Preimplantation embryonic mosaicism: origin, consequences and the reliability of comprehensive chromosome screening.. Curr Opin Obstet Gynecol. 2017 Jun;29(3):168-174. doi: 10.1097/GCO.0000000000000358. PubMed PMID: 28266934. Nguyen, Alexandra L; Marin, Diego; Zhou, Anbo; Gentilello, Amanda S; Smoak, Evan M; Cao, Zubing; Fedick, Anastasia; Wang, Yujue; Taylor, Deanne; Scott, Richard T Jr; Xing, Jinchuan; Treff, Nathan; Schindler, Karen. Identifcation and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.. Mol Hum Reprod. 2017 Jun 1;23(6):406-416. doi: 10.1093/molehr/gax018. PubMed PMID: 28369513. Marin, Diego; Wang, Yujue; Tao, Xin; Scott, Richard T Jr; Treff, Nathan R. Comprehensive chromosome screening and gene expression analysis from the same biopsy in human preimplantation embryos.. Mol Hum Reprod. 2017 May 1;23(5):330-338. doi: 10.1093/molehr/gax014. PubMed PMID: 28369516. Chia, Gloryn; Agudo, Judith; Treff, Nathan; Sauer, Mark V; Billing, David; Brown, Brian D; Baer, Richard; Egli, Dieter. Genomic instability during reprogramming by nuclear transfer is DNA replication dependent.. Nat Cell Biol. 2017 Apr;19(4):282-291. doi: 10.1038/ncb3485. Epub 2017 Mar 6. PubMed PMID: 28263958. Treff, Nathan R; Zhan, Yiping; Tao, Xin; Olcha, Meir; Han, Michael; Rajchel, Jessica; Morrison, Liza; Morin, Scott J; Scott, Richard T Jr. Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos.. Hum Reprod. 2017 Apr 1;32(4):954-962. doi: 10.1093/humrep/dex034. PubMed PMID: 28333210. Morin, Scott J; Treff, Nathan R; Tao, Xin; Scott, Richard T 3rd; Franasiak, Jason M; Juneau, Caroline R; Maguire, Marcy; Scott, Richard T. Combination of uterine natural killer cell immunoglobulin receptor haplotype and trophoblastic HLA-C ligand infuences the risk of pregnancy loss: a retrospective cohort analysis of direct embryo genotyping data from euploid transfers.. Fertil Steril. 2017 Mar;107(3):677-683.e2. doi: 10.1016/j.fertnstert.2016.12.004. Epub 2017 Jan 6. PubMed PMID: 28069185. Capalbo, Antonio; Ubaldi, Filippo Maria; Rienzi, Laura; Scott, Richard; Treff, Nathan. Detecting mosaicism in trophectoderm biopsies: current challenges and future possibilities.. Hum Reprod. 2017 Mar 1;32(3):492-498. doi: 10.1093/humrep/dew250. PubMed PMID: 27738115. Capalbo, Antonio; Ubaldi, Filippo; Rienzi, Laura; Scott, Richard; Treff, Nathan. Reply: Detecting mosaicism in trophectoderm biopsies.. Hum Reprod. 2017 Mar 1;32(3):714-715. doi: 10.1093/humrep/dew347. PubMed PMID: 28043946. Neal, Shelby A; Franasiak, Jason M; Forman, Eric J; Werner, Marie D; Morin, Scott J; Tao, Xin; Treff, Nathan R; Scott, Richard T Jr. High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes.. Fertil Steril. 2017 Mar;107(3):731-736.e1. doi: 10.1016/j.fertnstert.2016.11.013. Epub 2016 Dec 8. PubMed PMID: 27939761. Grifn, Darren K; Fishel, Simon; Gordon, Tony; Yaron, Yuval; Grifo, Jamie; Hourvitz, Ariel; Rechitsky, Svetlana; Elson, Janine; Blazek, Joshua; Fiorentino, Francesco; Treff, Nathan; Munne, Santiago; Leong, Milton; Schmutzler, Andreas; Vereczkey, Attila; Ghobara, Tarek; Nanassy, Laszlo; Large, Michael; Hamamah, Samir; Anderson, Robert; Gianaroli, Luca; Wells, Dagan. Continuing to deliver: the evidence base for pre-implantation genetic screening.. BMJ. 2017 Feb 14;356:j752. doi: 10.1136/bmj.j752. PubMed PMID: 28196796. Treff, Nathan R; Franasiak, Jason M. Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations.. Fertil Steril. 2017 Jan;107(1):27-31. doi: 10.1016/j.fertnstert.2016.09.039. Epub 2016 Nov 2. PubMed PMID: 27816233. Goodrich, David; Tao, Xin; Bohrer, Chelsea; Lonczak, Agnieszka; Xing, Tongji; Zimmerman, Rebekah; Zhan, Yiping; Scott, Richard T Jr; Treff, Nathan R. A randomized and blinded comparison of qPCR and NGS-based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism.. J Assist Reprod Genet. 2016 Nov;33(11):1473-1480. doi: 10.1007/s10815-016-0784-3. Epub 2016 Aug 6. PubMed PMID: 27497716. Franasiak, Jason M; Olcha, Meir; Shastri, Shefali; Molinaro, Thomas A; Congdon, Haley; Treff, Nathan R; Scott, Richard T Jr. Embryonic aneuploidy does not differ among genetic ancestry according to continental origin as determined by ancestry informative markers.. Hum Reprod. 2016 Oct;31(10):2391-5. doi: 10.1093/ humrep/dew195. Epub 2016 Sep 2. PubMed PMID: 27591228. Sermon, Karen; Capalbo, Antonio; Cohen, Jacques; Coonen, Edith; De Rycke, Martine; De Vos, Anick; Delhanty, Joy; Fiorentino, Francesco; Gleicher, Norbert; Griesinger, Georg; Grifo, Jamie; Handyside, Alan; Harper, Joyce; Kokkali, Georgia; Mastenbroek, Sebastiaan; Meldrum, David; Meseguer, Marcos; Montag, Markus; Munne, Santiago; Rienzi, Laura; Rubio, Carmen; Scott, Katherine; Scott, Richard; Simon, Carlos; Swain, Jason; Treff, Nathan; Ubaldi, Filippo; Vassena, Rita; Vermeesch, Joris Robert; Verpoest, Willem; Wells, Dagan; Geraedts, Joep. The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.. Mol Hum Reprod. 2016 Aug;22(8):845-57. doi: 10.1093/molehr/gaw034. Epub 2016 Jun 2. PubMed PMID: 27256483. Franasiak, Jason M; Barnett, Rebecca; Molinaro, Thomas A; Gabriele, David; Gartmond, Tori D; Treff, Nathan R; Scott, Richard T. CYP1A1 3801T>C polymorphism implicated in altered xenobiotic metabolism is not associated with variations in sperm production and function as measured by total motile sperm and fertilization rates with intracytoplasmic sperm injection.. Fertil Steril. 2016 Aug;106(2):481-6. doi: 10.1016/j.fertnstert.2016.04.003. Epub 2016 Apr 23. PubMed PMID: 27117375. Treff, Nathan R; Thompson, Katherine; Rafzadeh, Michael; Chow, Michael; Morrison, Liza; Tao, Xin; Garnsey, Heather; Reda, Christine V; Metzgar, Talia L; Neal, Shelby; Jalas, Chaim; Scott, Richard T Jr; Forman, Eric J. SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts.. J Assist Reprod Genet. 2016 Aug;33(8):1115-9. doi: 10.1007/s10815-016-0734-0. Epub 2016 May 30. PubMed PMID: 27241531. Olcha, Meir; Franasiak, Jason M; Shastri, Shefali; Molinaro, Thomas A; Congdon, Haley; Treff, Nathan R; Scott, Richard T Jr. Genotypically determined ancestry across an infertile population: ovarian reserve and response parameters are not infuenced by continental origin.. Fertil Steril. 2016 Aug;106(2):475-80. doi: 10.1016/j.fertnstert.2016.03.052. Epub 2016 Apr 14. PubMed PMID: 27087402. St Louis, Sarah; Scott, Richard; Lewis, Christa; Salamon, Charbel; Pagnillo, Jennifer; Treff, Nathan; Taylor, Deanne; Culligan, Patrick. Genetic Mutation that May Contribute to Failure of Prolapse Surgery in White Women: A Case-Control Study.. J Minim Invasive Gynecol. 2016 Jul-Aug;23(5):726-30. doi: 10.1016/ j.jmig.2016.02.019. Epub 2016 Mar 2. PubMed PMID: 26944198. Edvardson, Simon; Yi, Jae Kyo; Jalas, Chaim; Xu, Ruijuan; Webb, Bryn D; Snider, Justin; Fedick, Anastasia; Kleinman, Elisheva; Treff, Nathan R; Mao, Cungui; Elpeleg, Orly. Defciency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy.. J Med Genet. 2016 Jun;53(6):389-96. doi: 10.1136/jmedgenet-2015-103457. Epub 2016 Jan 20. PubMed PMID: 26792856. Juneau, Caroline; Franasiak, Jason; Treff, Nathan. Challenges facing contemporary preimplantation genetic screening.. Curr Opin Obstet Gynecol. 2016 Jun;28(3):151-7. doi: 10.1097/GCO.0000000000000270. PubMed PMID: 27042995. Treff, Nathan R; Krisher, Rebecca L; Tao, Xin; Garnsey, Heather; Bohrer, Chelsea; Silva, Elena; Landis, Jessica; Taylor, Deanne; Scott, Richard T; Woodruff, Teresa K; Duncan, Francesca E. Next Generation Sequencing-Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos.. Biol Reprod. 2016 Apr;94(4):76. doi: 10.1095/biolreprod.115.135483. Epub 2016 Feb 24. PubMed PMID: 26911429. Kort, Daniel H; Chia, Gloryn; Treff, Nathan R; Tanaka, Akemi J; Xing, Tongji; Vensand, Lauren Bauer; Micucci, Stephanie; Prosser, Robert; Lobo, Roger A; Sauer, Mark V; Egli, Dieter. Human embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy, and developmental arrest.. Hum Reprod. 2016 Feb;31(2):312-23. doi: 10.1093/humrep/dev281. Epub 2015 Nov 29. PubMed PMID: 26621855. Edvardson, Simon; Kose, Shingo; Jalas, Chaim; Fattal-Valevski, Aviva; Watanabe, Ai; Ogawa, Yutaka; Mamada, Hiroshi; Fedick, Anastasia M; Ben-Shachar, Shay; Treff, Nathan R; Shaag, Avraham; Bale, Sherri; Gartner, Jutta; Imamoto, Naoko; Elpeleg, Orly. Leukoencephalopathy and early death associated with an Ashkenazi- Jewish founder mutation in the Hikeshi gene.. J Med Genet. 2016 Feb;53(2):132-7. doi: 10.1136/jmedgenet-2015-103232. Epub 2015 Nov 6. PubMed PMID: 26545878. Zimmerman, Rebekah S; Jalas, Chaim; Tao, Xin; Fedick, Anastasia M; Kim, Julia G; Pepe, Russell J; Northrop, Lesley E; Scott, Richard T Jr; Treff, Nathan R. Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole genome amplifcation.. Fertil Steril. 2016 Feb;105(2):286-94. doi: 10.1016/j.fertnstert.2015.10.003. Epub 2015 Oct 23. PubMed PMID: 26602983. Patounakis, George; Bergh, Eric; Forman, Eric J; Tao, Xin; Lonczak, Agnieszka; Franasiak, Jason M; Treff, Nathan; Scott, Richard T Jr. Multiple thrombophilic single nucleotide polymorphisms lack a signifcant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients.. J Assist Reprod Genet. 2016 Jan;33(1):67-73. doi: 10.1007/s10815-015-0606-z. Epub 2015 Nov 6. PubMed PMID: 26545911. Gardner, David K; Meseguer, Marcos; Rubio, Carmen; Treff, Nathan R. Diagnosis of human preimplantation embryo viability.. Hum Reprod Update. 2015 Nov- Dec;21(6):727-47. doi: 10.1093/humupd/dmu064. Epub 2015 Jan 6. PubMed PMID: 25567750. Fellmeth, Jessica E; Gordon, Derek; Robins, Christian E; Scott, Richard T Jr; Treff, Nathan R; Schindler, Karen. Expression and characterization of three Aurora kinase C splice variants found in human oocytes.. Mol Hum Reprod. 2015 Aug;21(8):633-44. doi: 10.1093/molehr/gav026. Epub 2015 May 20. PubMed PMID: 25995441. Fedick, A M; Shi, L; Jalas, C; Treff, N R; Ekstein, J; Kornreich, R; Edelmann, L; Mehta, L; Savage, S A. Carrier screening of RTEL1 mutations in the Ashkenazi Jewish population.. Clin Genet. 2015 Aug;88(2):177-81. doi: 10.1111/cge.12459. Epub 2014 Sep 5. PubMed PMID: 25047097. Capalbo, Antonio; Treff, Nathan R; Cimadomo, Danilo; Tao, Xin; Upham, Kathleen; Ubaldi, Filippo Maria; Rienzi, Laura; Scott, Richard T Jr. Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies.. Eur J Hum Genet. 2015 Jul;23(7):901-6. doi: 10.1038/ejhg.2014.222. Epub 2014 Oct 29. PubMed PMID: 25351780. Anderson, S L; Jalas, C; Fedick, A; Reid, K F; Carpenter, T O; Chirnomas, D; Treff, N R; Ekstein, J; Rubin, B Y. A founder mutation in the TCIRG1 gene causes osteopetrosis in the Ashkenazi Jewish population.. Clin Genet. 2015 Jul;88(1):74-9. doi: 10.1111/cge.12448. Epub 2014 Jul 31. PubMed PMID: 24989235. Werner, Marie D; Scott, Richard T Jr; Treff, Nathan R. 24-chromosome PCR for aneuploidy screening.. Curr Opin Obstet Gynecol. 2015 Jun;27(3):201-5. doi: 10.1097/GCO.0000000000000167. PubMed PMID: 25699477. Fedick, Anastasia M; Jalas, Chaim; Treff, Nathan R; Knowles, Michael R; Zariwala, Maimoona A. Carrier frequencies of eleven mutations in eight genes associated with primary ciliary dyskinesia in the Ashkenazi Jewish population.. Mol Genet Genomic Med. 2015 Mar;3(2):137-42. doi: 10.1002/mgg3.124. Epub 2014 Dec 6. PubMed PMID: 25802884. Werner, Marie D; Leondires, Mark P; Schoolcraft, William B; Miller, Brad T; Copperman, Alan B; Robins, Edwin D; Arredondo, Francisco; Hickman, Timothy N; Gutmann, Jacqueline; Schillings, Wendy J; Levy, Brynn; Taylor, Deanne; Treff, Nathan R; Scott, Richard T Jr. Clinically recognizable error rate after the transfer of comprehensive chromosomal screened euploid embryos is low.. Fertil Steril. 2014 Dec;102(6):1613-8. doi: 10.1016/j.fertnstert.2014.09.011. Epub 2014 Oct 22. PubMed PMID: 25439802. Scott, Richard T 3rd; Su, Jing; Tao, Xin; Forman, Eric J; Hong, Kathleen H; Taylor, Deanne; Treff, Nathan R. Trophectoderm DNA fngerprinting by quantitative real- time PCR successfully distinguishes sibling human embryos.. J Assist Reprod Genet. 2014 Nov;31(11):1421-5. doi: 10.1007/s10815-014-0315-z. Epub 2014 Aug 17. PubMed PMID: 25129376. Franasiak, Jason M; Forman, Eric J; Hong, Kathleen H; Werner, Marie D; Upham, Kathleen M; Treff, Nathan R; Scott, Richard T. Aneuploidy across individual chromosomes at the embryonic level in trophectoderm biopsies: changes with patient age and chromosome structure.. J Assist Reprod Genet. 2014 Nov;31(11):1501-9. doi: 10.1007/s10815-014-0333-x. Epub 2014 Sep 21. PubMed PMID: 25241130. Gueye, Ndeye-Aicha; Jalas, Chaim; Tao, Xin; Taylor, Deanne; Scott, Richard T Jr; Treff, Nathan R. Improved sensitivity to detect recombination using qPCR for Dyskeratosis Congenita PGD.. J Assist Reprod Genet. 2014 Sep;31(9):1227-30. doi: 10.1007/s10815-014-0298-9. Epub 2014 Aug 7. PubMed PMID: 25099625. Salvaggio, C N; Forman, E J; Garnsey, H M; Treff, N R; Scott, R T Jr. Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potential.. J Assist Reprod Genet. 2014 Sep;31(9):1221-6. doi: 10.1007/s10815-014-0293-1. Epub 2014 Aug 9. PubMed PMID: 25106935. Fedick, Anastasia M; Eckert, Kyle; Thompson, Katharine; Forman, Eric J; Devkota, Batsal; Treff, Nathan R; Taylor, Deanne; Scott, Richard T Jr. Lack of association of KATNAL1 gene sequence variants and azoospermia in humans.. J Assist Reprod Genet. 2014 Aug;31(8):1065-71. doi: 10.1007/s10815-014-0269-1. Epub 2014 Jun 10. PubMed PMID: 24913027. Chung, Young Gie; Eum, Jin Hee; Lee, Jeoung Eun; Shim, Sung Han; Sepilian, Vicken; Hong, Seung Wook; Lee, Yumie; Treff, Nathan R; Choi, Young Ho; Kimbrel, Erin A; Dittman, Ralph E; Lanza, Robert; Lee, Dong Ryul. Human somatic cell nuclear transfer using adult cells.. Cell Stem Cell. 2014 Jun 5;14(6):777-80. doi: 10.1016/ j.stem.2014.03.015. Epub 2014 Apr 17. PubMed PMID: 24746675. Fedick, A; Jalas, C; Abeliovich, D; Krakinovsky, Y; Ekstein, J; Ekstein, A; Treff, N R. Carrier frequency of two BBS2 mutations in the Ashkenazi population.. Clin Genet. 2014 Jun;85(6):578-82. doi: 10.1111/cge.12231. Epub 2013 Jul 28. PubMed PMID: 23829372. Fedick, A; Jalas, C; Treff, N R. A deleterious mutation in the PEX2 gene causes Zellweger syndrome in individuals of Ashkenazi Jewish descent.. Clin Genet. 2014 Apr;85(4):343-6. doi: 10.1111/cge.12170. Epub 2013 May 3. PubMed PMID: 23590336. Franasiak, Jason M; Forman, Eric J; Hong, Kathleen H; Werner, Marie D; Upham, Kathleen M; Treff, Nathan R; Scott, Richard T Jr. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening.. Fertil Steril. 2014 Mar;101(3):656-663.e1. doi: 10.1016/j.fertnstert.2013.11.004. Epub 2013 Dec 17. PubMed PMID: 24355045. Gueye, Ndeye-Aicha; Devkota, Batsal; Taylor, Deanne; Pfundt, Rolph; Scott, Richard T Jr; Treff, Nathan R. Uniparental disomy in the human blastocyst is exceedingly rare.. Fertil Steril. 2014 Jan;101(1):232-6. doi: 10.1016/j.fertnstert.2013.08.051. Epub 2013 Sep 29. PubMed PMID: 24083874. Edvardson, Simon; Ashikov, Angel; Jalas, Chaim; Sturiale, Luisa; Shaag, Avraham; Fedick, Anastasia; Treff, Nathan R; Garozzo, Domenico; Gerardy-Schahn, Rita; Elpeleg, Orly. Mutations in SLC35A3 cause autism spectrum disorder, epilepsy and arthrogryposis.. J Med Genet. 2013 Nov;50(11):733-9. doi: 10.1136/ jmedgenet-2013-101753. Epub 2013 Sep 12. PubMed PMID: 24031089. Forman, Eric J; Upham, Kathleen M; Cheng, Michael; Zhao, Tian; Hong, Kathleen H; Treff, Nathan R; Scott, Richard T Jr. Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer.. Fertil Steril. 2013 Sep;100(3):718-24. doi: 10.1016/j.fertnstert.2013.04.043. Epub 2013 May 30. PubMed PMID: 23725804. Scott, Richard T Jr; Upham, Kathleen M; Forman, Eric J; Zhao, Tian; Treff, Nathan R. Cleavage-stage biopsy signifcantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial.. Fertil Steril. 2013 Sep;100(3):624-30. doi: 10.1016/j.fertnstert.2013.04.039. Epub 2013 Jun 15. PubMed PMID: 23773313. Scott, Richard T Jr; Upham, Kathleen M; Forman, Eric J; Hong, Kathleen H; Scott, Katherine L; Taylor, Deanne; Tao, Xin; Treff, Nathan R. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer signifcantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial.. Fertil Steril. 2013 Sep;100(3):697-703. doi: 10.1016/j.fertnstert.2013.04.035. Epub 2013 Jun 1. PubMed PMID: 23731996. Scott, Richard T Jr; Forman, Eric J; Treff, Nathan R. Reply of the authors.. Fertil Steril. 2013 Aug;100(2):e7-8. doi: 10.1016/j.fertnstert.2013.05.045. Epub 2013 Jun 24. PubMed PMID: 23806845. Forman, Eric J; Hong, Kathleen H; Ferry, Kathleen M; Tao, Xin; Taylor, Deanne; Levy, Brynn; Treff, Nathan R; Scott, Richard T Jr. In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial.. Fertil Steril. 2013 Jul;100(1):100-7.e1. doi: 10.1016/j.fertnstert.2013.02.056. Epub 2013 Mar 30. PubMed PMID: 23548942. Treff, Nathan R; Forman, Eric J; Katz-Jaffe, Mandy G; Schoolcraft, William B; Levy, Brynn; Scott, Richard T Jr. Incidental identifcation of balanced translocation carrier patients through comprehensive chromosome screening of IVF-derived blastocysts.. J Assist Reprod Genet. 2013 Jun;30(6):787-91. doi: 10.1007/ s10815-013-0008-z. Epub 2013 May 31. PubMed PMID: 23722938. Treff, Nathan R; Forman, Eric J; Scott, Richard T Jr. Next-generation sequencing for preimplantation genetic diagnosis.. Fertil Steril. 2013 May;99(6):e17-8. doi: 10.1016/j.fertnstert.2013.02.034. Epub 2013 Mar 5. PubMed PMID: 23481279. Treff, Nathan R; Fedick, Anastasia; Tao, Xin; Devkota, Batsal; Taylor, Deanne; Scott, Richard T Jr. Evaluation of targeted next-generation sequencing-based preimplantation genetic diagnosis of monogenic disease.. Fertil Steril. 2013 Apr;99(5):1377-1384.e6. doi: 10.1016/j.fertnstert.2012.12.018. Epub 2013 Jan 9. PubMed PMID: 23312231. Treff, Nathan R; Scott, Richard T Jr. Four-hour quantitative real-time polymerase chain reaction-based comprehensive chromosome screening and accumulating evidence of accuracy, safety, predictive value, and clinical efcacy.. Fertil Steril. 2013 Mar 15;99(4):1049-53. doi: 10.1016/j.fertnstert.2012.11.007. Epub 2012 Nov 30. PubMed PMID: 23206734. Forman, E J; Treff, N R; Stevens, J M; Garnsey, H M; Katz-Jaffe, M G; Scott, R T Jr; Schoolcraft, W B. Embryos whose polar bodies contain isolated reciprocal chromosome aneuploidy are almost always euploid.. Hum Reprod. 2013 Feb;28(2):502-8. doi: 10.1093/humrep/des393. Epub 2012 Nov 20. PubMed PMID: 23169867. Paull, Daniel; Emmanuele, Valentina; Weiss, Keren A; Treff, Nathan; Stewart, Latoya; Hua, Haiqing; Zimmer, Matthew; Kahler, David J; Goland, Robin S; Noggle, Scott A; Prosser, Robert; Hirano, Michio; Sauer, Mark V; Egli, Dieter. Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants.. Nature. 2013 Jan 31;493(7434):632-7. doi: 10.1038/nature11800. Epub 2012 Dec 19. PubMed PMID: 23254936. Fedick, Anastasia; Su, Jing; Jalas, Chaim; Northrop, Lesley; Devkota, Batsal; Ekstein, Josef; Treff, Nathan R. High-throughput carrier screening using TaqMan allelic discrimination.. PLoS One. 2013;8(3):e59722. doi: 10.1371/journal.pone.0059722. Epub 2013 Mar 26. PubMed PMID: 23555759. Treff, Nathan R; Campos, Jessyca; Tao, Xin; Levy, Brynn; Ferry, Kathleen M; Scott, Richard T Jr. Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder.. Fertil Steril. 2012 Nov;98(5):1236-40. doi: 10.1016/j.fertnstert.2012.07.1119. Epub 2012 Aug 21. PubMed PMID: 22921075. Fedick, Anastasia; Su, Jing; Jalas, Chaim; Treff, Nathan R. High-throughput real-time PCR-based genotyping without DNA purifcation.. BMC Res Notes. 2012 Oct 19;5:573. doi: 10.1186/1756-0500-5-573. PubMed PMID: 23083336. Forman, Eric J; Li, Xinying; Ferry, Kathleen M; Scott, Katherine; Treff, Nathan R; Scott, Richard T Jr. Oocyte vitrifcation does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fngerprinting.. Fertil Steril. 2012 Sep;98(3):644-9. doi: 10.1016/j.fertnstert.2012.04.028. Epub 2012 May 17. PubMed PMID: 22608316. Treff, Nathan R. Genome-wide analysis of human preimplantation aneuploidy.. Semin Reprod Med. 2012 Aug;30(4):283-8. doi: 10.1055/s-0032-1313907. Epub 2012 Jun 21. PubMed PMID: 22723009. Forman, Eric J; Hong, Kathleen H; Treff, Nathan R; Scott, Richard T. Comprehensive chromosome screening and embryo selection: moving toward single euploid blastocyst transfer.. Semin Reprod Med. 2012 Jun;30(3):236-42. doi: 10.1055/s-0032-1311526. Epub 2012 May 14. PubMed PMID: 22585635. Scott, Richard T Jr; Treff, Nathan R; Stevens, John; Forman, Eric J; Hong, Kathleen H; Katz-Jaffe, Mandy G; Schoolcraft, William B. Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploid polar bodies.. J Assist Reprod Genet. 2012 Jun;29(6):533-7. doi: 10.1007/s10815-012-9746-6. Epub 2012 Mar 30. PubMed PMID: 22460080. Treff, Nathan R; Scott, Richard T Jr. Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity.. J Assist Reprod Genet. 2012 May;29(5):381-90. doi: 10.1007/s10815-012-9727-9. Epub 2012 Mar 14. PubMed PMID: 22415246. Treff, Nathan R; Tao, Xin; Ferry, Kathleen M; Su, Jing; Taylor, Deanne; Scott, Richard T Jr. Development and validation of an accurate quantitative real-time polymerase chain reaction-based assay for human blastocyst comprehensive chromosomal aneuploidy screening.. Fertil Steril. 2012 Apr;97(4):819-24. doi: 10.1016/j.fertnstert.2012.01.115. Epub 2012 Feb 18. PubMed PMID: 22342859. Forman, E J; Tao, X; Ferry, K M; Taylor, D; Treff, N R; Scott, R T Jr. Single embryo transfer with comprehensive chromosome screening results in improved ongoing pregnancy rates and decreased miscarriage rates.. Hum Reprod. 2012 Apr;27(4):1217-22. doi: 10.1093/humrep/des020. Epub 2012 Feb 16. PubMed PMID: 22343551. Scott, Richard T Jr; Ferry, Kathleen; Su, Jing; Tao, Xin; Scott, Katherine; Treff, Nathan R. Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study.. Fertil Steril. 2012 Apr;97(4):870-5. doi: 10.1016/j.fertnstert.2012.01.104. Epub 2012 Feb 2. PubMed PMID: 22305103. Fedick, Anastasia; Su, Jing; Treff, Nathan R. Development of TaqMan allelic discrimination based genotyping of large DNA deletions.. Genomics. 2012 Mar;99(3):127-31. doi: 10.1016/j.ygeno.2012.01.003. Epub 2012 Jan 17. PubMed PMID: 22281206. Treff, Nathan R; Scott, Richard T Jr; Su, Jing; Campos, Jessyca; Stevens, John; Schoolcraft, William; Katz-Jaffe, Mandy. Polar body morphology is not predictive of its cell division origin.. J Assist Reprod Genet. 2012 Feb;29(2):137-9. doi: 10.1007/s10815-011-9683-9. Epub 2011 Dec 6. PubMed PMID: 22143866. Forman, Eric J; Treff, Nathan R; Scott, Richard T Jr. Fertility after age 45: From natural conception to Assisted Reproductive Technology and beyond.. Maturitas. 2011 Nov;70(3):216-21. doi: 10.1016/j.maturitas.2011.07.003. Epub 2011 Aug 2. PubMed PMID: 21813248. Schoolcraft, William B; Treff, Nathan R; Stevens, John M; Ferry, Kathleen; Katz-Jaffe, Mandy; Scott, Richard T Jr. Live birth outcome with trophectoderm biopsy, blastocyst vitrifcation, and single-nucleotide polymorphism microarray-based comprehensive chromosome screening in infertile patients.. Fertil Steril. 2011 Sep;96(3):638-40. doi: 10.1016/j.fertnstert.2011.06.049. Epub 2011 Jul 23. PubMed PMID: 21782169. A comment to the paper by Waltman et al., Scientometrics, 87, 467-481, 2011.. Scientometrics. 2011 Sep;88(3):1011-1016. Epub 2011 Jun 17. PubMed PMID: 21949453. Treff, Nathan R; Tao, Xin; Su, Jing; Lonczak, Agnieszka; Northrop, Lesley E; Ruiz, Andrew A; Scott, Richard T Jr. Tracking embryo implantation using cell-free fetal DNA enriched from maternal circulation at 9 weeks gestation.. Mol Hum Reprod. 2011 Jul;17(7):434-8. doi: 10.1093/molehr/gar016. Epub 2011 Feb 28. PubMed PMID: 21357209. Treff, Nathan R; Tao, Xin; Schillings, Wendy J; Bergh, Paul A; Scott, Richard T Jr; Levy, Brynn. Use of single nucleotide polymorphism microarrays to distinguish between balanced and normal chromosomes in embryos from a translocation carrier.. Fertil Steril. 2011 Jul;96(1):e58-65. doi: 10.1016/j.fertnstert.2011.04.038. Epub 2011 May 14. PubMed PMID: 21575938. Treff, Nathan R; Su, Jing; Taylor, Deanne; Scott, Richard T Jr. Telomere DNA defciency is associated with development of human embryonic aneuploidy.. PLoS Genet. 2011 Jun;7(6):e1002161. doi: 10.1371/journal.pgen.1002161. Epub 2011 Jun 30. PubMed PMID: 21738493. Treff, Nathan R; Su, Jing; Tao, Xin; Northrop, Lesley E; Scott, Richard T Jr. Single-cell whole-genome amplifcation technique impacts the accuracy of SNP microarray-based genotyping and copy number analyses.. Mol Hum Reprod. 2011 Jun;17(6):335-43. doi: 10.1093/molehr/gaq103. Epub 2010 Dec 21. PubMed PMID: 21177337. Treff, Nathan R; Northrop, Lesley E; Kasabwala, Khushabu; Su, Jing; Levy, Brynn; Scott, Richard T Jr. Single nucleotide polymorphism microarray-based concurrent screening of 24-chromosome aneuploidy and unbalanced translocations in preimplantation human embryos.. Fertil Steril. 2011 Apr;95(5):1606-12.e1-2. doi: 10.1016/j.fertnstert.2010.11.004. Epub 2010 Dec 3. PubMed PMID: 21122835. Kahan, Brenda; Magliocca, Joseph; Merriam, Fabiola; Treff, Nathan; Budde, Melisa; Nelson, Jeffrey; Browning, Victoria; Ziehr, Benjamin; Odorico, Jon. Elimination of tumorigenic stem cells from differentiated progeny and selection of defnitive endoderm reveals a Pdx1+ foregut endoderm stem cell lineage.. Stem Cell Res. 2011 Mar;6(2):143-57. doi: 10.1016/j.scr.2010.10.003. Epub 2010 Oct 30. PubMed PMID: 21130058. Treff, Nathan R; Su, Jing; Tao, Xin; Levy, Brynn; Scott, Richard T Jr. Accurate single cell 24 chromosome aneuploidy screening using whole genome amplifcation and single nucleotide polymorphism microarrays.. Fertil Steril. 2010 Nov;94(6):2017-21. doi: 10.1016/j.fertnstert.2010.01.052. Epub 2010 Feb 26. PubMed PMID: 20188357. Scott, Richard T Jr; Treff, Nathan R. Assessing the reproductive competence of individual embryos: a proposal for the validation of new "-omics" technologies.. Fertil Steril. 2010 Aug;94(3):791-4. doi: 10.1016/j.fertnstert.2010.03.041. Epub 2010 May 11. PubMed PMID: 20460188. Northrop, L E; Treff, N R; Levy, B; Scott, R T Jr. SNP microarray-based 24 chromosome aneuploidy screening demonstrates that cleavage-stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts.. Mol Hum Reprod. 2010 Aug;16(8):590-600. doi: 10.1093/molehr/gaq037. Epub 2010 May 17. PubMed PMID: 20479065. Treff, Nathan R; Levy, Brynn; Su, Jing; Northrop, Lesley E; Tao, Xin; Scott, Richard T Jr. SNP microarray-based 24 chromosome aneuploidy screening is signifcantly more consistent than FISH.. Mol Hum Reprod. 2010 Aug;16(8):583-9. doi: 10.1093/molehr/gaq039. Epub 2010 May 19. PubMed PMID: 20484246. Treff, Nathan R; Su, Jing; Tao, Xin; Miller, Kathleen A; Levy, Brynn; Scott, Richard T Jr. A novel single-cell DNA fngerprinting method successfully distinguishes sibling human embryos.. Fertil Steril. 2010 Jul;94(2):477-84. doi: 10.1016/j.fertnstert.2009.03.067. Epub 2009 Apr 25. PubMed PMID: 19394599. Treff, Nathan R; Su, Jing; Kasabwala, Natasha; Tao, Xin; Miller, Kathleen A; Scott, Richard T Jr. Robust embryo identifcation using frst polar body single nucleotide polymorphism microarray-based DNA fngerprinting.. Fertil Steril. 2010 May 1;93(7):2453-5. doi: 10.1016/j.fertnstert.2009.08.070. Epub 2009 Nov 6. PubMed PMID: 19896651. Patounakis, George; Treff, Nathan; Tao, Xin; Lonczak, Agnieszka; Scott, Richard T Jr; Frattarelli, John L. The p53 codon 72 single nucleotide polymorphism lacks a signifcant effect on implantation rate in fresh in vitro fertilization cycles: an analysis of 1,056 patients.. Fertil Steril. 2009 Oct;92(4):1290-6. doi: 10.1016/ j.fertnstert.2008.07.1783. Epub 2008 Oct 17. PubMed PMID: 18930193. Chung, Young; Bishop, Colin E; Treff, Nathan R; Walker, Stephen J; Sandler, Vladislav M; Becker, Sandy; Klimanskaya, Irina; Wun, Wan-Song; Dunn, Randall; Hall, Rebecca M; Su, Jing; Lu, Shi-Jiang; Maserati, Marc; Choi, Young-Ho; Scott, Richard; Atala, Anthony; Dittman, Ralph; Lanza, Robert. Reprogramming of human somatic cells using human and animal oocytes.. Cloning Stem Cells. 2009 Jun;11(2):213-23. doi: 10.1089/clo.2009.0004. PubMed PMID: 19186982. Oertling, W Anthony; Cornellison, Charisa D; Treff, Nathan R; Watanabe, Junji; Pressler, Michelle A; Small, Jeanne R. Photoacoustic characterization of protein dynamics following CO photodetachment from fully reduced bovine cytochrome c oxidase.. J Inorg Biochem. 2007 Apr;101(4):635-43. doi: 10.1016/ j.jinorgbio.2006.12.003. Epub 2006 Dec 21. PubMed PMID: 17280717. Vincent, Robert; Treff, Nathan; Budde, Melisa; Kastenberg, Zachary; Odorico, Jon. Generation and characterization of novel tetracycline-inducible pancreatic transcription factor-expressing murine embryonic stem cell lines.. Stem Cells Dev. 2006 Dec;15(6):953-62. doi: 10.1089/scd.2006.15.953. PubMed PMID: 17253956. Treff, Nathan R; Vincent, Robert K; Budde, Melisa L; Browning, Victoria L; Magliocca, Joseph F; Kapur, Vivek; Odorico, Jon S. Differentiation of embryonic stem cells conditionally expressing neurogenin 3.. Stem Cells. 2006 Nov;24(11):2529-37. doi: 10.1634/stemcells.2006-0082. Epub 2006 Jun 29. PubMed PMID: 16809427. Xu, Xiaofang; Kahan, Brenda; Forgianni, Andrea; Jing, Peicheng; Jacobson, Lynn; Browning, Victoria; Treff, Nathan; Odorico, Jon. Endoderm and pancreatic islet lineage differentiation from human embryonic stem cells.. Cloning Stem Cells. 2006 Summer;8(2):96-107. doi: 10.1089/clo.2006.8.96. PubMed PMID: 16776601. Cruz, Jeffrey A; Kanazawa, Atsuko; Treff, Nathan; Kramer, David M. Storage of light-driven transthylakoid proton motive force as an electric feld (Deltapsi) under steady-state conditions in intact cells of Chlamydomonas reinhardtii.. Photosynth Res. 2005 Aug;85(2):221-33. doi: 10.1007/s11120-005-4731-x. PubMed PMID: 16075322. Dement, Gregory A; Treff, Nathan R; Magnuson, Nancy S; Franceschi, Vincent; Reeves, Raymond. Dynamic mitochondrial localization of nuclear transcription factor HMGA1.. Exp Cell Res. 2005 Jul 15;307(2):388-401. doi: 10.1016/j.yexcr.2005.04.004. PubMed PMID: 15893306. Treff, Nathan R; Dement, Gregory A; Adair, Jennifer E; Britt, Rachel L; Nie, Rong; Shima, James E; Taylor, Wayne E; Reeves, Raymond. Human KIT ligand promoter is positively regulated by HMGA1 in breast and ovarian cancer cells.. Oncogene. 2004 Nov 4;23(52):8557-62. doi: 10.1038/sj.onc.1207926. PubMed PMID: 15378028.

Treff, Nathan R; Pouchnik, Derek; Dement, Gregory A; Britt, Rachel L; Reeves, Raymond. High-mobility group A1a protein regulates Ras/ERK signaling in MCF-7 human breast cancer cells.. Oncogene. 2004 Jan 22;23(3):777-85. doi: 10.1038/sj.onc.1207167. PubMed PMID: 14737112. Park, Ha-Jeung; Yang, Cheng; Treff, Nathan; Satterlee, James D; Kang, ChulHee. Crystal structures of unligated and CN-ligated Glycera dibranchiata monomer ferric hemoglobin components III and IV.. Proteins. 2002 Oct 1;49(1):49-60. doi: 10.1002/prot.10199. PubMed PMID: 12211015. Pedulla, M L; Treff, N R; Resar, L M; Reeves, R. Sequence and analysis of the murine Hmgiy (Hmga1) gene locus.. Gene. 2001 Jun 13;271(1):51-8. doi: 10.1016/ s0378-1119(01)00500-5. PubMed PMID: 11410365. Genetic Architecture of Complex Traits and Disease Risk Predictors. Validation of simultaneous preimplantation genetic testing (PGT) for aneuploidy, monogenic, and polygenic disorders.