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Global Forum of Sri Lankan Scientists December 2011
Science & Technology for Society Forum Sri Lanka - 07 -10 September 2016 SCIENCE AND TECHNOLOGY FOR SOCIETY FORUM SRI LANKA 2016 07 September 2016 NELUM POKUNA MAHINDA RAJAPAKSA THEATRE 08 -10 September 2016 WATERS EDGE Ministry of Science Technology & Research Ministry of Science Technology & Research 2 Science & Technology for Society Forum Sri Lanka - 07 -10 September 2016 Ministry of Science Technology & Research 3rd Floor, Sethsiripaya Stage 1, Battaramulla, Sri Lanka Cover page design: Ms. Nadeeka Dissanayake Compiled by: Ms. Nadeeka Dissanayake, National Research Council (NRC) and Dr. M.C.N. Jayasuriya, Coordinating Secretariat for Science Technology and Innovation, Ministry of Science Technology and Research Ministry of Science Technology & Research 3 Science & Technology for Society Forum Sri Lanka - 07 -10 September 2016 President’s Message HIS EXCELLENCY MAITHRIPALA SIRISENA PRESIDENT OF THE DEMOCRATIC SOCIALIST REPUBLIC OF SRI LANKA It is with great pleasure that I welcome the delegates from many countries present at the Science and Technology for Society Sri Lanka Forum 2016. I have confidence that the interactions and deliberations at this Forum with scientists from different countries would result in gaining broader insights and resolutions that would enhance sharing and facilitation of scientific knowledge and would benefit everyone in the respective scientific fields. Our society is now in the process of accelerating its progression. In order to understand the real needs and to offer solutions to the societal demands, scientific and professional communities must work closer with their clientele as well as among themselves, and adopt an integrated perspective. This is what is happening at the Forum and what my government aspires to address the real needs of our society, to reach accelerated development in the future. -
Structure¬タモactivity Relationship Study at C9 Position of Kaitocephalin
Bioorganic & Medicinal Chemistry Letters 26 (2016) 3543–3546 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Structure–activity relationship study at C9 position of kaitocephalin Yoko Yasuno a, Makoto Hamada a, Yuya Yoshida a, Keiko Shimamoto b, Yasushi Shigeri c, ⇑ Toshifumi Akizawa d, Motomi Konishi d, Yasufumi Ohfune a, Tetsuro Shinada a, a Graduate School of Science, Osaka City University, 3-3-138, Sugimoto, Sumiyoshi, Osaka 558-8585, Japan b Bioorganic Research Institute, Suntory Foundation for Life Sciences, 8-1-1, Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan c National Institute of Advanced Industrial Science and Technology, 1-8-31, Midorigaoka, Ikeda, Osaka 563-8577, Japan d Analytical Chemistry, Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan article info abstract Article history: Kaitocephalin (KCP) isolated from Eupenicillium shearii PF1191 is an unusual amino acid natural product Received 17 May 2016 in which serine, proline, and alanine moieties are liked with carbon–carbon bonds. KCP exhibits potent Revised 8 June 2016 and selective binding affinity for one of the ionotropic glutamate receptor subtypes, NMDA receptors Accepted 9 June 2016 (K = 7.8 nM). In this study, new structure–activity relationship studies at C9 of KCP were implemented. Available online 11 June 2016 i Eleven new KCP analogs with different substituents at C9 were prepared and employed for binding affin- ity tests using native ionotropic glutamate receptors. Replacement of the 3,5-dichloro-4-hydroxybenzoyl Keywords: group of KCP with a 3-phenylpropionyl group resulted in significant loss of binding affinity for NMDARs Ionotropic glutamate receptors (K = 1300 nM), indicating an indispensable role of the aromatic ring of KCP in the potent and selective Kaitocephalin i Natural product binding to NMDARs. -
New Challenges for the CBMS: Seeking Opportunities for a More Responsive Role
New Challenges for the CBMS: Seeking Opportunities for a More Responsive Role Proceedings of the 2005 CBMS Network Meeting June 13-17, 2005 Colombo, Sri Lanka CBMS CRDI IDRC D U De U SnUe University Angelo King Institute f — 4 New Challenges for the CBMS: Seeking Opportunities for a More Responsive Role Proceedings of the 2005 CBMS Network Meeting New Challenges for the CBMS: Seeking Opportunities for a More Responsive Role Proceedings of the 2005 CBMS Network Meeting June 13-17, 2005 Colombo, Sri Lanka The 2005 PEP Research Network General Meeting, of which the CBMS Network Meeting was part of was organized by the CBMS Network Coordinating Team of the Angelo King Institute for Economic and Business Studies in cooperation with Laval University-Canada and the Institute of Policy Studies, Sri Lanka with the aid of a grant from the International Development Research Centre (IDRC), Ottawa, Canada. New Challenges for the CBMS: Seeking Opportunities for a More Responsive Role Proceedings of the 2005 CBMS Network Meeting Copyright © CBMS Network Coordinating Team, 2006 ALL RIGHTS RESERVED. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means—whether virtual, electronic, mechanical, photocopying, recording, or otherwise—without the written permission of the copyright owner. The preparation of this report has been made possible with the assistance of staff of Institute of Policy Studies, Sri Lanka. The publication Qf this report has been made possible through the CBMS Network Coordinating Team of the Angelo King Institute for Economic and Business Studies of De La Salle University-Manila with the aid of a grant from the International Development Research Centre (IDRC), Ottawa, Canada. -
Comprehensive Review on the Interaction Between Natural Compounds and Brain Receptors: Benefits and Toxicity
European Journal of Medicinal Chemistry 174 (2019) 87e115 Contents lists available at ScienceDirect European Journal of Medicinal Chemistry journal homepage: http://www.elsevier.com/locate/ejmech Review article Comprehensive review on the interaction between natural compounds and brain receptors: Benefits and toxicity * Ana R. Silva a, Clara Grosso b, , Cristina Delerue-Matos b,Joao~ M. Rocha a, c a Centre of Molecular and Environmental Biology (CBMA), Department of Biology (DB), University of Minho (UM), Campus Gualtar, P-4710-057, Braga, Portugal b REQUIMTE/LAQV, Instituto Superior de Engenharia do Instituto Politecnico do Porto, Rua Dr. Antonio Bernardino de Almeida, 431, P-4249-015, Porto, Portugal c REQUIMTE/LAQV, Grupo de investigaçao~ de Química Organica^ Aplicada (QUINOA), Laboratorio de polifenois alimentares, Departamento de Química e Bioquímica (DQB), Faculdade de Ci^encias da Universidade do Porto (FCUP), Rua do Campo Alegre, s/n, P-4169-007, Porto, Portugal article info abstract Article history: Given their therapeutic activity, natural products have been used in traditional medicines throughout the Received 6 December 2018 centuries. The growing interest of the scientific community in phytopharmaceuticals, and more recently Received in revised form in marine products, has resulted in a significant number of research efforts towards understanding their 10 April 2019 effect in the treatment of neurodegenerative diseases, such as Alzheimer's (AD), Parkinson (PD) and Accepted 11 April 2019 Huntington (HD). Several studies have shown that many of the primary and secondary metabolites of Available online 17 April 2019 plants, marine organisms and others, have high affinities for various brain receptors and may play a crucial role in the treatment of diseases affecting the central nervous system (CNS) in mammalians. -
(12) Patent Application Publication (10) Pub. No.: US 2015/0202317 A1 Rau Et Al
US 20150202317A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0202317 A1 Rau et al. (43) Pub. Date: Jul. 23, 2015 (54) DIPEPTDE-BASED PRODRUG LINKERS Publication Classification FOR ALPHATIC AMNE-CONTAINING DRUGS (51) Int. Cl. A647/48 (2006.01) (71) Applicant: Ascendis Pharma A/S, Hellerup (DK) A638/26 (2006.01) A6M5/9 (2006.01) (72) Inventors: Harald Rau, Heidelberg (DE); Torben A 6LX3/553 (2006.01) Le?mann, Neustadt an der Weinstrasse (52) U.S. Cl. (DE) CPC ......... A61K 47/48338 (2013.01); A61 K3I/553 (2013.01); A61 K38/26 (2013.01); A61 K (21) Appl. No.: 14/674,928 47/48215 (2013.01); A61M 5/19 (2013.01) (22) Filed: Mar. 31, 2015 (57) ABSTRACT The present invention relates to a prodrug or a pharmaceuti Related U.S. Application Data cally acceptable salt thereof, comprising a drug linker conju (63) Continuation of application No. 13/574,092, filed on gate D-L, wherein D being a biologically active moiety con Oct. 15, 2012, filed as application No. PCT/EP2011/ taining an aliphatic amine group is conjugated to one or more 050821 on Jan. 21, 2011. polymeric carriers via dipeptide-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeu (30) Foreign Application Priority Data tically useful half-lives. The invention also relates to pharma ceutical compositions comprising said prodrugs and their use Jan. 22, 2010 (EP) ................................ 10 151564.1 as medicaments. US 2015/0202317 A1 Jul. 23, 2015 DIPEPTDE-BASED PRODRUG LINKERS 0007 Alternatively, the drugs may be conjugated to a car FOR ALPHATIC AMNE-CONTAINING rier through permanent covalent bonds. -
Natural Compounds and Neuroprotection: Mechanisms of Action and Novel Delivery Systems ELENI BAGLI 1,2 , ANNA GOUSSIA 3, MARILITA M
in vivo 30 : 535-548 (2016) Review Natural Compounds and Neuroprotection: Mechanisms of Action and Novel Delivery Systems ELENI BAGLI 1,2 , ANNA GOUSSIA 3, MARILITA M. MOSCHOS 4, NIKI AGNANTIS 3 and GEORGIOS KITSOS 2 1Institute of Molecular Biology and Biotechnology - FORTH, Division of Biomedical Research, Ioannina, Greece; 2Department of Ophthalmology, University of Ioannina, Ioannina, Greece; 3Department of Pathology, University of Ioannina, Ioannina, Greece; 4Department of Ophthalmology, University of Athens, Athens, Greece Abstract. Neurodegeneration characterizes pathologic pathological events, including oxidative stress, mitochondrial conditions, ranging from Alzheimer’s disease to glaucoma, dysfunction, inflammation and protein aggregation (2, 3). with devastating social and economic effects. It is a The increasing knowledge of the cellular and molecular complex process implicating a series of molecular and events underlying the degenerative process has greatly cellular events, such as oxidative stress, mitochondrial stimulated research for identifying compounds capable of dysfunction, protein misfolding, excitotoxicity and stopping or, at least, slowing the progress of neural inflammation. Natural compounds, because of their broad deterioration. spectrum of pharmacological and biological activities, Natural compounds are complex chemical multiple-target could be possible candidates for the management of such molecules found mainly in plants and microorganisms (4). multifactorial morbidities. However, their therapeutic These agents -
Student Handbook 2018$2019
Student Handbook 2018$2019 University of Kelaniya Sri Lanka i University of Kelaniya, Sri Lanka Telephone Numbers University of Kelaniya 011 2903903 011 2910164 011 2911391 011 2911397 011 2911407 011 2913855 011 2913856 011 2913858 Faculty of Computing & Technology 011 2912709 Faculty of Medicine 011 2958039 011 2956188 011 2958219 011 2956151 011 2956152 011 2961000 Fax University of Kelaniya 011 2913857 Faculty of Medicine 011 2958337 Website www.kln.ac.lk Official letters/correspondence should be forwarded to the Registrar Research & Publications Division University of Kelaniya Sri Lanka ii VISION OF THE UNIVERSITY OF KELANIYA To become a centre of excellence in creation and dissemination of knowledge for sustainable development. MISSION OF THE UNIVERSITY OF KELANIYA To nurture intellectual citizens through creativity and innovation, who contribute to the national development. iii Essential Telephone Numbers Intercom* Direct Inquiries - 0 2903903 Office of the Vice-Chancellor - 101 2914474 Office of the Deputy Vice-Chancellor - 318 2991977 Office of the Registrar - 103 2911569 Chief Student Counsellor - 157 2908161 Senior Student Counsellor (Faculty of Commerce & Management Studies) - 578 2903578 Senior Student Counsellor (Faculty of Computing & Technology) - 8667110 2912709 Senior Student Counsellor (Faculty of Humanities) - 663 2987101 Senior Student Counsellor (Faculty of Medicine) - 124 2961124 Senior Student Counsellor (Faculty of Science) - 251 2914486 Senior Student Counsellor (Faculty of Social Sciences) - 862 2903862 Office -
Presskitsanath 2
Press Kit EKAMATH EKA RATEKA A faceless fantasy dipped in scheming life journeying across endless time in search of a silver screen to unfold the story of one woman and two men. Based on Emile Zola’s short story Pour une nuit d’amour (For A Night Of Love) tucked away somewhere, sometime with an undefined destiny. An extra-ordinary take ; of an ordinary life ! A film by Sanath Gunatilake Produced by Janaka Ramanayake 1 EKAMATH EKA RATEKA Synopsis : The film EKAMATH EKA RATEKA ( Once Upon a Time) is based on the story Pour une nuit d’amour written by the French novelist Emile Zola (1840-1904). The young ravishing girl from an elite family whose strong character and headstrong behaviour make her parents unhappy. They send her abroad to complete her studies hoping that it would change their daughter’s strange behaviour for the better. The young girl and the nanny’s son who becomes a lawyer later on with the help of the noble family, build a strong friendship from childhood. The parents are trying to find a suitable partner to their young daughter who has come back after completing her studies. The young girl and nanny’s son are falling in love. The nanny‘s encouragement and the blessings strengthen the young couple’s love. Meanwhile the young girl falls in love with the music played by a hideous looking middle aged man who lives in the neighborhood. Her passion for the music leads her to a magnificently melodramatic climax as this man imagines that this young girl loves him and his entire existence builds around the young girl’s love. -
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry Accepted Manuscript This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication. Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available. You can find more information about Accepted Manuscripts in the Information for Authors. Please note that technical editing may introduce minor changes to the text and/or graphics, which may alter content. The journal’s standard Terms & Conditions and the Ethical guidelines still apply. In no event shall the Royal Society of Chemistry be held responsible for any errors or omissions in this Accepted Manuscript or any consequences arising from the use of any information it contains. www.rsc.org/obc Page 1 of 5 OrganicPlease & Biomoleculardo not adjust margins Chemistry Journal Name COMMUNICATION (7 S)-Kaitocephalin as a potent NMDA receptor selective ligand Yoko Yasuno a, Makoto Hamada a, Masanori Kawasaki a, Keiko Shimamoto b, Yasushi, Shigeri c, Received 00th January 20xx, Toshifumi Akizawa d, Motomi Konishi d, Yasufumi, Ohfune a, Tetsuro Shinada a* Accepted 00th January 20xx Manuscript DOI: 10.1039/x0xx00000x www.rsc.org/ Structure-activity relationship (SAR) study of kaitocephalin known from the glutamate overstimulation using NMDA antagonists to be a potent naturally occuring NMDA receptor ligand was has become a promising strategy for drug discovery of these performed. -
WO 2010/000073 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date 7 January 2010 (07.01.2010) WO 2010/000073 Al (51) International Patent Classification: mond Street W , Apt. 903, Toronto, Ontario M5V 1Y5 C07D 417/12 (2006.01) A61P 25/02 (2006.01) (CA). DOVE, Peter [CA/CA]; 568 Palmerston Avenue, A61K 31/538 (2006.01) C07D 413/12 (2006.01) Toronto, Ontario M6G 2P7 (CA). MADDAFORD, A61K 31/5415 (2006.01) C07D 413/14 (2006.01) Shawn [CA/CA]; 3 179 Folkway Drive, Mississauga, On A61P 25/00 (2006.01) C07D 417/14 (2006.01) tario L5L 1Y3 (CA). RAKHIT, Suman [CA/CA]; 856 Hidden Grove Lane, Mississauga, Ontario L5H 4L2 (CA). (21) International Application Number: PCT/CA2009/000923 (74) Agents: CHATTERJEE, Alakananda et al; Gowling Lafleur Henderson LLP, P.O. Box 30, Suite 2300, 550 (22) International Filing Date: Burrard Street, Vancouver, British Columbia V6C 2B5 3 July 2009 (03.07.2009) (CA). English (25) Filing Language: (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (30) Priority Data: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, 61/133,887 3 July 2008 (03.07.2008) U S DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (71) Applicant (for all designated States except US): NEU- HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, RAXON, INC. -
Professor Mervyn King
INTELLIGENCE & INSIGHT FROM CA SRI LANKA JUNE 2014 | WWW.CASRILANKA.COM MANAGING A RS6.7 TRILLION DEBT PORTFOLIO P.32 NEED INTEGRATED THINKING Professor Mervyn King ISSN 2279-3860 9 772279 386000 VOL.2 • ISSUE. 2 THE ABACUS | JUNE 2014 1 CONTENTS JUNE 2014 Features COVER STORY 26 | Mervyn King: You need integrated thinking from input to outcome South Africa is a pioneer in Integrated Reporting and Professor Mervyn King one of its leading advocates. IR is the new form of corporate reporting that goes beyond the numbers and looks at business in a broader sense, telling its story in a way more easily understood by ordinary people, or the shareholding public. 32 | Managing a Rs6.7 tn Debt Portfolio Dhammika Nanayakkara, Superintendent of Public Debt of the Central Bank of Sri Lanka, is one of 50 Chartered Accountants working in the bank regulator Professor Mervyn King: You need integrated thinking from input to outcome (PAGE 26) whose governor himself is a CA. Nanayakkara has the task Port City - creating new land of managing Rs6.7 trillion in (PAGE 44] public debt, a not inconsiderable responsibility given the multiple risks involved and its impact on the economy. 48 | Fayezul Choudhury: Imperative For Accounting Profession to Grow With Economy Founded in 1977, the International Federation of Accountants (IFAC) is the global organisation of the accountancy profession. Fayezul Choudhury: Imperative For Accounting Managing a Rs6.7 tn Debt Profession to Grow With Economy (PAGE 48) Portfolio (PAGE 32) 2 THE ABACUS | JUNE 2014 CONTENTS JUNE 2014 Clement Chan: We are Moving Towards a System Upgrading Service Culture Credit Unions – Banking of Principle - Based Standards (PAGE 38) (PAGE 14) and Social Responsibility (PAGE 18) 08 | Periscope 14 | Upgrading Service Culture The 21st century has been called the Age of the Customer, in which excellence in service has become the raison d’etre for organisational activities, in both business and the public service. -
Preventing Sexual and Gender-Based Violence (SGBV) Strategies for Universities
Preventing Sexual and Gender-based Violence (SGBV) Strategies for Universities ,sx.sl yd ia;%S mqreI iudcNdjuh ghypay; kw;Wk; ghy;epiyrhh; m%pKav;ajh je<elaùu td;Kiwfisj; jLj;jy; úYajúoHd, moaO;sh i`oyd l%fudamdhka gy;fiyf;fofq;fSf;fhd %Nyhghak; University Grants Commission Federation of University Teachers’ Associations CARE International Sri Lanka I © CARE International Sri Lanka. February 2015 All rights reserved. The views expressed in this book are those of the persons who contributed to this document and do not necessarily reflect the views and policies of CARE International Sri Lanka. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without full attribution. For further information please contact: CARE International Sri Lanka, No. 73, Isipathana Mawatha, Colombo 05, Sri Lanka. Tel : +94 115 399 299 Fax : +94 112 583 721 [email protected] www.care.lk ISBN 978-955-1138-07-3 Designed and Printed by II Endorsements by Academics NAME POSITION UNIVERSITY Dr. Shravika Dhamunupola Amarasekera Senior Lecturer, University of Colombo Department of English Professor Sarath Amarasingha Senior Professor, University of Ruhuna Department of Sociology Dr. Harini Amarasuriya Senior Lecturer, Open University of Sri Lanka Department of Social Studies Professor Sarath Amunugama Senior Professor and Former Vice University of Kelaniya Chancellor Professor Anbahan Ariadurai Professor and Dean, Faculty of Open University of Sri Lanka Engineering Technology Professor Nelum Deshappriya Professor, Department of Botany University of Kelaniya Professor Neloufer de Mel Senior Professor, Department of English University of Colombo Professor D.