HTA to Support Policy and Practice

What Does the Evidence Say? HTA to Support Policy and Practice

2015 CADTH Symposium April 12 to 14 | TCU Place | Saskatoon, SK THANK YOU TO OUR SPONSORS We gratefully acknowledge the contribution of our sponsors to the success of the 2015 CADTH Symposium. This event could not continue to grow and improve without you!

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We would also like to acknowledge the support of our funders. CADTH’s activities, programs, and services, including the CADTH Symposium, are made possible through financial contributions from Health Canada and the governments of:  Alberta  Nunavut  British Columbia  Ontario  Prince Edward Island  Saskatchewan  Manitoba  Newfoundland and Labrador  New Brunswick  Northwest Territories  Nova Scotia  Yukon 2015 CADTH Symposium

Welcome to the 2015 CADTH Symposium, the 11th annual pan-Canadian forum for producers and users of evidence-based information on drugs, medical devices, diagnostics, and procedures.

We’re very pleased to be holding the CADTH Symposium in Saskatoon, the Paris of the Prairies. Not only is Saskatoon a charming and vibrant city, but it’s also the largest city in Saskatchewan — the province where Canada’s publicly funded health system was born. Saskatchewan introduced the first provincial hospital insurance program in Canada in 1947 and the first free universal medical coverage in 1962. And so it seems appropriate that we’re gathering in Saskatchewan to discuss topics of great relevance to the continued quality and sustainability of the Canadian health care system.

This year’s theme — What Does the Evidence Say? HTA to Support Policy and Practice — reminds us to consider the evidence when making decisions about the uptake and use of health technologies. In the three plenary sessions, we’ll hear a wide range of perspectives from Canadian and international experts on what evidence they value, how they use it (or why they don’t), and what else they consider … we’ll also hear what the technologies of tomorrow will offer.

In addition, the CADTH Symposium offers 13 workshops, 20 panel sessions, 43 oral presentations, 4 breakfast sessions, and more than 60 scientific posters on a wide variety of topics including patient engagement, pharmaceutical and medical device policy issues, and applying evidence in a clinical setting.

There are also a number of informal networking opportunities at the CADTH Symposium, including the Welcome Reception and Scientific Poster Exhibition on Sunday evening, the 1910 Boomtown Dinner on Monday night, and the Awards Luncheon on Tuesday.

I hope that you find the discussions and networking productive and rewarding.

Dr. Brian O’Rourke President and CEO, CADTH

PROGRAM AT A GLANCE

SUNDAY, APRIL 12, 2015 Time Event Speakers Location 0800 – 1900 Registration Desk Open 0800 – 0900 Morning Workshop Registration Main Level Lobby

0900 – 1200 Workshop Full-Day 1  Karen Lee Gallery D Introduction to Economic Modelling:  Prof. Doug Coyle Concepts and Practical Applications 0900 – 1200 Workshop AM-1  Hayley Fitzsimmons Blair Nelson Finding the Evidence: Practical Tools  Caitlyn Ford for Literature Searching Workshop AM-2  Dr. Durhane Wong-Rieger Gallery B What the Evidence Says…May Depend  Dr. Andreas Laupacis on How It is Discussed  Wayne Critchley  Frank Gavin Workshop AM-3  Dr. Sarah Jennings Gallery A Critical Appraisal 101: Evidence  Brendalynn Ens Appraisal for the Non-Researcher  Dr. Gabrielle Zimmermann  Chris Kamel Workshop AM-4  Dr. Nicholas Mitsakakis Gallery C Issues in the Analysis of Health Care  Dr. Petros Pechlivanoglou Cost Data Workshop AM-5  Dr. Valeria Rac Gallery Suite 1 Complex Interventions for Comparative  Dr. Lusine Abrahamyan Effectiveness and Health Technology  Dr. Murray Krahn Assessment Workshop AM-6  Shannon Sullivan Regal B How Can Policy-Makers and  Dr. Andrea Tricco Practitioners Apply the Results of  Dr. Brian Hutton Network Meta-Analysis to Real-World Decisions? 1200 – 1300 Afternoon Workshop Registration

Abstracts are available on the USB stick in the delegate kit, online at www.cadth.ca/symposium2015, and through the CADTH Symposium App.

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PROGRAM AT A GLANCE

SUNDAY, APRIL 12, 2014 (cont’d) Time Event Speakers Location 1300 – 1600 Workshop PM-1  Dr. Petros Gallery B Integrating Network Meta-Analysis in Pechlivanoglou Economic Evaluations  Dr. Areti-Angeliki Veroniki  Dr. Nicholas Mitsakakis  Dr. Ba’ Pham Workshop PM-2  Dr. Shawn Bugden Blair Nelson Non-Inferiority Complex: Gaining  Lynette Kosar Confidence in the Appraisal of Non- Inferiority Trials Workshop PM-3  Dr. Sarah Jennings Gallery A Critical Appraisal 201: Evidence  Brendalynn Ens Appraisal for Non-Researchers  Dr. Gabrielle Zimmermann  Chris Kamel Workshop PM-4  Michelle Clark Gallery C Going Social: Social Media Literacy for  Caitlyn Ford the #HTA Crowd  Dr. Janice Mann Workshop PM-5  Dr. Susan Shaw Gallery Suite 1 Moving Evidence Into Daily Practice:  Debra-Jane Wright How Saskatchewan is Using “Industrial  Gary Teare Strength” Process Improvement (a.k.a.  Patrick Falastein “LEAN”) to Improve Patient Care  Petrina McGrath Across the Province Workshop PM-6  Dr. Larry Lynd Regal B Critical Appraisal of Clinical Trials  Dr. Carlo Marra Employing Adaptive Designs  Dr. Joel Singer 1700 – 1900 Welcome Reception and Scientific Poster Exhibition Salon Lobby

Abstracts are available on the USB stick in the delegate kit, online at www.cadth.ca/symposium2015, and through the CADTH Symposium App.

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PROGRAM AT A GLANCE

MONDAY, APRIL 13, 2015 Time Event Speakers Location 0730 – 1700 Registration Desk Open Main Level Lobby 0745 – 0845 Breakfast Salon Lobby 0845 – 0915 OFFICIAL OPENING  Dr. Brian O’Rourke Salon B/C/D  The Honourable Dustin Duncan 0915 – 1030 OPENING PLENARY SESSION  Dr. Tammy Clifford Salon B/C/D We Know What the Evidence Says…  Gail Attara Is Anybody Listening?  Dr. Édouard Hendriks  Suzanne McGurn  Dr. Jon Witt 1030 – 1100 Refreshment Break Salon Lobby 1100 – 1230 Concurrent Session A1  Dr. Stirling Bryan Gallery A In Search of Efficiency, Consistency,  Dr. Graham Scotland Fairness, and Impact in HTA: The Case  Dr. Mohsen Sadatsafavi for Clinical Pathway Management and Modelling Concurrent Session A2  Nicole Dekort Regal B Valuing Medical Technologies  Dr. Christina Farup  Dr. Don Juzwishin  Chantale Lessard  Janey Shin  Dr. Zayna Khayat  Kevin Samra Concurrent Session A3  Dr. Murray Krahn Gallery B Public Policy in the Post-Interferon  Dr. William Wong Era: Can We Afford to Cure  Dr. Alnoor Ramji Hepatitis C?  Kevin Wilson  Susan Pierce Concurrent Session A4  Dr. Jeffrey Hoch Gallery C New Methods in HTA to Support Policy  Dr. Nick Bansback and Practice: Can We Better  Dr. Carlo Marra Understand How Canadians Value  Dr. Dean Regier Health?  Mike Paulden Concurrent Session A5  Louise Binder Salon E The Role of Patients in Defining  Ken Bond “Value” and Engaging in Drug  Dr. Deborah Marshall Development From Bench to Bedside  Dr. Pauline McNulty  Dr. Laura Faye Concurrent Session A6  Dr. Paul Oh Gallery D Drug Class Reviews: Bridging  Dr. Muhammad Evidence, Values, and Health Policy Mamdani  Dr. Doug Coyle  Dr. George Wells

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PROGRAM AT A GLANCE

MONDAY, APRIL 13 (cont’d) Time Event Speakers Location 1100 – 1230 Concurrent Session A7  Rosmin Esmail Blair Nelson The Canadian Top Ten Watch List of  Cédric Jehanno New and Emerging Health  Andra Morrison Technologies: Methods, Lessons  John Soloninka Learned, and Impact  Alison Drinkwater  Alain Boisvert 1230 – 1330 Lunch Salon Lobby

1330 – 1500 Concurrent Session B1  Dr. S. Michelle Driedger Gallery A Cancer Care  Dr. Allan Grill  Dr. Yvonne Bombard  Reka Pataky Concurrent Session B2  Sarah Berglas Gallery B Patient Engagement in Health  Dr. Marc Rhainds Technology Assessment (HTA)  Susan Bazylewski  Louise Frederick Concurrent Session B3  Shannon Kelly Regal B Rapid Reviews  Dr. Lisa Hartling  Dr. Andrea Tricco Concurrent Session B4  Dr. Brenna Bath Blair Nelson Rural and Remote  Stacey Lovo Grona  Dr. Janice Mann Concurrent Session B5  Elena Lungu Gallery C Drug Reimbursement Decisions  Farzad Ali  Dr. François Dionne  Prof. Christopher McCabe Concurrent Session B6  Brendalynn Ens Salon E Evidence on the Front Lines  Dr. Mollie Butler  Sheila Tucker  Dr. Paule Poulin Concurrent Session B7  Anthony Budden Gallery D New Initiatives at CADTH  David Crosbie  Dr. Mona Sabharwal  Dr. Chander Sehgal 1500 – 1530 Refreshment Break Salon Lobby

Abstracts are available on the USB stick in the delegate kit, online at www.cadth.ca/symposium2015, and through the CADTH Symposium App.

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PROGRAM AT A GLANCE

MONDAY, APRIL 13 (cont’d) Time Event Speakers Location

1530 – 1700 Concurrent Session C1  Kristen Chelak Gallery A Impact of HTA Therapeutic Reviews  Dr. Alasdair Coles on Real-World Clinical Practice:  Dr. Karen Lee Multiple Sclerosis as a Case Study  Colin Vicente

Concurrent Session C2  Dr. Nick Bansback Gallery B New Methods in HTA to Support  Dr. Mohsen Policy and Practice: How Can We Sadatsafavi Better Conduct and Present  Prof. Christopher Economic Evaluations? McCabe  Dr. Stirling Bryan  Dr. Bohdan Nosyk

Concurrent Session C3  Shahira Bhimani Regal B The Evidence — Decision-Making  Dr. Zayna Khayat Disconnect: Evidence is Often Not  Dr. Don Juzwishin Enough  John Soloninka

Concurrent Session C4  Maureen Klenk Salon E HTA on the Front Lines: Using the  Dr. Janice Mann Evidence in Clinical Practice  Dr. Paul Salomon

Concurrent Session C5  Dr. Thierry Lacaze Gallery C Daring to Be Rare: Researchers,  Kirsten Harkins Regulators, HTA Organizations  Dr. David Whiteman Striving to Meet the Needs of  Dr. Neil Cashman Patients With Rare Diseases  Philip Schwab

Concurrent Session C6  Sirjana Pant Gallery D Exploring Opportunities for  Faith Louis Collaboration Across the Spectrum  Dr. William Semchuk of Formulary Decision-Making: From  Dr. Eric Lun Hospitals to Health Authorities to  Anne Hiltz Public Drug Plans  Stephanie Smith 1830 – 2230 SOCIAL EVENT - 1910 Boomtown Dinner Western Separate ticket required. Development Museum

Abstracts are available on the USB stick in the delegate kit, online at www.cadth.ca/symposium2015, and through the CADTH Symposium App.

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PROGRAM AT A GLANCE

TUESDAY, APRIL 14, 2015 Time Event Speakers Location 0700 – 1500 Registration Desk Open

0700 – 0815 Breakfast Salon Lobby

0715 – 0815 Breakfast Session 1  Chris Kamel Gallery A Quick and Snappy: A Decade of Rapid Response Evidence

Breakfast Session 2  Chris Cameron Gallery B CADTH Microsoft Excel-Based  Dr. Tammy Clifford Tools for Conducting Health  Dr. Michelle Mujoomdar Technology Assessments — An Overview

Breakfast Session 3  Dr. Brian Feagan Gallery C How HTA Recommendations  Cheryl Koehn Inform Decision-Makers on  Angela Rocchi Subsequent Entry Biologics  Dr. Chander Sehgal (SEBs): Post-HTA and Back  Dr. Carlyn Volume-Smith Again  Michele Evans

Breakfast Session 4  Karen Lee Gallery D CADTH Update of the Guidelines  Dr. Stirling Bryan for the Economic Evaluation of  Dr. Doug Coyle Health Technologies: Canada —  Dr. Murray Krahn Process and What’s Next  Dr. Carlo Marra  Prof. Christopher McCabe 0830 – 0945 PLENARY SESSION 2  Dr. Jeffrey Hoch Salon B/C/D Evidence of Value or  Vivian Coates Value of Evidence  Dr. Tony Fields  Anne Lee  Dr. Alric Rüther 0945 – 1015 Refreshment Break Salon Lobby

1015 – 1145 Concurrent Session D1  Dr. William Wong Gallery A Pharmaceutical Policy Issues  Satyin Kaura  Denise Budz  Dr. Qaiser Fahim  Kathy Gesy

Concurrent Session D2  Dr. Lois Macklin Salon E Medical Devices: Innovation,  Diane Simone Warren Assessment, Procurement  Dr. Fiona Miller

Concurrent Session D3  Deborah Bulych Blair Nelson Patient-Reported Outcomes  Prof. Christopher McCabe  Dr. David Whitehurst

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PROGRAM AT A GLANCE

TUESDAY, APRIL 14, 2015 (cont’d) Time Event Speakers Location

1015 – 1145 Concurrent Session D4  Mike Paulden Gallery C Health Economics  Lidia Engel  Lisa Masucci

Concurrent Session D5  Dr. Areti-Angeliki Veroniki Regal B Network Meta-Analysis  Dr. Petros Pechlivanoglou  Steve Kanters

Concurrent Session D6  Maureen Klenk Gallery B Supporting Policy and Practice  Leah Clement  Dale Backlin  Jacqueline Messer-Lepage  Sheila Tucker

Concurrent Session D7  Dr. Dean Regier Gallery D Patient and Public Engagement  Dr. Julia Abelson  Dr. Michael Burgess 1145 – 1300 Awards Luncheon Salon B/C/D Plated lunch. Please arrive promptly.

1300 – 1430 Concurrent Session E1  Dr. Cheri Deal Gallery A Integrating Evidence, Values,  Dr. Mireille Goetghebeur and Ethics From Policy to  Christa Harstall Practice: A Multi-criteria  Dr. Janet Martin Reflection

Concurrent Session E2  Dr. Fiona Miller Gallery B Improving the Appraisal of  Dr. Murray Krahn Non-Drug Technologies:  Dr. Ann-Sylvia Brooker Revising the Ontario Decision Framework

Concurrent Session E3  Dr. Feng Xie Regal B A Canadian Value Set for the  Dr. Jeff Johnson EQ-5D-5L: One Answer, More  Dr. Stirling Bryan Questions  Dr. Nick Bansback

Concurrent Session E4  Dr. Stuart MacLeod Gallery C Evolving Foundations: Impacts  Kristian Thorlund of Adaptive Clinical Trial  Dr. Newell McElwee Design on Market  Barbara Sabourin Authorization and  Dr. Anthony Fields Reimbursement

Concurrent Session E5  Dr. Sarah Jennings Salon E Cross-Canada Collaboration to  Lynette Kosar Promote Evidence-Based Use  Dr. Bronwen Jones of Anticoagulants  Isobel Fleming  Dr. Cait O’Sullivan

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PROGRAM AT A GLANCE

TUESDAY, APRIL 14, 2015 (cont’d) Time Event Speakers Location

1300 – 1430 Concurrent Session E6  Don Husereau Gallery D The Evolving Role of Real-  Julia Brown World Evidence to Support  Peter Fenwick Policy and Practice  Neil Corner 1430 – 1500 Refreshment Break Salon Lobby 1500 – 1615 CLOSING PLENARY  Dr. Brian O’Rourke Salon B/C/D The Health Technologies of  Dr. Jenny Basran Tomorrow — Will We Be  Dr. Brendan Carr Ready?  Dr. Thomas Luby  Dr. Tofy Mussivand  Sharon Lee Smith

1615 – 1630 Official Closing  Dr. Brian O’Rourke Salon B/C/D

Abstracts are available on the USB stick in the delegate kit, online at www.cadth.ca/symposium2015, and through the CADTH Symposium App.

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SPECIAL EVENTS

WELCOME RECEPTION AND SCIENTIFIC POSTER EXHIBITION

Sunday, April 12 The Welcome Reception features scientific posters and the 1700 – 1900 opportunity to meet and talk with the authors about their work. Salon Lobby A cash bar and light snacks will be available.

SOCIAL EVENT: 1910 BOOMTOWN DINNER

Monday, April 13 Join us at the Western Development Museum where you’ll be 1830 – 2230 transported back to a time when the clip-clop of horses filled the air. You don’t just visit this museum – you live it. Meet at front door of TCU Place for Take a stroll down the main street of Boomtown Saskatchewan circa bus pick-up. 1910, stopping for drinks and hors d’oeuvres or a chat with the blacksmith and other locals. Tuck into a dinner featuring hearty Shuttle will leave at traditional dishes and unique prairie flavours served in the midst of 6:15 p.m. sharp. Saskatchewan’s largest collection of vintage cars and trains. Tour

the exhibits, including the Cancer Bomb and Winning the Prairie

Gamble before the evening wraps up with some toe-tapping tunes

with the band, Don Griffith and The Second Line.

CADTH RECOGNITION AWARDS LUNCHEON

Tuesday, April 14 Join us in honouring the 2015 recipients of the CADTH 1145 – 1300 Recognition Awards. Presentations will be made to winners of Salon B/C/D the Dr. Jill M. Sanders Award of Excellence in HTA and the Maurice McGregor Award. The winners of our poster competition will also receive their awards at this luncheon. As this is a plated lunch, please arrive promptly.

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PLENARY SESSIONS

April 13, 2015 OFFICIAL OPENING 0845 – 0915 Dr. Brian O’Rourke, President and CEO of the Canadian Agency for Drugs and Technologies in Health, will welcome Symposium participants, describe some of the Symposium highlights and introduce The Honourable Dustin Duncan.

Mr. Duncan was first elected as MLA for the constituency of Weyburn-Big Muddy in a by-election in June 2006 at the age of 26. In Opposition, he served on the Crown and Central Agencies Committee and as Critic for Youth Opportunities and Immigration. Re-elected in the 2007 general election, Mr. Duncan served as Chair of the Standing Committee on Crown and Central Agencies prior to entering Cabinet.

On May 29, 2009 Premier Brad Wall appointed Dustin Duncan to the Saskatchewan Cabinet as Minister of Tourism, Parks, Culture and Sport. Appointed two months before his 30th birthday, Mr. Duncan is the youngest cabinet minister in Saskatchewan history and one of the youngest in Canadian history.

On June 29, 2010, Mr. Duncan was appointed as Minister of Environment, Minister Responsible for Saskatchewan Water Corporation and Minister Responsible for SaskEnergy Incorporated. Minister Duncan was re-elected by his constituents in 2011. On May 25, 2012, he was appointed as Minister of Health.

In addition to his various legislative roles, Mr. Duncan has served as a member of the Saskatchewan Legislative Internship Program Advisory Committee and in 2007 was named a BILLD Fellow after completing the Bowhay Institute for Legislative Leadership Development program at the University of Wisconsin - Madison.

Mr. Duncan is active in his community and is a past board member of the Family Place, a community funded, community driven resource center for families in Weyburn and the surrounding area.

Mr. Duncan grew up in Halbrite and graduated from Weyburn Comprehensive High in 1997. Mr. Duncan went on to complete an undergraduate degree in Canadian History from the University of Regina, graduating in 2002. He also completed the Canadian Securities Course.

Dustin and his wife Amanda, a musician, were born, raised and educated in the Weyburn area. They make their home on a farm east of Weyburn – the same land Dustin’s great-grandparents farmed nearly a century ago. On June 28th, 2014 Dustin and Amanda proudly welcomed Jack, their son and newest member of their family into the world.

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PLENARY SESSIONS

PLENARY 1 We Know What the Evidence Says… April 13, 2015 Is Anybody Listening 0915 – 1030 Health technology assessment (HTA) is a powerful tool that supports improved patient outcomes and health system sustainability. Sometimes, however, decisions are inconsistent with the evidence provided by HTA organizations. When that happens, it is hard not to wonder if anybody is listening. A panel will provide different perspectives on the role evidence plays in their decision-making and talk about other factors they consider. Here are some of the questions the panel will discuss: Is evidence considered when procurement decisions are made? What can be done to encourage health care providers to use evidence from HTA? Can health care professionals play a role in moving out-of-date technologies out of the health system? What evidence do patients value most? What can be done to ensure that HTA informs every health technology decision? What can be done to ensure that everybody is listening?

Gail Attara is the Chief Executive Officer of the Gastrointestinal Society. Gail’s motto, “the patient comes first,” directs her resolve for patient-focused health care and commitment to increasing awareness about the seriousness of gastrointestinal illnesses. Ms. Attara is an active community volunteer in Canada serving on numerous Boards and overseas, where she has worked with orphans. She has been an invited speaker coast-to-coast on numerous occasions, to wide-ranging audiences, including doctors, patients, pharmacists, and health care decision-makers. Participating as a member of the Best Medicines Coalition since 2005, Ms. Attara is now serving in her fifth year as its Chair. She is also co-counder of Advocacy Boot Camp, focussing her goal to expand the network of knowledgeable patient advocates within the health care system.

Dr. Édouard Hendriks is Vice-President of Medical, Academic and Research Affairs for the Horizon Health Network in New Brunswick. His portfolio includes medical manpower, the organization of medical services, academic affairs, relations with medical schools and oversight of reseach activities within the organization. He is the former President and CEO of Regional Health Authority 4 in Edmundston, New Brunswick, and has held various clinical and senior administrative positions with the Canadian Armed Forces and health institutions in Quebec, Ontario, and New Brunswick. Dr. Hendriks obtained his Master of Health Administration from the University of Ottawa, and his medical degree from the Université Laval in Quebec. He has a certificate in family medicine and a special certificate in emergency medicine, both from the College of Family Physicians of Canada. He is also a Fellow of the College. Dr. Hendriks has been a surveyor for Accreditation Canada for over 20 years. He has been and is involved with numerous national and provincial committees such as the Advisory Council for the EXTRA Program of the Canadian Health Services Research Foundation, the National Collaborating Centre for Healthy Public Policy, and the Board of Directors of the Canadian Patient Safety Institute.

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PLENARY SESSIONS

Suzanne McGurn is the Assistant Deputy Minister and Executive Officer (Interim) of Ontario Public Drug Programs. She is also the Assistant Deputy Minister in the Health Human Resources Strategy Division, Ministry of Health and Long-Term Care, and has been since 2011.McGurn has worked in health care environments for more than 25 years. She spent the first 15 years of her career in a variety of clinical, front-line, and service provision roles. This gave her the opportunity to see the difference health care providers make every day in touching the lives of patients and their families, often when they are at their most vulnerable. Despite her love of nursing, in 2000 McGurn accepted an offer from the Ontario government to explore public policy. Since then, she has held a number of positions over her 10-plus years with the Ministry. McGurn holds both a Bachelor of Science in Nursing and a Master of Public Administration from Queen’s University.

Dr. Jon Witt is a graduate of the University of Saskatchewan's College of Medicine, with subsequent residency training in emergency and family medicine, as well as a Master of Public Health. Clinically, he is an attending emergency physician in Saskatoon and a transport physician for STARS — the Shock Trauma Air Rescue Society. Dr. Witt has a strong interest in knowledge translation and systems of care, and is a member of the Saskatchewan Integrated Stroke Strategy steering committee.

MODERATOR: Dr. Tammy Clifford is the Vice-President, Strategic Initiatives, and Chief Scientist at CADTH. Her responsibilities include aligning the methods used in conducting CADTH's health technology assessments (HTAs) with best practices. She is also responsible for building capacity among producers and users of evidence-based assessments by providing education, training, and various brokering activities that facilitate the sharing of HTA work. Her portfolio also includes overseeing the Policy Forum, the Canadian Network for Environmental Scanning in Health (CNESH), the Health Technology Analysis Exchange, and horizon scanning. Dr. Clifford provides leadership to CADTH's scientific advice (early engagement) program, and to the agency's patient and citizen engagement activities. She has a keen interest in advancing evidence synthesis methods, and in promoting the value of transparency and collaboration. Dr. Clifford joined CADTH in 2005 as Director, Project Quality, and was appointed Vice-President of the Health Technology Assessment Directorate in 2008. She holds faculty appointments in Pediatrics, and in Epidemiology and Community Medicine, at the University of Ottawa. Dr. Clifford received her PhD in Epidemiology and Biostatistics from the University of Western Ontario, and both her BSc and MSc from McGill University. She is actively engaged with a number of national and international entities including the Canadian Institutes of Health Research and Health Technology Assessment international (HTAi), and serves as a reviewer for The Lancet, JAMA Pediatrics, PLOS ONE, Health Policy, and the International Journal of Technology Assessment in Health Care.

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PLENARY SESSIONS

PLENARY 2 Evidence of Value or Value of Evidence April 14, 2015 Regulatory assessments and clinical trials are intended to provide proof of concept 0830 – 0945 — whether a technology works; whereas reimbursement assessments or health technology assessments (HTAs) are intended to provide proof of value — whether a technology should be valued more highly than the alternatives. There are, however, many ways to look at value: from a financial to ethical, legal, and societal impact to patient preferences, and ease of use. In this session, an international panel of HTA experts will discuss whether cost-effectiveness carries more weight than other evidence, whether affordability trumps cost-effectiveness, and whether HTA is meeting the needs of decision-makers. Are there ways to increase the value of evidence and reduce the uncertainty that seems to go hand-in-hand with decision-making? What can be done to improve the availability, quality, and use of evidence in health policy development and clinical decision-making?

Vivian Coates is ECRI Institute’s Vice-President for Information Services and Health Technology Assessment (HTA). Ms. Coates developed and leads ECRI Institute’s evidence-based medicine and HTA program and works to enhance the program’s contribution to the health care community. Ms. Coates oversees ECRI Institute’s Evidence-based Practice Center (EPC), and all related evidence-based programs, including the Health Technology Assessment Information Service for hospitals and health systems, health plans, and health policy-makers. She initiates and fosters relationships with the users of comparative effectiveness research and HTA to promote the use of evidence-based medicine in health care purchasing, delivery, coverage, and clinical practice guideline development.

Dr. Anthony Fields, Professor Emeritus, Department of Oncology, University of Alberta and member of the medical staff at Alberta Health Services, recently retired from his appointment as Vice-President of Cancer Care at Alberta Health Services and Professor of Oncology, University of Alberta. During his time with Alberta Health Services, he was responsible for Alberta’s tertiary and associate cancer centres, community oncology program and cancer research programs. He received his medical degree from the University of Alberta and then trained in internal medicince and medical oncology at Toronto’s St. Michael’s Hospital and the Princess Margaret Cancer Centre respectively. In his clinical practice at the Cross Cancer Institute in Edmonton, he has specialized in the treatment of patients with gastrointestinal cancers. Dr. Fields has been recognized for his work by several awards, including an honorary doctorate of Athabasca University, the Distinguished alumni Award of the University of Alberta, and the R.M. Taylor Medal and Award of the Canadian Cancer Society and the National Cancer Institute of Canada. In Alberta’s centennial year 2005, he was named one of Alberta’s 100 Physicians of the Century. In 2012, he was appointed a Member of the Order of Canada. He is chair of the pan-Canadian Oncology Drug Review Expert Review Committee (pERC).

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PLENARY SESSIONS

Anne Lee is the Chief Pharmacist for the Scottish Medicines Consortium (SMC). SMC is part of Healthcare Improvement Scotland and carries out health technology assessment of all new medicines. Trained as a pharmacist, Ms. Lee has practised in hospital pharmacy, specializing in medicines management, working in Edinburgh, Newcastle, and Glasgow. She has research experience in medicines safety and has edited textbooks on adverse drug reactions and safe prescribing in pregnancy and breastfeeding. Ms. Lee began working for SMC in 2005, initially to set up its horizon scanning programme, which supports financial planning in NHS Scotland through the provision of early intelligence on new medicines in development.

Dr. Alric Rüther studied philosophy and human medicine in Munich, Budapest, and Alicante (Spain) before training in internal medicine and oncology at the Universities of Munich and Freiburg, and has received further training in medical informatics. He also participated in the establishment of the German Cochrane Centre at the Institute for Medical Informatics and Biometry, University of Freiburg. Since 1999 he has been with the German Institute for Medical Documentation and Information (DIMDI), Federal Ministry of Health, and has worked to establish and build the discipline of health technology assessment (HTA) in German health care. Mr. Rüther was founder and head of the German Agency for HTA (DAHTA) from 2001 to 2007. In 2008, Mr. Rüther took over the responsibility of the Department of Health Care Quality at the Institute for Quality and Efficiency in Health Care (IQWiG). At IQWiG, Mr. Rüther is also responsible for the institute’s international relationships. Mr. Rüther has been engaged in worldwide HTA development since 1999. He is a member of the German Society for Medical Informatics, Biometry and Statistics; chair of the HTA working group; and a member of the German Network for Evidence-Based Medicine, chair of the field of HTA. Mr. Rüther is an associate professor at the Universities of Bielefeld and Berlin, lecturing on HTA.

MODERATOR: Jeffrey Hoch received his PhD in health economics from the Johns Hopkins Bloomberg School of Public Health. He also holds a Masters in Economics from Johns Hopkins University, and a Bachelor of Arts in Quantitative Economics and Decision Sciences from the University of California at San Diego. An award winning teacher, Dr. Hoch has taught Health Economics and Economic Evaluation classes in Asia, Europe, North and South America. In 2007, Dr. Hoch was asked to develop and direct the Pharmacoeconomics Research Unit at Cancer Care Ontario. As Director, Dr. Hoch has pursued research that seeks to make health economics more useful to decision-makers. Dr. Hoch is also the co-Director of the Canadian Centre for Applied Research in Cancer Control (ARCC). ARCC is a national research centre funded by the Canadian Cancer Society and dedicated to cancer research, capacity building and knowledge transfer related to health economics, services, policy and ethics. Dr. Hoch’s research interests include health services research related to cancer, mental health, and other health issues affecting poor and vulnerable populations.

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PLENARY SESSIONS

PLENARY 3 The Health Technologies of Tomorrow — April 14, 2015 Will We Be Ready? 1500 – 1615 Regulators, health policy-makers, clinicians, payers, and health technology assessment (HTA) bodies are challenged by the pace of innovation in pharmaceuticals, medical devices, and procedures, and there are no signs that things will slow down anytime soon. Globally, there are more than 5,000 medicines in development with the potential to benefit Canadian patients, including precision medicines, therapeutic vaccines, numerous drugs for rate diseases and cancers, and gene therapies. Medical manufacturing companies are using 3-D printing to prototype and test products for a range of medical applications. Personal technologies (such as apps that allow your smart phone to double as a heart rate monitor or contact lenses that also monitor your blood sugar levels) have the potential to generate unprecedented volumes of personal data. Can this data be harnessed to improve the quality of care for individual patients and on a population health basis? Many of these new technologies will be disruptive to current clinical practice and reimbursement frameworks. Are we ready to manage the regulatory and reimbursement issues associated with these new technologies — and, if not, what do we have to do to get ready?

Dr. Jenny Basran is an Internist Geriatrician with a clinical practice that helps older patients and their families who are struggling with the challenges of cognitive and physical decline. In addition, Dr. Basran provides Internal Medicine services to the Acute Care Medicine service at Royal University Hospital. She has been the Head of the Division of Geriatric Medicine at the University of Saskatchewan since 2004. In this role, she has worked with the health region to restructure clinical services to meet the growing demand of an aging population. Through this process and her clinical experience, Dr. Basran has gained insight into both the gaps in the current system and how to effect change in a complex health system. She has led and participated in several regional, provincial, and national initiatives to improve health care for seniors. Dr. Basran has recently been named one of the physician co-leads for Saskatchewan Health's newest initiative, Emergency Department Waits and Patient Flow, a project aimed at decreasing wait times in emergency departments. Dr. Basran is a researcher with a tenured Associate Professor position at the University of Saskatchewan. She has received multiple national research grants from the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada. Her research is in the area of technology and older adults. She has worked with engineers on the development of a falls detection system, as well as with computer scientists on an electronic health record for the hospitals and on technology to allow older adults to age in their homes safely. Dr. Basran is currently evaluating the feasibility of using technology products with older adults. She is examining the hypothesis that technology will increase the quality of life for older adults and their caregivers, while at the same time increasing quality and efficiencies in the health care system. She has a particular interest in improving the quality and accessibility of health care in rural areas.

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PLENARY SESSIONS

Dr. Brendan Carr is the President and Chief Executive Officer of Vancouver Island Health Authority. He has held this position since August 6, 2013. Dr. Carr joined Island Health in March 2012 as the Executive Vice-President and Chief Medical Officer. Before joining the health authority, he served as Vice-President of Medicine with the Capital District Health Authority in Halifax and as an Assistant Professor at Dalhousie University. Dr. Carr holds Doctor of Medicine and Master of Business Administration degrees. He is a Canadian Certified Physician Executive and a Certified Health Executive and has completed a research fellowship with the Canadian Health Services Research Foundation. He is a skilled emergency department physician and continues to take an occasional shift in Emergency. Active in education and health services research, Dr. Carr is an advocate for innovation and transformation in health care.

Dr. Thomas Luby is Senior Director of New Ventures at Johnson & Johnson Innovation, Boston. He focuses primarily on cardiovascular and metabolic, infectious diseases and vaccines, and neurobiology. Prior to joining the Johnson & Johnson Family of Companies, Tom was the Sr. Director of Research Ventures at Shire Human Genetic Therapies. In this position, Tom played a central role in the evaluation, diligence, and deal processes across a number of successful early-stage investments in the rare disease space. He was member of the Board of Directors at Armagen Technologies, led the collaboration with Nimbus Discovery, and was instrumental in establishing and leading the alliance that Shire put in place with Atlas Venture. Prior to this, Tom held a variety of research and development roles in both start-up and mid-sized biotech. He has worked on multiple discovery through phase 2 programs in infectious disease, oncology, immunotherapy, and monogenetic disorders. His experience includes pre-clinical development, early-stage portfolio oversight, licensing, due diligence, company formation, alliance management, and key opinion leader outreach. Tom received his BS in Biology from State University of New York, his PhD in Immunology from Tufts University, and was a post-doctoral fellow in yeast genetics at Harvard School of Public Health.

Dr. Tofy Mussivand is Chair and Director of the Cardiovascular Devices Research Program at the University of Ottawa Heart Institute. He is also Chair of the Medical Devices program, Professor of Surgery in the Faculty of Medicine, and Professor of Engineering in the School of Information Technology and Engineering at the University of Ottawa. He has been actively involved in the medical devices field for more than 25 years in Canada and internationally. Mussivand received his undergraduate education and training in engineering and management. Following many successful years in senior positions in government, Crown corporations, and the private sector, he received his doctorate in Medical Engineering and Medical Sciences at the University of Akron and Northeastern Ohio Universities College of Medicine. Thereafter, he joined the internationally acclaimed Cleveland Clinic Hospital and Research Foundation, where he gained invaluable knowledge and experience in the development of medical devices, artificial hearts, and cardiac care. In 1989, he was invited to return to Canada to continue his pioneering work in the field of medical devices. Mussivand has achieved national and global recognition. His breakthroughs have led to Canada’s prominence in the fields of medical devices, artificial hearts, remote power transfer, and in situ sterilization. He has 15 patents to his name and another eight pending. Combining his scientific, management, and business expertise, Mussivand has chaired and served as a member on several

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PLENARY SESSIONS boards, and he has been a Chief Executive Officer of several successful corporations. His leadership has been responsible for creating more than 1,000 person-years in the Canadian workforce and has been the catalyst for an influx of more than $200 million, primarily from outside Canada, during the past 10 years. Mussivand is a Fellow of the International Academy of Cardiovascular Sciences and a Member of the European Academy of Sciences. In 2001, he won the Natural Sciences and Engineering Research Council of Canada University-Industry Synergy Award. He is a Fellow of the Royal Society of Canada (the highest scholarly honour in Canada) and has served the last three Canadian prime ministers as a member of the Prime Minister's Advisory Council on Science and Technology. Mussivand has published more than 250 papers, books, and technical articles, and he has supervised and taught more than 300 students, residents, and post-doctoral fellows.

Sharon Lee Smith has been Associate Deputy Minister (ADM), Policy and Transformation with the Ontario Ministry of Health and Long-Term Care since February 2015. An executive with more than 20 years of public service experience, Ms. Smith served most recently as ADM, Ministry of Health, Government of Saskatchewan. In this role, she was responsible for key areas, including public health, mental health and addictions, seniors’ and long-term care, laboratory services, and primary health care. Prior to joining the Ministry of Health in Saskatchewan, Ms. Smith was ADM for the Saskatchewan Region of Western Economic Diversification Canada. In 2013, as ADM, she received the Lieutenant Governor’s Gold Medal for Excellence in Public Administration. Her international work experience has included representing Canada in United Nations climate change negotiations in her role as Director General, International Affairs Branch, Environment Canada. She was also responsible for leading multilateral engagement and negotiations with international institutions, including the Organisation for Economic Co-operation and Development in Paris, Rome, and Nairobi, and the United Nations Environment Programme and the Commission for Sustainable Development in New York City. Sharon Lee has held leadership positions at Health Canada, as Regional Director for Northern Health and Executive Director, Aboriginal Health Secretariat – First Nations and Inuit Health Branch.

MODERATOR: Dr. Brian O’Rourke is the President and Chief Executive Officer of CADTH. He joined CADTH in January of 2009 as Vice-President of the CADTH Common Drug Review, following a distinguished career as a Pharmacist and Health Services Operations Officer with the Canadian Forces. With more than 30 years of experience in health care, Dr. O’Rourke actively positions CADTH as the leading source of health technology information in Canada. Dr. O’Rourke holds a Bachelor of Science in Pharmacy from Dalhousie University and a Doctor of Pharmacy from the University of Toronto.

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Join Canadian and International experts in the production and use of evidence-based information on health technologies, in Ottawa, for three days of education and networking.

MARK YOUR CALENDAR NOW: 2016 CADTH Symposium April 10 – 12, 2016 SHAW Centre Ottawa, Ontario

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