In Thrall to Uncertainty a History of How Quantum Theory Has Permeated Western Culture Refreshes Jim Baggott

Total Page:16

File Type:pdf, Size:1020Kb

In Thrall to Uncertainty a History of How Quantum Theory Has Permeated Western Culture Refreshes Jim Baggott PHYSICS In thrall to uncertainty A history of how quantum theory has permeated Western culture refreshes Jim Baggott. uantum theory is the most accu­ The Quantum Moment: punch — “wild and mysterious, packed rate and precise description of the How Planck, Bohr, with creative force” — and why it seems to Qmolecular, atomic, sub-atomic and Einstein, and Heisenberg be rediscovered in every generation. The sub-nuclear realms ever devised. It is also Taught Us to Love authors’ tale is structured along approxi­ utterly exasperating. To anyone tutored Uncertainty mately linear historical lines, from Max ROBERT P. CREASE in the language and the logic of classical AND ALFRED SCHARFF Planck’s discovery in 1900 that light can be physics, it is mathematically challenging, GOLDHABER described in terms of discrete ‘bundles’ of maddeningly bizarre and breathtakingly W. W. Norton: 2014. energy (quanta) to Bell’s theorem, which beautiful. As charismatic US physicist Rich­ opened the door from the 1960s onwards ard Feynman warned: “Nobody understands to some extraordinary experimental tests of quantum mechanics.” O2 arena. And UK-based dramatist Tom the nature of our physical reality. Each chap­ Given its recondite nature, quantum Stoppard’s 1988 play Hapgood blends the ter explores how some of the core ideas and weirdness has entered popular culture in duality of the double agent with a quantum principles that sprang from these historical remarkable ways. What might otherwise duality in which matter and light are both moments have been absorbed into (inevita­ have been the preserve of dry academic waves and particles. Both of these works are bly mostly US) popular culture. This makes texts and stuffy scientific conferences has cited in The Quantum Moment, in which for an entertaining read, even for those become common currency. Who hasn’t philosopher Robert Crease and physicist already familiar with the story. heard of Heisenberg’s uncertainty princi­ Alfred Goldhaber explore quantum theory’s As Crease and Goldhaber explain, much ple or Schrödinger’s cat? Quantum ideas of enduring cultural impact. of the impact on modern culture derives space, time and matter inspired British art­ Based on a class that the authors have from what quantum theory has to say about ist Anthony Gormley’s vast, enigmatic steel taught for six years at Stony Brook Univer­ the nature of reality. Arguably, centuries of sculpture Quantum Cloud near London’s sity, New York, the book asks why quan­ observation, experimentation and strenu­ tum theory carries such a metaphorical ous intellectual endeavour were founded NEW IN The Accidental Universe: The World You Thought You Knew PAPERBACK Alan Lightman (Vintage, 2014) Physicist and literary wizard Alan Lightman reflects on how our cosmos, potentially Highlights of this one among uncountable others, has fortuitously created the perfect conditions for life. season’s releases He considers intricate symmetries in nature and the unfathomable vastness of space. This journey through seven overlapping ‘universes’ — frameworks for exploring recent research — culminates in a vision of humanity hooked on technology, gradually detaching itself from reality. 308 | NATURE | VOL 513 | 18 SEPTEMBER 2014 © 2014 Macmillan Publishers Limited. All rights reserved AUTUMN BOOKS COMMENT on scientists’ expectation that the material elsewhere called “experimental philosophy”. (who should probably know better) have world is composed of some kind of funda­ It is this work that has prompted the current been more than willing to indulge their mental atoms of ‘stuff’. Quantum theory, interest in quantum cryptography, quantum inner metaphysician in research papers and however, has rewarded these endeavours computing and the teleportation of photons. popularizations on the mistaken principle with phantom particles that, like waves, I have only one quibble with The Quan- that, as the Canadian philosopher Marshall can be both here and there; a theoretical tum Moment. Crease and Goldhaber sup­ McLuhan once put it, “mud sometimes structure that tells us only what might hap­ port their narrative with ‘interludes’ after gives the illusion of depth”. pen (not what will); and quantum systems each chapter, designed to provide techni­ Thus we smile at the comical pronounce­ seemingly connected over great distances, cal details, including some equations. The ments on physics by US actress Shirley giving rise to extended, non-local effects, or exposition here is a little drier than in the MacLaine, until the authors point out that what Albert Einstein called “spooky action main chapters, but does not need to be. The she could be paraphrasing similar pro­ at a distance”. material also necessarily repeats much of nouncements made 55 years earlier by the Einstein famously rejected the element what has already been covered, which can British physicist James Jeans. I have else­ of chance that lies at the heart of quantum become a little tedious. The authors suggest where argued that contemporary theoreti­ theory, declaring that God does not play that readers might prefer to skip these inter­ cal physics has become rather self-indulgent dice. He argued that quantum theory is not ludes; for linear readers like me, that does and self-referential, a malaise that I have complete. Those scientists who, like Ein­ not really work. called fairy-tale physics. Deep questions stein, are less inclined to accept that we have Those versed in quantum theory’s about the nature of reality tend to provoke reached an ultimate limit of what is know­ practical applications might be tempted this kind of response, and it surely finds its able remain firmly in denial. So, in the past to dismiss its many manifestations in origin in the quantum moment. ■ 40 years or so, the efforts of agents provo­ popular culture as what the authors call cateurs such as John Bell and Tony Leggett “fruit­loopery”. And certainly, there is a Jim Baggott is the author of The Quantum have encouraged an orgy of sophisticated lot of nonsense out there. But, as Crease Story and Farewell to Reality. He is based in laser-based experiments to test the foun­ and Goldhaber make abundantly clear at Reading, UK. dations of quantum physics — what I have several points, many esteemed physicists e-mail: [email protected] LINGUISTICS the manual’s dismissal of the passive voice. Linguistic research, he later writes, has The write stuff shown that the pas­ sive actually “allows Steven Pinker’s provocative treatise on language use and the writer to direct the abuse would benefit from more data, finds Paul Raeburn. reader’s gaze, like a cin­ ematographer choos­ The Sense of Style: ing the best camera o conversation about the science Fowler’s Modern English Usage. We need a The Thinking angle”. What research, Person’s Guide to of language can get very far with­ new guide “infused by the spirit of scientific Writing in the 21st exactly? Pinker does out a mention of Steven Pinker, the skepticism”, he writes, using grammar and Century not tell us. His views NHarvard University cognitive scientist who research on “the mental dynamics of reading” STEVEN PINKER are informed by has not yet made linguistics as popular as to replace edicts with evidence. Pinker gave us Allen Lane: 2014. psycho­linguistics; that football — but is working on it. In The Sense the science in The Language Instinct (William is his day job. But he of Style, he wants to give us the cognitive Morrow, 1994); in The Sense of Style he sets promises us science, so I expected to see data. science, linguistics and psychology behind out to offer its practical application. However, in this instance, and in many others, classic debates over proper English, from He covers much of the same ground as the data are not there. passive voice to split infinitives. the classic guides, including frequently mis­ Similarly, Pinker’s view on infinitives is Plenty of others have given us stuffy decrees used words (“fulsome” and “noisome”) and to split them “if you need to”, a conclusion intended to end the interminable wrangling, the serial comma. His problem with Strunk backed by dictionaries and style manuals — but Pinker is different. He is unhappy with & White, however, is that the authors lack not research. And when he quotes with admi­ the classic style manuals — including revered tools for analysing language, and so end up ration the opening line of Richard Dawkins’ texts such as Strunk & White (William Strunk “vainly appealing to the writer’s ‘ear’”. That’s Unweaving the Rainbow (Houghton Mifflin, and E. B. White’s The Elements of Style) or on page two. By page three, he is challenging 1998) — “We are going to die, and that Love and Math: The Heart of Hidden Reality Life at the Speed of Light Edward Frenkel (Basic Books, 2014) J. Craig Venter (Abacus, 2014) With infinite passion, media-feted professor Biologist J. Craig Venter shares his life’s work of Edward Frenkel shares his rise to mathematical catalysing progress in biological engineering, greatness against a tide of Russian anti-Semitism. sequencing the human genome and ultimately Appeasing maths-haters, he uses a borscht recipe creating the first “synthetic cell” (Mycoplasma to explain quantum duality. (See Marcus du mycoides JCVI-syn1.0). (See Nathaniel Comfort’s Sautoy’s review: Nature 502, 36; 2013.) review: Nature 502, 436–437; 2013.) 18 SEPTEMBER 2014 | VOL 513 | NATURE | 309 © 2014 Macmillan Publishers Limited. All rights reserved COMMENT AUTUMN BOOKS makes us the lucky ones” — he offers a EVOLUTION detailed explanation of why it works that is, again, short on science. Pinker is a good writer and a deeply humanistic one, and there are many Tribes like us bright moments here. His lists explain­ ing right and wrong usage with a range of examples (enervate means to sap, not Tim Lenton is intrigued by E.
Recommended publications
  • NSABB June-July 2005 Meeting Agenda
    First Meeting of the National Science Advisory Board for Biosecurity June 30 – July 1, 2005 Hyatt Regency Bethesda 7400 Wisconsin Ave. Bethesda, Maryland, 20814 USA Hotel Phone: 301-657-1234 Agenda Webcast: To watch the live webcast of the meeting, click here. The webcast can only be viewed when the meeting is in session at 8:00am-6:00pm on June 30 and at 8:00am-1:30pm on July 1 Eastern Time. You will need RealOne Player to view the webcast. If you do not already have RealOne Player on your computer, download here. Presentation slides: To access the following PowerPoint presentations, click on the presentation titles below. June 30, 2005 Opening Remarks and Swearing in Ceremony Elias Zerhouni, M.D. Director of the National Institutes of Health (NIH) Chair's Remarks and Agenda Overview Dennis L. Kasper, M.D. NSABB Chair Harvard Medical School Introduction of NSABB Members NSABB Structure and Operations Thomas Holohan, M.D. NSABB Executive Director, NIH Office of Biotechnology Activities Break Perspectives on Biosecurity in the Life Sciences NSABB Voting Members Impetus for NSABB: Enhancing Biosecurity on the Life Sciences Rajeev Venkayya, M.D. Special Assistant to the President, Senior Director for Biological and Chemical Defense White House Homeland Security Council Perspectives on Biosecurity in the Life Sciences NSABB Ex Officio Members Lunch Session I- The Development of Criteria for Identifying Dual Use Research and Research Results Introduction: Issues of Relevance to Criteria Development Arturo Casadevall, M.D., Ph.D. Professor of Medicine and of Microbiology & Immunology and Chief of Infectious Diseases Albert Einstein College of Medicine National Research Council Perspective: Experiments of Concern Ron Atlas, Ph.D.
    [Show full text]
  • Michael S. Brown, MD
    DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine.
    [Show full text]
  • A Review of J. Craig Venter's a Life Decoded
    A peer-reviewed electronic journal published by the Institute for Ethics and Emerging Technologies ISSN 1541-0099 17(1) – March 2008 A review of J. Craig Venter’s A Life Decoded Randy Mayes, Duke University Journal of Evolution and Technology - Vol. 17 Issue 1 – March 2008 - pgs 71-72 http://jetpress.org/v17/mayes.htm In the early 1980s, a number of researchers suggested sequencing and mapping the human genome to help the science community better understand diseases and evolution. Following the announcement that the human genome had been sequenced, scientists wrote in peer-reviewed journals that we are not as hardwired as was once believed, and that the sequencing of the genome was just the beginning. Today, researchers have a new set of goals. In popular journalism, however, the science was lost in the shuffle. The media focused more on the dynamics of the conflicting philosophies of the private and public projects. This emphasis is also clear in the titles of several books chronicling the Human Genome Project, all appearing prior to the recent release of Craig Venter’s autobiography, A Life Decoded: My Genome: My Life (2007). Readers will find that Robert Cook-Deegan’s The Gene Wars (1995) and The Common Thread by Sir John Sulston and Georgina Ferry (2002), both written by insiders, are biased towards the philosophy of the public project, a commons approach. Sulston is a socialist who grows runner beans and drives a second hand car. By contrast, Venter travels in Lear jets and conducts business from his yacht. Three other books are more objective.
    [Show full text]
  • Humankind 2.0: the Technologies of the Future 6. Biotech
    Humankind 2.0: The Technologies of the Future 6. Biotech Piero Scaruffi, 2017 See http://www.scaruffi.com/singular/human20.html for the full text of this discussion A brief History of Biotech 1953: Discovery of the structure of the DNA 2 A brief History of Biotech 1969: Jon Beckwith isolates a gene 1973: Stanley Cohen and Herbert Boyer create the first recombinant DNA organism 1974: Waclaw Szybalski coins the term "synthetic biology” 1975: Paul Berg organizes the Asilomar conference on recombinant DNA 3 A brief History of Biotech 1976: Genentech is founded 1977: Fred Sanger invents a method for rapid DNA sequencing and publishes the first full DNA genome of a living being Janet Rossant creates a chimera combining two mice species 1980: Genentech’s IPO, first biotech IPO 4 A brief History of Biotech 1982: The first biotech drug, Humulin, is approved for sale (Eli Lilly + Genentech) 1983: Kary Mullis invents the polymerase chain reaction (PCR) for copying genes 1986: Leroy Hood invents a way to automate gene sequencing 1986: Mario Capecchi performs gene editing on a mouse 1990: William French Anderson’s gene therapy 1990: First baby born via PGD (Alan Handyside’s lab) 5 A brief History of Biotech 1994: FlavrSavr Tomato 1994: Maria Jasin’s homing endonucleases for genome editing 1996: Srinivasan Chandrasegaran’s ZFN method for genome editing 1996: Ian Wilmut clones the first mammal, the sheep Dolly 1997: Dennis Lo detects fetal DNA in the mother’s blood 2000: George Davey Smith introduces Mendelian randomization 6 A brief History of Biotech
    [Show full text]
  • On Jim Watson's APOE Status: Genetic Information Is Hard to Hide
    European Journal of Human Genetics (2009) 17, 147–150 & 2009 Macmillan Publishers Limited All rights reserved 1018-4813/09 $32.00 www.nature.com/ejhg LETTERS 15.6 (95% CI, 10.9–22.5) and 4.3 (95% CI, 3.3–5.5) for APOE e4 homozygotes and e4/e3 heterozygotes respectively, 6 On Jim Watson’s APOE compared to e3 homozygotes. The meta-analytic odds ratios in population-based Caucasian samples were 11.8 status: genetic (95% CI, 7.0–19.8) and 2.8 (95% CI, 2.3–3.5), respec- tively.6 In a large Rotterdam (Netherlands), population- information is hard to based prospective study of people aged 55 years or above, it hide was estimated that 17% of the overall risk of AD could be attributed to the e4 allele, with 3% (95% CI, 0–6%) of cases attributed to the e4/e4 genotype, and 14% (95% CI, 7–21%) European Journal of Human Genetics (2009) 17, 147–149; 7 to the e4/e3 genotype. doi:10.1038/ejhg.2008.198; published online 22 October 2008 A recent investigation of LD for 50 SNPs in and surrounding APOE in 550 Caucasians identified multiple SNPs in the TOMM40 gene B15 kb upstream of APOE, and The recent publication and release to public databases of at least one SNP in the other surrounding genes LU, PVRL2, Dr James Watson’s sequenced genome,1 with the exception APOC1, APOC4 and CLPTM1 were associated with LOAD of all gene information about apolipoprotein E (ApoE), risk.8 In particular, the C allele of SNP rs157581 in provides a pertinent example of the challenges concerning TOMM40 is in strong LD (r240.6) with the C allele of privacy and the complexities of informed consent in the rs429358 in APOE, which defines the e4 allele.
    [Show full text]
  • Synthetic Biology - Mapping the Patent Landscape Paul Oldham 1,2 Stephen Hall 3 1
    bioRxiv preprint doi: https://doi.org/10.1101/483826; this version posted November 30, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Synthetic Biology - Mapping the Patent Landscape Paul Oldham 1,2 Stephen Hall 3 1. Industrial Fellow, Manchester Institute of Innovation Research, Alliance Manchester Business School, Manchester University. 2 Senior Visiting Fellow, Institute for the Advanced Study of Sustainability, United Nations University 3. Information System Services, Lancaster University Abstract This article presents the global patent landscape for synthetic biology as a new and emerging area of science and technology. The aim of the article is to provide an overview of the emergence of synthetic biology in the patent system and to contribute to future research by providing a high quality tagged core dataset with 7,424 first filings and 71,887 family members. This dataset is intended to assist with evidence based exploration of synthetic biology in the patent system and with advancing methods for the analysis of new and emerging areas of science and technology. The starting point for the research is recognition that traditional methods of patent landscape analysis based on key word searches face limitations when addressing new and emerging areas of science and technology. Synthetic biology can be broadly described as involving the design, synthesis and assembly of biological parts, circuits, pathways, cells and genomes. As such synthetic biology can be understood as emerging from a combination of overlaps and convergences between existing fields and disciplines, such as biotechnology, genetic engineering, protein engineering and systems biology.
    [Show full text]
  • Scientists Create Cell Based on Man-Made Genetic Instructions
    25-5-2010 Scientists create cell based on man-m… Scientists create cell based on man•made genetic instructions By David Brown Friday, M ay 21, 2010; A03 Scientists reported Thursday that they have created a cell controlled entirely by man•made genetic instructions •• the latest step toward creating life from scratch. The achievement is a landmark in the emerging field of "synthetic biology," which aims to control the behavior of organisms by manipulating their genes. Although the ultimate goal of creating artificial organisms is still far off, the experiment points to a future in which microbes could be manufactured with novel functions, such as the ability to digest pollutants or produce fuels. Some ethicists fear that the strategy could also be used to produce biological weapons and other dangerous life forms. In a paper published online by the journal Science, researchers from the J. Craig Venter Institute described using off•the•shelf chemicals and the DNA sequence of Mycoplasma mycoides's genes to make an artificial copy of the bacterium's genome. The scientists then transplanted that genome into the cell of a different (but closely related) microbe. The donor genome reprogrammed the recipient cell, which went on to replicate and divide. The result was new colonies of Mycoplasma mycoides. "We think these are the first synthetic cells that are self• replicating and whose genetic heritage started in the computer. That changes conceptually how I think about life," said J. Craig Venter, 63, who gained fame a decade ago as the co•sequencer of the human genome. His institute has laboratories and offices in Rockville and San Diego.
    [Show full text]
  • Craig Venter's Bugs Might Save the World
    May 30, 2012 Craig Venter’s Bugs Might Save the World By WIL S. HYLTON In the menagerie of Craig Venter’s imagination, tiny bugs will save the world. They will be custom bugs, designer bugs — bugs that only Venter can create. He will mix them up in his private laboratory from bits and pieces of DNA, and then he will release them into the air and the water, into smokestacks and oil spills, hospitals and factories and your house. Each of the bugs will have a mission. Some will be designed to devour things, like pollution. Others will generate food and fuel. There will be bugs to fight global warming, bugs to clean up toxic waste, bugs to manufacture medicine and diagnose disease, and they will all be driven to complete these tasks by the very fibers of their synthetic DNA. Right now, Venter is thinking of a bug. He is thinking of a bug that could swim in a pond and soak up sunlight and urinate automotive fuel. He is thinking of a bug that could live in a factory and gobble exhaust and fart fresh air. He may not appear to be thinking about these things. He may not appear to be thinking at all. He may appear to be riding his German motorcycle through the California mountains, cutting the inside corners so close that his kneepads skim the pavement. This is how Venter thinks. He also enjoys thinking on the deck of his 95-foot sailboat, halfway across the Pacific Ocean in a gale, and while snorkeling naked in the Sargasso Sea surrounded by Portuguese men-of-war.
    [Show full text]
  • 10Th Anniversary of the Human Genome Project
    Grand Celebration: 10th Anniversary of the Human Genome Project Volume 3 Edited by John Burn, James R. Lupski, Karen E. Nelson and Pabulo H. Rampelotto Printed Edition of the Special Issue Published in Genes www.mdpi.com/journal/genes John Burn, James R. Lupski, Karen E. Nelson and Pabulo H. Rampelotto (Eds.) Grand Celebration: 10th Anniversary of the Human Genome Project Volume 3 This book is a reprint of the special issue that appeared in the online open access journal Genes (ISSN 2073-4425) in 2014 (available at: http://www.mdpi.com/journal/genes/special_issues/Human_Genome). Guest Editors John Burn University of Newcastle UK James R. Lupski Baylor College of Medicine USA Karen E. Nelson J. Craig Venter Institute (JCVI) USA Pabulo H. Rampelotto Federal University of Rio Grande do Sul Brazil Editorial Office Publisher Assistant Editor MDPI AG Shu-Kun Lin Rongrong Leng Klybeckstrasse 64 Basel, Switzerland 1. Edition 2016 MDPI • Basel • Beijing • Wuhan ISBN 978-3-03842-123-8 complete edition (Hbk) ISBN 978-3-03842-169-6 complete edition (PDF) ISBN 978-3-03842-124-5 Volume 1 (Hbk) ISBN 978-3-03842-170-2 Volume 1 (PDF) ISBN 978-3-03842-125-2 Volume 2 (Hbk) ISBN 978-3-03842-171-9 Volume 2 (PDF) ISBN 978-3-03842-126-9 Volume 3 (Hbk) ISBN 978-3-03842-172-6 Volume 3 (PDF) © 2016 by the authors; licensee MDPI, Basel, Switzerland. All articles in this volume are Open Access distributed under the Creative Commons License (CC-BY), which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications.
    [Show full text]
  • Bacterial Artificial Chromosomes (Bacs) Became the Most Broadly Used Resource for Several Reasons
    Bacterial Artificial Chromosomes STC Production on Human BACs Archive Provided for Historical Purposes Home STC Project History 1995 Meeting Articles Contacts Links HGP Sequences HGP Research Several types of DNA library resources were sponsored by the DOE before and during the Human Genome Program (HGP). These included both prokaryotic and eukaryotic vector systems, and clone libraries representing single chromosomes. Bacterial Artificial Chromosomes (BACs) became the most broadly used resource for several reasons. The large size was a good match for capabilities of high throughput sequencing centers. As contrasted to some earlier resources, chimerism (having gene segments from multiple chromosome sites combined in one clone) is substantially if not completely absent. With some interesting exceptions , the BACS are stable in their bacterial hosts. In support of the functional analysis of genes, the BACs are very useful for making transgenic animals with segments of human DNAs. A brief history of BAC development is available in a preface to a 2003 issue of Methods in Molecular Biology , wherein details of BAC related protocols reside. One particular BAC project was crucial to the timely completion of human genome sequencing. (See history .) In a 1996 initiative, the DOE Office of Biological and Environmental Research sponsored the production of sequence tag connectors (STCs) for the BACs being used in human genome sequencing. (STCs are sequence reads at the ends of cloned DNA segments; they mark the boundaries of the cloned DNA.) This publicly available resource has served both the international public collaboration and Celera Genomics Inc . in the generation of the human genome sequence. The BACs representing a genome can together serve as a scaffold on which much shorter DNA sequence assemblies can be located.
    [Show full text]
  • Craig Venter Vs the Human Genome Project
    BALLEN SCIENTIFIC RIVALRIES AND SCANDALS In the mid-1980s, some geneticists proposed a daring project to sequence the human genome. That meant figuring out the exact order of the three billion chemical pairs that make up human DNA. Sequencing the human genome could help scientists understand how our bodies work and help doctors diagnose, treat, and prevent certain diseases. The HUMAN GENOME PROJECT launched in 1990, with scientists around the world collaborating on the research. They worked slowly and methodically, trying to produce the most accurate information possible. By 1991 one of these scientists, CRAIG VENTER, became fed up with the HGP’s slow pace. He challenged the HGP to move faster and started his own company to compete with the HGP. OUR DNA OUR Racing neck and neck, the two organizations reached their goal years ahead of OUR schedule. But the challenge also led to a bitter public argument, especially over who could use the sequence and how. This book reveals how ambition, persistence, ego, greed, and principle combined—often with explosive results—in the quest to decode our DNA. READ ABOUT ALL OF THE DNA SCIENTIFIC RIVALRIES AND SCANDALS CRAIG VENTER BATTLE OF THE DINOSAUR BONES: Othniel Charles Marsh vs Edward Drinker Cope DECODING OUR DNA: Craig Venter vs the Human Genome Project THE RACE TO DISCOVER THE AIDS VIRUS: Luc Montagnier vs Robert Gallo THE HUMAN TWENTY-FIRST CENTURY VS WAR OF THE CURRENTS: Thomas Edison vs Nikola Tesla GENOME PROJECT KAREN GUNNISON BALLEN THIS PAGE INTENTIONALLY LEFT BLANK SCIENTIFIC RIVALRIES AND SCANDALS OUR DNA CRAIG VENTER VS THE HUMAN GENOME PROJECT KAREN GUNNISON BALLEN Twenty-First Century Books Minneapolis In loving memory of Tamara Grace Ballen, 1948–2010 I thank Christine Zuchora-Walske for her editorial guidance.
    [Show full text]
  • The Sequence of the Human Genome J
    The Sequence of the Human Genome J. Craig Venter, et al. Science 291, 1304 (2001); DOI: 10.1126/science.1058040 The following resources related to this article are available online at www.sciencemag.org (this information is current as of May 1, 2007 ): A correction has been published for this article at: http://www.sciencemag.org/cgi/content/full/295/5559/1466b Updated information and services, including high-resolution figures, can be found in the online version of this article at: http://www.sciencemag.org/cgi/content/full/291/5507/1304 Supporting Online Material can be found at: http://www.sciencemag.org/cgi/content/full/291/5507/1304/DC1 A list of selected additional articles on the Science Web sites related to this article can be found at: http://www.sciencemag.org/cgi/content/full/291/5507/1304#related-content on May 1, 2007 This article cites 152 articles, 52 of which can be accessed for free: http://www.sciencemag.org/cgi/content/full/291/5507/1304#otherarticles This article has been cited by 3917 article(s) on the ISI Web of Science. This article has been cited by 94 articles hosted by HighWire Press; see: http://www.sciencemag.org/cgi/content/full/291/5507/1304#otherarticles www.sciencemag.org This article appears in the following subject collections: Genetics http://www.sciencemag.org/cgi/collection/genetics Information about obtaining reprints of this article or about obtaining permission to reproduce this article in whole or in part can be found at: http://www.sciencemag.org/about/permissions.dtl Downloaded from Science (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005.
    [Show full text]