Endophthalmitis
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Differentiate Red Eye Disorders
Introduction DIFFERENTIATE RED EYE DISORDERS • Needs immediate treatment • Needs treatment within a few days • Does not require treatment Introduction SUBJECTIVE EYE COMPLAINTS • Decreased vision • Pain • Redness Characterize the complaint through history and exam. Introduction TYPES OF RED EYE DISORDERS • Mechanical trauma • Chemical trauma • Inflammation/infection Introduction ETIOLOGIES OF RED EYE 1. Chemical injury 2. Angle-closure glaucoma 3. Ocular foreign body 4. Corneal abrasion 5. Uveitis 6. Conjunctivitis 7. Ocular surface disease 8. Subconjunctival hemorrhage Evaluation RED EYE: POSSIBLE CAUSES • Trauma • Chemicals • Infection • Allergy • Systemic conditions Evaluation RED EYE: CAUSE AND EFFECT Symptom Cause Itching Allergy Burning Lid disorders, dry eye Foreign body sensation Foreign body, corneal abrasion Localized lid tenderness Hordeolum, chalazion Evaluation RED EYE: CAUSE AND EFFECT (Continued) Symptom Cause Deep, intense pain Corneal abrasions, scleritis, iritis, acute glaucoma, sinusitis, etc. Photophobia Corneal abrasions, iritis, acute glaucoma Halo vision Corneal edema (acute glaucoma, uveitis) Evaluation Equipment needed to evaluate red eye Evaluation Refer red eye with vision loss to ophthalmologist for evaluation Evaluation RED EYE DISORDERS: AN ANATOMIC APPROACH • Face • Adnexa – Orbital area – Lids – Ocular movements • Globe – Conjunctiva, sclera – Anterior chamber (using slit lamp if possible) – Intraocular pressure Disorders of the Ocular Adnexa Disorders of the Ocular Adnexa Hordeolum Disorders of the Ocular -
Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients
Journal of Clinical Medicine Article Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients 1,2, 1,2, 1,2, Alfonso Savastano y , Emanuele Crincoli y , Maria Cristina Savastano * , Saad Younis 3, Gloria Gambini 1,2, Umberto De Vico 1,2 , Grazia Maria Cozzupoli 1,2 , Carola Culiersi 1,2 , Stanislao Rizzo 1,2,4 and Gemelli Against COVID-19 Post-Acute Care Study Group 2 1 Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00196 Rome, Italy; [email protected] (A.S.); [email protected] (E.C.); [email protected] (G.G.); [email protected] (U.D.V.); [email protected] (G.M.C.); [email protected] (C.C.); [email protected] (S.R.) 2 Department of Ophthalmology, Catholic University of “Sacro Cuore”, 00168 Rome, Italy 3 Department of Ophthalmology, Western Eye Hospital, Imperial College Healthcare NHS Trust, London NW1 5QH, UK; [email protected] 4 Neuroscience Institute, Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, 56124 Pisa, Italy * Correspondence: [email protected]; Tel.: +39-063-015-4928 These authors contributed equally to this work. y Received: 5 August 2020; Accepted: 3 September 2020; Published: 8 September 2020 Abstract: The ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-20s) to cause multi-organ ischemia and coronavirus-induced posterior segment eye diseases in mammals gave concern about potential sight-threatening ischemia in post coronavirus disease 2019 patients. The radial peripapillary capillary plexus (RPCP) is a sensitive target due to the important role in the vascular supply of the peripapillary retinal nerve fiber layer (RNFL). -
Diagnosing Dry Eye
MEDICAL ED NG UC UI AT A CONTINUING TIN IO CON N MEDICAL EDUCATION PUBLICATION CME ISSUE 14 Diagnosing Dry Eye ERIC D. DONNENFELD, MD Dry eye a ects tens of millions of patients and is among the most common reasons for eye care provider visits. Knowing what to look for, how, and in whom (hint: everyone) can help stem the tide of this quiet epidemic. Th e exact prevalence of dry eye is diffi cult to ascertain, for several reasons, including the absence of a single test (or universally accepted sequence of tests) for its diagnosis, and the fact that patient-reported symptoms are oft en poorly con- cordant with objective assessments.1 Estimates based on cohort studies suggest that about 5% to 35% of adults worldwide have dry eye, a rate that is expected to rise in the upcoming decades FIGURE 1 Lid margin with inspissated meibomian glands and pasty as common risk factors, including advanced age, increase.2,3 secretions indicative of MGD. Sometimes even higher estimates are cited, as dry eye symp- toms are oft en camoufl aged by other ocular surface condi- tions such as allergic conjunctivitis, surgery, and contact lens CATEGORIES AND MECHANISMS discomfort; in addition, many patients—up to 60% of those Dry eye is generally divided into two main categories based with objective evidence of dry eye—are pre-symptomatic.3 on the underlying cause: aqueous defi cient and evaporative.4 Th e landmark 2007 International Dry Eye Workshop Aqueous defi ciency describes inadequate tear production by (DEWS) report off ered the fi rst thorough expert review around the lacrimal glands. -
Role of Intracameral Dexamethasone in Preventing Immediate Postoperative Anterior Uveitis in Paediatric Cataract Extraction
ORIGINAL ARTICLE Role of Intracameral Dexamethasone in Preventing Immediate Postoperative Anterior Uveitis in Paediatric Cataract Extraction CHAUDARY NASIR AHMAD, ASAD ASLAM KHAN, ZAHID SIDDIQUE, SHAKIL AHMED ABSTRACT Objective: Paediatric cataract surgery can result in several complications like post operative inflammation. Topical steroids are relied upon as mainstay of treatment and prevention, adjuvant periocular and systemic steroids may be required to control the inflammation. The purpose of study was to evaluate the role of intracameral dexamethasone in preventing immediate postoperative anterior uveitis in paediatric cataract extraction. Methods: This was comparative study done at institute of Ophthalmology Mayo Hospital Lahore. Sixty patients were selected and divided into two equal groups. Group I were given routinely subconjuctival injection of gentamycin 20 mg and dexamethasone 2 mg while patients in group II were given subconjuctival injection of gentamycin 20 mg and intracameral dexamethasone 0.4 mg (0.1ml). Evaluation was done on 1st and 3rd postoperative day and on first follow up visit. Examination of children was done with help of slit lamp for cells, flare or any other sign of inflammation. In case of non cooperative children examination was done with microscope under sedation/general anesthesia for fibrinous reaction, exudative membrane, posterior synechiae and red reflex. Results: There were total of sixty patients age below 12 years divided into two equal groups, 43 were males and 17were females. Group I was given routinely subconjuctival injection of dexamethasone, while group II patients were given intracameral injection of dexamethasone. Group II patients showed better results than that of group I. Conclusion: Intracameral injection of dexamethasone was found superior to subconjuctival injection of dexamethasone in preventing immediate postoperative anterior uveitis. -
Olivia Steinberg ICO Primary Care/Ocular Disease Resident American Academy of Optometry Residents Day Submission
Olivia Steinberg ICO Primary Care/Ocular Disease Resident American Academy of Optometry Residents Day Submission The use of oral doxycycline and vitamin C in the management of acute corneal hydrops: a case comparison Abstract- We compare two patients presenting to clinic with an uncommon complication of keratoconus, acute corneal hydrops. Management of the patients differs. One heals quickly, while the other has a delayed course to resolution. I. Case A a. Demographics: 40 yo AAM b. Case History i. CC: red eye, tearing, decreased VA x 1 day OS ii. POHx: (+) keratoconus OU iii. PMHx: depression, anxiety, asthma iv. Meds: Albuterol, Ziprasidone v. Scleral CL wearer for approximately 6 months OU vi. Denies any pain OS, denies previous occurrence OU, no complaints OD c. Pertinent Findings i. VA cc (CL’s)- 20/25 OD, 20/200 PH 20/60+2 OS ii. Slit Lamp 1. Inferior corneal thinning and Fleisher ring OD, central scarring OD, 2+ diffuse microcystic edema OS, Descemet’s break OS (photos and anterior segment OCT) 2. 2+ diffuse injection OS 3. D&Q A/C OU iii. Intraocular Pressures: deferred OD due to CL, 9mmHg OS (tonopen) iv. Fundus Exam- unremarkable OU II. Case B a. Demographics: 39 yo AAM b. Case History i. CC: painful, red eye, tearing, decreased VA x 1 day OS ii. POHx: unremarkable iii. PMHx: hypertension iv. Meds: unknown HTN medication v. Wears Soflens toric CL’s OU; reports previous doctor had difficulty achieving proper fit OU; denies diagnosis of keratoconus OU vi. Denies any injury OS, denies previous occurrence OU, no complaints OD c. -
Smoking and Eye Disease
Smoking and Eye Disease Here are some eye problems that are made worse Smoking and eye disease by smoking: Smoking tobacco (cigarettes, cigars or pipes) can cause lung disease, heart disease, cancer, and Dry eye. This is when your eyes do not have many other serious health problems. But did you enough—or the right kind of—tears. Smoking know that smoking can also harm your eyes? with dry eye will make your eyes more likely to feel scratchy, sting, burn or be red. Eye Words to Know Cataracts. If you smoke you are at increased risk for getting cataracts. A cataract is clouding of Retina: Layer of nerve cells lining the back your eye’s naturally clear lens. It causes blurry wall inside the eye. This layer senses light and vision and makes colors look dull, faded or sends signals to the brain so you can see. yellowish. Cataracts are removed in surgery. Macula: Small but important area in the center of the retina. You need the macula to Age-related macular degeneration (AMD). This clearly see details of objects in front of you. disease happens when a part of the retina called the macula is damaged. You lose your central Lens: Clear part of the eye behind the colored vision and cannot see fine details. But your iris. It helps to focus light on the retina (back peripheral (side) vision stays normal. Sometimes of the eye) so you can see. medicine or surgery can help certain people with Optic nerve: A nerve at the back of your AMD from getting worse. -
Intracameral Therapeutics for Cataract Surgery
s THE LITERATURE INTRACAMERAL THERAPEUTICS FOR CATARACT SURGERY Closing in on no-drop surgery. BY MARK A. KONTOS, MD; AND KENDALL E. DONALDSON, MD, MS DEXAMETHASONE INTRACAMERAL ninety-four patients scheduled for Anterior chamber cell clearing at DRUG-DELIVERY SUSPENSION FOR cataract surgery at 27 sites were day 8 was achieved in 25% of eyes INFLAMMATION ASSOCIATED WITH randomly assigned to three groups. in group 1, 63% in group 2, and CATARACT SURGERY: A RANDOMIZED, Group 1 received a 5-µL injection of 66% in group 3 (P > .001). Anterior PLACEBO-CONTROLLED PHASE III TRIAL placebo. Groups 2 and 3, respectively, chamber flare clearing at day 8 was received a 5-µL injection of 342 µg or achieved in 63.8% of eyes in group 1, Donnenfeld E, Holland E1 517 µg dexamethasone drug delivery 92.4% in group 2, and 89.1% in group suspension into the anterior chamber 3 (P > .001). Adverse events were ABSTRACT SUMMARY at the conclusion of cataract surgery. similar among the three groups with In this randomized, double-masked, Patients were observed for 90 days no serious adverse events reported up placebo-controlled study, inves- after surgery. to postoperative day 90. tigators sought to determine the The primary outcome measure safety and efficacy of dexamethasone was anterior chamber cell clearing DISCUSSION intraocular suspension 9% (Dexycu, at postoperative day 8. Secondary The appropriate postoperative EyePoint Pharmaceuticals) for measures were anterior chamber flare medical regimen for cataract surgery intracameral administration in and anterior chamber cell plus flare remains a hotly debated subject. The two dosages in patients undergoing clearing in the study eyes. -
Acute Keratoconus-Like Corneal Hydrops Secondary to Ocular
perim Ex en l & ta a l ic O p in l h Journal of Clinical & Experimental t C h f a o l m l a o Ke et al., J Clin Exp Ophthalmol 2017, 8:6 n l o r g u y o Ophthalmology J DOI: 10.4172/2155-9570.1000694 ISSN: 2155-9570 Case Report Open Access Acute Keratoconus-Like Corneal Hydrops Secondary to Ocular Massage Following Trabeculectomy Hongmin Ke, Chengguo Zuo and Mingkai Lin* State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Nan Road, Guangzhou, China *Corresponding author: Mingkai Lin, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, 54 Xianlie Nan Road, Guangzhou, China, 510060, E- mail: [email protected] Received date: November 13, 2017; Accepted date: November 21, 2017; Published date: November 23, 2017 Copyright: © 2017 Ke H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Purpose: To report a case of acute keratoconus-like corneal hydrops in a patient with long-term ocular massage following trabeculectomy. Methods: Case report and review of medical literature. Results: A rare complication of acute keratoconus-like corneal hydrops occurred in a patient following the use of ocular massage to maintain satisfactory aqueous humor filtration after trabeculectomy. The patient had a history of high myopia but denied previous ocular trauma, allergic disease and a family history of keratoconus. Slit-lamp examination demonstrated keratoconus-like corneal hydrops with formation of epithelial microcystic, and intrastromal cleft. -
CAUSES, COMPLICATIONS &TREATMENT of A“RED EYE”
CAUSES, COMPLICATIONS & TREATMENT of a “RED EYE” 8 Most cases of “red eye” seen in general practice are likely to be conjunctivitis or a superficial corneal injury, however, red eye can also indicate a serious eye condition such as acute angle glaucoma, iritis, keratitis or scleritis. Features such as significant pain, photophobia, reduced visual acuity and a unilateral presentation are “red flags” that a sight-threatening condition may be present. In the absence of specialised eye examination equipment, such as a slit lamp, General Practitioners must rely on identifying these key features to know which patients require referral to an Ophthalmologist for further assessment. Is it conjunctivitis or is it something more Iritis is also known as anterior uveitis; posterior uveitis is serious? inflammation of the choroid (choroiditis). Complications include glaucoma, cataract and macular oedema. The most likely cause of a red eye in patients who present to 4. Scleritis is inflammation of the sclera. This is a very rare general practice is conjunctivitis. However, red eye can also be presentation, usually associated with autoimmune a feature of a more serious eye condition, in which a delay in disease, e.g. rheumatoid arthritis. treatment due to a missed diagnosis can result in permanent 5. Penetrating eye injury or embedded foreign body; red visual loss. In addition, the inappropriate use of antibacterial eye is not always a feature topical eye preparations contributes to antimicrobial 6. Acid or alkali burn to the eye resistance. The patient history will usually identify a penetrating eye injury Most general practice clinics will not have access to specialised or chemical burn to the eye, but further assessment may be equipment for eye examination, e.g. -
The Red Eye Differential Diagnosis Differential Diagnosis of “Red Eye”
The Red Eye Differential Diagnosis Differential Diagnosis of “red eye” Conjunctiva Pupil Cornea Anterior IOP chamber Subconjunctival Bright red Normal Normal Normal Normal Haemorrhage Conjunctivitis Injected Normal Normal Normal Normal vessels, fornices. Discharge Iritis Injected Small, Normal, Turgid, Normal around cornea fixed, KPs deep irregular Acute glaucoma Entire eye red Fixed, Hazy Shallow High dilated, oval Conjunctivitis Papillae Follicles Purulent discharge Redness Chemosis Subconjunctival Haemorrhage • Diffuse or localised area of blood under conjunctiva. Asymptomatic • Idiopathic, trauma, cough, sneezing, aspirin, HT • Resolves within 10-14 days Dry Eye Syndrome • Poor quality – Meibomian gland disease,Acne rosacea – Lid related – Vitamin A deficiency • Poor quantity –KCS • Sjogren Syndrome • Rheumatoid Arthritis – Lacrimal disease ie, Sarcoidosis – Paralytic ie, VII CN palsy Corneal Abrasion • Surface epithelium sloughed off. • Stains with fluorescein • Usually due to trauma • Pain, FB sensation, tearing, red eye Corneal Ulcer • Infection – Bacterial: Adnexal infection, lid malposition, dry eye, CL – Viral: HSV, HZO – Fungal: –Protozoan:Acanthamoeba in CL wearer • Mechanical or trauma • Chemical: Alkali injuries are worse than acid Episcleritis • Superficial • Idiopathic, collagen vascular disorder (RA) • Asymptomatic, mild pain • Self-limiting or topical treatment Scleritis •Deep • Idiopathic • Collagen vascular disease (RA,AS, SLE, Wegener, PAN) • Zoster • Sarcoidosis • Dull, deep pain wakes patient at night • Systemic -
Intracameral Antibiotics for the Prevention of Endophthalmitis Post-Cataract Surgery: Review of Clinical and Cost-Effectiveness and Guidelines
Canadian Agency for Agence canadienne Drugs and Technologies des médicaments et des in Health technologies de la santé Rapid Response Report: Peer-Reviewed Summary with Critical Appraisal CADTH Intracameral Antibiotics for the Prevention of Endophthalmitis Post-Cataract Surgery: Review of Clinical and Cost-Effectiveness and Guidelines October 2010 Supporting Informed Decisions Until April 2006, the Canadian Agency for Drugs and Technologies in Health (CADTH) was known as the Canadian Coordinating Office for Health Technology Assessment (CCOHTA). Publications can be requested from: CADTH 600-865 Carling Avenue Ottawa ON Canada K1S 5S8 Tel.: 613-226-2553 Fax: 613-226-5392 Email: [email protected] or downloaded from CADTH’s website: http://www.cadth.ca Cite as: Ndegwa S, Cimon K, Severn M. Intracameral Antibiotics for the Prevention of Endophthalmitis Post-Cataract Surgery: Review of Clinical and Cost-Effectiveness and Guideline [Internet]. Ottawa: Canadian Agency for Drugs and Technologies in Health; 2010 (Rapid Response Report: Peer-Reviewed Summary with Critical Appraisal). [cited 2010-10-07]. Available from: http://www.cadth.ca/index.php/en/hta/reports-publications/search/publication/2683 Production of this report is made possible by financial contributions from Health Canada and the governments of Alberta, British Columbia, Manitoba, New Brunswick, Newfoundland and Labrador, Northwest Territories, Nova Scotia, Nunavut, Prince Edward Island, Saskatchewan, and Yukon. The Canadian Agency for Drugs and Technologies in Health takes sole responsibility for the final form and content of this report. The views expressed herein do not necessarily represent the views of Health Canada, or any provincial or territorial government. Reproduction of this document for non-commercial purposes is permitted provided appropriate credit is given to CADTH. -
How to Address Dry Eye in the Challenging Cornea Understand Dry Eye’S Various Factors and Causes to Get Ahead of the Treatment Curve
MARCH 2021 | 16 Ocular Surface Disease How to address dry eye in the challenging cornea Understand dry eye’s various factors and causes to get ahead of the treatment curve By Seema Nanda, OD Levels of severity y eyes are getting watery after log- For everyone who has been stuck at home binge ging off my tenth Zoom meeting watching Netflix, you know exactly what it feels this week, which makes me think like to have dry eyes. For the sake of simplic- of the others Zooming away and ity, dry eye symptoms can be reduced to the Mexperiencing dry eye symptoms. As an optom- levels of mild, moderate, or severe. etrist who sees corneal calamities on a contin- For mild cases, preservative-free artificial ual basis, it can become a challenge to treat. tears, such as Refresh Relieva (Allergan) and At first, clinicians may Retaine MGD (OCuSOFT), are excellent options. diagnose dry eye dis- Refresh Relieva contains an inactive ingredi- ease (DED) by observing ent, hyaluronic acid, that I have personally and simple superficial punc- anecdotally found to soothe the corneal sur- tate keratitis at the slit face. For moderate conditions, twice-daily use of lamp. However, compli- Retaine MGD drops combined with a clinically cations may ensue, such validated nutritional supplement can provide as recurrent epithelial ero- relief to the deficient lipid profile. For severe sions or persistent epithe- symptoms, additional therapies should be imple- SEEMA NANDA, lial defects, causing more mented to maintain the corneal integrity. OD, is in practice in Houston, Texas. problems. These chal- lenges could lead to neu- Use a supplement rotrophic ulcers and become even more difficult A supplement such as HydroEye (ScienceBased to handle.