Histone H3K4 Methylation Regulates Deactivation of the Spindle Assembly Checkpoint Through Direct Binding of Mad2
Downloaded from genesdev.cshlp.org on September 29, 2021 - Published by Cold Spring Harbor Laboratory Press Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2 Andria Schibler,1,2,3,4 Evangelia Koutelou,3,4 Junya Tomida,4,5 Marenda Wilson-Pham,6,9 Li Wang,2,3,4,7 Yue Lu,4 Alexa Parra Cabrera,4 Renee J. Chosed,6,10 Wenqian Li,2,3,4,7 Bing Li,8 Xiaobing Shi,1,2,3,4 Richard D. Wood,2,4,5,7 and Sharon Y.R. Dent2,3,4,7 1Program in Genes and Development, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA; 2The Graduate School of Biomedical Sciences (GSBS) at Houston, Houston, Texas 77030, USA; 3Center for Cancer Epigenetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA; 4Department of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA; 5Center for Environmental and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA; 6The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA; 7Program in Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Smithville, Texas 78957, USA; 8Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA Histone H3 methylation on Lys4 (H3K4me) is associated with active gene transcription in all eukaryotes. In Sac- charomyces cerevisiae, Set1 is the sole lysine methyltransferase required for mono-, di-, and trimethylation of this site.
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