RESEARCH ARTICLE Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Eurasier Dogs with Familial Non-Progressive Ataxia: A Retrospective and Prospective Clinical Cohort Study Filipa Bernardino1, Kai Rentmeister2, Martin J. Schmidt3, Andreas Bruehschwein4, Kaspar Matiasek5, Lara A. Matiasek1, Alexander Lauda1, Heinz A. Schoon6, Andrea Fischer1* 1 Centre for Clinical Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig Maximilian University, Munich, Germany, 2 Tierärztliche Praxis für Neurologie, Dettelbach, Germany, 3 Department of Veterinary Clinical Science, Small Animal Clinic, Justus-Liebig-University, Giessen, Germany, 4 Centre for Clinical Veterinary Medicine, Clinic of Small Animal Surgery and Reproduction, Ludwig Maximilian University, Munich, Germany, 5 Centre for Clinical Veterinary Medicine, Section of Clinical and Comparative Neuropathology, Ludwig Maximilian University, Munich, Germany, 6 Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany OPEN ACCESS *
[email protected] Citation: Bernardino F, Rentmeister K, Schmidt MJ, Bruehschwein A, Matiasek K, Matiasek LA, et al. (2015) Inferior Cerebellar Hypoplasia Resembling a Dandy-Walker-Like Malformation in Purebred Abstract Eurasier Dogs with Familial Non-Progressive Ataxia: Cerebellar malformations can be inherited or caused by insults during cerebellar develop- A Retrospective and Prospective Clinical Cohort Study. PLoS ONE 10(2): e0117670. doi:10.1371/ ment. To date, only sporadic cases of cerebellar malformations have been reported in dogs, journal.pone.0117670 and the genetic background has remained obscure. Therefore, this study`s objective was to Academic Editor: Fernando de Castro, Hospital describe the clinical characteristics, imaging features and pedigree data of a familial cere- Nacional de Parapléjicos—SESCAM, SPAIN bellar hypoplasia in purebred Eurasier dogs.