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Expanding Frontiers, Transforming Cancer Treatment

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Expanding Frontiers, Transforming Cancer Treatment Expanding frontiers, transforming cancer treatment Your day-by-day guide to ASCO 1 – 5 June 2012 McCormick Place Convention Center Chicago, Illinois, USA Congress site plan Key presentations Product key A Avastin E Erivedge H Herceptin MT MabThera MM Onartuzumab (MetMAb) P Pertuzumab T Tarceva T Trastuzumab emtansine (T–DM1) X Xeloda Z Zelboraf Friday June 1 POSTER DISCUSSION SESSION Gynecologic Cancer Session time: 13.00 - 17.00 Venue: E450a Presentation time: 16.30 - 17.30 Venue: E354a A Safety of front-line bevacizumab (BEV) combined with weekly paclitaxel (wPAC) and q3w carboplatin (C) for ovarian cancer (OC): results from OCTAVIA. (A. Gonzalez-Martin; Poster Board 6, Abstract # 5017) Saturday June 2 ORAL ABSTRACT SESSIONS Gynecologic Cancer Session time: 15.00 – 18.00 Venue: E354b Presentation time: 15.00 – 15.15 T Randomised phase III study of erlotinib versus observation in patients with no evidence of disease progression after first line platin-based chemotherapy for ovarian carcinoma. A Gynecological Cancer Intergroup and EORTC-GCG study. (I. Vergote; Abstract # LBA5000) Session time: 15.00 - 18.00 Venue: E354b Presentation time: 15.30 – 15.45 A AURELIA, a randomized phase III trial evaluating bevacizumab (BEV) combined with chemotherapy (CT) for platinum-resistant recurrent ovarian cancer (OC). (E. Pujade-Lauraine; Abstract # LBA5002) A Avastin H Herceptin P Pertuzumab E Erivedge MTP MabThera T Tarceva POSTER DISCUSSION SESSION Head and Neck Cancer Session time: 08.00 - 12.00 Venue: S102 Presentation time: 12.00 - 13.00 Venue S100a T Expression of p16, ERCC1 and EGFR amplification as predictors of responsiveness of locally advanced squamous cell carcinomas of head and neck (SCCHN) to cisplatin, radiotherapy and erlotinib - a phase II randomized trial. (M.C. Austin; Poster Board 5, Abstract # 5515) Breast Cancer – HER2/ER Session time: 13.15 - 17.15 Venue: E450a Presentation time: 16.45 - 17.45 Venue: E Hall D2 Results from a phase 1b study of trastuzumab emtansine P (T-DM1), paclitaxel (T), and pertuzumab (P) in patients with T HER2-positive metastatic breast cancer (MBC) previously treated with trastuzumab. (S. Modi; Poster Board 18, Abstract # 528) Session time: 13.15 - 17.15 Venue: E450a Presentation time: 16.45 - 17.45 Venue: E Hall D2 Cardiac safety in a phase II study of trastuzumab emtansine T (T-DM1) following anthracycline-based chemotherapy as adjuvant or neoadjuvant therapy for early-stage HER2-positive breast cancer. (C.T. Dang; Poster Board 22, Abstract # 532) MM Onartuzumab (MetMAb) X Xeloda T Trastuzumab emtansine (T–DM1) Z Zelboraf Saturday June 2 Breast Cancer – HER2/ER Session time: 13.15 - 17.15 Venue: E450a Presentation time: 16.45 - 17.45 Venue: E Hall D2 H Cardiac tolerability of pertuzumab plus trastuzumab plus docetaxel in patients with HER2-positive metastatic breast P cancer in the CLEOPATRA study. (M.S. Ewer; Poster Board 23, Abstract # 533) GENERAL POSTER SESSION Lung Cancer – Non-small Cell Metastatic Session time: 13.15 – 17.15 Venue: S Hall A2 T Skin toxicity associated with outcome to erlotinib in non-small- cell lung cancer (NSCLC) patients (p) with EGFR mutations in the EURTAC study. (C. Buges; Poster Board 44H, Abstract # 7542) Session time: 13.15 – 17.15 Venue: S Hall A2 T Differential progression-free survival (PFS) to erlotinib according to EGFR exon 19 deletion type in non-small-cell lung cancer (NSCLC) patients (p) in the EURTAC study. (C.E. Carcereny; Poster Board 44F, Abstract # 7540) A Avastin H Herceptin P Pertuzumab E Erivedge MTP MabThera T Tarceva Lung Cancer – Non-small Cell Metastatic Session time: 13.15 – 17.15 Venue: S Hall A2 T Cutaneous toxicity secondary to erlotinib therapy in patients with non-small cell lung cancer in the NCIC CTG BR.21 study: time course and correlation. (R. Perez-Soler; Poster Board 48G, Abstract # 7573) Session time: 13.15 – 17.15 Venue: S Hall A2 A AvaALL: open-label randomized phase IIIb trial evaluating the efficacy and safety of standard of care with or without continuous bevacizumab (BV) treatment beyond disease progression in patients (pts) with advanced nonsquamous non-small cell lung cancer (NSCLC) after first-line (1L) treatment with BV plus platinum-doublet chemotherapy (CT). (C. Gridelli; Poster Board 53F, Abstract # TPS7612) Session time: 13.15 – 17.15 Venue: S Hall A2 T ASPIRATION: Phase II study of continued erlotinib beyond RECIST progression in Asian patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). (K. Park; Poster Board 53H, Abstract # TPS7614) MM Onartuzumab (MetMAb) X Xeloda T Trastuzumab emtansine (T–DM1) Z Zelboraf Saturday June 2 Lung Cancer – Non-small Cell Metastatic Session time: 13.15 – 17.15 Venue: S Hall A2 MM The MetLUNG study: a randomized, double-blind, phase III study of onartuzumab (MetMAb) + erlotinib versus placebo + erlotinib T in patients with advanced, Met-positive non-small cell lung cancer (NSCLC). (D.R. Spigel; Poster Board 54B, Abstract # TPS7616) A Avastin H Herceptin P Pertuzumab E Erivedge MTP MabThera T Tarceva Breast Cancer – HER2/ER Session time: 08.00 – 12.00 Venue: S Hall A2 H Adverse events with pertuzumab and trastuzumab: Evolution during treatment with and without docetaxel in CLEOPATRA. P (J. Baselga; Poster Board 8H, Abstract # 597) Session time: 08.00 – 12.00 Venue: S Hall A2 H A randomized phase III double-blinded placebo-controlled trial of first-line chemotherapy and trastuzumab with or without bevacizumab for patients with HER2/neu over-expressing metastatic breast cancer (HER2+ MBC): a trial of the Eastern Cooperative Oncology Group (E1105). (C.L. Arteaga; Poster Board 9H, Abstract # 605) Session time: 13.15 – 17.15 Venue: E450a H Quality of Life Assessment in CLEOPATRA, a Phase III Study Combining Pertuzumab with Trastuzumab and Docetaxel P in Metastatic Breast Cancer. (J. Cortes; Poster Board 9A, Abstract # 598) Breast Cancer – Triple-Negative/Cytotoxics/Local Therapy Session time: 08.00 – 12.00 Venue: S Hall A2 Analysis according to prognostic factors in patients (pts) treated A with first-line bevacizumab (BEV) combined with paclitaxel (PAC) for HER2-negative metastatic breast cancer (mBC) in a routine oncology practice study. (I. Schrader; Poster Board 24D, Abstract # 1077) MM Onartuzumab (MetMAb) X Xeloda T Trastuzumab emtansine (T–DM1) Z Zelboraf Sunday June 3 PLENARY SESSION Plenary Session Including Science of Oncology Award and Lecture Session time: 13.00 – 16.00 Venue: N Hall B1 Presentation time: 13.45 – 14.00 T Primary results from EMILIA, a phase III study of trastuzumab emtansine (T-DM1) vs capecitabine (X) and lapatinib (L) in X HER2-positive locally advanced or metastatic breast cancer (MBC) previously treated with trastuzumab (T) and a taxane. (K. Blackwell; Abstract # LBA1) Session time: 13.00 – 16.00 Venue: N Hall B1 Presentation time: 14.45 – 15.00 Bendamustine plus rituximab (B-R) versus CHOP plus MT rituximab (CHOP-R) as first-line treatment in patients with indolent and mantle cell lymphomas (MCL): Updated results from the StiL NHL1 study. (M. Rummel; Abstract # 3) A Avastin H Herceptin P Pertuzumab E Erivedge MTP MabThera T Tarceva ORAL ABSTRACT SESSION Gastrointestinal (colorectal cancer) Session time: 09.45 – 12.45 Venue: E Hall D1 Presentation time: 09.45 – 10.00 T Bevacizumab (Bev) with or without erlotinib as maintenance therapy, following induction first-line chemotherapy plus Bev, in A patients (pts) with metastatic colorectal cancer (mCRC): Efficacy and safety results of the International GERCOR DREAM phase X III trial. (C. Tournigand; Abstract # LBA3500) Session time: 09.45 – 12.45 Venue: E Hall D1 Presentation time: 10.45 – 11.00 Bevacizumab (BEV) plus chemotherapy (CT) continued A beyond first progression in patients with metastatic colorectal cancer (mCRC) previously treated with BEV + CT: results of a randomised phase III intergroup study (TML study). (D.E. Arnold, Abstract # CRA3503) MM Onartuzumab (MetMAb) X Xeloda T Trastuzumab emtansine (T–DM1) Z Zelboraf Sunday June 3 POSTER DISCUSSION SESSION Lung Cancer - Non-small Cell Local-regional/Small Cell/Other Thoracic Cancers Session time: 08.00 - 12.00 Venue: E450a Presentation time: 11.30 - 12.30 Venue: E Hall D2 A SWOG S0533: A pilot trial of cisplatin (C)/etoposide (E)/ radiotherapy (RT) followed by consolidation docetaxel (D) and bevacizumab (B) (NSC-704865) in three cohorts of patients (pts) with inoperable locally advanced stage III non-small cell lung cancer (NSCLC). (A.J. Wozniak; Poster Board 10, Abstract # 7018) Session time: 08.00 - 12.00 Venue: E450a Presentation time: 11.30 - 12.30 Venue: E Hall D2 T The SELECT study: a multicenter phase II trial of adjuvant erlotinib in resected EGFR mutation-positive NSCLC. (J.W. Neal JW; Poster Board 2, Abstract # 7010) Cancer Prevention/Epidemiology Session time: 08.00 - 12.00 Venue: S102 H Presentation time: 11.30 - 12.30 Venue: S100a Racial disparities in treatment patterns and clinical outcomes P in patients with HER2-positive metastatic breast cancer. (A.M. T Brufsky; Poster Board 15, Abstract # 1526) A Avastin H Herceptin P Pertuzumab E Erivedge MTP MabThera T Tarceva GENERAL POSTER SESSION Melanoma/Skin Cancers Session time: 08.00 – 12.00 Venue: S Hall A2 E Efficacy and safety of the hedgehog pathway inhibitor vismodegib in patients with advanced basal cell carcinoma (BCC): Erivance BCC study update. (A. Sekulic; Poster Board 36E, Abstract # 8579) Session time: 08.00 – 12.00 Venue: S Hall A2 Metastatic basal cell carcinoma: Differences in survival by site of E spread. (McCusker M; Poster Board 37C, Abstract # 8585) Gynecologic Cancer Session time: 08.00 – 12.00 Venue: S Hall A2 A An updated safety analysis of OCEANS, a randomized, double- blind, phase III trial of gemcitabine (G) and carboplatin (C) with bevacizumab (BV) or placebo (PL) followed by BV or PL to disease progression (PD) in patients with platinum-sensitive (Plat-S) recurrent ovarian cancer.
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