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Supplementary Document Supplementary Document: Drug-Gene Modeling in Pediatric T-Cell Acute Lymphoblastic Leukemia Highlights Importance of 6-Mercaptopurine for Outcome. Alex H Beesley1, Martin J Firth2, Denise Anderson2, Amy L Samuels1, Jette Ford1 and Ursula R Kees1. Division of Children’s Leukaemia and Cancer Research1 and Division of Bioinformatics and Biostatistics2, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia. 1 Supplementary Tables Table S1 – Top 50 Correlating Probes For Each Drug Used in the 10 Drug Model. Drug Probe Set Gene Symbol Description Correlation Cytoband 6MP 201384_s_at LOC100133166 /// similar to neighbor of BRCA1 gene 1 /// neighbor of 0.868 17q21.31 NBR1 BRCA1 gene 1 6MP 201383_s_at LOC100133166 /// similar to neighbor of BRCA1 gene 1 /// neighbor of 0.848 17q21.31 NBR1 BRCA1 gene 1 6MP 213180_s_at GOSR2 golgi SNAP receptor complex member 2 0.837 17q21 6MP 205355_at ACADSB acyl-Coenzyme A dehydrogenase, short/branched chain 0.835 10q26.13 6MP 203644_s_at MON1B MON1 homolog B (yeast) 0.828 16q23.1 6MP 218352_at RCBTB1 regulator of chromosome condensation (RCC1) and BTB 0.811 13q14 (POZ) domain containing protein 1 6MP 214140_at SLC25A16 solute carrier family 25 (mitochondrial carrier; Graves 0.799 10q21.3 disease autoantigen), member 16 6MP 219734_at SIDT1 SID1 transmembrane family, member 1 0.795 3q13.2 6MP 204067_at SUOX sulfite oxidase 0.793 12q13.2 6MP 207223_s_at ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.778 9q32 6MP 202131_s_at RIOK3 RIO kinase 3 (yeast) 0.774 18q11.2 6MP 203353_s_at MBD1 methyl-CpG binding domain protein 1 0.773 18q21 6MP 204568_at KIAA0831 KIAA0831 0.772 14q22.3 6MP 202129_s_at RIOK3 RIO kinase 3 (yeast) 0.763 18q11.2 6MP 213572_s_at SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.747 6p25 6MP 209155_s_at NT5C2 5'-nucleotidase, cytosolic II 0.737 10q24.32-q24.33 6MP 202663_at WIPF1 WAS/WASL interacting protein family, member 1 0.735 2q31.1 6MP 202804_at ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), 0.731 16p13.1 member 1 6MP 216812_at --- --- -0.732 --- 6MP 217768_at C14orf166 chromosome 14 open reading frame 166 -0.733 14q22.1 6MP 219800_s_at THNSL1 threonine synthase-like 1 (S. cerevisiae) -0.737 10p12.1 2 6MP 217366_at CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.739 5q31 6MP 220062_s_at MAGEC2 melanoma antigen family C, 2 -0.740 Xq27 6MP 215298_at --- --- -0.742 --- 6MP 207320_x_at STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) -0.743 20q13.1 6MP 222052_at C19orf54 chromosome 19 open reading frame 54 -0.743 19q13.2 6MP 219909_at MMP28 matrix metallopeptidase 28 -0.744 17q11-q21.1 6MP 201764_at TMEM106C transmembrane protein 106C -0.745 12q13.1 6MP 214104_at GPR161 G protein-coupled receptor 161 -0.750 1q24.2 6MP 215471_s_at MAP7 microtubule-associated protein 7 -0.751 6q23.3 6MP 210212_x_at LOC100133946 /// similar to mature T-cell proliferations 1 /// mature T-cell -0.753 Xq28 MTCP1 proliferation 1 6MP 219569_s_at TMEM22 transmembrane protein 22 -0.753 3q22.3 6MP 216428_x_at KIR3DX1 killer cell immunoglobulin-like receptor, three domains, -0.758 19q13.42 X1 6MP 220437_at LOC55908 hepatocellular carcinoma-associated gene TD26 -0.759 19p13.2 6MP 209747_at TGFB3 transforming growth factor, beta 3 -0.760 14q24 6MP 220003_at LRRC36 leucine rich repeat containing 36 -0.760 16q22.1 6MP 221157_s_at FBXO24 F-box protein 24 -0.760 7q22 6MP 218075_at AAAS achalasia, adrenocortical insufficiency, alacrimia -0.761 12q13 (Allgrove, triple-A) 6MP 207617_at DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked -0.763 Xp11.3-p11.23 6MP 211441_x_at CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -0.763 7q21.1 6MP 211431_s_at TYRO3 TYRO3 protein tyrosine kinase -0.766 15q15.1-q21.1 6MP 213651_at INPP5J inositol polyphosphate-5-phosphatase J -0.771 22q11.2-q13.2 6MP 217385_at --- --- -0.771 --- 6MP 202276_at SHFM1 split hand/foot malformation (ectrodactyly) type 1 -0.774 7q21.3-q22.1 6MP 220993_s_at GPR63 G protein-coupled receptor 63 -0.776 6q16.1-q16.3 6MP 213037_x_at STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) -0.784 20q13.1 6MP 215506_s_at DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.798 1p31 6MP 208098_at OR12D3 /// OR5V1 olfactory receptor, family 12, subfamily D, member 3 /// -0.807 6p22.1 olfactory receptor, family 5, subfamily V, member 1 6MP 216659_at LOC1720 dihydrofolate reductase pseudogene -0.807 2p12 6MP 216619_at GTPBP10 GTP-binding protein 10 (putative) (GTPBP10), transcript -0.856 7q21.13 3 variant 2, mRNA 6TG 204067_at SUOX sulfite oxidase 0.915 12q13.2 6TG 215399_s_at OS9 amplified in osteosarcoma 0.888 12q13 6TG 1729_at TRADD TNFRSF1A-associated via death domain 0.879 16q22 6TG 200743_s_at TPP1 tripeptidyl peptidase I 0.862 11p15 6TG 205639_at AOAH acyloxyacyl hydrolase (neutrophil) 0.840 7p14-p12 6TG 210140_at CST7 cystatin F (leukocystatin) 0.838 20p11.21 6TG 213501_at ACOX1 acyl-Coenzyme A oxidase 1, palmitoyl 0.834 17q24-q25|17q25.1 6TG 204085_s_at CLN5 ceroid-lipofuscinosis, neuronal 5 0.831 13q21.1-q32 6TG 216749_at --- --- 0.827 --- 6TG 208499_s_at DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.826 13q32 6TG 218130_at C17orf62 chromosome 17 open reading frame 62 0.825 17q25.3 6TG 200742_s_at TPP1 tripeptidyl peptidase I 0.824 11p15 6TG 205419_at GPR183 G protein-coupled receptor 183 0.822 13q32.3 6TG 213485_s_at ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), 0.821 6p21.1 member 10 6TG 213733_at MYO1F myosin IF 0.821 19p13.3-p13.2 6TG 206342_x_at IDS iduronate 2-sulfatase 0.820 Xq28 6TG 210946_at PPAP2A phosphatidic acid phosphatase type 2A 0.820 5q11 6TG 214196_s_at TPP1 tripeptidyl peptidase I 0.815 11p15 6TG 212144_at UNC84B unc-84 homolog B (C. elegans) 0.814 22q13.1 6TG 204655_at CCL5 chemokine (C-C motif) ligand 5 0.813 17q11.2-q12 6TG 203988_s_at FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.812 14q24.3 6TG 212777_at SOS1 son of sevenless homolog 1 (Drosophila) 0.811 2p22-p21 6TG 221491_x_at HLA-DRB1 /// HLA- major histocompatibility complex, class II, DR beta 1 /// 0.811 14q24-q31 /// DRB2 /// HLA-DRB3 major histocompatibility complex, class II, DR beta 2 19q13.43 /// 6p21.3 /// HLA-DRB4 /// (pseudogene) /// major histocompatibility complex, class HLA-DRB5 II, DR beta 3 /// major histocompatibility complex, class II, DR beta 4 /// major histocompatibility complex, class II, DR beta 5 6TG 212961_x_at CXorf40A /// chromosome X open reading frame 40A /// chromosome X 0.809 Xq28 CXorf40B open reading frame 40B 6TG 222239_s_at INTS6 integrator complex subunit 6 0.808 13q14.12-q14.2 4 6TG 212184_s_at MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 0.805 6q25.1-q25.3 interacting protein 2 6TG 209147_s_at PPAP2A phosphatidic acid phosphatase type 2A 0.804 5q11 6TG 201444_s_at ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.803 Xp11.4 6TG 214696_at C17orf91 chromosome 17 open reading frame 91 0.803 17p13.3 6TG 218571_s_at CHMP4A chromatin modifying protein 4A 0.803 14q12 6TG 210743_s_at CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae) 0.801 1p21 6TG 218193_s_at GOLT1B golgi transport 1 homolog B (S. cerevisiae) 0.801 12p12.1 6TG 205926_at IL27RA interleukin 27 receptor, alpha 0.800 19p13.11 6TG 200620_at TMEM59 transmembrane protein 59 0.799 1p36-p31 6TG 200796_s_at MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.799 1q21 6TG 215723_s_at PLD1 phospholipase D1, phosphatidylcholine-specific 0.799 3q26 6TG 201920_at SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.797 2q11-q14 6TG 206195_x_at GH2 growth hormone 2 -0.798 17q24.2 6TG 217904_s_at BACE1 beta-site APP-cleaving enzyme 1 -0.798 11q23.2-q23.3 6TG 206573_at KCNQ3 potassium voltage-gated channel, KQT-like subfamily, -0.799 8q24 member 3 6TG 220698_at MGC4294 hypothetical protein MGC4294 -0.800 20q13.32 6TG 215755_at --- --- -0.802 --- 6TG 216699_s_at KLK1 kallikrein 1 -0.805 19q13.3 6TG 204756_at MAP2K5 mitogen-activated protein kinase kinase 5 -0.806 15q23 6TG 219264_s_at LOC100134089 /// similar to protein phosphatase 2 (formerly 2A), regulatory -0.809 Xp22.33; Yp11.3 PPP2R3B subunit B, beta /// protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta 6TG 218080_x_at FAF1 Fas (TNFRSF6) associated factor 1 -0.816 1p33 6TG 209014_at MAGED1 melanoma antigen family D, 1 -0.817 Xp11.23 6TG 217589_at RAB40A RAB40A, member RAS oncogene family -0.818 Xq22.1 6TG 203446_s_at OCRL oculocerebrorenal syndrome of Lowe -0.821 Xq25-q26.1 6TG 204763_s_at GNAO1 guanine nucleotide binding protein (G protein), alpha -0.902 16q13 activating activity polypeptide O ARAC 202767_at ACP2 acid phosphatase 2, lysosomal 0.881 11p11.2- p11.11|11p12-p11 ARAC 208315_x_at TRAF3 TNF receptor-associated factor 3 0.845 14q32.32 5 ARAC 202495_at TBCC tubulin folding cofactor C 0.843 6pter-p12.1 ARAC 209215_at MFSD10 major facilitator superfamily domain containing 10 0.822 4p16.3 ARAC 212342_at YIPF6 Yip1 domain family, member 6 0.807 Xq12 ARAC 215185_at --- --- 0.800 --- ARAC 43544_at MED16 mediator complex subunit 16 0.784 19p13.3 ARAC 217790_s_at SSR3 signal sequence receptor, gamma (translocon-associated 0.783 3q25.31 protein gamma) ARAC 221545_x_at MED16 mediator complex subunit 16 0.776 19p13.3 ARAC 204149_s_at GSTM4 glutathione S-transferase mu 4 0.775 1p13.3 ARAC 207460_at GZMM granzyme M (lymphocyte met-ase 1) 0.773 19p13.3 ARAC 205078_at PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.771 2p21-p16 ARAC 207375_s_at IL15RA interleukin 15 receptor, alpha 0.771 10p15-p14 ARAC 33760_at PEX14 peroxisomal biogenesis factor 14 0.771 1p36.22 ARAC 201250_s_at SLC2A1 solute carrier family 2 (facilitated glucose transporter), 0.770 1p35-p31.3 member 1 ARAC 220134_x_at FAM176B family with sequence similarity 176, member B 0.766 1p34.3 ARAC 218282_at EDEM2 ER degradation enhancer, mannosidase alpha-like 2 0.763 20q11.22 ARAC 221218_s_at TPK1 thiamin pyrophosphokinase 1 0.762 7q34-q35 ARAC 210112_at HPS1 Hermansky-Pudlak syndrome 1 0.761 10q23.1-q23.3 ARAC 217881_s_at CDC27 cell division cycle 27 homolog (S.
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