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Join the Team Fighting Cancer One Home Run at a Time! the Quest to Cure Cancer

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Join the Team Fighting Cancer One Home Run at a Time! the Quest to Cure Cancer JUNE 11-21, 2009 VOLUME NO. 14 “ F RO M COA S T TO COA S T ” 14TH SEASON 1996-2009 Join the team FIGHTING CANCER one home run at a time! THE QUEST TO CURE CANCER Hall of Fame pitcher Nolan Ryan famously said, “A beautiful thing about baseball is that every once in a while, you come into a situation where you want to, and where you have to, reach down and prove something.” That’s the situation cancer researchers face every day—they want to prove that cancer can be beaten. Thanks in part to your support, they’re making great progress in doing just that. Since 1993, the Prostate Cancer Foundation has accelerated development of more effective treatments, expanded our understanding of how cells become cancerous, produced new insights into areas like nutrition, and raised awareness of preventive activities. Most importantly, fewer men are PCF dying—as much as 50% below projections made in the 1990s. Mike Milken - Founder & Chairman By raising nearly $400 million directly, and guiding another $10 billion in funding from others—industry, government, philanthropists, people like you—the PCF has “Kept Dad in the Game.” More than 80 percent of prostate-cancer research leaders have been supported by the PCF, and a majority of drugs currently in the pipeline have our imprint on them. But as more men live longer, more will be diagnosed—this year alone, 192,000 more. So we must continue to support these remarkable researchers. This is the PCF Home Run Challenge’s 14th season—a partnership with Major League Baseball (MLB), its players, managers Jonathan Simons - President and CEOPCF and teams, as well as prominent sponsors, who raise awareness about prostate cancer worldwide and generate millions of dollars for crucial research. MLB players have averaged 135 home runs during the 60 Home Run Challenge games each year—they hit 143 last year. Please use the enclosed form or visit www.pcf.org to make a generous pledge that can help put an end to prostate cancer. Thank you! Mike Milken Jonathan Simons, MD Chairman President and CEO Home Run Challenge Sponsors HOW TO PARTICIPATE • Fans attending games around the country contribute hundreds of thousands of dollars to fight prostate cancer. • Dedicated people like you make a donation for every home run hit in 60 Home Run Challenge games this year. • Safeway Corporation has raised more than $36 million for prostate cancer research through its annual June fundraising campaigns over the past eight years. Customers of Safeway stores (including Vons, Randalls, Tom Thumb, Pavilions, Genuardi’s, Carrs and Dominick’s) donate to the PCF at checkout counters, and with blue ribbon tear-off sheets and other in-store promotions. Safeway employees also contribute to the prostate cancer campaign. See page 2. Make a pledge at www.pcf.org One-A-Day and Major League Baseball will donate $10 to the Prostate Cancer Foundation for every strikeout in MLB games over the next three years. Visit www.pcf.org. 1 SAFEWAY AND EmPLOYEES A $36 Million Team. Each year Safeway and its affiliated stores host an in-store campaign for customers, vendors and employees to donate money for prostate cancer research. Since 2001, the company has raised more than $36 million. Surprise Visits to Safeway Tommy Lasorda makes surprise visits to Safeway stores during the Home Run Challenge to promote Safeway’s annual effort to raise funds for prostate cancer research. Mayoral Kickoff San Francisco Mayor Gavin Newsom helps launch Safeway’s annual prostate cancer fundraising drive in 2008. Ready for the Big Leagues? Larree Renda, Safeway executive vice president, shows off her fastball by throwing out the first pitch at a San Francisco Giants game. Keep on Truckin’ Safeway promotes its prostate cancer fundraising Steve Burd, Safeway chairman, efforts in California by outfitting its delivery trucks with president and CEO, always brings 2 special graphics. a glove to HRC ball games. HRC Baseball a family affair Baseball games have always been a time for dads, their families and friends to spend time together, and Home Run Challenge games carry on that tradition. Watching BP Kids and their parents often get a “behind the scenes” opportunity to watch teams take batting practice. 2008 PCF HOME RRUN CCHALLENGE Three HRC Baseball: A Family Affair Generations Jeffries CEO Richard Baseball games have always been a time for dads, their families and friends to spend Handler and his family time together, and Home Run Challenge games carry on that tradition. enjoy the view from the Check out the next three pages of family fun. Steinbrenner suite. Budding Stars Brothers Tommy (left) and Tony Renda join USC football coach Pete Carroll at a San Francisco Giants game. The Renda brothers both play collegiate baseball. Gin Rummy on the Plane Gin Rummy on the Plane Three Generations at Chavez Ravine andThere’s Yankee always Stadium time for a family There’s always time for Daddy’sa family card Littlegame on Girls the plane Above, Lance Milken, his daughter, Maddie,card andgame grandpa on the planeMike relaxduring in the during the HRC Road Trip.HRC supporter Nelson Peltz gives dugout at Dodger Stadium before a game.the Be low,HRC three Road generations Trip. of Jeffries’ a squeeze to his daughters before CEO Richard Handler’s family enjoy the view from the Steinbrenner suite. an HRC game. 3 Watching BP Kids and their parents often get a “behind the scenes” opportunity to watch teams take batting practice. Brothers Tommy (left) and Tony Renda join USC football Daddy’s coach Pete Little Girls Carroll at a San HRC supporter Francisco Giants Nelson Peltz game. The Renda gives a squeeze brothers both play to his daughters collegiate before an HRC baseball. game. 5 PCF: LEVERAGING MILLIONS INTO BILLIONS How does the PCF grow million-dollar investments into billion-dollar medical advances? Financial Capital The $400 million raised directly by the PCF has attracted the infusion of more than $10 billion of additional funding for prostate cancer research—from government agencies, venture capital investments, the pharmaceutical and biotechnology sections, academic sectors and other philanthropists. Human Capital From what Forbes called “a research backwater” in 1993, the prostate cancer field—because of interest and funding generated by the PCF—has attracted more than 1,000 medical scientists into prostate cancer research. The PCF now plays a part in 90 percent of the field’s published research, a human-capital contribution exceeding $100 billion. Social Capital Fragmented and underfunded in 1993, the community of medical institutions actively pursuing a prostate cancer cure, and applying their findings to other deadly diseases, has grown to include virtually every major cancer research center in North America, and dozens more worldwide. In 1993, it was rare for men to get Incalculable life-saving screening tests; today, because of PCF awareness Social Capital programs, more than 60 percent do. $100 billion Human Capital $ $ 10 billion 400 million Financial Capital Prostate Cancer Foundation 4 6 Researchers Changing the WORLD Breakthroughs Funded by PCF Donors Steven Balk, MD, PhD David Heber, MD, PhD DANA FarbER / Harvard UCLA CENTER for HumaN CANCER CENTER NutritioN Studying the mechanisms of resistance Discovered that macrophage (specialized to new medications that are used to white blood cells that scavenge invading block the production of testosterone microbes and tissue debris) activation, a (cancer fuel) directly in the tumor sites. condition that promotes prostate cancer Studies may lead to prolonged drug progression, is associated with obesity. usefulness and the definition of the Clinical investigations are underway to next-generation treatments. determine if dietary changes can reverse macrophage activation, establishing a marker for successful dietary intervention. Todd Golub, MD Howard Scher, MD THE Broad INstituTE of MIT MEMorial SloaN-KEttEriNG AND Harvard UNivErsitY CANCER CENTER Using some of the world’s most Developing two promising drug advanced screening biotechnologies to candidates for treatment of discover molecules that block the effects advanced prostate cancer. These of genetic alterations in prostate cancer. oral medicines have few side effects These molecules could be featured in and represent a new generation of the next generation of treatments for treatments for patients who fail to prostate cancer. respond to current therapies. Daniel Haber, MD, PhD Muneesh Tewari, MD, PhD Harvard MEdical School, FRED HutchiNsoN CANCER MassachusEtts GENEral RESEarch CENTER AND thE Hospital CANCER CENTER UNivErsitY of WashiNgtoN Leading a research team that is refining Discovered small regulatory RNA a system to measure and identify molecules that circulate in the blood circulating tumor cells in patient blood. of prostate cancer patients. Testing is This system may provide an early signal underway to validate a cancer-specific of prostate cancer progression, allowing diagnostic test for prostate cancer doctors to better identify cancers and that enables doctors to profile tumors provide more informed treatments. and customize therapy. 5 Hall of Fame Some of Major League Baseball’s greatest players participate in the Home Run Challenge, often joining the Road Trip team. The Incomparable Vin Scully Hall of Fame players, managers Hall of Fame broadcaster Vin Scully spends time with the HRC Road Trip team. and broadcasters who’ve participated in HRC events: Ernie Banks Marty Brennaman Dennis Eckersley Rich “Goose” Gossage Reggie Jackson Sandy Koufax Mr. October and Tommy Lasorda Mr. Garvey Hall of Fame slugger Willie McCovey Reggie Jackson (left) and Dodgers perennial All-Star Joe Morgan Steve Garvey at a pregame ceremony. Jim Palmer Little Joe Frank Robinson Mike and Hall of Fame second baseman Joe Morgan Vin Scully review the HRC schedule. 6 Brooklyn Dodger Legend Don Newcombe is the only pitcher to win the Rookie of the Year and Cy Young Award in the same year (1949).
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