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US 20120074014A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2012/0074014 A1 Tran et al. (43) Pub. Date: Mar. 29, 2012 (54) PRODUCT TYPICALLY BASED ON SALT OF Publication Classi?cation PEROXYMONOSULFURIC ACID AND (51) Int Cl SUITABLE FOR MEDICINAL USAGE, AND A 6} B 29/02 (200601) ASSOCIATED PRODUCT FABRICATION 3231) 19/00 (200601) A61K 33/42 (2006.01) (75) Inventors: David Van Tran, San Jose, CA A61K 9/14 (200601) (Us). David Nguyen Tran San C07C 409/44 (2006.01) Jose ’CA (Us) ’ A61K 31/327 (2006.01) ’ (52) US. Cl. ........... .. 206/438; 562/1; 514/578; 424/605; . 424/400; 29/428 (73) Ass1gnee: LuTran Industries, Inc. (57) ABSTRACT (21) App1.No.: 13/047,742 Products based on salt of peroxymonosulfuric acid are suit able for treating or/and preventing diseases and other debili tating medical conditions caused by bacterial, eukaryotic, (22) Filed: Mar. 14, 2011 prion, and viral pathogens and by non-pathogenic in?amma tion. The products may alternatively be based on inorganic Related US. Application Data halide and an oxidizing agent reactable in Water With the inorganic halide to generate hypohalite ions. In addition, the (60) Provisional application No. 61/386,928, ?led on Sep. products can be employed in other applications such as com 27, 2010. mercial and industrial applications. 36 26/ 56 Patent Application Publication Mar. 29, 2012 Sheet 1 0f 2 US 2012/0074014 A1 Fig. 2a Fig. 2b Patent Application Publication Mar. 29, 2012 Sheet 2 0f 2 US 2012/0074014 A1 70 76 72 74 US 2012/0074014 A1 Mar. 29, 2012 PRODUCT TYPICALLY BASED ON SALT OF the antibiotic. The adverse side effects of antibiotics are var PEROXYMONOSULFURIC ACID AND ied, and range from fever and nausea to major allergic reac SUITABLE FOR MEDICINAL USAGE, AND tions. ASSOCIATED PRODUCT FABRICATION [0007] Fungi are eukaryotic pathogens similar to bacteria. Spores are metabolic byproducts of the life cycle of some CROSS-REFERENCE TO RELATED bacteria and fungi. Bacteria produce endospores located APPLICATION Within the cytoplasm of the parental cells. Fungi produce a [0001] This claims priority to US. provisional patent appli variety of exospores. Spores are highly resistant to physical and chemical agents. cation 61/386,928, ?led 27 Sep. 2010, the contents of Which are incorporated by reference to the extent not repeated [0008] In medical parasitology, the term “parasite” means a herein. This is also related to US. patent application Ser. No. eukaryotic pathogenic organism. Hence, protoZoan and meta 12/726,326, ?led 17 Mar. 2009, the contents of Which are Zoan infectious agents are classi?ed as parasites Whereas likeWise incorporated by reference to the extent not repeated bacteria and viruses are not. Many parasites, such as proto herein. Zoa, ?eas, and Worms (helminths), carry disease or cause sores or lesions Which can become infected. FIELD OF USE [0009] Parasites live on or in the host from Which it gets some or all of its nourishment. Parasites are generally harmful [0002] This relates to products suitable for treating and to their hosts. The damage ranges Widely from minor incon preventing debilitating conditions, including debilitating venience to debilitating or fatal disease. An ectoparasite, such medical conditions of humans. This also relates to manufac as a louse, tick, or leech, lives or feeds on the outer surface of turing such products. the host’s body. Ectoparasites do not usually cause disease themselves. HoWever, they are frequently a vector of disease. BACKGROUND OF THE INVENTION For example, tick parasites transmit organisms that can cause [0003] In?ammation is caused by tissue injury consisting disease. An endoparasite lives inside the body of its host. of complex reactions involving vascular and connective tis Endoparasites include organisms such as tapeWorms, hook sues. Tissue damage may result from microbial invasion, Worms, and trypano somes that live Within the ho st’s organs or auto-immune processes, tissue infection, allograft rejection, tissues as Well as organisms such as sporoZoans that invade and such hurtful and/or destructive external in?uences as the host’s cells. heat, cold, radiant energy, electrical or chemical stimuli, and [0010] A prion is an infectious agent generally made solely mechanical trauma. Tissue damage may involve any part of of protein and lacking nucleic acid. Prions are believed to the human body such as the joints (arthritis), boWels (in?am infect and propagate by refolding abnormally into a structure matory boWel disease), and lungs (pulmonary in?ammation). Which converts normal molecules of the protein into an abnor Whatever the cause or bodily site, in?ammatory responses to mally structured form. Prions are generally quite resistant to tissue damage are quite similar, consisting of complicated denaturation by protease, heat, radiation, and formalin treat functional and cellular adjustments involving microcircula ments, although potency or infectivity may be reduced. tion, ?uid shifts, and in?ammatory cells (leukocytes). When [0011] A virus consists of a single nucleic acid, either deox tissue damage occurs, soluble chemical substances are elabo yribonucleic acid (“DNA”) or ribonucleic acid (“RNA”), and rated Which initiate the in?ammatory response. In?ammation a protein shell or coat surrounding the nucleic acid. A com can be mild and self-limited or prolonged and seriously plete viral particle is called a virion. A virus uses the machin debilitating and chronic. ery of a host cell to reproduce and resides Within the host cell. [0004] Numerous drugs have been developed to ?ght Consequently, viruses are di?icult to eliminate Without kill in?ammation in humans. The mo st prominent in current treat ing the host cells. It is believed that viral infections trigger ment are anti-in?ammatory steroidal drugs, corticosteroids in?ammatory responses Which do not respond to anti-viral and non-steroidal anti-in?ammatory drugs such as salicy drugs. Patients often ask for, and physicians often prescribe, lates. While these drugs are generally effective, they often antibiotics. While antibiotics destroy or prevent the groWth of have adverse side effects. bacteria, antibiotics are useless in treating viral (and fungal) [0005] A pathogen is an infectious biological agent, some infections. Their misuse in treating viral diseases is one of the times referred to as a germ, Which causes disease or illness to causes of antibiotic resistance to bacteria. its host. Many medical advances, such as vaccination, antibi [0012] Sporkenbach et al. (“Sporkenbach”), US. Pat. No. otics, and fungicides, have been used to safeguard against 4,404,191, discloses a viricide technique for inactivating infection by pathogens. Nevertheless, pathogens continue to viruses on animate and inanimate surfaces by contacting the threaten human life. Primary pathogens are bacteria, eukary surfaces With a salt of peroxymonosulfuric acid (H2SO5) otes, prions, and viruses. commonly knoWn as Caro’s acid. The peroxymonosulfuric [0006] Bacteria constitute one of the smallest organisms acid salt, applied from an aqueous solution, can be a salt of an containing all the material required for groWth and self-rep alkali metal such as potassium, sodium, or lithium, a salt of an lication. Bacterial infections can be treated With antibiotics, alkaline earth metal such as calcium or magnesium, or an classi?ed as bacteriocidal if they kill bacteria and as bacte ammonium salt. Sporkenbach preferably employs KHSO5 as riostatic if they prevent the bacteria from multiplying so the the peroxymonosulfuric acid salt. KHSO5 is provided from human immune system can overcome them. There are many the mixed triple salt having the chemical formula 2KHSO5. types of antibiotics. Each type of antibiotic inhibits a process KHSO4.K2SO4 Where KHSO4 is potassium hydrogen sulfate Whose pathogen is different from that found in the host. The and K2SO4 is potassium sulfate sometimes referred to as effectiveness of individual antibiotics varies With the location dipotassium sulfate. of the infection, the ability of the antibiotic to reach the site of [0013] KHSO5 and 2KHSO5.KHSO4.K2SO4 each have infection, and the ability of the bacteria to resist or inactivate multiple chemical names. Both KHSO5 and 2KHSO5. US 2012/0074014 A1 Mar. 29, 2012 KHSO4.K2SO4 are commonly referred to as “potassium phosphate, disodium phosphate, trisodium phosphate, tetra monopersulfate”. To avoid confusion, KHSO5 is referred to sodium pyrophosphate, monopotassium phosphate, dipotas herein as “potassium hydrogen peroxymonosulfate” or sim sium phosphate, tripotassium phosphate, and tetrapotassium ply “potassium peroxymonosulfate”. 2KHSO5.KHSO4. pyrophosphate. According to Auchincloss, one embodiment K2SO4 is referred to herein as “potassium monopersulfate of the biocide apparently consisted of 1.5 parts of sodium triple salt” or sometimes simply as “potassium monopersul chloride, 50 parts of potassium monopersulfate triple salt, 10 fate”. parts of sulfamic acid, 5 parts of malic or succinic acid, 18.5 [0014] Sporkenbach identi?es poliovirus, coxsackie virus, parts of sodium hexametaphosphate and (possibly) other simian vacuolating virus 40 and adenovirus as being inacti alkali metal phosphate, and 15 parts of sodium dodecylben vated by potassium hydrogen peroxymonosulfate. Poliovirus Zene sulfonate as the surfactant. causes poliomyelitis. There are tWo forms of coxsackie virus, [0019] Auchincloss reported generally good results in vari type A and type B. Coxsackie A virus causes hand, foot,
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    USOO5939039A United States Patent (19) 11 Patent Number: 5,939,039 Sapieszko et al. (45) Date of Patent: Aug. 17, 1999 54 METHODS FOR PRODUCTION OF Mirtchi et al. Calcium phosphate cements: Effect of fluorides CALCUM PHOSPHATE on the Setting and hardening of beta-tricalcium phosphate -dicalcium phosphate -calcite cements Biomat. 1991 75 Inventors: Ronald S. Sapieszko, Woodbury, 12:505. No Month. Minn.; Erik M. Erbe, Berwyn, Pa. J.L. Lacout Calcium phosphate as bioceramicS Biomateri als-Hard Tissue Repair and Replacement 81-95 1992 73 Assignee: Orthovita, Inc., Malvern, Pa. Elsevier Science Publishers. No Month H. Monma et al. Properties of hydroxyapatite prepared by 21 Appl. No.: 08/784,439 the hydrolysis of triacalcium phosphate J. Chem. Tech. Biotechnol. 1981 31:15. No Month. 22 Filed: Jan. 16, 1997 H. Chaair et al. Precipitation of stoichiometric apatitic (51) Int. Cl." ..................................................... C01B 15/16 tricalcium phosphate prepared by a continuous process J. Mater. Chem. 1995 5(6):895. No Month. 52 U.S. Cl. ............................................. 423/311; 423/305 R. Famery et al. Preparation of alpha-and beta-triacalcium 58 Field of Search ..................................... 423/305, 311, phosphate ceramics, with and without magnesium addition 423/314, 315 Ceram. Int. 1994 20:327. No Month. 56) References Cited Y. Fukase et al. Setting reactions and compressive Strengths of calcium phosphate cements J. Dent. Res. 1990 U.S. PATENT DOCUMENTS 69(12):1852. No Month. F. Abbona et al. Crystallization of calcium and magnesium 3,679,360 7/1972 Rubin et al. .............................. 23/109 4,149,893 4/1979 Aoki et al. ................................ 106/35 phosphate from Solutions of medium and low concentrations 4,612,053 9/1986 Brown et al.
  • Naming and Indexing of Chemical Substances for Chemical Abstractstm

    Naming and Indexing of Chemical Substances for Chemical Abstractstm

    Naming and Indexing of Chemical Substances for Chemical AbstractsTM 2007 Edition A publication of Chemical Abstracts Service Published by the American Chemical Society Naming and Indexing of Chemical Substances for Chemical AbstractsTM A publication of Chemical Abstracts Service Published by the American Chemical Society Copyright © 2008 American Chemical Society All Rights Reserved. Printed in the USA Inquiries concerning editorial content should be sent to: Editorial Office, Chemical Abstracts Service, 2540 Olentangy River Road, P.O. Box 3012, Columbus, Ohio 43210-0012 USA SUBSCRIPTION INFORMATION Questions about CAS products and services should be directed to: United States and Canada: CAS Customer Care Phone: 800-753-4227 (North America) 2540 Olentangy River Road 614-447-3700 (worldwide) P.O. Box 3012 Fax: 614-447-3751 Columbus, Ohio 43210-0012 USA E-mail: [email protected] Japan: JAICI (Japan Association for International Phone: 81-3-5978-3621 Chemical Information) Fax: 81-3-5978-3600 6-25-4 Honkomagome E-mail: [email protected] Bunkyo-ku, Tokyo Japan, 113-0021 Countries not named above: Contact CAS Customer Care, 2540 Olentangy River Road, P.O. Box 3012, Columbus, Ohio 43210-0012 USA; Telephone 614-447-3700; Fax 614-447-3751; E-mail [email protected]. For a list of toll-free numbers from outside North America, visit www.cas.org. 1 Naming and Indexing of Chemical Substances for Chemical Abstracts 2007 ¶ 102 NAMING AND INDEXING OF CHEMICAL SUBSTANCES 101. Foreword. Although the account which follows describes in consid- zwitterions (inner salts, sydnones). The changes for the Fourteenth (1997- erable detail the selection of substance names for Chemical Abstracts (CA) in- 2001) Collective Index period affect coordination nomenclature, stereochemi- dexes, it is not a nomenclature manual.