DOCSLIB.ORG

AKC AGILITY STATS End-Of-Year PACH Totals for 2019 #1 PACH Dog - Radiance END-OF-YEAR RANKINGS from the PREFERRED CLASS

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
AKC AGILITY STATS End-Of-Year PACH Totals for 2019 #1 PACH Dog - Radiance END-OF-YEAR RANKINGS from the PREFERRED CLASS AKC AGILITY STATS End-of-Year PACH Totals for 2019 #1 PACH Dog - Radiance END-OF-YEAR RANKINGS FROM THE PREFERRED CLASS The AKC® agility program ended its 25th year with 3996 agility trials held, 1,202,711 2019 Top PACH dogs by Group entries recorded, and 49,908 total new agility titles earned from January 1 to December Sporting - MACH4 PACH2 Credit Kaze With A Perfect Diamond MXG2 MJB3 31, 2019. Many of these achievements were in the PACH program. MXP8 MXPG MJP9 MJPG PAX2 MFG TQX T2B5 TKI, a Brittany owned by Victoria From January 1, 2019 through December 31, 2019, the number of Preferred Agility MacVicar & Robert J Howell & Jessie Schulz Champion (PACH) titles earned was: PACH – 423; PACH2 – 177; PACH3 – 82; PACH4 Hound - CH MACH5 PACH2 Highland Storytime CD BN RI MXG2 PAD MJG2 MXP6 – 38; PACH5 – 32. This year the top PACH earned was one dog achieved a PACH 15. In MXPS MJP6 MJPS PAX2 MXF TQX MFPB TQXP T2B3 T2BP, a Norwegian Elkhound 2019, 65 Dogs earned their Agility Grand Championship owned by Christine Mayer & Andrea Schokker 2019 Top PACH Dog Working - CH PACH3 Brush Hill’s Debutante At Sinnott MXP8 MXPG PADP MJP13 AGCH MACH13 PACH8 Trivia’s Forever Your Girl MXS4 MJG4 MXP18 MXPG2 MJPB2 PJDP PAX3 MFPB TQXP T2BP3 CAA BCAT CGC TKI, a Boxer owned by Cara PADP MJP19 MJPG2 PJDP PAX8 MFB TQX MFPB TQXP T2B T2BP3 TKN, a Armour & Gerard Armour Shetland Sheepdog owned by Patricia Gagnon Terrier - MACH5 PACH4 Tear Em Up Tammy Trinity MXS2 MJG2 MXP13 MXPB2 MJP17 MJPG2 PAX4 MFG TQX MFP, a Miniature Schnauzer owned by April Lynn Top PACH Dog Lifetime Johnson-Mozzetti & Bruce K Mozzetti (2018 Top PACH Terrier Group) MACH PACH15 Bam-Bam MXB MJB MXP37 MXPS4 MJP50 MJPC5 PAX15 CGC, a Toy - MACH22 PACH6 Daisylane And The Beat Goes On MXS6 MJS7 MXP14 MXPB2 Pomeranian owned by Ronda L. Harvey has earned 303 Double Q’s and 13,338 points. MJP14 MJPB2 PAX6 XF T2B2, a Cavalier King Charles Spaniel owned Antonia Rotelle 2019 Top PACH Dogs by Height Non-Sporting - MACH9 PACH4 Asher’s Pass From Peyton MXC3 MJC3 MXP11 MXPC MJP10 MJPC PAX4 MFB TQX T2B6 T2BP2, a Poodle owned by Barbara Carper 4” – PNAC AGCH MACH21 PACH11 Chinak La Ren On A Whim MXB6 PDG MJB6 PJG MXP23 MXPB3 PDSP MJP24 MJPB3 PJSP PAX11 FTC2 MFS3 TQX MFP TQXP Herding - AGCH MACH13 PACH8 Trivia’s Forever Your Girl MXS4 MJG4 MXP18 T2B18 T2BP, a Papillion owned by Robin Cohen & Robin Kletke (2018 #1 4” PACH MXPG2 PADP MJP19 MJPG2 PJDP PAX8 MFB TQX MFPB TQXP T2B T2BP3 TKN, a Dog) Shetland Sheepdog owned by Patricia Gagnon 8” – AGCH MACH13 PACH8 Trivia’s Forever Your Girl MXS4 MJG4 MXP18 MXPG2 PADP MJP19 MJPG2 PJDP PAX8 MFB TQX MFPB TQXP T2B T2BP3 TKN, a The ranking statistics on the following pages are reported using the score formula, (double Shetland Sheepdog owned by Patricia Gagnon (2018 #1 8” PACH Dog) Q’s x 10) + PACH points. Example 1,100 PACH points + (40 Double Q’s x 10) would equal a score of 1,500 points. This score is used to announce the Top PACH dog for the 12” – MACH4 PACH2 Credit Kaze With A Perfect Diamond MXG2 MJB3 MXP8 year. The lifetime statistics will continue to be ranked by Title/Points/2Q’s as in the past. MXPG MJP9 MJPG PAX2 MFG TQX T2B5 TKI, a Brittany owned by Victoria MacVicar & Robert J Howell & Jessie Schulz. Each year, AKC honors the Top Dogs of each breed at a banquet held at the AKC Agility Invitational (AGI), with a Special Award of Merit based on the end-of-year rankings 16” – MACH8 PACH6 Grand Oakes Knock On Wood MXC3 MJC3 MXP17 MXPG2 (January-December) shown on the following pages. MJP21 MJPC2 PAX6 MFB T2B11, a Border Collie owned by Amanda Moller We are looking forward to another exceptional year of Agility in 2020. Congratulations to 20” – MACH9 PACH4 Asher’s Pass From Peyton MXC3 MJC3 MXP11 MXPC MJP10 all of our exhibitors for their many accomplishments in 2019. MJPC PAX4 MFB TQX T2B6 T2BP2, a Poodle owned by Barbara Carper. Carrie DeYoung AKC DIRECTOR OF AGILITY Lifetime Top Overall Dogs Title/Points/”2Q’s” Rank Name Breed Owner Points Double Q’s 1 MACH PACH15 Bam-Bam MXB MJB MXP37 MXPS4 MJP50 MJPC5 PAX15 CGC Pomeranian Ronda L. Harvey 13,338 303 2 PACH14 Fyfa MXP37 MXPG4 MJP40 MJPC4 PAX14 OFP Shetland Sheepdog Terese Rakow 13,959 293 3 GCH CH AGCH MACH25 PACH14 Pinpaps Little Bit Of Bling MXB7 MJC7 MXP34 MXPB4 PADP MJP36 MJPS4 PJDP PAX15 FTC2 MFG3 TQX MFPG TQXP T2B2 T2BP2 Papillon Robin Cohen & Robin Kletke 10,842 319 4 PACH14 Polygor’s Worth The Wait MXP42 MXPB5 MJP45 MJPS5 PAX16 XFP T2BP CGC TKI Petit Basset Griffon Vendeen Kathy Marshall 10,753 326 5 MACH2 PACH13 Shy’Anne Pepperablo MXG MJG MXP35 MXPS4 MJP32 MJPC3 PAX13 XF T2B Australian Shepherd Stefani Gantt 13,482 278 6 MACH5 PACH12 Accent’s Mighty Rock MXG2 MJB3 MXP31 MXPC3 MJP34 MJPB4 PAX14 NFP T2BP3 CGC TKI Shetland Sheepdog Kathy M Burns & Steve Burns 9,433 283 7 PACH12 Harvey’s Casper AX AXJ MXP41 MXPC4 MJP44 MJPB5 PAX15 CGCA Maltese RONDA LAUREN HARVEY & Ronda Harvey 9,240 308 8 PNAC AGCH MACH21 PACH11 Chinak La Ren On A Whim MXB6 PDG MJB6 PJG MXP23 MXPB3 PDSP MJP24 MJPB3 PJSP PAX11 FTC2 MFS3 TQX MFP TQXP T2B18 T2BP Papillon Robin Cohen & Robin Kletke 14,198 223 9 PACH10 Tumbleweed Chasin Aftrthwind NA NAJ MXP28 MXPG3 MJP32 MJPC3 PAX10 OFP T2BP2 Schipperke Lori Brison 11,023 200 10 AGCH PACH10 Blue Moon Ilusion Of Chaos At Sea VCD2 PCDX BN GN RAE TDX MX MXB MXJ MJB MXP27 MXPG3 PDSP MJP31 MJPC3 PJSP PAX11 XF MFPC TQXP T2B T2BP6 TKI English Cocker Spaniel Ms. Roxanne I Spilman-Bush 8,041 238 11 PACH9 Crosby’s Quinn MXP22 MXPC2 MJP29 MJPG3 PAX9 MFP T2BP6 All American Dog Krisanne Crosby 10,261 181 12 MACH7 PACH9 Nojo’s Diamond Fire MXC2 MJC2 MXP23 MXPB3 PADP MJP25 MJPS3 PJDP PAX9 XF T2B10 T2BP6 CGCA CGCU TKN Cavalier King Charles Spaniel Joan Williams & Norman Williams 7,158 194 13 MACH6 PACH9 Toby Wan Kenobi Trede MXS3 MJS3 MXP24 MXPB3 MJP21 MJPC2 PAX9 T2BP CGC Miniature Schnauzer Brian Trede & Janice Hertz 6,945 196 14 PACH8 General Tommy Franks AX MXJ MJB MXP20 MXPC2 MJP28 MJPG3 PAX8 XF OFP T2BP Parson Russell Terrier Cherie Whittenberg & Deva Wilson 12,091 167 15 PNAC MACH9 PACH8 Logan Lake Hope MXC2 MJG3 MXP18 MXPG2 MJP20 MJPC2 PAX8 XF T2B CGC All American Dog Kimberly Barton 11,846 169 16 PACH8 Toven Sweet Memory RAE MXP25 MXPS3 MJP25 MJPS3 PAX8 MFPC TQXP T2BP5 CGC Shetland Sheepdog Marion Hansen 11,300 175 17 AGCH MACH13 PACH8 Trivia’s Forever Your Girl MXS4 MJG4 MXP18 MXPG2 PADP MJP19 MJPG2 PJDP PAX8 MFB TQX MFPB TQXP T2B T2BP3 TKN Shetland Sheepdog Patricia Gagnon 10,825 164 18 AGCH PACH8 Moonstones Femme Fatale NAJ MXP25 MXPS3 PDSP MJP30 MJPC3 PJSP PAX8 NF MFPG TQXP T2BP6 Poodle Brenda Weitzel & NAJEH FAUZ 10,579 176 19 PACH8 Amazing Grace MXP22 MXPC2 MJP29 MJPG3 PAX8 XFP T2BP4 Australian Shepherd Sheila Boone & Jeffrey Boone 9,553 169 20 MACH2 PACH8 Lime Creek’s Punkin Patootie VCD3 MH MXG MJG MXP25 MXPS3 MJP27 MJPS3 PAX8 MFP Labrador Retriever Deborah A Joseph & Paul R Young 8,859 166 Top Overall Dogs Based on Score (2Q’s x 10) + Points Rank Name Breed Owner Points Doube Q’s Score 1 AGCH MACH13 PACH8 Trivia’s Forever Your Girl MXS4 MJG4 MXP18 MXPG2 PADP MJP19 MJPG2 PJDP PAX8 MFB TQX MFPB TQXP T2B T2BP3 TKN Shetland Sheepdog Patricia Gagnon 7,612 117 8,782 2 MACH22 PACH6 Daisylane And The Beat Goes On MXS6 MJS7 MXP14 MXPB2 MJP14 MJPB2 PAX6 XF T2B2 Cavalier King Charles Spaniel Antonia Rotelle 7,185 124 8,425 3 PNAC AGCH MACH21 PACH11 Chinak La Ren On A Whim MXB6 PDG MJB6 PJG MXP23 MXPB3 PDSP MJP24 MJPB3 PJSP PAX11 FTC2 MFS3 TQX MFP TQXP T2B18 T2BP Papillon Robin Cohen & Robin Kletke 6,014 94 6,954 4 MACH12 PACH2 Karmayne’s Champagne Wishes Makenzie CDX GO RAE MXC3 MJB5 MXP7 MXPS MJP8 MJPG PAX2 T2B Shetland Sheepdog Judy Livingston & Joe Livingston 3,905 53 4,435 5 MACH9 PACH7 Beau James Rotten To The Core CD BN RE MXG3 MJC3 MXP17 MXPS2 MJP19 MJPG2 PAX7 OF T2B2 CGC TKN Pomeranian Kathryn J Baumler 3,518 47 3,988 6 MACH8 PACH6 Grand Oakes Knock On Wood MXC3 MJC3 MXP17 MXPG2 MJP21 MJPC2 PAX6 MFB T2B11 Border Collie Amanda Moller 3,475 44 3,915 7 MACH5 PACH8 Streffield Anna Sewell MXC2 MJC2 MXP18 MXPG2 MJP20 MJPC2 PAX8 Cavalier King Charles Spaniel Lisa Johnson 3,097 80 3,897 8 MACH PACH4 China Road Q Tee MXB MJS MXP14 MXPB2 MJP15 MJPS2 PAX4 Chinese Crested Patty Wiedeman 3,172 63 3,802 9 MACH9 PACH4 Asher’s Pass From Peyton MXC3 MJC3 MXP11 MXPC MJP10 MJPC PAX4 MFB TQX T2B6 T2BP2 Poodle Barbara E Carper 3,046 60 3,646 10 PACH4 Shetara’s Shadow Of The Sun BN RE MXP12 MXPB2 PADP MJP13 MJPB2 PJSP PAX4 MFPB TQXP T2BP4 CGC TKI Belgian Sheepdog Sonia lachapelle 3,110 51 3,620 11 MACH11 PACH6 Cabonina La Saltadora MXC3 MJC3 MXP13 MXPB2 MJP15 MJPS2 PAX6 CGCA CGCU TKA All American Dog Jason D Meier & Melissa I. B. Meier 2,790 82 3,610 12 MACH5 PACH4 Tear Em Up Tammy Trinity MXS2 MJG2 MXP13 MXPB2 MJP17 MJPG2 PAX4 MFG TQX MFP Miniature Schnauzer April Lynn Johnson-Mozzetti & Bruce K Mozzetti 3,235 33 3,565 13 MACH6 PACH3 Flyin’ Aces Miss Bee Haven BN RN MXG2 MJC2 MXP8 MXPG MJP11 MJPC PAX3 Chinese Crested Gregg Wagner & Rachelle Wagner 2,936 50 3,436 14 MACH4 PACH2 Credit Kaze With A Perfect Diamond MXG2 MJB3 MXP8 MXPG MJP9 MJPG PAX2 MFG TQX T2B5 TKI Brittany Victoria MacVicar & Robert J Howell & Jessie Schulz 3,004 38 3,384 15 MACH20 PACH2 Regen’s Anduril Forged By Fire CD RE JH MXB6 MJB7 MXP5 MXPS MJP6 MJPS PAX2 MFB TQX T2B8 CGCA TKI Weimaraner Sheila J Cook 2,902 45 3,352 16 MACH6 PACH2 Tollegend Winning Streak CDX RA MXG2 MJB3 MXP7 MXPS MJP7 MJPG PAX2 OF T2B2 Papillon Kathy Hightshoe 2,948 31 3,258 17 MACH2 PACH6 Besota’s Carved By Fire CD BN RA MXS MJB2 MXP18 MXPG2 MJP24 MJPB3 PAX6 XF MFP TQXP T2BP CGC TKN American Eskimo Dog Rebecca L Smith & Glenn C Rawsky 2,693 52 3,213 18 NAC MACH12
Load more

Recommended publications
  • The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer
    Published OnlineFirst October 26, 2016; DOI: 10.1158/2159-8290.CD-15-1263 RESEARCH ARTICLE The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer Jennifer L. Bishop1, Daksh Thaper1,2, Sepideh Vahid1,2, Alastair Davies1, Kirsi Ketola1, Hidetoshi Kuruma1, Randy Jama1, Ka Mun Nip1,2, Arkhjamil Angeles1, Fraser Johnson1, Alexander W. Wyatt1,2, Ladan Fazli1,2, Martin E. Gleave1,2, Dong Lin1, Mark A. Rubin3, Colin C. Collins1,2, Yuzhuo Wang1,2, Himisha Beltran3, and Amina Zoubeidi1,2 ABSTRACT Mechanisms controlling the emergence of lethal neuroendocrine prostate cancer (NEPC), especially those that are consequences of treatment-induced suppression of the androgen receptor (AR), remain elusive. Using a unique model of AR pathway inhibitor–resistant prostate cancer, we identified AR-dependent control of the neural transcription factor BRN2 (encoded by POU3F2) as a major driver of NEPC and aggressive tumor growth, both in vitro and in vivo. Mecha- nistic studies showed that AR directly suppresses BRN2 transcription, which is required for NEPC, and BRN2-dependent regulation of the NEPC marker SOX2. Underscoring its inverse correlation with clas- sic AR activity in clinical samples, BRN2 expression was highest in NEPC tumors and was significantly increased in castration-resistant prostate cancer compared with adenocarcinoma, especially in patients with low serum PSA. These data reveal a novel mechanism of AR-dependent control of NEPC and suggest that targeting BRN2 is a strategy to treat or prevent neuroendocrine differentiation in prostate tumors. SIGNIFICANCE: Understanding the contribution of the AR to the emergence of highly lethal, drug- resistant NEPC is critical for better implementation of current standard-of-care therapies and novel drug design.
    [Show full text]
  • Clones Stick Together
    TVhome The Daily Home April 12 - 18, 2015 Clones Stick Together Sarah (Tatiana Maslany) is on a mission to find the 000208858R1 truth about the clones on season three of “Orphan Black,” premiering Saturday at 8 p.m. on BBC America. The Future of Banking? We’ve Got A 167 Year Head Start. You can now deposit checks directly from your smartphone by using FNB’s Mobile App for iPhones and Android devices. No more hurrying to the bank; handle your deposits from virtually anywhere with the Mobile Remote Deposit option available in our Mobile App today. (256) 362-2334 | www.fnbtalladega.com Some products or services have a fee or require enrollment and approval. Some restrictions may apply. Please visit your nearest branch for details. 000209980r1 2 THE DAILY HOME / TV HOME Sun., April 12, 2015 — Sat., April 18, 2015 DISH AT&T DIRECTV CABLE CHARTER CHARTER PELL CITY PELL ANNISTON CABLE ONE CABLE TALLADEGA SYLACAUGA BIRMINGHAM BIRMINGHAM BIRMINGHAM CONVERSION CABLE COOSA SPORTS WBRC 6 6 7 7 6 6 6 6 AUTO RACING Friday WBIQ 10 4 10 10 10 10 6 p.m. FS1 St. John’s Red Storm at Drag Racing WCIQ 7 10 4 Creighton Blue Jays (Live) WVTM 13 13 5 5 13 13 13 13 Sunday Saturday WTTO 21 8 9 9 8 21 21 21 7 p.m. ESPN2 Summitracing.com 12 p.m. ESPN2 Vanderbilt Com- WUOA 23 14 6 6 23 23 23 NHRA Nationals from The Strip at modores at South Carolina WEAC 24 24 Las Vegas Motor Speedway in Las Gamecocks (Live) WJSU 40 4 4 40 Vegas (Taped) 2 p.m.
    [Show full text]
  • Core Transcriptional Regulatory Circuitries in Cancer
    Oncogene (2020) 39:6633–6646 https://doi.org/10.1038/s41388-020-01459-w REVIEW ARTICLE Core transcriptional regulatory circuitries in cancer 1 1,2,3 1 2 1,4,5 Ye Chen ● Liang Xu ● Ruby Yu-Tong Lin ● Markus Müschen ● H. Phillip Koeffler Received: 14 June 2020 / Revised: 30 August 2020 / Accepted: 4 September 2020 / Published online: 17 September 2020 © The Author(s) 2020. This article is published with open access Abstract Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward transcriptional loops to establish and reinforce the cell-type- specific gene-expression program; the ensemble of core TFs and their regulatory loops constitutes core transcriptional regulatory circuitry (CRC). Here, we summarize recent progress in computational reconstitution and biologic exploration of CRCs across various human malignancies, and consolidate the strategy and methodology for CRC discovery. We also discuss the genetic basis and therapeutic vulnerability of CRC, and highlight new frontiers and future efforts for the study of CRC in cancer. Knowledge of CRC in cancer is fundamental to understanding cancer-specific transcriptional addiction, and should provide important insight to both pathobiology and therapeutics. 1234567890();,: 1234567890();,: Introduction genes. Till now, one critical goal in biology remains to understand the composition and hierarchy of transcriptional Transcriptional regulation is one of the fundamental mole- regulatory network in each specified cell type/lineage.
    [Show full text]
  • Booklist 3-4.Xlsx
    2019 Years 3-4 Booklist Author Book Title ISBN Year Level Abela, Deborah The Stupendously Spectacular Spelling Bee 9781925324822 3-4, 5-6 Abramson, Ruth The Cresta Adventure 978-0-87306-493-4 3-4 Agard, John Hello New! 978-1-84121-621-8 3-4 Ahlberg, Allan Please Mrs Butler 9780140314946 3-4 Ahlberg, Allan The Bravest Ever Bear 9780744578645 3-4 Ahlberg, Allan; Ingham, Bruce The Pencil 9781406309621 3-4 Ahlberg, Allan; Ingman, Bruce Previously 9781844280629 3-4 Ahlberg, Allan; Ingman, Bruce (ill.) Everybody Was a Baby Once 9781406321562 EC-2, 3-4 Airey, Miriam No Hat Brigade 978-1-74051-773-7 3-4 Alderson, Maggie Evangeline 9780670075355 EC-2, 3-4 Alexander, Goldie The Youngest Cameleer 978-1-74130-495-4 3-4, 5-6 Alexander, Goldie; Gaudion, Michele (ill.) Lame Duck Protest 978-1-921479-13-7 3-4 Allaby, Michael DK Guide to Weather 978-0-7513-2856-1 3-4 Allen, Emma; Blackwood, Freya (ill.) The Terrible Suitcase 9781862919402 EC-2, 3-4 Allen, Judy Anthology for the Earth 978-0-7636-0301-4 3-4 Allen, Scott Jesse the Elephant 9781921638138 3-4 Almond, David; Pinfold, Levi (ill.) The Dam 9781406304879 EC-2, 3-4 Almond, David; Smith, Alex T. The Tale of Angelino Brown 9781406358070 3-4, 5-6 Amadio, Nadine; Blackman, Charles (ill.) The New Adventures of Alice in Rainforest Land 978-0-949284-07-5 3-4 Andreae, Giles; Sharrat, Nick (ill.) Billy Bonkers series 3-4 Anholt, Laurence Camille and the Sunflowers 978-0-7112-1050-9 3-4 Anholt, Laurence Frida Kahlo and the Bravest Girl in the World 9781847806666 3-4 Anna Ciddor A Roman Day to Remember 978-0816767960
    [Show full text]
  • PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain
    Published OnlineFirst April 26, 2017; DOI: 10.1158/2159-8290.CD-16-1297 RESEARCH ARTICLE PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability Berkley E. Gryder 1 , Marielle E. Yohe 1 , 2 , Hsien-Chao Chou 1 , Xiaohu Zhang 3 , Joana Marques 4 , Marco Wachtel4 , Beat Schaefer 4 , Nirmalya Sen 1 , Young Song 1 , Alberto Gualtieri 5 , Silvia Pomella 5 , Rossella Rota5 , Abigail Cleveland 1 , Xinyu Wen 1 , Sivasish Sindiri 1 , Jun S. Wei 1 , Frederic G. Barr 6 , Sudipto Das7 , Thorkell Andresson 7 , Rajarshi Guha 3 , Madhu Lal-Nag 3 , Marc Ferrer 3 , Jack F. Shern 1 , 2 , Keji Zhao8 , Craig J. Thomas 3 , and Javed Khan 1 Downloaded from cancerdiscovery.aacrjournals.org on September 29, 2021. © 2017 American Association for Cancer Research. 16-CD-16-1297_p884-899.indd 884 7/20/17 2:21 PM Published OnlineFirst April 26, 2017; DOI: 10.1158/2159-8290.CD-16-1297 ABSTRACT Alveolar rhabdomyosarcoma is a life-threatening myogenic cancer of children and ado- lescent young adults, driven primarily by the chimeric transcription factor PAX3–FOXO1. The mechanisms by which PAX3–FOXO1 dysregulates chromatin are unknown. We fi nd PAX3–FOXO1 repro- grams the cis -regulatory landscape by inducing de novo super enhancers. PAX3–FOXO1 uses super enhancers to set up autoregulatory loops in collaboration with the master transcription factors MYOG, MYOD, and MYCN. This myogenic super enhancer circuitry is consistent across cell lines and primary tumors. Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3–FOXO1-occupied super enhancers.
    [Show full text]
  • 2Friday 1Thursday 3Saturday 4Sunday 5Monday 6Tuesday 7Wednesday 8Thursday 9Friday 10Saturday
    JULY 2021 1THURSDAY 2FRIDAY DAYTIME THEME: DAYTIME THEME: TCM BIRTHDAY TRIBUTE: WILLIAM WYLER KEEPING THE KIDS BUSY PRIMETIME THEME: PRIMETIME THEME: SELVIS FRIDAY NIGHT NEO-NOIR Seeing Double 8:00 PM Harper (‘66) 8:00 PM Kissin’ Cousins (‘64) 10:15 PM Point Blank (‘67) 10:00 PM Double Trouble (‘67) 12:00 AM Warning Shot (‘67) 12:00 AM Clambake (‘67) 2:00 AM Live A Little, Love a Little (‘68) 3SATURDAY 4SUNDAY DAYTIME THEME: DAYTIME THEME: SATURDAY MATINEE HAPPY INDEPENDENCE DAY PRIMETIME THEME: PRIMETIME THEME: GABLE GOES WEST HAPPY INDEPENDENCE DAY 8:00 PM The Misfits (‘61) 8:00 PM Yankee Doodle Dandy (‘42) 10:15 PM The Tall Men (‘55) 10:15 PM 1776 (‘72) JULY JailhouseThes Stranger’s Rock(‘57) Return (‘33) S STAR OF THE MONTH: Elvis 5MONDAY 6TUESDAY 7WEDNESDAY P TCM SPOTLIGHT: Star Signs DAYTIME THEME: DAYTIME AND PRIMETIME THEME(S): DAYTIME THEME: MEET CUTES DAYTIME THEME: TY HARDIN TCM PREMIERE PRIMETIME THEME: SOMETHING ON THE SIDE PRIMETIME THEME: DIRECTED BY BRIAN DE PALMA PRIMETIME THEME: THE GREAT AMERICAN MIDDLE TWITTER EVENTS 8:00 PM The Bonfire of the Vanities (‘90) PSTAR SIGNS Small Town Dramas NOT AVAILABLE IN CANADA 10:15 PM Obsession (‘76) Fire Signs 8:00 PM Peyton Place (‘57) 12:00 AM Sisters (‘72) 8:00 PM The Cincinnati Kid (‘65) 10:45 PM Picnic (‘55) 1:45 AM Blow Out (‘81) (Steeve McQueen – Aries) 12:45 AM East of Eden (‘55) 4:00 AM Body Double (‘84) 10:00 PM The Long Long Trailer (‘59) 3:00 AM Kings Row (‘42) (Lucille Ball – Leo) 5:15 AM Our Town (‘40) 12:00 AM The Bad and the Beautiful (‘52) (Kirk Douglas–Sagittarius)
    [Show full text]
  • PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1 Alexandra Lacey1, Aline Rodrigues-Hoffman2, and Stephen Safe1
    Published OnlineFirst November 18, 2016; DOI: 10.1158/0008-5472.CAN-16-1546 Cancer Therapeutics, Targets, and Chemical Biology Research PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1 Alexandra Lacey1, Aline Rodrigues-Hoffman2, and Stephen Safe1 Abstract Alveolar rhabdomyosarcoma (ARMS) is a devastating pediatric PAX3-FOXO1A. Mechanistic investigations revealed a requirement disease driven by expression of the oncogenic fusion gene PAX3- for the NR4A1/Sp4 complex to bind GC-rich promoter regions FOXO1A. In this study, we report overexpression of the nuclear to elevate transcription of the PAX3-FOXO1A gene. In parallel, receptor NR4A1 in rhabdomyosarcomas that is sufficient to NR4A1 also regulated expression of b1-integrin, which with PAX3- drive high expression of PAX3-FOXO1A there. RNAi-mediated FOXO1A, contributed to tumor cell migration that was blocked by silencing of NR4A1 decreased expression of PAX3-FOXO1A and C-DIM/NR4A1 antagonists. Taken together, our results provide a its downstream effector genes. Similarly, cell treatment with the preclinical rationale for the use of NR4A1 small-molecule antago- NR4A1 small-molecule antagonists 1,1-bis(3-indolyl)-1-(p- nists to treat ARMS and other rhabdomyosarcomas driven by hydroxy or p-carbomethoxyphenyl)methane (C-DIM) decreased PAX3-FOXO1A. Cancer Res; 77(3); 1–10. Ó2016 AACR. Introduction activity for NR4A1. In contrast, NR4A1 exhibits tumor promoter activity (6, 7) in solid tumors. NR4A1 is also overexpressed in Rhabdomyosarcoma is the most common soft-tissue sarco- tumors from patients with breast, lung, pancreatic, colon, and ma that is primarily observed in children and adolescents and ovarian cancer and is a negative prognostic factor for patients with accounts for 50% of all pediatric cancers and 50% of soft-tissue breast, lung, and ovarian cancer (9–15).
    [Show full text]
  • Hypersphere Anonymous
    Hypersphere Anonymous This work is licensed under a Creative Commons Attribution 4.0 International License. ISBN 978-1-329-78152-8 First edition: December 2015 Fourth edition Part 1 Slice of Life Adventures in The Hypersphere 2 The Hypersphere is a big fucking place, kid. Imagine the biggest pile of dung you can take and then double-- no, triple that shit and you s t i l l h a v e n ’ t c o m e c l o s e t o o n e octingentillionth of a Hypersphere cornerstone. Hell, you probably don’t even know what the Hypersphere is, you goddamn fucking idiot kid. I bet you don’t know the first goddamn thing about the Hypersphere. If you were paying attention, you would have gathered that it’s a big fucking 3 place, but one thing I bet you didn’t know about the Hypersphere is that it is filled with fucked up freaks. There are normal people too, but they just aren’t as interesting as the freaks. Are you a freak, kid? Some sort of fucking Hypersphere psycho? What the fuck are you even doing here? Get the fuck out of my face you fucking deviant. So there I was, chilling out in the Hypersphere. I’d spent the vast majority of my life there, in fact. It did contain everything in my observable universe, so it was pretty hard to leave, honestly. At the time, I was stressing the fuck out about a fight I had gotten in earlier. I’d been shooting some hoops when some no-good shithouses had waltzed up to me and tried to make a scene.
    [Show full text]
  • Helter Skelter” and Sixties Revisionism “Helter Skelter” Et L'héritage Polémique Des Années 1960
    Volume ! La revue des musiques populaires 9 : 2 | 2012 Contre-cultures n°2 “Helter Skelter” and Sixties Revisionism “Helter Skelter” et l'héritage polémique des années 1960 Gerald Carlin and Mark Jones Electronic version URL: http://journals.openedition.org/volume/3407 DOI: 10.4000/volume.3407 ISSN: 1950-568X Printed version Date of publication: 15 December 2012 Number of pages: 34-49 ISBN: 978-2-913169-33-3 ISSN: 1634-5495 Electronic reference Gerald Carlin and Mark Jones, « “Helter Skelter” and Sixties Revisionism », Volume ! [Online], 9 : 2 | 2012, Online since 15 June 2014, connection on 10 December 2020. URL : http:// journals.openedition.org/volume/3407 ; DOI : https://doi.org/10.4000/volume.3407 This text was automatically generated on 10 December 2020. L'auteur & les Éd. Mélanie Seteun “Helter Skelter” and Sixties Revisionism 1 “Helter Skelter” and Sixties Revisionism “Helter Skelter” et l'héritage polémique des années 1960 Gerald Carlin and Mark Jones EDITOR'S NOTE This text was published in Countercultures & Popular Music (Farnham, Ashgate, 2014), while its French translation appeared in this issue of Volume! in 2012. “Helter Skelter” and the End of the Sixties Volume !, 9 : 2 | 2012 “Helter Skelter” and Sixties Revisionism 2 1 In late August 1968, within a few days of each other, new singles were released by the Beatles and the Rolling Stones. The unusual proximity of release dates by the world’s two most significant rock bands was echoed by the congruity of the songs’ themes: the Stones’ “Street Fighting Man” and the Beatles’ “Revolution” were both responses to the political unrest and protest which characterised the spring and summer of 1968.
    [Show full text]
  • PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1 Alexandra Lacey1, Aline Rodrigues-Hoffman2, and Stephen Safe1
    Published OnlineFirst November 18, 2016; DOI: 10.1158/0008-5472.CAN-16-1546 Cancer Therapeutics, Targets, and Chemical Biology Research PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1 Alexandra Lacey1, Aline Rodrigues-Hoffman2, and Stephen Safe1 Abstract Alveolar rhabdomyosarcoma (ARMS) is a devastating pediatric PAX3-FOXO1A. Mechanistic investigations revealed a requirement disease driven by expression of the oncogenic fusion gene PAX3- for the NR4A1/Sp4 complex to bind GC-rich promoter regions FOXO1A. In this study, we report overexpression of the nuclear to elevate transcription of the PAX3-FOXO1A gene. In parallel, receptor NR4A1 in rhabdomyosarcomas that is sufficient to NR4A1 also regulated expression of b1-integrin, which with PAX3- drive high expression of PAX3-FOXO1A there. RNAi-mediated FOXO1A, contributed to tumor cell migration that was blocked by silencing of NR4A1 decreased expression of PAX3-FOXO1A and C-DIM/NR4A1 antagonists. Taken together, our results provide a its downstream effector genes. Similarly, cell treatment with the preclinical rationale for the use of NR4A1 small-molecule antago- NR4A1 small-molecule antagonists 1,1-bis(3-indolyl)-1-(p- nists to treat ARMS and other rhabdomyosarcomas driven by hydroxy or p-carbomethoxyphenyl)methane (C-DIM) decreased PAX3-FOXO1A. Cancer Res; 77(3); 1–10. Ó2016 AACR. Introduction activity for NR4A1. In contrast, NR4A1 exhibits tumor promoter activity (6, 7) in solid tumors. NR4A1 is also overexpressed in Rhabdomyosarcoma is the most common soft-tissue sarco- tumors from patients with breast, lung, pancreatic, colon, and ma that is primarily observed in children and adolescents and ovarian cancer and is a negative prognostic factor for patients with accounts for 50% of all pediatric cancers and 50% of soft-tissue breast, lung, and ovarian cancer (9–15).
    [Show full text]
  • Ebook Download Elvis Presley: a Life in Pictures
    ELVIS PRESLEY: A LIFE IN PICTURES PDF, EPUB, EBOOK none | 48 pages | 01 Jul 2012 | Atlantic Publishing,Croxley Green | 9781908533975 | English | Croxley Green, United Kingdom Elvis Presley: A Life in Pictures PDF Book Sunset Boulevard Getty Images. TIME Apps. He was stationed in Germany for two years. Today's Top Stories. Office of Presidential Libraries. Space He received deferment so that he could complete production on King Creole and entered the army as a private in A young Elvis, age 10, is pictured with his parents outside his family home in Tupelo, Mississippi in While living on the German army base, Presley met year-old Priscilla Beaulieu , who was living there with her parents. Your email address will not be published. Presley brought his iconic gold Cadillac on tour with him to promote his film Tickle Me. TIME Shop. Published in the Memphis Commercial Appeal. He released his first two albums and a string of singles including the US number one, Heartbreak Hotel. Sign In. After his film success started to decline and it became clear Presley was losing some of his box office charm, he returned to TV with a special in Available via Getty. Or subscribe to articles in the subject area by email or RSS. Originally published in the Memphis Press-Scimitar. His new single "Heartbreak Hotel" climbed the charts and quickly took over the top spot. A year later, Elvis would be given his first guitar. Paramount Pictures Getty Images. The Comeback Special, which saw the King in raucous form, was a massive success. TIME Magazine's first-ever consideration of Elvis Presley, a snippet review of the single Heartbreak Hotel in , did not contain many clues about what was to come.
    [Show full text]
  • In Mediating Transcriptional Activity of Androgen Receptor Splice Variants
    ROLE OF TRANSCRIPTIONAL ACTIVATION UNIT 5 (TAU5) IN MEDIATING TRANSCRIPTIONAL ACTIVITY OF ANDROGEN RECEPTOR SPLICE VARIANTS A THESIS SUBMITTED TO THE FACULTY OF THE GRADUATE SCHOOL OF THE UNIVERSITY OF MINNESOTA BY SARITA KUMARI MUTHA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE SCOTT DEHM & JIM McCARTHY DECEMBER 2012 © Sarita Kumari Mutha 2012 ACKNOWLEDGEMENTS I would like to thank the Dehm Lab: Scott Dehm, Yingming Li, Siu Chiu Chan, and Luke Brand for the support, discussions, journal clubs, and training. I would like to thank MCBD&G faculty Kathleen Conklin and Meg Titus for their support. Finally, I would also to acknowledge my committee Scott Dehm, Jim McCarthy, and Kaylee Schwertfeger for their time and support. i DEDICATION This thesis is dedicated to my mentor and advisor Scott Dehm. This work would not have been possible without his support. I am very grateful for my time under his mentorship and the opportunity to learn from him. ii ABSTRACT The standard treatment for advanced prostate cancer is chemical castration, which inhibits the activity of the androgen receptor (AR). Eventually, prostate cancer reemerges with a castration-resistant phenotype (CRPC) but still depends on AR signaling. One mechanism of AR activity in CRPC is the synthesis of AR splice variants, which lack the ligand binding domain. These splice variants function as constitutively active transcription factors that promote expression of endogenous AR target genes and support androgen independent prostate cancer cell growth. Previous work has shown transcriptional activation unit 5 (TAU5) is necessary for ligand independent activity of the full length AR in low or no androgen conditions and that this activation is mediated by the WHTLF motif.
    [Show full text]