Brucella Suis in Feral Pigs Fact Sheet
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EFFECTIVE NEBRASKA DEPARTMENT of 01/01/2017 HEALTH and HUMAN SERVICES 173 NAC 1 I TITLE 173 COMMUNICABLE DISEASES CHAPTER 1
EFFECTIVE NEBRASKA DEPARTMENT OF 01/01/2017 HEALTH AND HUMAN SERVICES 173 NAC 1 TITLE 173 COMMUNICABLE DISEASES CHAPTER 1 REPORTING AND CONTROL OF COMMUNICABLE DISEASES TABLE OF CONTENTS SECTION SUBJECT PAGE 1-001 SCOPE AND AUTHORITY 1 1-002 DEFINITIONS 1 1-003 WHO MUST REPORT 2 1-003.01 Healthcare Providers (Physicians and Hospitals) 2 1-003.01A Reporting by PA’s and APRN’s 2 1-003.01B Reporting by Laboratories in lieu of Physicians 3 1-003.01C Reporting by Healthcare Facilities in lieu of Physicians for 3 Healthcare Associated Infections (HAIs) 1-003.02 Laboratories 3 1-003.02A Electronic Ordering of Laboratory Tests 3 1-004 REPORTABLE DISEASES, POISONINGS, AND ORGANISMS: 3 LISTS AND FREQUENCY OF REPORTS 1-004.01 Immediate Reports 4 1-004.01A List of Diseases, Poisonings, and Organisms 4 1-004.01B Clusters, Outbreaks, or Unusual Events, Including Possible 5 Bioterroristic Attacks 1-004.02 Reports Within Seven Days – List of Reportable Diseases, 5 Poisonings, and Organisms 1-004.03 Reporting of Antimicrobial Susceptibility 8 1-004.04 New or Emerging Diseases and Other Syndromes and Exposures – 8 Reporting and Submissions 1-004.04A Criteria 8 1-004.04B Surveillance Mechanism 8 1-004.05 Sexually Transmitted Diseases 9 1-004.06 Healthcare Associated Infections 9 1-005 METHODS OF REPORTING 9 1-005.01 Health Care Providers 9 1-005.01A Immediate Reports of Diseases, Poisonings, and Organisms 9 1-005.01B Immediate Reports of Clusters, Outbreaks, or Unusual Events, 9 Including Possible Bioterroristic Attacks i EFFECTIVE NEBRASKA DEPARTMENT OF -
Brucellosis Tip Sheet June 2018
BRUCELLOSIS Background Brucellosis is an infectious disease caused by Brucella species such as Brucella melitensis, Brucella abortus, and Brucella suis. People can get the disease when they are in contact with infected animals or animal products contaminated with the bacteria. From 1993 through 2010, the number of brucellosis cases reported in the US ranged from 79 to 139, with an average of 109 cases per year. In 2010, the highest number (56.5%) of brucellosis cases was reported by California, Texas, Arizona, and Florida. Michigan reported four cases that same year (range=0‐10 cases per year). Signs and Symptoms Acute Non‐specific: fever, sweats, malaise, anorexia, headache, pain in muscles, joint, and/or back pain, fatigue Sub‐clinical infections are common Lymphadenopathy (10–20%), splenomegaly (20–30%) Chronic Recurrent fever Arthritis and spondylitis Swelling of the testicle and scrotum area Swelling of the heart (endocarditis) Swelling of the liver and/or spleen Neurologic symptoms (in up to 5% of all cases) Possible focal organ involvement Chronic fatigue Depression Brucellosis in Pregnant Women Brucellosis during pregnancy carries the risk of causing spontaneous abortion, particularly during the first and second trimesters; therefore, women should receive prompt medical treatment with the proper antimicrobials. Incubation Period Highly variable (5 days–6 months) Average onset 2–4 weeks Transmission Ingestion: The most common way to be infected is by eating or drinking unpasteurized/raw dairy products. When sheep, goats, cows, or camels are infected, their milk becomes contaminated with the bacteria. If milk from infected animals is not pasteurized, the infection will be transmitted to people who consume the milk and/or cheese products. -
Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development
The Open Veterinary Science Journal, 2010, 4, 101-107 101 Open Access Recent Advances in Understanding Immunity Against Brucellosis: Application for Vaccine Development Sérgio Costa Oliveira*,1, Gilson Costa Macedo1, Leonardo Augusto de Almeida1, Fernanda Souza de Oliveira1, Angel Onãte2, Juliana Cassataro3 and 3 Guillermo Hernán Giambartolomei 1Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte-Minas Gerais, Brazil 2Department of Microbiology, Faculty of Biological Sciences, Molecular Immunology Laboratory, Universidad de Concepción, Concepción, Chile 3Instituto de Estudios de la Inmunidad Humoral (CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina Abstract: Brucellosis is an important zoonotic disease of nearly worldwide distribution. This pathogen causes abortion in cattle and undulant fever, arthritis, endocarditis and meningitis in human. The immune response against B. abortus involves innate and adaptive immunity involving antigen-presenting cells, NK cells and CD4+ and CD8+ T cells. IFN- is a crucial immune component that results from Brucella recognition by host immune receptors such as Toll-like receptors (TLRs) that lead to IL-12 production. Although great efforts to elucidate immunity against Brucella have been employed, the subset of cells and factors involved in host immune response remains not completely understood. Our group and others have been working in an attempt to understand the mechanisms involved in innate responses to Brucella. Understanding the requirements for immune protection can help the design of alternative vaccines that would avoid the drawbacks of currently available vaccines to Brucella. This review discusses recent studies in host immunity to Brucella and new approaches for vaccine development. -
Genital Brucella Suis Biovar 2 Infection of Wild Boar (Sus Scrofa) Hunted in Tuscany (Italy)
microorganisms Article Genital Brucella suis Biovar 2 Infection of Wild Boar (Sus scrofa) Hunted in Tuscany (Italy) Giovanni Cilia * , Filippo Fratini , Barbara Turchi, Marta Angelini, Domenico Cerri and Fabrizio Bertelloni Department of Veterinary Science, University of Pisa, Viale delle Piagge 2, 56124 Pisa, Italy; fi[email protected] (F.F.); [email protected] (B.T.); [email protected] (M.A.); [email protected] (D.C.); [email protected] (F.B.) * Correspondence: [email protected] Abstract: Brucellosis is a zoonosis caused by different Brucella species. Wild boar (Sus scrofa) could be infected by some species and represents an important reservoir, especially for B. suis biovar 2. This study aimed to investigate the prevalence of Brucella spp. by serological and molecular assays in wild boar hunted in Tuscany (Italy) during two hunting seasons. From 287 animals, sera, lymph nodes, livers, spleens, and reproductive system organs were collected. Within sera, 16 (5.74%) were positive to both rose bengal test (RBT) and complement fixation test (CFT), with titres ranging from 1:4 to 1:16 (corresponding to 20 and 80 ICFTU/mL, respectively). Brucella spp. DNA was detected in four lymph nodes (1.40%), five epididymides (1.74%), and one fetus pool (2.22%). All positive PCR samples belonged to Brucella suis biovar 2. The results of this investigation confirmed that wild boar represents a host for B. suis biovar. 2 and plays an important role in the epidemiology of brucellosis in central Italy. Additionally, epididymis localization confirms the possible venereal transmission. Citation: Cilia, G.; Fratini, F.; Turchi, B.; Angelini, M.; Cerri, D.; Bertelloni, Keywords: Brucella suis biovar 2; wild boar; surveillance; epidemiology; reproductive system F. -
DIAGNOSIS and TREATMENT of BRUCELLOSIS (Undulant Fever)
DIAGNOSIS AND TREATMENT OF BRUCELLOSIS (Undulant Fever) CHARLES L. HARTSOCK, M.D. Not only the treatment but also the diagnosis of undulant fever are far from being satisfactory, although many types of therapy are being tried and critically evaluated. Because of the tremendous scope of the disease, frequent discussions and reappraisals of our ideas about bru- cellosis will be absolutely essential for some time. Some physicians more or less disregard brucellosis and even scoff at the chronic phase of this new intruder in the realm of human disease. Others are overenthusi- astic and attempt to explain many vague and indefinite problems upon the basis of chronic brucellosis without sufficient evidence. Still other physicians have lost their original enthusiasm and have reverted to the first viewpoint, probably because of the great difficulty in coping with the caprices and vagaries of this disease and the marked uncertainties in diagnosis and treatment. Even though this disease is extremely protean and remarkably bizarre in its manifestations, it is a disease of known causative organism to which the generic term of brucella has been given. The original infection in man was traced to the drinking of goat's milk on the Island of Malta, and for many years this disease was known as Malta fever. Because of the undulating character of the fever with a tendency for remissions and recurrences, it was later called undulant fever which proved to be a very poor description of the febrile reaction in many instances. Brucellosis is the more specific term derived from the organism causing the disease. Three strains of the brucella organism have been isolated and named for their respective hosts: b. -
European Conference on Rare Diseases
EUROPEAN CONFERENCE ON RARE DISEASES Luxembourg 21-22 June 2005 EUROPEAN CONFERENCE ON RARE DISEASES Copyright 2005 © Eurordis For more information: www.eurordis.org Webcast of the conference and abstracts: www.rare-luxembourg2005.org TABLE OF CONTENT_3 ------------------------------------------------- ACKNOWLEDGEMENTS AND CREDITS A specialised clinic for Rare Diseases : the RD TABLE OF CONTENTS Outpatient’s Clinic (RDOC) in Italy …………… 48 ------------------------------------------------- ------------------------------------------------- 4 / RARE, BUT EXISTING The organisers particularly wish to thank ACKNOWLEDGEMENTS AND CREDITS 4.1 No code, no name, no existence …………… 49 ------------------------------------------------- the following persons/organisations/companies 4.2 Why do we need to code rare diseases? … 50 PROGRAMME COMMITTEE for their role : ------------------------------------------------- Members of the Programme Committee ……… 6 5 / RESEARCH AND CARE Conference Programme …………………………… 7 …… HER ROYAL HIGHNESS THE GRAND DUCHESS OF LUXEMBOURG Key features of the conference …………………… 12 5.1 Research for Rare Diseases in the EU 54 • Participants ……………………………………… 12 5.2 Fighting the fragmentation of research …… 55 A multi-disciplinary approach ………………… 55 THE EUROPEAN COMMISSION Funding of the conference ……………………… 14 Transfer of academic research towards • ------------------------------------------------- industrial development ………………………… 60 THE GOVERNEMENT OF LUXEMBOURG Speakers ……………………………………………… 16 Strengthening cooperation between academia -
Acute Brucella Melitensis M16 Infection Model in Mice Treated with Tumor Necrosis Factor-Alpha Inhibitors
Original Article Acute Brucella melitensis M16 infection model in mice treated with tumor necrosis factor-alpha inhibitors Murat Kutlu1, Çağrı Ergin2, Nilay Şen-Türk3, Selda Sayin-Kutlu1, Orçun Zorbozan2, Şerife Akalın1, Barboros Şahin4, Veli Çobankara5, Neşe Demirkan3 1 Department of Infectious Diseases and Clinical Microbiology, Pamukkale University, Faculty of Medicine, Denizli, Turkey 2 Department of Medical Microbiology, Pamukkale University, Faculty of Medicine, Denizli, Turkey 3 Department of Pathology, Pamukkale University, Faculty of Medicine, Denizli, Turkey 4 Animal Research Laboratory, Pamukkale University, Denizli, Turkey 5 Department of Internal Medicine, Section of Rheumatology, Pamukkale University, Faculty of Medicine, Denizli, Turkey Abstract Introduction: There is limited data in the literature about brucellosis related to an intracellular pathogen and anti-tumor necrosis factor alpha (anti-TNFα) medication. The aim of this study was to evaluate acute Brucella infections in mice receiving anti-TNFα drug treatment. Methodology: Anti-TNFα drugs were injected in mice on the first and fifth days of the study, after which the mice were infected with B. melitensis M16 strain. Mice were sacrificed on the fourteenth day after infection. Bacterial loads in the liver and spleen were defined, and histopathological changes were evaluated. Results: Neither the liver nor the spleen showed an increased bacterial load in all anti-TNFα drug groups when compared to a non-treated, infected group. The most significant histopathological findings were neutrophil infiltrations in the red pulp of the spleen and apoptotic cells with hepatocellular pleomorphism in the liver. There was no significant difference among the groups in terms of previously reported histopathological findings, such as extramedullary hematopoiesis and granuloma formation. -
Diseases Transmitted Through the Food Supply
DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Diseases Transmitted through the Food Supply AGENCY: Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS). ACTION: Notice of annual update of list of infectious and communicable diseases that are transmitted through handling the food supply and the methods by which such diseases are transmitted. SUMMARY: Section 103 (d) of the Americans with Disabilities Act of 1990, Public Law 101–336, requires the Secretary to publish a list of infectious and communicable diseases that are transmitted through handling the food supply and to review and update the list annually. The Centers for Disease Control and Prevention (CDC) published a final list on August 16, 1991 (56 FR40897) and updates on September 8, 1992 (57 FR 40917); January 13, 1994 (59 FR 1949); August 15, 1996 (61 FR 42426); September 22, 1997 (62 FR 49518–9); September 15, 1998 (63 FR 49359); September 21, 1999 (64 FR 51127); September 27, 2000 (65 FR 58088); September 10, 2001 (66 FR 47030); September 27, 2002 (67 FR 61109); September 26, 2006 (71 FR 56152); November 17, 2008 (73 FR 67871); and November 29, 2009 (74 FR 61151). The final list has been reviewed in light of new information and has been revised as set forth below. DATES: Effective Date: January 31, 2014. FOR FURTHER INFORMATION CONTACT: Dr. Art Liang, Division of Foodborne Waterborne and Environment Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, NE., Mailstop G–24, Atlanta, Georgia 30333. -
“List of Occupational Diseases” Annexed to the List of Occupational Diseases Recommendation, 2002 (No
MEULOD/2005/1 INTERNATIONAL LABOUR ORGANIZATION Report on the replies to the questionnaire on the updating of the “list of occupational diseases” annexed to the List of Occupational Diseases Recommendation, 2002 (No. 194) and on the amendments to the list of occupational diseases submitted to the Committee on Occupational Accidents and Diseases of the 90th Session of the International Labour Conference in 2002 Working document for the Meeting of Experts on updating the List of Occupational Diseases (Geneva, 13-20 December 2005) InFocus Programme on Safety and Health at Work and the Environment (SafeWork) Geneva, October 2005 INTERNATIONAL LABOUR OFFICE GENEVA MEULOD/2005/1 INTERNATIONAL LABOUR ORGANIZATION Report on the replies to the questionnaire on the updating of the “list of occupational diseases” annexed to the List of Occupational Diseases Recommendation, 2002 (No. 194) and on the amendments to the list of occupational diseases submitted to the Committee on Occupational Accidents and Diseases of the 90th Session of the International Labour Conference in 2002 Working document for the Meeting of Experts on updating the List of Occupational Diseases (Geneva, 13-20 December 2005) InFocus Programme on Safety and Health at Work and the Environment (SafeWork) Geneva, October 2005 INTERNATIONAL LABOUR OFFICE GENEVA Copyright © International Labour Organization 2005 Publications of the International Labour Office enjoy copyright under Protocol 2 of the Universal Copyright Convention. Nevertheless, short excerpts from them may be reproduced without authorization, on condition that the source is indicated. For rights of reproduction or translation, application should be made to the Publications Bureau (Rights and Permissions), International Labour Office, CH-1211 Geneva 22, Switzerland. -
ICD-10 International Statistical Classification of Diseases and Related Health Problems
ICD-10 International Statistical Classification of Diseases and Related Health Problems 10th Revision Volume 2 Instruction manual 2010 Edition WHO Library Cataloguing-in-Publication Data International statistical classification of diseases and related health problems. - 10th revision, edition 2010. 3 v. Contents: v. 1. Tabular list – v. 2. Instruction manual – v. 3. Alphabetical index. 1.Diseases - classification. 2.Classification. 3.Manuals. I.World Health Organization. II.ICD-10. ISBN 978 92 4 154834 2 (NLM classification: WB 15) © World Health Organization 2011 All rights reserved. Publications of the World Health Organization are available on the WHO web site (www.who.int) or can be purchased from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press through the WHO web site (http://www.who.int/about/licensing/copyright_form). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. -
FAQ REGARDING DISEASE REPORTING in MONTANA | Rev
Disease Reporting in Montana: Frequently Asked Questions Title 50 Section 1-202 of the Montana Code Annotated (MCA) outlines the general powers and duties of the Montana Department of Public Health & Human Services (DPHHS). The three primary duties that serve as the foundation for disease reporting in Montana state that DPHHS shall: • Study conditions affecting the citizens of the state by making use of birth, death, and sickness records; • Make investigations, disseminate information, and make recommendations for control of diseases and improvement of public health to persons, groups, or the public; and • Adopt and enforce rules regarding the reporting and control of communicable diseases. In order to meet these obligations, DPHHS works closely with local health jurisdictions to collect and analyze disease reports. Although anyone may report a case of communicable disease, such reports are submitted primarily by health care providers and laboratories. The Administrative Rules of Montana (ARM), Title 37, Chapter 114, Communicable Disease Control, outline the rules for communicable disease control, including disease reporting. Communicable disease surveillance is defined as the ongoing collection, analysis, interpretation, and dissemination of disease data. Accurate and timely disease reporting is the foundation of an effective surveillance program, which is key to applying effective public health interventions to mitigate the impact of disease. What diseases are reportable? A list of reportable diseases is maintained in ARM 37.114.203. The list continues to evolve and is consistent with the Council of State and Territorial Epidemiologists (CSTE) list of Nationally Notifiable Diseases maintained by the Centers for Disease Control and Prevention (CDC). In addition to the named conditions on the list, any occurrence of a case/cases of communicable disease in the 20th edition of the Control of Communicable Diseases Manual with a frequency in excess of normal expectancy or any unusual incident of unexplained illness or death in a human or animal should be reported. -
Optional Ashkenazi Panel Brochure
בס’’ד Fulfilling Our Responsibility To The Next Generation A VITAL PROGRAM THAT SAVES LIVES! The Dor Yeshorim mission: For over 30 years, Dor Yeshorim has successfully prevented the occurrence of genetic diseases in our NOW AVAILABLE: families. Since 1983, Dor Yeshorim with Hashem’s help NEW PANEL OF TESTS has successfully prevented genetic diseases from affecting our Jewish Community by conducting mass screenings in high schools, colleges, universities, FOR SEVEN ADDITIONAL yeshivas and seminaries worldwide- throughout the United States, Israel, Canada, Europe, and countless other orthodox Jewish communities. DEVASTATING AND The Dor Yeshorim genetic screening program was established to provide protection from Jewish genetic diseases, while safeguarding individuals from the potentiallY FatAL psychological stigma associated with knowing their carrier status. DISEASES To date, approximately 375,000 individual genetic screening tests have been performed, and nearly 2,000 potential couples have been spared the List of Diseases: agony of giving birth to a child or children with a 1. Bardet–Biedl Syndrome Type 2 (BBS2) devastating or fatal genetic disease. The birth of a sick child not only impacts the parents of this child 2. Nemaline Myopathy (NM) but also the siblings, grandpare nts and the extended 3. Dihyrolipoamide Dehydrogenase Deficiency (DLDD) family. B’H Dor Yeshorim has been able to spare over 4. Usher Syndrome Type 1 (USH1) 2,000 families the hardships associated with having such a child. 5. Joubert Syndrome (JBTS) DY benefits from