fnins-14-00730 August 4, 2020 Time: 15:39 # 1 ORIGINAL RESEARCH published: 06 August 2020 doi: 10.3389/fnins.2020.00730 Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms Joanna Kowalczyk1,2, Łukasz Kurach2, Anna Boguszewska-Czubara3, Krystyna Skalicka-Wo´zniak4, Marta Kruk-Słomka5, Jacek Kurzepa3, Małgorzata Wydrzynska-Ku´zma5, Grazyna˙ Biała5, Adrianna Skiba4 and Barbara Budzynska´ 2* 1 Chair and Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland, 2 Independent Laboratory of Behavioral Studies, Medical University of Lublin, Lublin, Poland, 3 Chair and Department of Medicinal Chemistry, Medical University of Lublin, Lublin, Poland, 4 Chair and Department of Pharmacognosy with Medicinal Plant Unit, Medical University Edited by: of Lublin, Lublin, Poland, 5 Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Maria Javier Ramirez, Lublin, Poland University of Navarra, Spain Reviewed by: Patrizio Blandina, Bergapten is a furanocoumarin naturally occurring in the Apiaceae family and it is a well- University of Florence, Italy known photosensitizing agent used in photochemotherapy. In this study, we investigated Mariela Fernanda Perez, the influence of bergapten on cognitive function and mechanism underlying these effects National University of Córdoba, Argentina in scopolamine-induced memory impairment in male Swiss mice. The passive avoidance *Correspondence: test was used to evaluate the efficiency of memory acquisition and consolidation. Barbara Budzynska´ The results demonstrated that both single and repeated administration of bergapten
[email protected] improved not only the acquisition but also consolidation of memory. The behavioral Specialty section: tests showed that bergapten prevented memory impairment induced by administration This article was submitted to of scopolamine.