DOCSLIB.ORG

Life Sciences in London and the South East 02–03 Medcity at a Glance: Life Sciences in London and the South East Welcome

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Life Sciences in London and the South East 02–03 Medcity at a Glance: Life Sciences in London and the South East Welcome At a glance Life sciences in London and the south east 02–03 MedCity At a glance: Life sciences in London and the south east Welcome The ‘golden triangle’ is the The golden triangle is being boosted world-leading life sciences cluster further by a wave of significant new of London, Oxford, Cambridge and investment, including: England’s greater south east. The Francis Crick Institute – At a glance: Life sciences in London bringing together 1,500 scientists and the south east has been created under one roof to help you navigate this exciting Imperial West – co-locating ecosystem. It provides a snapshot of researchers and businesses this evolving community, its current on 25 acres strengths and the plans for future UCL East – a cross-discipline investment and growth. enterprise and innovation centre focused on health and biological This cluster is a rich network of technologies on the site of renowned research centres, healthcare Queen Elizabeth Olympic Park providers and medical charities, The Institute of Cancer Research innovative SMEs and large industry – creating the world’s second largest players, all based within a compact and cancer research campus in south London well-connected geographical region. AstraZeneca’s Global R&D Centre – bringing together 2,000 employees in Cambridge This region is a hotbed of innovation, home to: To maximise this wave of new investment four of the world’s top MedCity was launched in April 2014. 10 universities This unique enterprise is your portal to five out of seven of the UK’s the diverse expertise, innovation and academic health science centres infrastructure of the region. Whether you leading medical research are looking for academic, healthcare or institutes including the Wellcome business partners, research infrastructure, Trust, the Medical Research office and incubator space or guidance Council, Cancer Research UK, and through tax and regulatory processes, the national Cell Therapy Catapult, MedCity is here to help. focusing on stem cell research Imperial West, co-locating world-class researchers, and industrialisation. medcitylondon.com businesses and higher education partners. +44 (0)20 7691 3588 04–05 MedCity 09 24 At a glance: Life sciences in London and the south east 115 CAMBRIDGE 88 16 91 64 39 67 118 36 Ipswich Stratford Camden Hackney Community 113 103 65 66 112 Hoxton M1 M11 Colchester 72 41 82 King’s Cross 89 17 Luton 117 57 76 10 8 115 106 58 56 116 93 45 07 95 35 59 10 4 38 The City OXFORD 23 18 97 15 114 71 10 5 37 98 92 51 29 80 M40 M25 Paddington 44 83 Whitechapel 10 0 Notting Hill 11 50 19 Mayfair 120 101 63 84 05 34 20 48 Westminster 90 102 119 08 79 10 28 122 87 Swindon 54 Kensington Canary Wharf 42 99 46 Waterloo 73 22 04 06 26 49 32 40 47 74 Bermondsey Hammersmith 94 M4 Reading 85 43 21 86 55 01 33 121 75 110 25 27 109 53 14 LONDON 02 Chelsea 111 60 12 13 81 31 Canterbury 68 52 61 Guildford 70 M25 M20 M3 30 78 62 Dover Fulham 96 03 77 69 Hastings 107 Southampton Brighton Portsmouth Commercial/R&D/Manufacturing Academic/Healthcare Agency 01–05 Abbott 33 Chugai Pharma 54 London East 82 Stevenage Biocatalyst 88 Cambridge University 98 Imperial College 109 –111 The Institute of 119 European Medicines 06 Abbvie 34 Daiichi Sankyo Science Park 83–84 Takeda Health Partners Academic Health Cancer Research Agency 07 Abcodia 35 Eisai 55 Merck Serono 85 UCB 89 Cancer Research UK Science Centre 112 The Royal 12 0 Medical Research 08 Allergan 36–37 Genzyme 56 Mitsubishi 86 UK BioIndustry 90 Cell Therapy Catapult 99 Imperial College London Veterinary College Council 09–11 Amgen 38–40 Gilead Sciences Tanabe Pharma Association 91 Genomic Medicine 100 Imperial West 113 UCL East 121 Medicines and 12 Association of the 41–43 GlaxoSmithKline 57 MRC Technology 87 Verona Pharma Centre East of England 101 King’s College London 114 UCLPartners Healthcare Products British Healthcare 44 GW Pharmaceuticals 58–59 MSD 92 Genomic Medicine 102 King’s Health Partners 115 University College Regulatory Agency Industries 45 Immodulon 60–61 Novartis Centre Imperial College 103 London BioScience London 122 National Institute for 13 Association of the Therapeutics 62 Novo Nordisk Health Partners Innovation Centre 115 University of Health Research British Pharmaceutical 46 ImmuPharma 63 OBN 93 Genomic Medicine 104 London School of Cambridge Industry 47 Imperial College 64 One Nucleus Centre Oxford Hygiene and 116 University of Oxford 14 Astellas Bio Incubator 65–70 Pfizer 94 Genomic Medicine Tropical Medicine 117 Wellcome Trust 15–17 AstraZeneca 48 Imperial College 71 Queen Mary Centre South London 105 Oxford Academic Health 118 Wellcome Trust 18–23 Baxter ThinkSpace Bio Enterprises 95 Genomic Medicine Science Centre Sanger Institute 24–25 Bayer 49 Ipsen 72–75 Quintiles Centre UCLPartners 106 Queen Mary University 26 Biogen Idec 50 Janssen 76–77 Roche 96 Genomic Medicine of London 27 Boehringer Ingelheim 51 Johnson & Johnson 78 Sanofi Centre Wessex 107 St. George’s, 28 Bristol-Myers Squibb Innovation Centre 79 Servier 97 Imanova University of London 29–31 BTG 52–53 Lilly 80 Shionogi Limited 108 The Francis Crick 32 Celgene 81 Shire Institute 06–07 MedCity At a glance: Life sciences in London and the south east A world-class centre Leading the for clinical research genomics revolution London is home to a highly diverse Clinical research within the National Launched in 2012, the UK-wide 100,000 Eleven genomic medicine centres have population supported by a large single Health Service is supported by the Genomes Project will sequence 100,000 now been set up to support the project, healthcare system that maintains National Institute for Health Research, genomes in four years; an immensely including five in London, Oxford and extensive patient records – over eight which provides: ambitious project that has never been done Cambridge. They are recruiting people million patients use the NHS in the on this scale anywhere in the world. with cancer or rare diseases and their a single point of contact for capital, over a third of whom were born families to take part in a project that industry studies outside the UK. By providing better insight into the will bring benefit to patients for years centralised and coordinated causes of diseases and how diseases to come. study feasibility assessment This concentration of diverse patient develop in each individual, genomics support with patient recruitment. groups in a small geography makes can be used to make medicine more genomicsengland.co.uk it easier and faster to set up complex It also runs the Coordinated System for tailored and personalised, minimising trials, and identify and recruit the right gaining NHS Permission (CSP), which unwanted side effects. patient groups working across primary streamlines the process of gaining care, general hospital and specialist permission to carry out clinical trials clinical services. within the NHS. 08–09 MedCity At a glance: Life sciences in London and the south east Financial strength Abcodia and the world’s largest clinical trial Case study The UK biotechnology, healthcare Over the past five years, the FTSE and life sciences industries offer a Healthcare Indices have significantly wide range of investment opportunities outperformed others, with the FTSE with diverse business models. All Share Healthcare Index rising by 10% in 2014, compared to a 3% drop 2014 saw robust levels of public market for the FTSE All Share. activity in healthcare, with £1.25bn ($1.9bn) raised in life sciences IPOs The UK has the largest pipeline of new and follow on offerings on the London pharmaceutical product candidates in Stock Exchange. Europe, with over 460 in 2013. University College London The trial also generated a biobank of spin-out Abcodia is commercialising 5.5 million serum samples that can technology licensed from be used to develop and test other Massachusetts General Hospital to diagnostics for early detection of develop the world’s first ovarian cancer cancer and other diseases of aging. diagnostic with accuracy high enough The serum is stored in the UK by to be applied to population screening. ThermoFisher. The test defines what a woman’s The clinical trial will report this healthy level of CA125, a substance in year. Results indicate that this test the blood, should be and detects the has huge potential to enable early rise early should ovarian cancer start diagnosis at a stage when women to develop. It has been validated in the are not showing any symptoms of the world’s largest prospective clinical trial, disease, hopefully leading to improved which recruited over 202,000 women survival rates. over 10 years and is managed by University College London. 10 –11 MedCity At a glance: Life sciences in London and the south east Pfizer and the rare Useful contacts diseases consortium Case study London & Partners Healthcare centres Clinical trials support London & Partners are the Cambridge University National Institute for experts on doing business Health Partners Health Research in London, helping overseas cuhp.org.uk nihr.ac.uk businesses set up and grow in the capital. Imperial College Academic Membership organisations Health Science Centre +44 (0)20 7234 5800 ahsc.org.uk BioIndustry Association [email protected] bioindustry.org invest.london King’s Health Partners @L_PBusiness kingshealthpartners.org OBN obn.org.uk Academic centres Oxford Academic Health Science Network One Nucleus University of Cambridge oxfordahsn.org onenucleus.com cam.ac.uk UCLPartners Imperial College London uclpartners.com imperial.ac.uk Research institutes King’s College London kcl.ac.uk Cell Therapy Catapult Better therapies for rare diseases are Analysis of patients’ genomes allows ct.catapult.org.uk the target of a consortium made up researchers to identify the pathways University of Oxford of Pfizer, the University of Cambridge, that cause disease, enabling the ox.ac.uk Francis Crick Institute crick.ac.uk Imperial College London, King’s targeted design of new treatments.
Load more

Recommended publications
  • Biology Powerhouse Raises Railway Alarm
    NEWS IN FOCUS to enrol all participants by 2018. Certain factors make researchers optimis- tic that the British study will succeed where the US one failed. One is the National Health Service, which provides care for almost all pregnant women and their children in the United Kingdom, and so offers a centralized means of recruiting, tracing and collecting medical information on study participants. In the United States, by contrast, medical care is provided by a patchwork of differ- ent providers. “I think that most researchers in the US recognize that our way of doing population-based research here is simply different from the way things can be done in the UK and in Europe, and it will almost always be more expensive here,” says Mark Klebanoff, a paediatric epidemiologist at Nationwide Children’s Hospital in Colum- bus, Ohio, who was involved in early dis- cussions about the US study. The Francis Crick Institute sits at the nexus of three central London railway hubs. At one stage, US researchers had planned to knock on doors of random houses looking URBAN SCIENCE for women to enrol before they were even pregnant. “It became obvious that that wasn’t going to be a winning formula,” says Philip Pizzo, a paediatrician at Stanford University Biology powerhouse in Palo Alto, California, who co-chaired the working group that concluded that the National Children’s Study was not feasible. raises railway alarm “The very notion that someone was going to show up on your doorstep as a representa- tive from a govern­ment-funded study and Central London’s Francis Crick Institute fears that proposed say ‘Are you thinking of getting pregnant?’ train line will disrupt delicate science experiments.
    [Show full text]
  • Bloomsbury Scientists Ii Iii
    i Bloomsbury Scientists ii iii Bloomsbury Scientists Science and Art in the Wake of Darwin Michael Boulter iv First published in 2017 by UCL Press University College London Gower Street London WC1E 6BT Available to download free: www.ucl.ac.uk/ ucl- press Text © Michael Boulter, 2017 Images courtesy of Michael Boulter, 2017 A CIP catalogue record for this book is available from the British Library. This book is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Attribution should include the following information: Michael Boulter, Bloomsbury Scientists. London, UCL Press, 2017. https://doi.org/10.14324/111.9781787350045 Further details about Creative Commons licenses are available at http://creativecommons.org/licenses/ ISBN: 978- 1- 78735- 006- 9 (hbk) ISBN: 978- 1- 78735- 005- 2 (pbk) ISBN: 978- 1- 78735- 004- 5 (PDF) ISBN: 978- 1- 78735- 007- 6 (epub) ISBN: 978- 1- 78735- 008- 3 (mobi) ISBN: 978- 1- 78735- 009- 0 (html) DOI: https:// doi.org/ 10.14324/ 111.9781787350045 v In memory of W. G. Chaloner FRS, 1928– 2016, lecturer in palaeobotany at UCL, 1956– 72 vi vii Acknowledgements My old writing style was strongly controlled by the measured precision of my scientific discipline, evolutionary biology. It was a habit that I tried to break while working on this project, with its speculations and opinions, let alone dubious data. But my old practices of scientific rigour intentionally stopped personalities and feeling showing through.
    [Show full text]
  • Stem Strategy
    SUCCESS THROUGH STEM STEM STRATEGY In response to the ‘Report of the STEM Review’ HELPING TO EMPOWER FUTURE GENERATIONS THROUGH SCIENCE, TECHNOLOGY, ENGINEERING AND MATHEMATICS TO GROW A DYNAMIC, INNOVATIVE ECONOMY 2011 CONTENTS 1. INTRODUCTION 4 2. CONTEXT 5 3. THE ROLE OF THE DEMAND SIDE 8 4. THE ROLE OF THE SUPPLY SIDE 10 5. RECOMMENDATIONS FOR ACTION 15 6. STRUCTURES FOR IMPLEMENTATION 23 7. CONCLUSION AND PRIORITY ACTIONS 25 ANNEX A – Existing Government STEM Activity ANNEX B – Government STEM Action Plan 1. INTRODUCTION Commissioned by the Department for Employment The Report contains 20 recommendations grouped and Learning (DEL) and the Department of Education under four ‘imperatives’. (DE), the review of Science, Technology, Engineering • Imperative 1 - Business must take the lead and Mathematics (STEM) commenced formally on in promoting STEM. 29 June 2007. Chaired by Dr Hugh Cormican, founder and former Chief Executive of Andor Technologies • Imperative 2 - The key constraints in the STEM Ltd., the steering group comprised representatives artery must be alleviated. from business, government and academia and the Programme Manager for the review was Dr Alan Blair, • Imperative 3 - There needs to be increased from the Association of NI Colleges (now Colleges NI). flexibility in the provision of STEM education. Three working groups reported to the steering group, • Imperative 4 - Government must better each of which was responsible for taking forward a coordinate its support for STEM. key strand of the Review. These working groups ensured This STEM Strategy forms Government’s response a focus on the respective roles of business, education, to the ‘Report of the STEM Review’.
    [Show full text]
  • Jeremy Farrar
    FEATURE The BMJ THE BMJ INTERVIEW BMJ: first published as 10.1136/bmj.n459 on 19 February 2021. Downloaded from [email protected] Cite this as: BMJ 2021;372:n459 http://dx.doi.org/10.1136/bmj.n459 Jeremy Farrar: Make vaccine available to other countries as soon as Published: 19 February 2021 our most vulnerable people have received it The SAGE adviser and Wellcome Trust director tells Mun-Keat Looi how the UK government acted too slowly against the pandemic, about the perils of vaccine nationalism, and why he is bullish about controlling covid variants Mun-Keat Looi international features editor “Once the UK has vaccinated our most vulnerable among healthcare workers. We had no human communities and healthcare workers we should make immunity, no diagnostics, no treatment, and no vaccines available to other countries,” insists the vaccines. infectious disease expert Jeremy Farrar. This could Every country should have acted then. Singapore, avert further public health and economic disaster, China, and South Korea did. Yet most of Europe and he says, describing it as “enlightened self-interest, North America waited until the middle of March, and as well as the right ethical thing to do.” that defined the first wave. Countries including the In April 2020, soon after the first UK lockdown began, UK were unwilling to act early, before they felt Farrar predicted that the UK would have one of the comfortable; were unwilling to go deeper than they worst covid-19 death rates in Europe. As a member thought they had to; and were unwilling to keep of the Scientific Advisory Group for Emergencies restrictions in place for as long as was needed.
    [Show full text]
  • Programme Final (1).Pages
    BSHS Postgraduate Conference 2015 Programme !1 The British Society for the History of Science is a company limited by guarantee: registration number 562208 and charity number 258854. BSHS Executive Secretary PO Box 3401, Norwich NR7 7JF (+44) 01603516236 Email: offi[email protected] Webpage: www.bshs.org.uk © 2014, British Society for the History of Science !2 BSHS POSTGRADUATE CONFERENCE UCL Department of Science and Technology Studies 7 – 8 – 9 JANUARY 2015 The Department of Science and Technology Studies at University College London welcomes you to the BSHS Postgraduate Conference 2015! This event is an annual conference for postgraduate scholars in the history, philosophy and sociology of science, technology and medicine interested in meeting and sharing research with other postgraduate scholars. This is a great opportunity to build professional and social networks within a supportive and constructive environment. We had an outstanding response for paper submissions and postgraduate attendance, and we are looking forward to an extraordinary conference this year. Thank you for your contribution! Sincerely, BSHS Postgraduate Conference 2015 Committee Elizabeth Jones Raquel Velho Erman Sozudogru !3 " !4 Blue: Grey: Yellow: Grant Museum of Zoology UCL Roberts Building Holiday Inn Bloomsbury 21 University Street Torrington Place Coram Street London WC1E 6DE London WC1E 7JE London WC1N 1HT CONFERENCE INFORMATION Webpage: http://www.bshs.org.uk/conferences/postgraduate-conference/2015- postgraduate-conference-ucl Facebook: https://www.facebook.com/BSHS.PG.15
    [Show full text]
  • Uclpartners Academic Health Science Partnership
    UCLPartners academic health science partnership Professor the Lord Ajay Kakkar, Chair, UCLPartners Professor Sir David Fish, Managing Director, UCLPartners Dr Charlie Davie, Director of UCLPartners AHSN Clare Panniker, Chief Executive, Basildon and Thurrock University Hospitals NHS Foundation Trust What is UCLPartners? Six million population 23 healthcare organisations acute and 11 higher education institutes mental health trusts; community providers and research networks 20 Clinical Commissioning Groups (CCGs) Industry partnerships in research and 26 boroughs and local councils translation of innovation into health and wealth 2 Local Enterprise Partnership – key challenge • Working with the London Enterprise Panel, established by the Mayor of London • Professor Stephen Caddick, Vice Provost (Enterprise), UCL, is the only academic representative on the Panel • Key challenges of the panel: to compete with Boston and San Francisco; improve access to the NHS market to increase venture capital • How UCLPartners is contributing: working with industry to co-create technology and devices; creating long-term partnerships with industry and giving confidence to entrepreneurs, e.g. through new business models and procurement initiatives • Other areas of joint working: MedCity, Care City, London Health Commission, three London AHSNs and preparing to enable the success of the Francis Crick Institute 3 Defragmenting the pathway – an integrated journey to transform healthcare through innovation into practice Bringing together formal designations under
    [Show full text]
  • London: an Innovation Hub for Health & Life Sciences Through
    LONDON: AN INNOVATION HUB FOR HEALTH & LIFE SCIENCES THROUGH THE APPLICATION OF DATA AND AI SUPPORTED BY Next page Access the market: 19 from NHS to Biopharma CONTENTS Foreword 3 The NHS adoption of AI technologies 20 This is an interactive guide, London’s key strengths 4 l Spotlight on UCLPartners 21 so click on the title to jump to any section. An Innovative Biopharma Cluster 22 An ecosystem built for growth 5 l Case study - MultiplAI 23 Access to funding 6 Government support 7 An accessible, diverse 24 l Case study - Kheiron Medical 9 and data-rich environment Diverse population and data 24 London’s life sciences clusters 10 Partner with the Health Data 25 The Knowledge Quarter 11 Research Hubs Whitechapel: Barts Life Sciences Hub 12 l Spotlight on DATA-CAN HDR 26 White City Innovation District 13 Southbank to Sutton 14 London’s resilient COVID-19 response 27 l Case study - InstaDeep 28 Talent and educational excellence 15 Existing talent 16 How can we help 29 The next generation 17 How London & Partners can support 29 l Case study - PEP Health 18 How MedCity can support 29 2 Contents page FOREWORD COVID-19 has accelerated data-driven innovation across often siloed organisations. Similarly, policy is being the globe, with artificial intelligence and data science at developed to overcome legacy systems and regulations, the forefront of addressing human disease and health. which will underpin and speed up innovations. The coronavirus pandemic has led to increased acceptance of new technologies with strong buy-in from all corners Not only can bioinformatics and use of healthcare Allen Simpson Neelam Patel data lead to better health systems and outcomes, this of the life sciences and healthcare sector determined to CEO also has the potential to create many new jobs Acting CEO keep this momentum going.
    [Show full text]
  • Evidence Synthesis on the EU-UK Relationship on Research and Innovation January 2018
    Evidence synthesis on the EU-UK relationship on research and innovation January 2018 1. Introduction The Royal Society and the Wellcome Trust have undertaken a rapid evidence synthesis on the EU-UK research and innovation relationship as part of their Future Partnership Project. Organisations and individuals were invited to submit evidence and analyses for inclusion. Evidence was also gathered through internet searches to ensure an inclusive approach. The Annex is a summary of the methods. Two questions were used in gathering evidence and in determining the material in scope: 1. What incentives, infrastructure and mechanisms can be accessed by research and innovation organisations, funders and individuals in Member States to support collaborations? 2. How do Member States currently use and benefit from these and how might they be affected by Brexit? This paper is a synthesis of the evidence and covers funding, infrastructures, mobility, collaboration and regulation, with a focus on links between the EU and the UK. 2. Overview of the evidence base A few major reports were of particular relevance; the Royal Society’s three reports on the role of the EU in UK research and innovation and two reports commissioned from Technopolis Group by UK organisations, on the role of EU funding in UK research and innovation and the impact of collaboration: the value of UK medical research to EU science and health1,2. These documents were often referenced in other submissions. A report from the Lords Science and Technology Committee’s inquiry on EU Membership and UK Science also summarises many sources of evidence relevant to this synthesis.
    [Show full text]
  • 2021 Phd Projects and Supervisory Teams Doctoral Fellowships for Clinicians
    2021 PhD projects and supervisory teams Doctoral Fellowships for Clinicians The role of “persistent PAMPs” in the cytokine storm and ARDS during severe COVID-19 and highly pathogenic influenza infection. Supervisory team: David Bauer (primary supervisor, Crick) and Mahdad Noursadeghi (UCL). Inflammation associated with SARS-CoV-2 infection. Supervisory team: Rupert Beale (primary supervisor, Crick) and Wendy Barclay (Imperial College London) Effect of acute myeloid leukaemia on normal haematopoiesis. Supervisory team: Dominique Bonnet (primary supervisor, Crick) and David Taussig (The Institute of Cancer Research, Royal Marsden) Investigation and modelling of multiple myeloma pathogenetic evolution. Supervisory team: Dinis Calado (primary supervisor, Crick), Richard Houlston (The Institute of Cancer Research) and Martin Kaiser (The Institute of Cancer Research, Royal Marsden) TGF-b family ligands as potential therapeutic targets in pancreatic cancer. Supervisory team: Caroline Hill (primary supervisor, Crick) and Debashis Sarker (King’s College London) Development of multisynaptic tracing technologies to target and manipulate disease- relevant neural circuits. Supervisory team: Johannes Kohl (primary supervisor, Crick), Andrew Murray (UCL) and Rickie Patani (Crick/UCL) Human Cell Atlas: single-cell transcriptomics of vitiligo. Supervisory team: Nicholas Luscombe (primary supervisor, Crick), Magnus Lynch (King’s College London) and John Ferguson (King’s College London) Structural and biochemical analysis of Salmonella effector functions and their interaction with host proteins. Supervisory team: Katrin Rittinger (primary supervisor, Crick), Teresa Thurston (Imperial College London) and Rupert Beale (Crick) Developing new viral vectors for in vivo gene therapy. Supervisory team: Sam Rodriques (primary supervisor, Crick), Matthew Walker (UCL) and Rob Brownstone (UCL) Identifying and functionally characterising non-coding drivers of renal cancer evolution.
    [Show full text]
  • Janet Thornton / 19 July 2018
    Oral History: Janet Thornton / 19 July 2018 DISCLAIMER The information contained in this transcript is a textual representation of the recoded interview which took place on 2018-07-19 as part of the Oral Histories programme of the EMBL Archive. It is an unedited, verbatim transcript of this recorded interview. This transcript is made available by the EMBL Archive for free reuse for research and personal purposes, providing they are suitably referenced. Please contact the EMBL Archive ([email protected]) for further information and if you are interested in using material for publication purposes. Some information contained herein may be work product of the interviewee and/or private conversation among participants. The views expressed herein are solely those of the interviewee in his private capacity and do not necessary reflect the views of the EMBL. EMBL reserves the right not to be responsible for the topicality, accuracy, completeness or quality of the information provided. Liability claims regarding damage caused by the use of any information provided, including any kind of information which is incomplete or incorrect, will therefore be rejected. 2 2018_07_19_JanetThornton Key MG: Mark Green, former head of Administration at EMBL-EBI JT: Participant, Janet Thornton, former Director of EMBL-EBI and current EMBL-EBI Research Group Leader [??? At XX:XX] = inaudible word or section at this time MG: My name is Mark Green. This is Thursday 19th July 2018 and I’m in the Pompeian Room in Hinxton Hall on the Wellcome Genome Campus where EMBL-EBI is based and I’m about to do an interview as part of the oral histories programme of the EMBL Archive, with Janet Thornton, and I’d just like to ask Janet to introduce herself and to say a bit about her life before EMBL.
    [Show full text]
  • Applying Polygenic Risk Scoring for Psychiatric Disorders to a Large
    http://www.diva-portal.org This is the published version of a paper published in . Citation for the original published paper (version of record): de Jong, S., Abdalla Diniz, M J., Saloma, A., Gadelha, A., Santoro, M L. et al. (2018) Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder Communications Biology, 1: 163 https://doi.org/10.1038/s42003-018-0155-y Access to the published version may require subscription. N.B. When citing this work, cite the original published paper. Permanent link to this version: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-157800 ARTICLE DOI: 10.1038/s42003-018-0155-y OPEN Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder Simone de Jong1,2, Mateus Jose Abdalla Diniz3,4, Andiara Saloma3,4, Ary Gadelha3, Marcos L. Santoro5, 1234567890():,; Vanessa K. Ota3,5, Cristiano Noto3, Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium#, Charles Curtis1,2, Stephen J. Newhouse2,6,7, Hamel Patel2,6, Lynsey S. Hall8, Paul F. O`Reilly1, Sintia I. Belangero3,5, Rodrigo A. Bressan3 & Gerome Breen 1,2 Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder.
    [Show full text]
  • Francis Crick Institute-CS-JB080719.Indd
    The Francis Crick Institute THE FRANCIS CRICK INSTITUTE The Crick is a landmark partnership between three of the UK’s largest funders of biomedical research: the Medical Research Council, Cancer Research UK and the Wellcome Trust, and three of its leading universities: UCL, Imperial College London and King’s College London. This represents an unprecedented joining of forces to tackle major scientific problems and generate solutions to the emerging health challenges of the 21st century. Business Challenge: The VIRTUS Solution: The Crick is being built in central London, where space is at a Collaboration is at the heart of the Crick’s vision. Its work premium. It was decided, early in the planning process, that will help to understand why disease develops and to find most of the Crick’s data would need to be stored off-site. new ways to diagnose, prevent and treat a range of illnesses However, the institute realised there were major benefits to – such as cancer, heart disease and stroke, infections and sharing resources with other institutions, particularly in terms neurodegenerative diseases. The Crick will bring together of scientific analysis. As the Crick’s plans developed, a number outstanding scientists from all disciplines, carrying out research of institutions – both within the original partners and more that will help improve the health and quality of people’s lives, broadly - had similar requirements and identified the same and keeping the UK at the forefront of medical innovation. potential for collaboration in having a colocated shared data centre. “The Crick has been proud to take a leading role in support of Janet.
    [Show full text]