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INDEX 6 1. Presentation 125 NEC.11 Neural Plasticity 10 2. Research Structure 126 NEC.12 Pharmacology on Neurosecretion (FARMASER) 12 3. Main Figures of IdISSC Activity 128 NEC.13 Neurotransmission and Purinergic Signaling 16 4. Human Resources 130 NEC.14 DEDINUC. Degeneration and Differentiation 18 5. Research Projects through Nucleotides 20 6. Networks and Alliances 132 NEC.17 Neurobiology of Hearing 21 7. Economic Activity 133 NEC.18 Research in Ocular Pathology and Visual Pathways 22 8. Bibliometric Analysis 140 NEC.20 Neurotransmission and Neuromodulation 26 9. Other Scientific Activities in the Central and Peripheral Nervous System 27 10. Technology Transfer 142 NEC.21 Pharmaceutical Innovation in Ophthalmology 29 11. Scientific Dissemination Activities 145 NEC.22 Pathophysiology and INA Neurological Therapeutics (NEURO-INA-IN) CARDIOVASCULAR AREA (CV) ONCOLOGY AREA (ONC) 33 CV.1 Technology Assessment and Therapeutic Strategies in Coronary Arteriosclerosis 151 ONC.1 Clinical and Translational Research in Oncology 41 CV.2 Cardiovascular Imaging 173 ONC.2 Cancer and Obesity 176 ONC.3 Pathological Anatomy 44 CV.4 Arrhythmia 179 ONC.4 Cell Signaling Mechanisms during Development 48 CV.6 Cardiovascular Research Unit and Tumor Progression 51 CV.7 ValvularPathology and Large Vessels 181 ONC.5 Cannabinoid Signaling in Tumor Cells 53 CV.8 Translational Research in Acute Myocardial Syndromes (INTEGRA) 183 ONC.6 “Women’s Health Research Group” 60 CV.10 Myocardial Regeneration Therapy OTHER LARGE SYSTEMS AREA (OGS) 65 CV.11 Cardiovascular Risk 67 CV.12 Vascular Biology 189 OGS.1 Brain Glucose Sensors, Control of Satiety, Obesity and Type 2 Diabetes INFLAMMATION, INFECTION, 191 OGS.5 Sports Medicine IMMUNITY AND ALLERGY AREA (IIIA) 193 OGS.6 Diabetes and Cardiovascular 73 IIIA.1 Allergy 194 OGS.9 Endocrinology of Metabolic Diseases 76 IIIA.2 Immunology 197 OGS.10 Nutrition, Obesity and Vascular Risk 79 IIIA.3 Musculoskeletal Pathology 200 OGS.12 Clinical Pharmacology 83 IIIA.6 Research on Sexually Transmitted Diseases 203 OGS.13 Innovation and surgery and HIV 207 OGS.14 Medical Physics 86 IIIA.7 Molecular and Epidemiological Study 209 OGS.15 Aging of Resistant Microorganisms of Clinical Interest 211 OGS.16 Diabetes Mellitus / Obesity 89 IIIA.08 Kidney transplant 213 OGS.17 Biomedical Imaging Research 91 IIIA.09 Infectious Diseases/HIV 215 OGS.18 Health Care Research 94 IIIA.10 Research on INA Infectious Disease 217 OGS.19 Epidemiology and Health Services 97 IIIA.11 Cell-biomaterial Interactions (BIO UCM) 222 OGS.20 Prevention of Occupational Hazards 224 OGS.21 Research in Urology. Cancer and New Therapies NEUROSCIENCE AREA (NEC) 226 OGS.22 Research in Physiotherapy 103 NEC.1 Clinical and Neurobiological Research 228 OGS.23 The Digestive System in Psychiatry and Mental Health 232 OGS.24 Hematology 105 NEC.2 Advanced Research in Personality Disorders, 236 OGS.25 Pathology of Emergency Aggression and Impulse Control 243 OGS.27 The Interdisciplinary Study Group 107 NEC.3 Psychoneuroendocrinology, Molecular of Diabetic Foot Neuroimaging and Genetics 245 OGS.29 Socioeconomic Health Determinants in Neuropsychiatric Diseases 247 OGS.30 AFUSAN 109 NEC.5 Applied Research in Neuroscience 250 OGS.31 Hematology: Megakaryopoiesis and Platelets (to: Neuromodulation and Neurorepair) 252 OGS.32 Forensic Science: Forensic Genetics and Toxicology 113 NEC.6 Neurological Diseases 121 NEC.7 Multiple Sclerosis 254 Appendix I 123 NEC.9 Brain Mapping 262 Appendix II Launched in 2012, the IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) tries to accelerate scientific progress by advancing basic, translational, and clinical research across five areas of biomedical study: Cardiovascular; Oncology; Neuroscience; Inflammation, Infection, Immunity and Allergy; and Other Large Systems. Regardless of where IdISSC investigators land on this spectrum, they wish to improve human health. We invite you to learn about their research activity, always striving to make a difference surmounting tough financial times. IdISSC belongs to the nation’s foremost biomedical research institution, and during this year a rigorous external review was followed to remain an accredited Research Institute. After an extensive analysis conducted by IdISSC investigators, a new strategic plan identified the opportunities for the future and defined the long-term vision for the institute. These opportunities were chosen based on their potential to transform the healthcare field, and taking advantage of the diversity of resources, infrastructure, and scientific expertise. The unique environment of IdISSC, with the Hospital Clínico San Carlos in the Complutense University campus, facilitates high-impact science that would otherwise be difficult to undertake. In 2017 IdISSC was responsible for many scientific accomplishments which are summarized in this annual report. With 797 investigators conducting translational research, IdISSC was leader on a wide array of health projects to pursue the treatment, prevention, diagnosis, and understanding of human disease. Competitive selection ensured that only the most outstanding research obtained funding, and so 31 national and 5 international competitive projects began during 2017. The workforces of the research groups were organized around common goals and approaches devoted to reach their aims. In 2017 over 560 clinical studies were opened at the IdISSC, where the proximity of labs, equipment, and patient care units was expected to rapidly move biomedical laboratory findings into the clinic. The knowledge and experience of the researchers have lend a total of 728 scientific articles and reviews, with near 20% of them in the first deciles of the specific areas evidencing the quality and value of the research being performed. IdISSC investigators work in research networks that involve collaboration to improve results; different groups participate in RETICs and CIBERs (dealing with ophthalmology, multiple sclerosis, oncology, mental health, or diabetes and endocrinology diseases, to name a few), as well as in international consortia. IdISSC aims to facilitate partnerships, with researches focused on an area of expertise, but encouraged to collaborate across disciplines so that they can study health questions holistically. As a way to foster the exchange of ideas and opinions among scientists, the IdISSC seminars allow them to identify potential collaborators whose interests and skills complement their own. IdISSC supported core facilities, which provided investigators with access to platforms and services that would be difficult to host in individual laboratories, among them nationwide platforms such as Biobank, the Innovation Unit included in ITEMAS to leverage technology transfer, and SCReN, a clinical trial network headed by IdISSC. The Metagenomics Unit opened in 2017 in complying with the regulatory requirements for a clinical laboratory, shaping the basis of modern medicine. Since its inception IdISSC has led scientific breakthroughs. Its researchers at the forefront of scientific discovery work on a daily basis pushing the boundaries of knowledge. Results shown in this annual report attest how their joint effort make this goal a reality. Elena Urcelay Elena Urcelay García Antonio Portolés Pérez José Soto Bonel Scientific Director (IdISSC) Director (FIB HCSC) President (FIB HCSC) SCIENTIFIC REPORT 2017 1. Presentation IdISSC Organizational Chart and Research Structure The Health Research Institute of the Hospital Clínico San Carlos in Madrid was created with the intention of promoting research and planning the scientific activity in line with the areas defined in the strategic plan. It consists of the following entities Its mission is to promote and consolidate the activities of biomedical research from groups within the Institute, building an organiza- tion of excellence for the generation of scientific knowledge, oriented to health care practice, and thus, improving the citizens health through the interrelation of basic and clinical research, integration of resources, the encouraging of innovation and internationali- zation, as well as the empowerment and recognition of researchers and support staff, all underpinned by a dynamic management, based on continuous improvement and learning. Its vision is to be an organization of scientific excellence with international visibility, conducting network research, and with a com- mitment to innovation and technological advance through the development of a sustainable research and the promotion of gender equality and internationalization. The values of the Health Research Institute of the Hospital Clínico are: accessibility, transparency, dedication to service and respect. Moreover, the groups of interest are the citizens, researchers, participating institutions, funding agencies and entities providing services. 6 IdISSC Scientific Report 2017 SCIENTIFIC REPORT 2017 MANAGEMENT BODY GOVERNMENT BODIES CONSULTING BODIES OTHER BODIES Management Body External Scientific Ethical Committee Governing Council (FIBHCSC) Committee in Clinical Research Ethical Committee in Animal Executive Committee Experimentation SCIENTIFIC DIRECTION BODY Scientific Direction Research Committee Research Areas Inflammation, Infection, Other Large Cardiovascular Neuroscience Oncology Inmunity and Allergy Systems Core Facilities: Transversal Support Units Government Bodies GOVERNING COUNCIL Manuel Molina Muñoz Full position at SERMAS Ignacio Lizasoain Hernández President of the Universidad Complutense de