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Pulmonary Hypertension Post Liver-Kidney Transplant

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Pulmonary Hypertension Post Liver-Kidney Transplant CONTRIBUTION Pulmonary Hypertension Post Liver-Kidney Transplant HAFIZ IMRAN, MD; MATTHEW JANKOWICH, MD; GAURAV CHOUDHARY, MD 23 26 EN ABSTRACT pulmonary pressures on echocardiogram 9 months after Porto-pulmonary hypertension has been recently rec- simultaneous liver-kidney transplants. The patient received ognized in patients post-liver transplantation with or deceased donor simultaneous liver-kidney transplants for without pre-transplant hepatopulmonary syndrome. We liver cirrhosis (secondary to chronic hepatitis C infection present a unique case of pulmonary hypertension in a and alcohol use) and end-stage renal disease (secondary to 65-year-old patient after simultaneous liver-kidney trans- diabetic nephropathy). The patient’s medical history was sig- plantation for cirrhosis secondary to chronic hepatitis C nificant for systemic hypertension, diabetes mellitus with infection and alcohol use disorder and end-stage renal diabetic nephropathy and neuropathy and permanent atrial disease secondary to diabetic nephropathy. He presented fibrillation. The patient had quit drinking and smoking 8 to pulmonary hypertension clinic with progressive short- years ago after 50-pack years and had denied any illicit sub- ness of breath and elevated right-sided pulmonary pres- stance use since then. His pre-transplant course was compli- sures on echocardiogram. He did not have pre-transplant cated by portal hypertension, ascites and variceal bleeding hepatopulmonary syndrome and his post-transplant liver requiring band ligation and hepatocellular carcinoma treated and kidney functions were normal. His right heart cath- with radiofrequency ablation. His pre-transplant echocar- eterization showed normal capillary wedge pressure, diogram showed normal left ventricular systolic function elevated mean pulmonary artery pressure and high pul- (Ejection Fraction- 65–70%) with severe left atrial dilata- monary vascular resistance with normal cardiac index. tion, moderately dilated right ventricule with normal sys- His symptoms and pulmonary pressures improved with tolic function (tricuspid annular plane systolic excursion 2.1 ligation of AV fistula. cm). A pre-transplant right heart catheterization had demon- KEYWORDS: pulmonary hypertension, liver transplant, strated borderline pulmonary hypertension with a normal renal transplant, simultaneous liver-kidney transplant, pulmonary vascular resistance (PVR), but an elevated cardiac post-transplant pulmonary hypertension index (Table). Table. Summary of Right Heart Catheterization Results Pre- Post- Post AVF Transplant Transplant closure INTRODUCTION Right Atrial Pressure 10 11 4 Portopulmonary hypertension (PoPH) de novo after liver (mm Hg) transplantation has been recognized recently either with or Right Ventricular Pressure 1,2 38/10 47/11 27/5 without pre-transplant hepatopulmonary syndrome (HPS). (mm Hg) There are no reports of pulmonary hypertension occurrence Pulmonary Artery Pressure 38/14 49/21 29/11 following simultaneous liver-kidney transplants, which is (mm Hg) (22) (31) (19) becoming a more common procedure. We present a unique Pulmonary Capillary Wedge case of heart failure and pulmonary hypertension (PH) after 14 15 12 Pressure (mm Hg) simultaneous liver-kidney transplants in a patient, whose Cardiac Output 8.0 (TD) 4.55 (TD) pulmonary artery pressures improved during post-trans- 3.4 (F) (L/minute) 9.7 (F) 4.75 (F) plant course without use of pulmonary arterial hyperten- Cardiac Index 4.17 (TD) 2.25 (TD) sion (PAH) specific therapy, but with arteriovenous (AV) 1.73 (F) (L/minute/m2) 5.05 (F) 2.35 (F) fistula closure. Pulmonary Vascular Resistance 1.0 3.67 2.1 (Woods Unit) CASE PRESENTATION Systemic Vascular Resistance 7.75 12.45 25.31 A 65-year-old male was referred to pulmonary hyperten- (Woods Unit) sion clinic for evaluation of exertional dyspnea and elevated Abbreviations: AVF; arteriovenous fistula, F; Fick’ s method, TD; Thermodilution RIMJ ARCHIVES | NOVEMBER ISSUE WEBPAGE | RIMS NOVEMBER 2019 RHODE ISLAND MEDICAL JOURNAL 23 CONTRIBUTION Two months after uncomplicated liver-kidney transplant, shortness of breath improved over the course of several the patient reported shortness of breath after walking about months without further intervention. A repeat right heart 20 feet, abdominal distension and leg swelling. He had expe- catheterization showed a decrease in cardiac index to 1.73 L/ rienced a weight gain of as much as 30 pounds above his minute/m2, mean pulmonary artery pressure to 19 mm Hg, pre-transplant weight and he was also noted to have pleu- pulmonary capillary occlusion pressure 12 mm Hg and PVR ral effusion. Laboratory values for his liver (Total bilirubin to 2.1 Woods units (Table). The patient is now able to walk 1.2 mg/dl, Aspartate aminotransaminase 15 Units/L, Ala- 2 miles every day without any difficulty and his furosemide nine aminotransaminase 12 Units/L, Alkaline phosphatase has been titrated down to 20 mg/day. 101 Uniy/L) and kidney functions were normal. He was started on oral furosemide with some improvement in his symptoms along with a decrease in body weight. His trans- DISCUSSION thoracic echocardiogram showed normal left ventricular Our patient developed symptomatic pulmonary hyperten- systolic function with (Ejection Fraction 65–70%), mild con- sion and heart failure following simultaneous liver-kidney centric left ventricular hypertrophy, severe bi-atrial enlarge- transplants, in the absence of pre-existing HPS, and despite ment, normal right ventricular size and function (tricuspid some improvement in hyperdynamic circulation after annular plane systolic excursion 2.4 cm), moderate to severe transplant. He then improved symptomatically and hemo- tricuspid regurgitation with estimated right ventricular sys- dynamically over the course of several months following AV tolic pressure 50–60 mm of Hg, an increase from pre-trans- fistula closure. plant estimates. He underwent a right heart catheterization Development of de novo PH has been reported in 14 at this time which showed pulmonary hypertension with patients post-orthotropic liver transplant (OLT).1,2 It can a cardiac index 2.35 L/minute/m2, mean pulmonary artery occur in 3 settings, 1) presence of pre-OLT HPS, 2) recurrent pressure 31 mm Hg, pulmonary capillary occlusion pressure cirrhosis with PoPH and 3) isolated PoPH without any prior of 15 mm Hg and pulmonary vascular resistance of 3.67 HPS.3 Development of PoPH after liver transplant varies Woods units consistent with pulmonary hypertension with in different patients. Patients with prior HPS may develop a pre-capillary component (Table). Post-right heart catheter- PoPH usually within 1 year of OLT, whereas it may take ization, while on twice daily furosemide, he reported that he years to develop in patients with recurrent acquired liver could walk one mile on alternate days without any dyspnea, disease. Aucejo et al. proposed 2 mechanisms to explain and reported improved orthopnea and leg swelling, though PoPH in patients with HPS, 1) resolution of HPS and hence his weight remained about 20 pounds above his pre-trans- decrease in intrapulmonary vasodilation, and 2) hyperdy- plant weight. His medications at this time included aspirin namic pulmonary circulation with arteriolar remodeling 81 mg, cholecalciferol 2000 units, ferrous sulfate 325 mg, leading to increased PVR.2 Both these processes make diag- furosemide 60/40 mg, gabapentin 600mg three times daily, nosis of PoPH difficult, until post operatively. Acquired Insulin glargine 15 units bedtime and aspart 4 units three recurrent liver disease leads to portal hypertension and sub- times daily, omeprazole 20 mg, quetiapine 25 mg bedtime, sequent PoPH years after OLT. There is no clear etiology co-trimethoprim-sulfamethoxazole 400/800 mg and tacro- behind development of PoPH in patients without anteced- limus 2/1 mg daily. Physical examination showed jugular ent HPS or recurrent liver disease. It is not clear either if venous distension of ~9 cm of water, a palpable thrill over PoPH in these patients was idiopathic or as result of organ right supraclavicular region with dilated veins around a transplant. Unique to mechanisms discussed above, our right arm AV fistula, an irregularly irregular pulse, mildly patient developed PH within months after OLT in absence of decreased air entry in right lower lung and 1+ pitting edema. pre-OLT HPS and post-OLT liver disease and does not clearly His arterial blood gases prior to (pH-7.52, pCO2-25 mmHg, fall in the category of PoPH. pO2-92 mmHg, SatO2-98% and HCO3-20.4 mEq on room air) Prognosis of new PH post-liver transplant is poor regard- 4 and after (pH-7.44, pCO2-44 mmHg, pO2-81 mmHg, SatO2- less of predisposing etiology. Patients with delayed onset 96% and HCO3-29.9 mEq on room air) transplantation have relatively better prognosis than patients who have ear- did not show any evidence of hypoxia. His liver enzymes lier recognition of PH. Prostacyclin, prostacyclin analogues, post-transplantation were normal work up for pulmonary phosphodiestrase inhibitors and endothelin receptor antag- hypertension including serologic tests for connective tissue onists have been used in treatment of pre-transplant PH diseases, chest imaging, pulmonary function tests (forced with improvement in 6-minute walk distance, New York expiratory volume-84% of predicted and forced vital capac- Heart Association (NYHA) functional class and survival ity-92% of predicted without any bronchodilator response) rates.5-9 Liver transplant improves or completely normal- and ventilation-perfusion
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