Renal Doppler Complete (Renal Artery Stenosis)
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Overview of Peripheral Vascular Disease
Overview of Peripheral Vascular Disease NN Khanna Consultant Interventional Cardiologist with Special Interest in Peripheral Vascular Interventions, Escorts Heart Institute, Okhla Road, New Delhi & Incharge Escorts Heart Centre, Pandu Nagar, Kanpur 19 Peripheral Vascular Disease of the lower extremity is an important RISK FACTORS FOR ATHEROSCLEROTIC 1 cause of morbidity and affects 10 million people in India. It is VASCULAR DISEASE a common condition with variable morbidity affecting men and See Table 2 for risk factors. women over the age of 45 years. It is going to be a major health problem in our country as the Indian population is aging. RENAL ARTERY STENOSIS Atherosclerosis is a generalized disorder and involves medium The most common causes of renal artery stenosis are atherosclerosis and large sized arteries. It is estimated that 74% patients of and fibrous dysplasia. Asymptomatic renal artery stenosis is atherosclerotic coronary artery disease have involvement of some present in 40% cases.The common presentations of renal artery other vascular bed also. 40% patients of coronary artery disease stenosis are hypertension, deterioration of renal functions and have associated peripheral vascular disease, 14% have carotid acute pulmonary edema artery stenosis and 17% have associated renal artery stenosis. Atherosclerotic renal artery stenosis is common in males over Therefore it becomes very important for the physicians to know the age of 55 years, in diabetics and patients who have coronary the pathology, clinical presentations and treatment of common artery stenosis or carotid artery stenosis. It should be suspected vascular disorders. when the hypertension is of recent onset, when it is poorly Increasingly, peripheral vascular disease is becoming a focus Table 2 : Risk factors for Atherosclerotic Vascular Disease of involvement for primary care physicians and cardiovascular specialists who must work in partnership. -
The Incidence and Risk Factors of Renal Artery Stenosis in Patients with Severe Carotid Artery Stenosis
839 Hypertens Res Vol.30 (2007) No.9 p.839-844 Original Article The Incidence and Risk Factors of Renal Artery Stenosis in Patients with Severe Carotid Artery Stenosis Satoko NAKAMURA1), Koji IIHARA2), Tetsutaro MATAYOSHI1), Hisayo YASUDA1), Fumiki YOSHIHARA1), Kei KAMIDE1), Takeshi HORIO1), Susumu MIYAMOTO2), and Yuhei KAWANO1) We previously showed that renal artery stenosis (RAS) was commonly found in patients with cardiovascular disease (CVD) such as myocardial infarction, stroke, or abdominal aneurysm. The aim of the present study was to evaluate the incidence and risk factors for RAS in patients with severe carotid artery stenosis (CAS) considered to need carotid endarterectomy. From February to August 2006, 41 consecutive patients with severe CAS were admitted to the Department of Neurosurgery of the National Cardiovascular Center. Each patient was examined for renal function and urinary albumin excretion, and renal artery duplex scanning was also performed. The patients were classified into two groups according to the findings of renal Doppler sonography, 11 patients with RAS and 30 patients without RAS. We evaluated the differences in clinical find- ings and renal function between the groups and clarified the risk factors for RAS. In RAS patients, smoking and incidence of other CVDs were evident, and renal function was impaired significantly compared with the patients without RAS. Multivariate logistic regression showed that the presence of other CVDs, renal func- tion, and smoking were significant clinical predictors for RAS. In patients with severe CAS, RAS was fre- quently detected with the same frequency as ischemic heart disease. The RAS risk factors were the presence of other CVDs, renal dysfunction, and smoking. -
Anatomy and Physiology of the Bowel and Urinary Systems
PMS1 1/26/05 10:52 AM Page 1 Anatomy and Physiology of the Bowel and 1 Urinary Systems Anthony McGrath INTRODUCTION The aim of this chapter is to increase the reader’s under- standing of the small and large bowel and urinary system as this will enhance their knowledge base and allow them to apply this knowledge when caring for patients who are to undergo stoma formation. LEARNING OBJECTIVES By the end of this chapter the reader will have: ❏ an understanding of the anatomy and physiology of the small and large bowel; ❏ an understanding of the anatomy and physiology of the urinary system. GASTROINTESTINAL TRACT The gastrointestinal (GI) tract (Fig. 1.1) consists of the mouth, pharynx, oesophagus, stomach, duodenum, jejunum, small and large intestines, rectum and anal canal. It is a muscular tube, approximately 9m in length, and it is controlled by the autonomic nervous system. However, while giving a brief outline of the whole system and its makeup, this chapter will focus on the anatomy and physiology of the small and large bowel and the urinary system. The GI tract is responsible for the breakdown, digestion and absorption of food, and the removal of solid waste in the form of faeces from the body. As food is eaten, it passes through each section of the GI tract and is subjected to the action of various 1 PMS1 1/26/05 10:52 AM Page 2 1 Anatomy and Physiology of the Bowel and Urinary Systems Fig. 1.1 The digestive system. Reproduced with kind permission of Coloplast Ltd from An Introduction to Stoma Care 2000 2 PMS1 1/26/05 10:52 AM Page 3 Gastrointestinal Tract 1 digestive fluids and enzymes (Lehne 1998). -
Urinary System
OUTLINE 27.1 General Structure and Functions of the Urinary System 818 27.2 Kidneys 820 27 27.2a Gross and Sectional Anatomy of the Kidney 820 27.2b Blood Supply to the Kidney 821 27.2c Nephrons 824 27.2d How Tubular Fluid Becomes Urine 828 27.2e Juxtaglomerular Apparatus 828 Urinary 27.2f Innervation of the Kidney 828 27.3 Urinary Tract 829 27.3a Ureters 829 27.3b Urinary Bladder 830 System 27.3c Urethra 833 27.4 Aging and the Urinary System 834 27.5 Development of the Urinary System 835 27.5a Kidney and Ureter Development 835 27.5b Urinary Bladder and Urethra Development 835 MODULE 13: URINARY SYSTEM mck78097_ch27_817-841.indd 817 2/25/11 2:24 PM 818 Chapter Twenty-Seven Urinary System n the course of carrying out their specific functions, the cells Besides removing waste products from the bloodstream, the uri- I of all body systems produce waste products, and these waste nary system performs many other functions, including the following: products end up in the bloodstream. In this case, the bloodstream is ■ Storage of urine. Urine is produced continuously, but analogous to a river that supplies drinking water to a nearby town. it would be quite inconvenient if we were constantly The river water may become polluted with sediment, animal waste, excreting urine. The urinary bladder is an expandable, and motorboat fuel—but the town has a water treatment plant that muscular sac that can store as much as 1 liter of urine. removes these waste products and makes the water safe to drink. -
'I Can Assure You, There Is Nothing Wrong with Your Kidney'
FUNCTIONAL DISORDERS Clinical Medicine 2021 Vol 21, No 1: 4–7 ‘I can assure you, there is nothing wrong with your kidney’ Author: Tamara KeithA Normal baseline investigation results in a patient with identified, and she was treated for latent TB. No evidence of renal common symptoms is often labelled as being due to a TB was found. functional disorder, with all the pejorative connotations that No cause for the recurrent episodes could be found and she was go along with that term. When given the opportunity to repeatedly told, ‘I can assure you, there is nothing wrong with your see a patient for a second opinion, it is important to retain kidney.’ ABSTRACT an open mind rather than assuming previous assessments While on clinical attachment as a medical student, she presented are correct. Such an attitude helps with both attaining the again with an acute episode of left loin pain. Renal ultrasound definitive diagnosis but is also crucial to helping give hope to revealed a ‘swollen’ left kidney. Magnetic resonance angiography the patient. Understanding the patient’s concerns about the (MRA) followed. The arterial studies were normal, however, the meaning of their symptoms is critical in finding the balance venous images showed compression of the left renal vein between between advanced investigation to identify a putative cause the aorta and the superior mesenteric artery (SMA) consistent with versus a decision to proceed with symptomatic control. the diagnosis of nutcracker syndrome (Fig 1). Aspirin was started due to reports of symptomatic benefit but KEYWORDS: patient, GP, kidney, history made no significant difference.1 Given that weight gain had been reported to provide benefit, the patient, who had a body mass DOI: 10.7861/clinmed.2020-0990 index of 19 kg/m2, gained 5 kg in weight which provided only a short-term benefit before a return in symptoms. -
Normal Vascular and Glomerular Anatomy
Normal Vascular and Glomerular Anatomy Arthur H. Cohen Richard J. Glassock he topic of normal vascular and glomerular anatomy is intro- duced here to serve as a reference point for later illustrations of Tdisease-specific alterations in morphology. CHAPTER 1 1.2 Glomerulonephritis and Vasculitis FIGURE 1-1 A, The major renal circulation. The renal artery divides into the interlobar arteries (usually 4 or 5 divisions) that then branch into arcuate arteries encompassing the corticomedullary Interlobar junction of each renal pyramid. The interlobular arteries (multiple) originate from the artery arcuate arteries. B, The renal microcirculation. The afferent arterioles branch from the interlobular arteries and form the glomerular capillaries (hemi-arterioles). Efferent arteri- Arcuate oles then reform and collect to form the post-glomerular circulation (peritubular capillar- artery Renal ies, venules and renal veins [not shown]). The efferent arterioles at the corticomedullary artery junction dip deep into the medulla to form the vasa recta, which embrace the collecting tubules and form hairpin loops. (Courtesy of Arthur Cohen, MD.) Pyramid Pelvis Interlobular Ureter artery A Afferent arteriole Interlobular artery Glomerulus Arcuate artery Efferent arteriole Collecting tubule Interlobar artery B Normal Vascular and Glomerular Anatomy 1.3 FIGURE 1-2 (see Color Plate) Microscopic view of the normal vascular and glomerular anatomy. The largest intrarenal arteries (interlobar) enter the kidneys between adjacent lobes and extend toward the cortex on the side of a pyramid. These arteries branch dichotomously at the corti- comedullary junction, forming arcuate arteries that course between the cortex and medulla. The arcuate arteries branch into a series of aa ILA interlobular arteries that course at roughly right angles through the cortex toward the capsule. -
Renal Artery Stenosis and Acute Pulmonary Edema-A Possible
& Experim l e ca n i t in a l l C C f a Journal of Clinical & Experimental o r d l i a o n l o r Dorabont et al., J Clin Exp Cardiolog 2015, 6:6 g u y o J Cardiology DOI: 10.4172/2155-9880.1000377 ISSN: 2155-9880 Research Article Open Access Renal Artery Stenosis and Acute Pulmonary Edema-A Possible Correlation beyond Pickering Syndrome Darabont Roxana Oana1*, Corlan Alexandru Dan2, Vinereanu Dragos1 1University of Medicine and Pharmacy “Carol Davila”, Internal Medicine and Cardiology Department at University Emergency Hospital, Bucharest, Romania 2Cardiology Department at University Emergency Hospital, Bucharest, Romania *Corresponding author: Darabont Roxana Oana, University of Medicine and Pharmacy “Carol Davila”, Internal Medicine and Cardiology Department at University Emergency Hospital, Bucharest, Romania, Tel: +40-723-441-315; Fax: + 40-21-3180576; E-mail: [email protected] Received date: April 30, 2015; Accepted date: June 26, 2015, Published date: June 29, 2015 Copyright: © 2015 Darabont RO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Objectives: The association of renal artery stenosis (RAS) with acute pulmonary edema (APE) is considered specific for bilateral or solitary functioning kidney (SFK) RAS. We aimed to check if APE is also associated with unilateral RAS when both kidneys are functional. Method: A series of 189 patients with uncontrolled hypertension were investigated for RAS suspicion by duplex ultrasonography. Clinical criteria considered in current guidelines as predictors of RAS were recorded and analysed. -
Kidney Structure Renal Lobe Renal Lobule
Kidney Structure Capsule Hilum • ureter → renal pelvis → major and minor calyxes • renal artery and vein → segmental arteries → interlobar arteries → arcuate arteries → interlobular arteries Medulla • renal pyramids • cortical/renal columns Cortex • renal corpuscles • cortical labryinth of tubules • medullary rays Renal Lobe Renal Lobule = renal pyramid & overlying cortex = medullary ray & surrounding cortical labryinth Cortex Medulla Papilla Calyx Sobotta & Hammersen: Histology 1 Uriniferous Tubule Nephron + Collecting tubule Nephron Renal corpuscle produces glomerular ultrafiltrate from blood Ultrafiltrate is concentrated • Proximal tubule • convoluted • straight • Henle’s loop • thick descending • thin • thick ascending • Distal tubule • Collecting tubule Juxtaglomerular apparatus • macula densa in distal tubule •JG cells in afferent arteriole •extraglomerular mesangial cells Glomerulus • fenestrated capillaries • podocytes • intraglomerular mesangial cells 2 Urinary Filtration Urinary Membrane Membrane Podocytes • Endothelial cell • 70-90 nm fenestra restrict proteins > 70kd • Basal lamina • heparan sulfate is negatively charged • produced by endothelial cells & podocytes • phagocytosed by mesangial cells • Podocytes • pedicels 20-40 nm apart • diaphragm 6 nm thick with 3-5 nm slits • podocalyxin in glycocalyx is negatively charged 3 Juxtaglomerular Apparatus Macula densa in distal tubule • monitor Na+ content and volume in DT • low Na+: • stimulates JG cells to secrete renin • stimulates JG cells to dilate afferent arteriole • tall, -
Micardis® Tablets, 20 Mg, 40 Mg and 80 Mg
Micardis® (telmisartan) Tablets, 20 mg, 40 mg and 80 mg Prescribing Information USE IN PREGNANCY When used in pregnancy during the second and third trimesters, drugs that act directly on the renin- angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, MICARDIS® tablets should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality DESCRIPTION MICARDIS® (telmisartan) is a nonpeptide angiotensin II receptor (type AT1) antagonist. Telmisartan is chemically described as 4'-[(1,4'-dimethyl-2'-propyl [2,6'-bi-1H-benzimidazol]-1'- yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid. Its empirical formula is C33H30N4O2, its molecular weight is 514.63, and its structural formula is: CH3 N CH3 N N O O H N CH 3 Telmisartan is a white slightly yellowish solid. It is practically insoluble in water and in the pH range of 3 to 9, sparingly soluble in strong acid (except insoluble in hydrochloric acid), and soluble in strong base. MICARDIS is available as tablets for oral administration, containing 20 mg, 40 mg or 80 mg of telmisartan. The tablets contain the following inactive ingredients: sodium hydroxide, meglumine, povidone, sorbitol, and magnesium stearate. MICARDIS tablets are hygroscopic and require protection from moisture. CLINICAL PHARMACOLOGY Mechanism of Action Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. -
Letters to the Editor
DEPARTMENTS Letters to the Editor Indium-i 11 Neutrophil Imaging in Isehemic Colitis TO THE EDITOR: lndium-l 11 (II‘In)autologous neutro phils are used for imaging the colon in inflammatory bowel disease (1) and clostridium difficile colitis (2) allowing non invasive assessment of colonic involvement in these condi tions but not differentiating between the different forms of @ colitis. We report a case where I‘Inlabeled neutrophil uptake in the colon of a patient with unsuspected ischemic colitis demonstrates the usefulness ofthe technique both in assessing the extent of colonic involvement and as an aid to diagnosis, but emphasise the importance of confirming the diagnosis of colitis by other techniques. A 61-yr-old white female was referred for assessment by her family physician because of systemic hypertension resist ant to therapy. Physical examination confirmed features of hypertension with elevated blood pressure at 230/1 15 mmHg, a grade 2/6 mid-systolic murmur at the left sternal edge and grade 2 hypertensive retinopathy. Combination therapy with beta-blockers, diuretics, and FIGURE 1 vasodilatorshad failed to control the blood pressure ade Indium-i11 neutrophil image (anterior) showing abnormal quately and therefore the patient was commenced on an uptake in sigmoid and descending colon with no uptake angiotensin converting enzyme (ACE) inhibitor (captopril) beyond splenic flexure and a diuretic (furosemide). This regimen caused an abrupt deterioration in renal function, blood urea rising to 22.7 mmol/l (136.2 mg/lOO ml) and creatinine to 220 zmol/l clinical and radiological signs of bowel perforation which (2.42 mg/100 ml). -
Anatomy of the Kidney
Anatomy of the kidney Renal block-Anatomy-Lecture 1 Editing file Color guide : Only in boys slides in Green Objectives Only in girls slides in Purple important in Red Notes in Grey By the end of this course you should be able to discuss : ● Components of the urinary system ● Kidney : 1. Shape & Position 2. Surface anatomy 3. External features 4. Hilum & its contents 5. Relation 6. Internal features 7. Blood supply 8. Lymph drainage 9. Nerve supply Introduction 3 ● Every day, each kidney filters liters (around 150 L per day ) of fluid from the bloodstream. ● Although the lungs and the skin also play roles in excretion, The kidneys bear the major responsibility for eliminating nitrogenous (nitrogen-containing) wastes, toxins, and drugs from the body. Excretes most of the Maintain acid-base waste products of balance of the blood. metabolism. By Erythropoietin Controls hormone stimulates Function of water & electrolyte bone marrow for RBCs kidney balance of the body. formation. Converts By Rennin vitamin D to its enzyme regulates active form. the blood pressure. The kidney : ● Kidneys are reddish brown in color. 4 ● Lie behind the peritoneum (retroperitoneal) on the posterior abdominal wall on either side of the vertebral column. ● They are largely under cover of the costal margin. kidney lies between T12-L3 ● With contraction of the diaphragm (during inspiration) the kidney moves downward as much as 2.5 cm. T12 Comparison between : L3 Right kidney Left kidney Anterior view lies slightly lower than the left due Location to the large size of the right lobe of Upper than the right the liver. -
Urinary System
Urinary system Sándor Katz M.D.,Ph.D. Urinary system - constituents • kidneys • ureters • urinary bladder • urethra Kidney Weight: 130-140g Kidneys - location 1. On the posterior body wall 2. Posterior to parietal peritoneum – retroperitoneal organ 3. At the level of T12-L2 (left kidney) and L1-L3 (right kidney) Kidneys - location Kidneys – covering structures 1. Renal (Gerota’s) fascia 2. Adipose capsule 3. Fibrous capsule Kidneys - neighbouring organs and structures Kidney – gross anatomy External structures: Hilum of kidney: 1. Renal vein 2. Renal artery 3. Ureter Internal structures: 1. Cortex 2. Medulla 3. Minor calyces 4. Major calyces 5. Renal pelvis Renal cortex Renal columns (Bertini’s columns) Renal medulla – renal pyramids A p p r o x i m a t e l y 3 0 pyramids are in each kidney and many of them are fused together. renal papilla Minor calyces 8-9 in each kidney Major calyces Approx. 3 in each kidney Renal pelvis Renal hilum - L1/L2 level renal sinus From anterior to posterior direction: 1. renal vein 2. renal artery 3. ureter From superior to inferior direction: 1. renal artery 2. renal vein 3. ureter Renal arteries - L1 level Renal artery • segmental arteries • interlobar arteries • arcuate arteries • interlobular arteries • afferent arterioles Renal veins left renal vein is longer than the right one and crosses over the aorta Renal veins right renal vein left renal vein is longer than the right one and crosses over the aorta left renal vein Tributaries of the renal veins • (stellate veins – only under the fibrous capsule) • interlobular veins • arcuate veins • interlobar veins • segmental veins Renal veins left suprarenal vein (empties into the left renal vein) left gonadal (testicular or ovarian) vein (empties into the left renal vein) The right suprarenal and gonadal veins empty into the IVC.