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BASIL HETZEL INSTITUTE RESEARCH REPORT Translational Health Research Creating Positive Outcomes for Thousands of South Australians DR BASIL S HETZEL 1922–2017

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BASIL HETZEL INSTITUTE RESEARCH REPORT Translational Health Research Creating Positive Outcomes for Thousands of South Australians DR BASIL S HETZEL 1922–2017 BASIL HETZEL INSTITUTE RESEARCH REPORT Translational health research creating positive outcomes for thousands of South Australians DR BASIL S HETZEL 1922–2017 The research community at The Queen Elizabeth Hospital (TQEH) was saddened by the death of Dr Basil S Hetzel AC on February 4 2017. Basil was appointed as the first Michell Professor of Medicine at the University of Adelaide, TQEH in 1959. He will be remembered around the world for his pioneering work on iodine deficiencies and thyroid disease. Since visiting the highland villages of Papua We thank THRF staff for New Guinea in 1964, Basil became an international advocate for providing content and photos iodine supplementation and ultimately co-founded the International for this report. We also thank Council for Control of Iodine Deficiency Disorders (ICCIDD) which the Royal Australasian College had its inaugural meeting in Kathmandu, Nepal in 1986. Today this of Surgeons and the Adelaide organisation is known as the Iodine Global Network (IGN). G-TRAC Centre for allowing us to use some of their images. In 2001 the long-standing research activities of TQEH were renamed Additional photos used in as the Basil Hetzel Institute. Basil was a proud supporter of all this report were taken by research endeavours and regularly attended the annual TQEH Andrew Beveridge (ASB Research Day. In addition he was a great mentor and active supporter Creative), Basil Popowycz of research and of people doing research. and Rebecca Anderson. The photo on the front cover of this report was taken at the unveiling of the portrait of Basil by South Australian artist Avril Thomas. This portrait is on display in the atrium of the Basil Hetzel Institute. Contact The Queen Elizabeth Hospital Research Secretariat DX465101 28 Woodville Road Woodville South, South Australia 5011 T: +61 8 8222 7836 F: +61 8 8222 7872 E: [email protected] www.basilhetzelinstitute.com.au CONTENTS Director’s Report 03 Research Staff 63 Significant Impact Publications 04 Research Students 72 Themes 10 Grants 79 Ageing 11 Publications 84 Adelaide Geriatrics Training and Research High Profile International Talks 2016 99 with Aged Care (G-TRAC) Centre 12 TQEH Research Day 2016 102 Cancer 14 Acute Myeloid Leukaemia Research Group 15 Awards 104 Breast Biology and Cancer Unit 17 Community Engagement 107 Breast Cancer Research Unit 18 Support Structures 108 Colorectal Cancer Research Group 20 Liver Metastasis Research Group 21 Human Research Ethics Committee Report 2016 110 Northern Network Colorectal Surgical Service 22 Solid Cancer Research Group 23 The Hospital Research Foundation 113 South Australian Prostate Cancer Clinical Message from the Chair 114 Outcomes Collaborative (SA-PCCOC) 24 THRF Board Members 115 Cardiovascular Disease 25 THRF Corporate and Community Support 118 Cardiovascular Pathophysiology and BHI Research Equipment 124 Therapeutics Group 27 THRF Fundraising Events Clinical Pharmacology Research Group 29 and Activities 126 Translational Vascular Function Research Collaborative 29 Appendix A: Research Group Members 134 Vascular Surgery Research Group 33 Zinc and Cardiovascular Disease Research Group 33 Appendix B: Community Engagement Activities 2016 149 Chronic Disease 34 Clinical Pharmacology Research Group 35 Endocrinology Unit 36 Special Features Department of Gastroenterology & Hepatology 38 Stroke Research Programme 38 Researcher Stories The Health Observatory 39 Dr Beatriz Arakawa Martins 13 Vahid atashgaran 16 Clinical Sciences,Health Services And Population Health 41 Dr Irene Zinonos 19 Anaesthesia Research Group 42 Dr Doan Ngo 26 Gastrointestinal Health and Disease 42 Clementine Labrosciano 28 Health Performance and Policy Research Unit 44 Sivabaskari (Tharshy) Pasupathy 32 Intensive Care Medicine Research Group 45 Dr Isuru Ranasinghe 43 Psychiatry Research Group 46 Justyna Pollok 48 Respiratory Medicine Unit & Clinical Practice Unit 47 Professor Catherine hill 50 Rheumatology Research Group 49 Khamis Tomusange 57 Dijana Miljkovic 61 Surgical Science Research Group 51 Dr Nicky Thomas 98 Drug And Vaccine Development 52 Therapeutics Research Centre 53 Patient Stories Virology Group 56 Daniel’s Story 31 Helen’s Story 37 Inflammatory Disease 58 Martin’s Story 59 ENT Surgery 60 Gastroenterology and Hepatology 62 Pharmacist Practitioner Pilot Program Outcomes Report 54 Zinc and Inflammatory Disease Research Group 62 RESEARCH REPORT 01 2016 BASIL HETZEL INSTITUTE Research at The Queen Elizabeth Hospital 2016 $20M REVENUE grants, clinical academic salaries, scholarships and infrastructure support 350+ PEER REVIEWED PUBLICATIONS 100+ CLINICAL/RESEARCH STAFF TQEH & BHI 84 HIGHER DEGREE STUDENTS 150+ COMMUNITY ENGAGEMENT PRESENTATIONS BHI RESEARCH 02 REPORT 2016 DIRECTOR’S REPORT Successful research depends on many things, but outstanding staff and adequate funding is certainly a good place to start. The Basil Hetzel Institute (BHI) continues to feel the effects of a national downturn in research support and locating sufficient funds to maintain its strong research success is becoming increasingly challenging. Without funds it is impossible to provide the infrastructure We will continue to source funds from a variety of that then supports the staff who wish to come and work in a opportunities as this is the only way of ensuring that the research environment. This is a problem which is having an ongoing research develops and flourishes. With the certain impact around Australia and many excellent research groups move of the Royal Adelaide Hospital during 2017 there will are shrinking or disappearing as a result of insufficient also be an opportunity to help research groups displaced funding being made available. Despite this, the sum of from the Royal Adelaide Hospital. The new Royal Adelaide money invested annually in research at the BHI is still in the Hospital has no “wet lab” facilities and the opportunity to order of $20 million a year and this has been maintained support strong, viable and relevant groups at the BHI will despite the contractions that are being felt elsewhere. be an important development over the next twelve months. While the new Royal Adelaide Hospital will continue to have The outputs as measured by publications and successful a significant focus of clinical activity, The Queen Elizabeth grants continues to be strong, with some outstanding Hospital’s volume of work continues to increase. The two research being generated over the past twelve months. institutions provide a substantial pool of patients on which Nonetheless, the support from NHMRC is not growing but important studies can be conducted. This will continue to we have been fortunate in that other sources of funds have be developed in the foreseeable future with the research staff been identified that have enabled the BHI to continue to potentially being located at The Queen Elizabeth Hospital flourish. Funding comes from many sources in research and and BHI and the patients being investigated and researched it is becoming increasingly important to diversify sources at both venues. With respect to ongoing funding, the of funds rather than to rely on NHMRC which in real terms Medical Research Future Fund provides an opportunity for nationally has reduced and in proportionate terms to South increased research initiatives. A number of our research Australia has shrunk even further. groups have grown in strength and size in recent years and Specialty funding groups such as the Kidney Foundation and it will be essential that we consolidate these groups. At the Heart Foundation are, of course, valuable alternate funding same time it will be important to foster new and embryonic sources, along with the Commonwealth Government, the groups in order to continue to be the “incubator” of research Royal Australasian College of Surgeons and, perhaps most activity in South Australia. importantly, The Hospital Research Foundation. Because of The Hospital Research Foundation’s support in providing Guy Maddern basic infrastructure and equipment, we continue to have a Director of Research viable institution which is able to offer researchers most of Basil Hetzel Institute for Translational Health Research the equipment requirements necessary for their research. The Queen Elizabeth Hospital 16 February 2017 BHI RESEARCH 03 REPORT 2016 BASIL HETZEL INSTITUTE RESEARCH REPORT 2016 SIGNIFICANT IMPACT PUBLICATIONS Rachel Jakobczak, Translational Vascular Function Research Collaborative. BHI RESEARCH 04 REPORT 2016 SIGNIFICANT IMPACT PUBLICATIONS 2016 AGEING Colorectal Cancer Research Group Impact Factor: 4.7 Dorward HS, Du A, Bruhn MA, Wrin J, Pei JV, Evdokiou A, Adelaide G-TRAC Centre Price TJ, Yool AJ, Hardingham JE. Pharmacological Impact Factor: 3.8 blockade of aquaporin-1 water channel by AqB013 Theou O, Tan ECK, Bell JS, Emery T, Robson L, Morley restricts migration and invasiveness of colon cancer JE, Rockwood K, Visvanathan R. Frailty levels in cells and prevents endothelial tube formation in vitro. residential aged care facilities measured with the J Exp Clin Cancer Res 2016;24;35:36. Frailty Index and FRAIL-NH Scale. J Am Geriatrics Society. 2016;64(11):207-212. www.ncbi.nlm.nih.gov/pubmed/26912239 This paper, published in one of the highest ranked https://www.ncbi.nlm.nih.gov/pubmed/27783396 experimental cancer journals, reflects work done at the BHI Through this paper we confirmed that 85% of residents in collaboration with Professor AJ Yool. New drug therapies are frail and 25% of them are severely frail. Professors are needed for
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