Deaths in Children and Adolescents Associated with COVID-19 and MIS-C in the United States

Prepublication Release Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States David W. McCormick, MD, MPH, LaTonia Clay Richardson, PhD, MS, Paul R. Young, MD, Laura J. Viens, MD, MPH, Carolyn V. Gould, MD, MSCR, Anne Kimball, MD, MPH, Talia Pindyck, MD, MPH, Hannah G. Rosenblum, MD, David A. Siegel, MD, MPH, Quan M. Vu, MD, Ken Komatsu, MPH, Heather Venkat, DVM, MPH, John J. Openshaw, MD, Breanna Kawasaki, MPH, Alan J. Siniscalchi, MPH, MS, Megan Gumke, MPH, CPH, Andrea Leapley, MPH, Melissa Tobin-D’Angelo, MD, MPH, Judy Kauerauf, MPH, Heather Reid, BS, CHES, Kelly White, MPH, CPH, Farah S. Ahmed, PhD, MPH, Gillian Richardson, MPH, Julie Hand, MSPH, Kim Kirkey, PhD, MPH, Linnea Larson, MPH, Paul Byers, MD, Ali Garcia, MPH, Mojisola Ojo, MPH, Ariela Zamcheck, DO, Maura K. Lash, RN, MPH, Ellen H. Lee, MD, MPH, Kathleen H. Reilly, PhD, MPH, Erica Wilson, MD, MPH, Sietske de Fijter, MS, Ozair H. Naqvi, MS, Laurel Harduar-Morano, PhD, MPH, Anna-Kathryn Burch, MD, Adele Lewis, MD, Jonathan Kolsin, MPH, Stephen J. Pont, MD, MPH, Bree Barbeau, MPH, Danae Bixler, MD, MPH, Sarah Reagan-Steiner, MD, MPH, Emilia H. Koumans, MD, on behalf of the Pediatric Mortality Investigation Team DOI: 10.1542/peds.2021-052273 Journal: Pediatrics Article Type: Regular Article Citation: McCormick DW, Richardson LC, Young PR, et al. Deaths in children and adolescents associated with COVID-19 and MIS-C in the United States. Pediatrics. 2021; doi: 10.1542/peds.2021-052273 This is a prepublication version of an article that has undergone peer review and been accepted for publication but is not the final version of record. This paper may be cited using the DOI and date of access. This paper may contain information that has errors in facts, figures, and statements, and will be corrected in the final published version. The journal is providing an early version of this article to expedite access to this information. The American Academy of Pediatrics, the editors, and authors are not responsible for inaccurate information and data described in this version. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits noncommercial distribution and reproduction in any medium, provided the original author and source are credited. Downloaded from www.aappublications.org/news by guest on September 24, 2021 Prepublication Release Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States David W. McCormicka,b*, MD, MPH, LaTonia Clay Richardsona, PhD, MS, Paul R. Younga, MD, Laura J. Viensa, MD, MPH, Carolyn V. Goulda, MD, MSCR, Anne Kimballa,b, MD, MPH, Talia Pindycka, MD, MPH, Hannah G. Rosenbluma,b, MD, David A. Siegela, MD, MPH, Quan M. Vua, MD, Ken Komatsuc, MPH, Heather Venkatc,d, DVM, MPH, John J. Openshawe, MD, Breanna Kawasakif, MPH, Alan J. Siniscalchig, MPH, MS, Megan Gumkeh, MPH, CPH, Andrea Leapleyh, MPH, Melissa Tobin-D’Angeloi, MD, MPH, Judy Kaueraufj, MPH, Heather Reidj, BS, CHES, Kelly Whitek, MPH, CPH, Farah S. Ahmedl, PhD, MPH, Gillian Richardsonm, MPH, Julie Handm, MSPH, Kim Kirkeyn, PhD, MPH, Linnea Larsono, MPH, Paul Byersp, MD, Ali Garciaq, MPH, Mojisola Ojor, MPH, Ariela Zamchecks, DO, Maura K. Lasht, RN, MPH, Ellen H. Leet, MD, MPH, Kathleen H. Reillyt, PhD, MPH, Erica Wilsonu, MD, MPH, Sietske de Fijterv, MS, Ozair H. Naqviw, MS, Laurel Harduar-Moranox,d, PhD, MPH, Anna-Kathryn Burchy, MD, Adele Lewisz, MD, Jonathan Kolsinaa, MPH, Stephen J. Pontaa, MD, MPH, Bree Barbeauab, MPH, Danae Bixlera, MD, MPH, Sarah Reagan-Steinera*, MD, MPH, Emilia H. Koumansa*, MD, on behalf of the Pediatric Mortality Investigation Team† * Contributed equally as co-senior authors † A complete list of members of the Pediatric Mortality Investigation Team appears in the Appendix. Affiliations: aCDC COVID-19 Response Team; bEpidemic Intelligence Service, CDC; cArizona Department of Health Services; dCDC Career Epidemiology Field Officer Program; eCalifornia Department of Public Health; fColorado Department of Public Health and Environment; gState of Connecticut Department of Public Health; hFlorida Department of Health; iGeorgia Department of Public Health; jIllinois Department of Public Health; kIndiana Department of Health; lKansas Department of Health and Environment; mLouisiana Department of Health; nMichigan Department of Health and Human Services; oMinnesota Department of Health; pMississippi State Department of Health; qNevada Department of Health and Human Services; rNew Jersey Department of Health; sNew York State Department of Health; tNew York City Department of Health and Mental Hygiene, uNorth Carolina Department of Health and Human Services; vOhio Department of Health; wOklahoma State Department of Health; xPennsylvania Department of Health; ySouth Carolina Department of Health and Environmental Control; zTennessee Department of Health; aaTexas Department of State Health Services; and abUtah Department of Health. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Address correspondence to: David McCormick, Division of Vector-borne Disease, Centers for Disease Control and Prevention, 3156 Rampart Rd, Fort Collins, CO 80521, [email protected], 970-225-4272. Downloaded from www.aappublications.org/news by guest on September 24, 2021 Prepublication Release Conflict of Interest Disclosures: The authors have no conflicts of interest relevant to this article to disclose. Funding/Support: This work was conducted as part of the US Centers for Disease Control and Prevention’s COVID-19 response. Role of Funder/Sponsor: None. Abbreviations: Body mass index (BMI), US Centers for Disease Control and Prevention (CDC), coronavirus disease 2019 (COVID-19), erythrocyte sedimentation rate (ESR), lactate dehydrogenase (LDH), intensive care unit (ICU), interquartile range (IQR), multisystem inflammatory syndrome in children (MIS-C), REDCap (Research Electronic Data Capture), respiratory rate (RR), severe acute respiratory system coronavirus 2 (SARS-CoV-2) Article Summary We report the clinical characteristics and hospital course of persons <21 years of age with SARS-CoV-2-associated deaths in the United States during February–July, 2020. What’s Known on This Subject Pediatric mortality from SARS-CoV-2 is uncommon. Previous studies have reported risk factors associated with severe COVID-19 disease and MIS-C, and case series from Europe and China have described clinical features of pediatric SARS-CoV-2-associated deaths. What This Study Adds SARS-CoV-2-associated deaths among persons <21 years of age during February–July 2020 occurred predominantly among older adolescent males and Black (non-Hispanic) and Hispanic persons. Obesity, asthma, and developmental disorders were the most commonly reported underlying conditions. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits noncommercial distribution and reproduction in any medium, provided the original author and source are credited. Downloaded from www.aappublications.org/news by guest on September 24, 2021 Prepublication Release Contributors’ Statement Page Dr. McCormick coordinated and supervised data collection, collected data, drafted the initial manuscript, and reviewed and revised the manuscript. Dr. Richardson performed all statistical analyses, assisted with drafting the initial manuscript, and reviewed and revised the manuscript. Dr. Young coordinated and supervised data collection, collected data, and reviewed and revised the manuscript. Dr. Viens designed data collection instruments, coordinated and supervised data collection, collected data, assisted with drafting the initial manuscript, and reviewed and revised the manuscript. Dr. Gould, Dr. Reagan-Steiner, and Dr. Koumans coordinated and supervised data collection, reviewed and revised the manuscript, and critically reviewed the manuscript for important intellectual content. Dr. Kimball and Dr. Rosenblum collected data, assisted with drafting the initial manuscript, and reviewed and revised the manuscript. Dr. Pindyck coordinated and supervised data collection, assisted with drafting the initial manuscript, and critically reviewed the manuscript for important intellectual content. Dr. Siegel assisted with drafting the initial manuscript and critically reviewed the manuscript for important intellectual content. Dr. Vu collected data, carried out the initial analyses, and critically reviewed the manuscript for important intellectual content. Ms. Barbeau, Dr. Burch, Dr. Byers, Ms. de Fijter, Mr. Garcia, Ms. Gumke, Ms. Hand, Dr. Harduar-Morano, Ms. Kauerauf, Dr. Kawasaki, Dr. Kirkey, Mr. Kolsin, Mr. Komatsu, Ms. Larson, Ms. Lash, Ms. Leapley, Dr. Lee, Dr. Lewis, Mr. Naqvi, Ms. Ojo, Dr. Openshaw, Dr. Pont, Ms. Reid, Dr. Reilly, Ms. Richardson, Mr. Siniscalchi, Dr. Tobin-D’Angelo, Dr. Venkat, Dr. White, Dr. Wilson, and Dr. Zamcheck collected data and critically reviewed the manuscript for important intellectual content. Dr. Bixler reviewed and revised the manuscript and critically reviewed the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. Downloaded from www.aappublications.org/news by guest on September 24, 2021 Prepublication Release Abstract

Load more