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Natural Products in Cancer Therapy International PSE Symposium on Natural Products in Cancer Therapy 23-26 September 2008 Naples, Italy Abstracts The printing of abstract book has been financed by DISTAAM e DISTAT, University of Molise. Editorial coordination by doppiavoce – www.doppiavoce.it Organizing Commitee Virginia Lanzotti, Chairman (Campobasso, Italy) Ernesto Fattorusso (Naples, Italy) Vincenzo Fogliano (Naples, Italy) Maria Iorizzi (Isernia, Italy) Secretariat Raffaele Troiano Scientific Committee Giovanni Appendino (Novara, Italy) Randolph Arroo (Leicester, UK) Pinarosa Avato (Bari, Italy) Maurizio Bifulco (Salerno, Italy) Lars Bohlin (Uppsala, Sweden) Ernesto Fattorusso (Naples, Italy) Simon Gibbons (London, UK) Maike Petersen (Marburg, Germany) Cosimo Pizza (Salerno, Italy) Raffaele Riccio (Salerno, Italy) Vassilios Roussis (Athens, Greece) Angela Stafford (Sheffield, UK) Franca Tomé (Milan, Italy) Rob Verpoorte (Leiden, The Netherlands) Franco Zollo (Naples, Italy) Conference venue Historical building Faculty of Economy located at Via Partenope, 36 on the opposite side of Castel dell’Ovo. http://www.phytochemicalsociety.org/naples 3 Programme Tuesday – September 23 15.00 Opening Ceremony Virginia Lanzotti, Chairman Guido Trombetti, Rector of University of Naples Federico II Luciano Mayol, President of the School of Life Sciences and Technologies, University of Naples Federico II Paolo Masi, Dean of Faculty of Agricultural, University of Naples Federico II Giuseppe Cirino, Dean of Faculty of Pharmacy, University of Naples Federico II Giovanangelo Oriani, Dean of Faculty of Medicine, University of Molise Raffaele Riccio, President of Italian Chemical Society (SCI), Division of Organic Chemistry Cosimo Pizza, President of Italian Phychemical Society (SIF) Lars Bohlin, President of Phytochemical Society of Europe (PSE) CHAIRMAN: GIOVANNI APPENDINO, ITALY 15.30-16.10 PL1 – Gordon M. Cragg (U.S.A.) “Nature. A Vital Source of Leads for Anticancer Drug Development” 16.10-16.30 O1 – Francesco De Riccardis (Italy) “Synthesis of Antiproliferative Anion Transporters Inspired by Nature” 16.30-16.50 O2 – Caterina Fattorusso (Italy) “Taxol: a Great Peptido Mimetic Produced by Nature” 16.50-17.30 Coffee Break CHAIRMAN: LARS BOHLIN, SWEDEN 17.30-18.10 PL2 – Raffaele Riccio (Italy) “Synthetic and Computational Approaches towards the Development of New HDAC Inhibitors Useful in Cancer Therapy” 18.10-18.30 O3 – Henrik T. Simonsen (Denmark) “Alternative Production of Thapsigargin – A Prostate Cancer Drug” 18.30-18.50 O4 – Peter G. Parsons (Australia) “Anticancer Activity of a Novel Struc- tural Class of Spiroketals Isolated from Australian Rainforest Plants” 19.00 Welcome Mixer Wednesday – September 24 CHAIRMAN: VINCENZO FOGLIANO, ITALY 09.00-09.40 PL3 – Young-Joon Surh (South Korea) “Signal Transduction Network as Road Map in Search of Natural Products with Cancer Chemopreventive and Cytoprotective Activities” 09.40-10.00 O5 – Donatella Tramontano (Italy) “Resveratrol and EGCG Differently Regulate p66Shc” 10.00-10.20 O6 – Marco Romano (Italy) “Beneficial Effects of Apple Polyphenol Extract in the Gastrointestinal Tract” 10.20-10.40 O7 – Antonio Cilla (Spain) “Antiproliferative Activity of Zinc-fortified Fruit Beverages Subjected to in vitro Gastrointestinal Digestion in Human Colon Cancer Caco-2 Cells” 10.40-11.10 Coffee Break 4 CHAIRMAN: VASSILIOS ROUSSIS, GREECE 11.10-11.50 PL4 – Marco Falasca (United Kingdom) “Anticancer Activity of the Bioactive Compound Inositol Pentakisphosphate” 11.50 12.10 O8 – Mario Zoratti (Italy) “Mitochondria-targeted Polyphenol Derivatives” 12.10-12.30 O9 – Jan Schripsema (Brazil) “Quantitative Determination of Rumenic Acid, a Putative Anti-cancer Compound from Butter, by 1H-NMR” 12.30-12.50 O10 – Tania Pannellini (Italy) “Dietary Supplementation of Tomato Prevents Prostate Cancer in Tramp Mice” 13.00-14.00 Lunch 14.00-15.00 Free Poster Session CHAIRMAN: GERHARD HAMILTON, AUSTRIA 15.00-15.40 PL5 – Randolph Arroo (United Kingdom) “Chemopreventive Effects of Orange Peel Extract” 15.40-16.00 O11 – Pinarosa Avato (Italy) “Cytotoxic Effect of Saponins from Medicago on Tumor Cellular Lines” 16.00-16.20 O12 – Wieslaw Szeja (Poland) “Sugar Moiety Structure as a Principal Determinant of Antitumor Glycosides Biological Activity. Genistein Case Study” 16.20-17.00 Coffee Break CHAIRMAN: ALESSANDRO PICCOLO, ITALY 17.00-17.40 PL6 – Teris A. van Beek (The Netherlands) “Recent Developments in the Rapid Analysis of Plants and Tracking their Bioactive Constituents” 17.40-18.00 O13 – Daniela Smejkalova (Italy) “Metabolic Profile of Uterine Leiomyomas Using High Resolution Magic-angle Spinning 1H NMR Spectroscopy” 18.00-18.20 O14 – Yee V. Tang (Malaysia) “Photosensitisers from Malaysian Seaweeds for Photodynamic Therapy of Cancers” 19.00 Concert Thursday – September 25 CHAIRMAN: ANGELA STAFFORD, UNITED KINGDOM 09.00-09.40 PL7 – Dale G. Nagle (U.S.A.) “Discovery of Marine Natural Products that Target Tumor Hypoxia” 09.40-10.00 O15 – Yu-Dong Zhou (U.S.A.) “Pharmacological and Preclinical Evaluation of Manassantins: Potent Inhibitors of Hypoxia-induced HIF-1 Activation” 10.00-10.20 O16 – Salvatore Passarella (Italy) “Mitocondria as a Target of Drugs in Cancer and Diseases” 10.20-10.40 O17 – Maria V. D’Auria (Italy) “Homophymines, a New Family of Marine Cyclodepsipeptides” 10.40-11.10 Coffee Break CHAIRMAN: ERNESTO FATTORUSSO, ITALY 11.10-11.50 PL8 – Jörn Piel (Germany) “New Insights into Anitumor Polyketide Biosynthesis in Marine Sponges” 11.50 12.10 O18 – Antonio Randazzo (Italy) “Interaction of Distamycin A and its Derivatives with DNA Quadruplex Structures” 5 12.10-12.30 O19 – Dagmar Blaesius (Germany) “On The Pathways of Cell Death Induction by Myrtucommulone from Myrtus communis” 12.30-12.50 O20 – Antonio Evidente (Italy) “Anticancer Evaluation of Structurally Diverse Amaryllidaceae Alkaloids and their Synthetic Derivatives” 13.00-14.00 Lunch 14.00-15.00 Free Poster Session CHAIRMAN: FRANCA TOMÉ, ITALY 15.00-15.40 PL9 – Attilio Di Pietro (France) “Plant Products and Synthetic Derivatives as Specific Modulators of Multidrug ABC Transporters Responsible for Resistance to Anticancer Chemotherapeutics” 15.40-16.00 O21 – Gabriella Corea (Italy) “Jatrophane Diterpenes from Euphorbia spp. as Modulators of Multidrug Resistance in Cancer Therapy” 16.00-16.20 022 – Sonia Piacente (Italy) “Pergularia tomentosa: a Rich Source of Antiproliferativecardenolide Glycosides Targeting Na+/K+-ATP- ase Pump” 16.20-17.00 Coffee Break CHAIRMAN: DENIZ TASDEMIR, UNITED KINGDOM 17.00-17.40 PL10 – Eduardo Muñoz (Spain) “Antitumoral Activity of Naturally Occurring 1-4 Phenanthrenequinones. Mechanisms of Action” 17.40-18.00 O23 – Marialuisa Menna (Italy) “Antitumor Potential of Natural Products from Mediterranean Ascidians” 18.00-18.20 O24 – Tatjana Mijatovic (Belgium) “Sodium Pump Antagonist UNBS1450: a Novel Means to Combat Apoptosis and Multi-drug Resistant Cancer Cells” 18.30-20.00 Poster Session 20.30 Symposium Dinner Friday – September 26 CHAIRMAN: FATIH DEMIRCI, TURKEY 09.00-09.40 PL11 – Miroslav Strnad (Czech Republic) “Plant Hormone-derived Anticancer Drugs” 09.40-10.00 O25 – Francesco Epifanio (Italy) “Prenyloxyphenylpropanoids as a Novel Class of Colon Cancer Chemopreventive Agents” 10.00-10.20 O26 – Carlos Armando López-Moreno (Mexico) “Phytotherapy of Malignant and Benign Tumors with Mixtures of Extracts of Angiosperms from Arid Zones of North of Mexico” 10.20-10.50 Coffee Break CHAIRMAN: SATYA SARKER, UNITED KINGDOM 10.50-11.30 PL12 – Marc Diederich (Luxembourg) “Marine Compounds as Promising Anti-cancer Agents” 11.30-11.50 O27 – Francesca Borrelli (Italy) “Investigation of Cytotoxic, Genotoxic and Proliferative Effects of Rhein, an Anthraquinone Compound Isolated from Cassia Species, on Caco-2 Human Adenocarcinoma Cells” 11.50-12.10 O28 – Srinivas Gopala (India) “Molecular Mechanism of Plumbagin Action: an Update on its Antitumor Function” 12.10-12.30 Closure 6 List of Participants Australia Hungary Parsons, Maxine Sedlak, Eva P43 Parsons, Peter G. O4, P38 India Austria Babykutty, Suboj P41 Bukar, Franz Gopala, Srinivas O28 Hamilton, Gerhard P32 Sathiadevan, Priya Prasanna P41 Kretschmer, Nadine P25 Olszewski, Ulrike P32 Italy Appendino, Giovanni Belgium Avato, Pinarosa O11 Ingrassia, Laurent P23, P27 Bitam, Fatma P1 Kiss, Robert O22, O24, P23, P27 Borrelli, Francesca O27, P6 Mathieu, Veronique P27 Bradaschia, Alice O8, P3, P4 Mijatovic, Tatjana O22, O24, P23 Buommino, Elisabetta P5, P31 Cammareri, Maria P6, P33 Brazil Carbone, Marianna P7 Schripsema, Jan O9 Catalano, Giuseppe P59 Chillemi, Rosa P8 Bulgaria Chiummiento, Lucia P9 Ionkova, Iliana P24 Corea, Gabriella O21 Curini, Massimo O25 Congo D'Auria, Maria V. O17 Sinda, Julienne Daquino, Carmelo P11 De Riccardis, Francesco O1 Czech Republic De Socio, Paolo Hoffmannova, Lucie P21 Epifano, Francesco O25 Pribylova, Marie P37 Evidente, Antonio O20, P15 Slapetova, Tereza P46, P47 Fattorusso, Caterina O2 Šmejkal, Karel P46, P47 Fattorusso, Ernesto PL9, O21 Steigerova, Jana P51 Festa, Carmen P16, P56 Strnad, Miroslav PL11, P21, P51, P52 Fogliano, Vincenzo O6, O10 Svacinova, Jana P54 Garbisa, Spiridione O8, P3, P4, P28 Švarcova-Palikova, Irena P55 Incollingo, Filomena P22 Vrublova, Eva P55, P60 Iorizzi, Maria P16, P22, P56 Lanzotti, Virginia PL9, O21, P33 Denmark Magno, Silvana G. Knudsen, Lif Rødtness Vestrby O3 Mattarei, Andrea O8, P3, P28 Simonsen, Henrik T. O3 Menna, Marialuisa O23 Sølvhøj Søgard, Pernille Navarra, Michele P59 Nicoletti, Rosario P5, P31 Finland Pannellini, Tania O10 Aura, Anna-Marja Passarella,
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