ASC Webinar: Practical Approach to Liver Cytology Indication
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Impact of HIV on Gastroenterology/Hepatology
Core Curriculum: Impact of HIV on Gastroenterology/Hepatology AshutoshAshutosh Barve,Barve, M.D.,M.D., Ph.D.Ph.D. Gastroenterology/HepatologyGastroenterology/Hepatology FellowFellow UniversityUniversityUniversity ofofof LouisvilleLouisville Louisville Case 4848 yearyear oldold manman presentspresents withwith aa historyhistory ofof :: dysphagiadysphagia odynophagiaodynophagia weightweight lossloss EGDEGD waswas donedone toto evaluateevaluate thethe problemproblem University of Louisville Case – EGD Report ExtensivelyExtensively scarredscarred esophagealesophageal mucosamucosa withwith mucosalmucosal bridging.bridging. DistalDistal esophagealesophageal nodulesnodules withwithUniversity superficialsuperficial ulcerationulceration of Louisville Case – Esophageal Nodule Biopsy InflammatoryInflammatory lesionlesion withwith ulceratedulcerated mucosamucosa SpecialSpecial stainsstains forfor fungifungi revealreveal nonnon-- septateseptate branchingbranching hyphaehyphae consistentconsistent withwith MUCORMUCOR University of Louisville Case TheThe patientpatient waswas HIVHIV positivepositive !!!! University of Louisville HAART (Highly Active Anti Retroviral Therapy) HIV/AIDS Before HAART After HAART University of Louisville HIV/AIDS BeforeBefore HAARTHAART AfterAfter HAARTHAART ImmuneImmune dysfunctiondysfunction ImmuneImmune reconstitutionreconstitution OpportunisticOpportunistic InfectionsInfections ManagementManagement ofof chronicchronic ¾ Prevention diseasesdiseases e.g.e.g. HepatitisHepatitis CC ¾ Management CirrhosisCirrhosis NeoplasmsNeoplasms -
Steatosis in Hepatitis C: What Does It Mean? Tarik Asselah, MD, Nathalie Boyer, MD, and Patrick Marcellin, MD*
Steatosis in Hepatitis C: What Does It Mean? Tarik Asselah, MD, Nathalie Boyer, MD, and Patrick Marcellin, MD* Address Steatosis *Service d’Hépatologie, Hôpital Beaujon, Mechanisms of steatosis 100 Boulevard du Général Leclerc, Clichy 92110, France. Hepatic steatosis develops in the setting of multiple E-mail: [email protected] clinical conditions, including obesity, diabetes mellitus, Current Hepatitis Reports 2003, 2:137–144 alcohol abuse, protein malnutrition, total parenteral Current Science Inc. ISSN 1540-3416 Copyright © 2003 by Current Science Inc. nutrition, acute starvation, drug therapy (eg, corticosteroid, amiodarone, perhexiline, estrogens, methotrexate), and carbohydrate overload [1–4,5••]. Hepatitis C and nonalcoholic fatty liver disease (NAFLD) are In the fed state, dietary triglycerides are processed by the both common causes of liver disease. Thus, it is not surprising enterocyte into chylomicrons, which are secreted into the that they can coexist in the same individual. The prevalence of lymph. The chylomicrons are hydrolyzed into fatty acids by steatosis in patients with chronic hepatitis C differs between lipoprotein lipase. These free fatty acids are transported to the studies, probably reflecting population differences in known liver, stored in adipose tissue, or used as energy sources by risk factors for steatosis, namely overweight, diabetes, and muscles. Free fatty acids are also supplied to the liver in the dyslipidemia. The pathogenic significance of steatosis likely form of chylomicron remnants, which are then hydrolyzed by differs according to its origin, metabolic (NAFLD or non- hepatic triglyceride lipase. During fasting, the fatty acids sup- alcoholic steatohepatitis) or virus related (due to hepatitis C plied to the liver are derived from hydrolysis (mediated by a virus genotype 3). -
In Colorectal Cancer
Article Evaluation of Adjuvant Chemotherapy-Associated Steatosis (CAS) in Colorectal Cancer Michelle C. M. Lee 1,2 , Jacob J. Kachura 3, Paraskevi A. Vlachou 1,2, Raissa Dzulynsky 1, Amy Di Tomaso 3, Haider Samawi 1,2, Nancy Baxter 1,2 and Christine Brezden-Masley 1,3,4,* 1 St. Michael’s Hospital, 30 Bond St, Toronto, ON M5B 1W8, Canada; [email protected] (M.C.M.L.); [email protected] (P.A.V.); [email protected] (R.D.); [email protected] (H.S.); [email protected] (N.B.) 2 Medical Sciences Building, 1 King’s College Circle, University of Toronto, Toronto, ON M5S 1A8, Canada 3 Mount Sinai Hospital, 1284-600 University Avenue, Toronto, ON M5G 1X5, Canada; [email protected] (J.J.K.); [email protected] (A.D.T.) 4 Lunenfeld-Tanenbaum Research Institute, 600 University Ave, Toronto, ON M5G 1X5, Canada * Correspondence: [email protected]; Tel.: +416-586-8605; Fax: +416-586-8659 Abstract: Chemotherapy-associated steatosis is poorly understood in the context of colorectal can- cer. In this study, Stage II–III colorectal cancer patients were retrospectively selected to evaluate the frequency of chemotherapy-associated steatosis and to determine whether patients on statins throughout adjuvant chemotherapy develop chemotherapy-associated steatosis at a lower frequency. Baseline and incident steatosis for up to one year from chemotherapy start date was assessed based on radiology. Of 269 patients, 76 (28.3%) had steatosis at baseline. Of the remaining 193 cases, patients receiving adjuvant chemotherapy (n = 135) had 1.57 (95% confidence interval [CI], 0.89 to 2.79) times the adjusted risk of developing steatosis compared to patients not receiving chemotherapy (n = 58). -
Symmetrical Peripheral Gangrene Associated with Low Output Cardiac Failure
Tower Health Scholar Commons @ Tower Health Reading Hospital Internal Medicine Residency Internal Medicine Residency 7-17-2019 Symmetrical Peripheral Gangrene Associated with Low Output Cardiac Failure. Sijan Basnet Reading Hospital-Tower Health Priya Rajagopalan Thomas Jefferson University Hospital Rashmi Dhital Reading Hospital-Tower Health Ataul Qureshi Thomas Jefferson University Hospital Follow this and additional works at: http://scholarcommons.towerhealth.org/ gme_int_med_resident_program_read Part of the Cardiology Commons Recommended Citation Basnet, S., Rajagopalan, P., Dhital, R., & Qureshi, A. (2019). Symmetrical Peripheral Gangrene Associated with Low Output Cardiac Failure.. Medicina (Kaunas, Lithuania), 55 (7) https://doi.org/10.3390/ medicina55070383. This Article is brought to you for free and open access by the Internal Medicine Residency at Scholar Commons @ Tower Health. It has been accepted for inclusion in Reading Hospital Internal Medicine Residency by an authorized administrator of Scholar Commons @ Tower Health. For more information, please contact [email protected]. medicina Case Report Symmetrical Peripheral Gangrene Associated with y Low Output Cardiac Failure Sijan Basnet 1,* , Priya Rajagopalan 2, Rashmi Dhital 1 and Ataul Qureshi 2 1 Department of Medicine, Reading Hospital and Medical Center, West Reading, PA 19611, USA 2 Thomas Jefferson University Hospital, 1025 Walnut Street, Philadelphia, PA 19107, USA * Correspondence: [email protected]; Tel.: +484-628-8255 The abstract was accepted for poster presentation at “Heart Failure Society of America 2018 Annual y Meeting” and was published in Journal of Cardiac Failure. Received: 15 January 2019; Accepted: 15 July 2019; Published: 17 July 2019 Abstract: Symmetrical peripheral gangrene (SPG) is a rare entity characterized by ischemic changes of the distal extremities with maintained vascular integrity. -
Abdominal and Pelvic Imaging Findings Associated with Sex Hormone Abnormalities
UCSF UC San Francisco Previously Published Works Title Abdominal and pelvic imaging findings associated with sex hormone abnormalities. Permalink https://escholarship.org/uc/item/7cq623wg Journal Abdominal radiology (New York), 44(3) ISSN 2366-004X Authors Kurzbard-Roach, Nicole Jha, Priyanka Poder, Liina et al. Publication Date 2019-03-01 DOI 10.1007/s00261-018-1844-1 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Abdominal Radiology https://doi.org/10.1007/s00261-018-1844-1 (0123456789().,-volV)(0123456789().,-volV) REVIEW Abdominal and pelvic imaging findings associated with sex hormone abnormalities 1 1 1 2 Nicole Kurzbard-Roach • Priyanka Jha • Liina Poder • Christine Menias Ó Springer Science+Business Media, LLC, part of Springer Nature 2018 Abstract Hormones are substances that serve as chemical communication between cells. They are unique biological molecules that affect multiple organ systems and play a key role in maintaining homoeostasis. In this role, they are usually produced from a single organ and have defined target organs. However, hormones can affect non-target organs as well. As such, biochemical and hormonal abnormalities can be associated with anatomic changes in multiple target as well as non-target organs. Hormone-related changes may take the form of an organ parenchymal abnormality, benign neoplasm, or even malignancy. Given the multifocal action of hormones, the observed imaging findings may be remote from the site of production, and may actually be multi-organ in nature. Anatomic findings related to hormone level abnormalities and/or laboratory biomarker changes may be identified with imaging. The purpose of this image-rich review is to sensitize radiologists to imaging findings in the abdomen and pelvis that may occur in the context of hormone abnormalities, focusing primarily on sex hormones and their influence on these organs. -
Acute Pancreatitis, Non-Alcoholic Fatty Pancreas Disease, and Pancreatic Cancer
JOP. J Pancreas (Online) 2017 Sep 29; 18(5):365-368. REVIEW ARTICLE The Burden of Systemic Adiposity on Pancreatic Disease: Acute Pancreatitis, Non-Alcoholic Fatty Pancreas Disease, and Pancreatic Cancer Ahmad Malli, Feng Li, Darwin L Conwell, Zobeida Cruz-Monserrate, Hisham Hussan, Somashekar G Krishna Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA ABSTRACT Obesity is a global epidemic as recognized by the World Health Organization. Obesity and its related comorbid conditions were recognized to have an important role in a multitude of acute, chronic, and critical illnesses including acute pancreatitis, nonalcoholic fatty pancreas disease, and pancreatic cancer. This review summarizes the impact of adiposity on a spectrum of pancreatic diseases. INTRODUCTION and even higher mortality in the setting of AP based on multiple reports [8, 9, 10, 11, 12]. Despite the rising incidence Obesity is a global epidemic as recognized by the World of AP over the past two decades, there has been a decrease Health Organization [1]. One third of the world’s population in its overall mortality rate without any obvious decrement is either overweight or obese, and it has doubled over the in the mortality rate among patients with concomitant AP past two decades with an alarming 70% increase in the and morbid obesity [12, 13]. Several prediction models and prevalence of morbid obesity from year 2000 to 2010 [2, risk scores were proposed to anticipate the severity and 3, 4]. Obesity and its related comorbid conditions were prognosis of patient with AP; however, their clinical utility recognized to have an important role in a multitude of is variable, not completely understood, and didn’t take acute, chronic, and critical pancreatic illnesses including obesity as a major contributor into consideration despite the acute pancreatitis, non-alcoholic fatty pancreas disease, aforementioned association [14]. -
Non - Alcoholic Fatty Liver Disease
NON - ALCOHOLIC FATTY LIVER DISEASE Author: Nicolene Naidu Bachelor of Biological Science (Cellular Biology), Bachelor of Medical Science (Medical Microbiology) (Honours) Non - Alcoholic Fatty Liver Disease (termed NAFLD for short) is a condition characterized by the significant accumulation of lipids in the hepatocytes of the liver parenchyma. While non - alcoholic fatty liver disease and alcoholic liver disease are pathologically similar, unlike alcoholic liver disease, non - alcoholic fatty liver disease occurs in patients who do not have a history of excessive alcohol intake. Another term closely related to NAFLD but more histologically and clinically specific is Non - Alcoholic Steatohepatitis(NASH). It was coined by Ludwig et al in 1980 and is characterised by a fatty liver accompanied by inflammation and hepatocyte injury (“Ballooning”). Fibrosis may or may not be present. It should be noted that the histological appearance of non – alcoholic steatohepatitis is identical to that of alcoholic liver disease. Distinction between the two is based on the amount of alcohol intake. Non - alcoholic fatty liver disease is the loose term used to describe a wide spectrum of liver damage ranging from hepatic steatosis (simple benign fatty liver), non - alcoholic steatohepatitis, chronic fibrosis and cirrhosis (P Angulo, 2002). Figure 1: Showing a drawing of the various stages of liver damage, including a normal liver; fatty liver in which deposits of fat cause liver enlargement; liver fibrosis in which scar tissueforms and more liver cell injury occurs and cirrhosis in which scar tissue makes the liver hard and unable to work properly.(www.liverfoundation.org). 1 Pseudo-alcoholic liver disease, non - alcoholic Laennec’s disease, alcohol-like hepatitis, diabetic hepatitis and steatonecrosis are among the terms that have been used to refer to non – alcoholic fatty liver disease (Shethet al, 1997). -
Primary Renal Carcinoid Tumor: a Radiologic Review
Radiology Case Reports Volume 9, Issue 2, 2014 Primary renal carcinoid tumor: A radiologic review Leslie Lamb, MD, Msc, Bsc; Wael Shaban, MBBCH, MD, PhD Carcinoid tumor is the classic famous anonym of neuroendocrine neoplasms. Primary renal carcinoid tumors are extremely rare, first described by Resnick and colleagues in 1966, with fewer than a total of 100 cases reported in the literature. Thus, given the paucity of cases, the clinical and histological behav- ior is not well understood, impairing the ability to predict prognosis. Computed tomography and (occa- sionally) octreotide studies are used in the diagnosis and followup of these rare entites. A review of 85 cases in the literature shows that no distinctive imaging features differentiate them from other primary renal masses. The lesions tend to demonstrate a hypodense appearance and do not usually enhance in the arterial phases, but can occasionally calcify. Octreotide scans do not seem to help in the diagnosis; however, they are more commonly used in the postoperative followup. In addition, we report a new case of primary renal carcinoid in a horseshoe kidney. Case report Imaging findings 40-year-old male initially presented to a community hos- pital with a 20-lb weight loss over a few months. In retro- CT of the abdomen and pelvis, done in the portal ve- spect, the patient recalled mild left-flank discomfort and nous phase, demonstrated a solid, hypodense, 4.5-cm renal fatigue, but denied any hematuria. Blood work revealed an mass containing calcifications, located in the posterior as- elevated serum glucose, and he was diagnosed with type 2 pect of the medial diabetes. -
Liver & Pancreas
276A ANNUAL MEETING ABSTRACTS 1263 Renal Pathology in Hematopoeitic Cell Transplantation Design: We studied 58 consecutive liver allografts from 53 pediatric patients (<18 Recipients yrs) who underwent OLT from 1995-2006. All allograft biopsies were scored for the ML Troxell, M Pilapil, D Miklos, JP Higgins, N Kambham. OHSU, Portland, OR; following features: 1) CLH (mild, moderate, severe), 2) portal AR (mild, moderate, Stanford Univ, Stanford, CA. severe), 3) zone 3 fibrosis (mild=perivenular or severe=bridging), and 4) ductopenia. Background: Hematopoietic cell transplantation (HCT) associated acute and chronic Five explanted livers that were removed during the course of retransplantation for graft renal toxicity can be due to cytotoxic conditioning agents, radiation, infection, failure in this group were also reviewed. immunosuppressive agents, ischemia, and graft versus host disease (GVHD). We have Results: Mean age at OLT was 7 yrs (range 7 wks-18 yrs) with 29 boys and 24 girls. reviewed consecutive renal biopsy specimens in HCT patients from a single center. We reviewed a total of 417 allograft biopsies (mean 7.2 per allograft) obtained 2 days Design: The files of Stanford University Medical Center Department of Pathology were - 11 yrs post-OLT; 200 (48%) of these were protocol biopsies. Forty-six allografts (79%) searched for renal biopsy specimens in patients who received HCT (1995-2005); 11 had >1 yr of histologic follow-up, 29 (50%) had >3 yrs, and 21 (36%) >5 yrs. Overall, cases were identified (post BMT time 0.7 to 14.5 years). The biopsies were processed CLH was observed on at least one occasion in 38 (66%) allografts. -
Solitary Duodenal Metastasis from Renal Cell Carcinoma with Metachronous Pancreatic Neuroendocrine Tumor: Review of Literature with a Case Discussion
Published online: 2021-05-24 Practitioner Section Solitary Duodenal Metastasis from Renal Cell Carcinoma with Metachronous Pancreatic Neuroendocrine Tumor: Review of Literature with a Case Discussion Abstract Saphalta Baghmar, Renal cell cancinoma (RCC) is a unique malignancy with features of late recurrences, metastasis S M Shasthry1, to any organ, and frequent association with second malignancy. It most commonly metastasizes Rajesh Singla, to the lungs, bones, liver, renal fossa, and brain although metastases can occur anywhere. RCC 2 metastatic to the duodenum is especially rare, with only few cases reported in the literature. Herein, Yashwant Patidar , 3 we review literature of all the reported cases of solitary duodenal metastasis from RCC and cases Chhagan B Bihari , of neuroendocrine tumor (NET) as synchronous/metachronous malignancy with RCC. Along with S K Sarin1 this, we have described a unique case of an 84‑year‑old man who had recurrence of RCC as solitary Departments of Medical duodenal metastasis after 37 years of radical nephrectomy and metachronous pancreatic NET. Oncology, 1Hepatology, 2Radiology and 3Pathology, Keywords: Late recurrence, pancreatic neuroendocrine tumor, renal cell carcinoma, second Institute of Liver and Biliary malignancy, solitary duodenal metastasis Sciences, New Delhi, India Introduction Case Presentation Renal cell carcinoma (RCC) is unique An 84‑year‑old man with a medical history to have many unusual features such as notable for hypertension and RCC, 37 years metastasis to almost every organ in the body, postright radical nephrectomy status, late recurrences, and frequent association presented to his primary care physician with second malignancy. The most common with fatigue. When found to be anemic, sites of metastasis are the lung, lymph he was treated with iron supplementation nodes, liver, bone, adrenal glands, kidney, and blood transfusions. -
Genital Necrotizing Fasciitis: Fournier's Gangrene
DERMATOLOGY ISSN 2473-4799 http://dx.doi.org/10.17140/DRMTOJ-1-109 Open Journal Case Report Genital Necrotizing Fasciitis: Fournier's * Corresponding author Gangrene Sara Yáñez Madriñán, PhD Department of Obstetrics and Gynecology Service University Hospital of Santiago de Manuel Macía Cortiñas, PhD; Maite Peña Fernández, PhD; Susana González López, * Compostela PhD; Sara Yáñez Madriñán, PhD Corunna, Spain Tel. 650927231 E-mail: [email protected] Department of Obstetrics and Gynecology Service, University Hospital of Santiago de Com- postela, Corunna, Spain Volume 1 : Issue 2 Article Ref. #: 1000DRMTOJ1109 ABSTRACT Article History Necrotizing fasciitis is characterized by a rapidly progressive infectious disease affecting skin Received: January 30th, 2016 and soft tissue, usually accompanied by severe systemic toxicity. In fact, it is considered the Accepted: May 18th, 2016 most serious expression of soft tissue infection, by its rapid destruction and tissue necrosis, Published: May 18th, 2016 reaching more than 30% of patients checkered shock and organ failure. In recent years, its incidence is reported at 1: 100,000. This entity in the case of perineal and genital tract Citation involvement, it is called Fournier’s gangrene. In the specialty of Obstetrics and Gynecology is Cortiñas MM, Fernández MP, López a rare infectious complication. SG, Madriñán SY. Genital necrotizing fasciitis: fournier's gangrene. Derma- INTRODUCTION tol Open J. 2016; 1(2): 30-34. doi: 10.17140/DRMTOJ-1-109 Necrotizing fasciitis is a term that describes a disease condition of rapidly spreading infection, usually located in fascial planes of connective tissue necrosis. Fascial planes are bands of connective tissue tha surround muscles, nerves and blood vessels. -
"Gastrointestinal Tract Pathology"
IIC,J CALIFORNIA TUMOR TISSUE REGISTRY "GASTROINTESTINAL TRACT PATHOLOGY" Study Cases, Subscription A March 2000 California Tumor Tissue Registry c/o: De1mrtment of Pathology and Human Anatomy Loma Linda Univcr.;ily School ofMcd.icine 11021 Campus Avenue, AH 335 Lomn Linda, California 92350 (909) 558-4788 FAX: (909) 558·0188 E-mail: [email protected] Case oftbe Month: www.llu.edu/Uu/cttr/cotm Target audience: Practicing pathologists and pathology residents. Goal: To acquairu the participam with the hiswlogic featu res of a variety of benign and malignant neoplasms and tumor-l ike conditions. Objectives: n1e participant will be able to recognize morphologic features ofa variety of benign and malignam neoplasms and tWllOr-like conditions and relate those processes to pertinent references in d1e medical literature. Educational methods and media: Review of representative glass slides v.ith associated histories. Feedback on consensus diagnoses lt·om participating pathologists. Listing of selected references from the medical literature. Principal faculty: Weldon K. Bullock, Ml) Donald R. Chase, MD CME Credit: Lorna Li.nda University School of Medicine designates this continuing medical education·activity for up to 2 hours of Category I of the Physician's Recogn ition Award oft he· American Medical Association. CME credit is offered for d1e subscription year only. Accreditation: Loma Linda University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians. Contributor: James A. Henry, M.D. Case No. 1 - March 2000 Woodbridge, VA Tissue from: Terminal ileum Accession #28502 Clinical Abstract: This 37-year-old black female presented with several weeks' history of right lower quadrant abdominal pain radiating to the right side of the back and right inguinal area.