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Biodefense in the Age of Synthetic Biology.Pdf THE NATIONAL ACADEMIES PRESS This PDF is available at http://nap.edu/24890 SHARE Biodefense in the Age of Synthetic Biology (2018) DETAILS 188 pages | 8.5 x 11 | PAPERBACK ISBN 978-0-309-46518-2 | DOI 10.17226/24890 CONTRIBUTORS GET THIS BOOK Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology; Board on Chemical Sciences and Technology; Board on Life Sciences; Division on Earth and Life Studies; FIND RELATED TITLES National Academies of Sciences, Engineering, and Medicine SUGGESTED CITATION National Academies of Sciences, Engineering, and Medicine 2018. Biodefense in the Age of Synthetic Biology. Washington, DC: The National Academies Press. https://doi.org/10.17226/24890. Visit the National Academies Press at NAP.edu and login or register to get: – Access to free PDF downloads of thousands of scientific reports – 10% off the price of print titles – Email or social media notifications of new titles related to your interests – Special offers and discounts Distribution, posting, or copying of this PDF is strictly prohibited without written permission of the National Academies Press. (Request Permission) Unless otherwise indicated, all materials in this PDF are copyrighted by the National Academy of Sciences. Copyright © National Academy of Sciences. All rights reserved. Biodefense in the Age of Synthetic Biology Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology Board on Chemical Sciences and Technology Board on Life Sciences Division on Earth and Life Studies Copyright National Academy of Sciences. All rights reserved. Biodefense in the Age of Synthetic Biology THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001 This project was supported by Contract No. HQ0034-16-C-0062 between the National Academy of Sciences and the U.S. Department of Defense. Any opinions, findings, conclusions, or recommendations expressed in this publication do not neces- sarily reflect the view of any organization or agency that provided support for the project. International Standard Book Number-13: 978-0-309-46518-2 International Standard Book Number-10: 0-309-46518-4 Library of Congress Control Number: 2018911261 Digital Object Identifier: https://doi.org/10.17226/24890 Copyright 2018 by the National Academy of Sciences. All rights reserved. Printed in the United States of America Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2018. Biodefense in the Age of Synthetic Biology. Washington, DC: The National Academies Press. doi: https://doi.org/10.17226/24890. Copyright National Academy of Sciences. All rights reserved. Biodefense in the Age of Synthetic Biology The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for out- standing contributions to research. Dr. Marcia McNutt is president. The National Academy of Engineering was established in 1964 under the charter of the National Academy of Sciences to bring the practices of engineering to advising the nation. Members are elected by their peers for extraordinary contributions to engineer- ing. Dr. C. D. Mote, Jr., is president. The National Academy of Medicine (formerly the Institute of Medicine) was established in 1970 under the charter of the National Academy of Sciences to advise the nation on medical and health issues. Members are elected by their peers for distinguished contribu- tions to medicine and health. Dr. Victor J. Dzau is president. The three Academies work together as the National Academies of Sciences, Engineering, and Medicine to provide independent, objective analysis and advice to the nation and conduct other activities to solve complex problems and inform public policy decisions. The National Academies also encourage education and research, recognize outstanding contributions to knowledge, and increase public understanding in matters of science, engineering, and medicine. Learn more about the National Academies of Sciences, Engineering, and Medicine at www.nationalacademies.org. Copyright National Academy of Sciences. All rights reserved. Biodefense in the Age of Synthetic Biology Consensus Study Reports published by the National Academies of Sciences, Engineering, and Medicine document the evidence-based consensus on the study’s statement of task by an authoring committee of experts. Reports typically include findings, conclusions, and recommendations based on information gathered by the committee and the committee’s deliberations. Each report has been subjected to a rigorous and independent peer-review process and it represents the position of the National Academies on the statement of task. Proceedings published by the National Academies of Sciences, Engineering, and Medicine chronicle the presentations and discussions at a workshop, symposium, or other event convened by the National Academies. The statements and opinions contained in proceed- ings are those of the participants and are not endorsed by other participants, the planning committee, or the National Academies. For information about other products and activities of the National Academies, please visit www.nationalacademies.org/about/whatwedo. Copyright National Academy of Sciences. All rights reserved. Biodefense in the Age of Synthetic Biology COMMITTEE ON STRATEGIES FOR IDENTIFYING AND ADDRESSING POTENTIAL BIODEFENSE VULNERABILITIES POSED BY SYNTHETIC BIOLOGY Members MICHAEL IMPERIALE (Chair), University of Michigan Medical School PATRICK BOYLE,1 Ginkgo Bioworks PETER A. CARR, Massachusetts Institute of Technology Lincoln Laboratory DOUGLAS DENSMORE, Boston University DIANE DIEULIIS, National Defense University ANDREW ELLINGTON, University of Texas at Austin GIGI KWIK GRONVALL, Johns Hopkins Center for Health Security CHARLES HAAS, Drexel University JOSEPH KANABROCKI, University of Chicago KARA MORGAN, Quant Policy Strategies, LLC KRISTALA JONES PRATHER, Massachusetts Institute of Technology THOMAS SLEZAK, Lawrence Livermore National Laboratory JILL TAYLOR, New York State Department of Health Staff MARILEE SHELTON-DAVENPORT, Study Director KATHERINE BOWMAN, Senior Program Officer JENNA OGILVIE, Research Associate JARRETT NGUYEN, Senior Program Assistant 1 See Appendix E, Disclosure of Conflict of Interest. v Copyright National Academy of Sciences. All rights reserved. Biodefense in the Age of Synthetic Biology BOARD ON CHEMICAL SCIENCES AND TECHNOLOGY Co-Chairs DAVID BEM, PPG Industries JOAN BRENNECKE, NAE, University of Texas, Austin Members GERARD BAILLELY, Procter and Gamble MARK A. BARTEAU, NAE, Texas A&M MICHELLE V. BUCHANAN, Oak Ridge National Laboratory JENNIFER SINCLAIR CURTIS, University of California, Davis RICHARD EISENBERG, NAS, University of Rochester SAMUEL H. GELLMAN, NAS, University of Wisconsin–Madison SHARON C. GLOTZER, NAS, University of Michigan MIRIAM E. JOHN, Sandia National Laboratories (retired) ALAN D. PALKOWITZ, Eli Lilly and Company (retired) JOSEPH B. POWELL, Shell PETER J. ROSSKY, NAS, Rice University RICHMOND SARPONG, University of California, Berkeley TIMOTHY SWAGER, NAS, Massachusetts Institute of Technology National Academies of Sciences, Engineering, and Medicine Staff TERESA FRYBERGER, Board Director MARILEE SHELTON-DAVENPORT, Senior Program Officer CAMLY TRAN, Senior Program Officer ANNA SBEREGAEVA, Associate Program Officer JARRETT I. NGUYEN, Senior Program Assistant JESSICA WOLFMAN, Senior Program Assistant SHUBHA BANSKOTA, Financial Associate vi Copyright National Academy of Sciences. All rights reserved. Biodefense in the Age of Synthetic Biology BOARD ON LIFE SCIENCES Chair JAMES P. COLLINS, Arizona State University Members ALONSO AGUIRRE, George Mason University ENRIQUETA C. BOND, Burroughs Wellcome Fund DOMINIQUE BROSSARD, University of Wisconsin-Madison ROGER D. CONE, University of Michigan NANCY D. CONNELL, Rutgers New Jersey Medical School SEAN M. DECATUR, Kenyon College JOSEPH R. ECKER, Salk Institute for Biological Studies SCOTT V. EDWARDS, Harvard University GERALD L. EPSTEIN, National Defense University ROBERT J. FULL, University of California, Berkeley ELIZABETH HEITMAN, Vanderbilt University Medical Center JUDITH KIMBLE, University of Wisconsin–Madison MARY E. MAXON, Lawrence Berkeley National Laboratory ROBERT NEWMAN, Independent Consultant STEPHEN J. O’BRIEN, Nova Southeastern University CLAIRE POMEROY, Albert and Mary Lasker Foundation MARY E. POWER, University of California, Berkeley SUSAN RUNDELL SINGER, University of California, Berkeley LANA SKIRBOLL, Sanofi DAVID R. WALT, Harvard Medical School Staff FRANCES SHARPLES, Director KATHERINE BOWMAN, Senior Program Officer ANDREA HODGSON, Program Officer JO HUSBANDS, Senior Scholar KEEGAN SAWYER, Senior Program Officer AUDREY THEVENON, Program Officer JESSICA DE MOUY, Senior Program Assistant KOSSANA YOUNG, Senior Program Assistant vii Copyright National Academy of Sciences. All rights reserved. Biodefense in the Age of Synthetic Biology Copyright National Academy of Sciences. All rights reserved. Biodefense in the Age of Synthetic Biology Acknowledgment of Reviewers This Consensus Study Report was reviewed in draft form by individuals chosen for their diverse perspec- tives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the National Academies of
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