bioRxiv preprint doi: https://doi.org/10.1101/2020.09.29.319590; this version posted October 1, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Enhanced Anticoagulation Activity of Functional RNA Origami Abhichart Krissanaprasit, Carson M. Key, Kristen Froehlich, Sahil Pontula, Emily Mihalko, Daniel M. Dupont, Ebbe S. Andersen, Jørgen Kjems, Ashley C. Brown, and Thomas H. LaBean* Dr. A Krissanaprasit, C. M. Key, Prof. T. H. LaBean Department of Materials Science and Engineering, College of Engineering, North Carolina State University, Raleigh, NC, 27695, USA. E-mail:
[email protected] K. Froehlich, E. Mihalko, Prof. A. C. Brown Joint Department of Biomedical Engineering, College of Engineering, North Carolina State University and University of North Carolina - Chapel Hill, Raleigh, NC, 27695, USA. S. Pontula William G. Enloe High School, Raleigh, NC 27610, USA Dr. D. M. Dupont, Prof. E. S. Andersen, Prof. J. Kjems Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C, Denmark Prof. A. C. Brown, Prof. T. H. LaBean Comparative Medicine Institute, North Carolina State University and University of North Carolina - Chapel Hill, Raleigh, NC, 27695, USA. Keywords: anticoagulant, RNA origami, nucleic acid, RNA nanotechnology, aptamer, direct thrombin inhibitor, reversal agent 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.09.29.319590; this version posted October 1, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Abstract Anticoagulants are commonly utilized during surgeries and to treat thrombotic diseases like stroke and deep vein thrombosis.