DOCSLIB.ORG

June 2007 (PDF)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
June 2007 (PDF) STRONG HEART STUDY I NVESTIGATING C ARDIOVASCULAR D ISEASE IN A MERICAN I NDIANS newsletter strongheart.ouhsc.edu Volume 19, Number 1 June 2007 Working with Scientists Across the Country Helps the Strong Heart Study Benefit our Communities Because the Strong Heart Study (SHS) has been The scientists at CNMC are also working on other ongoing for eighteen years, it has a tremendous projects. One project studies athletes before and collection of data from the blood and urine samples after training and conditioning. They hope to find that were collected, from questionnaires, and from changes in the way certain genes work that might the DNA samples that were stored. As you know, pinpoint what genes control energy use and me- SHS studies are focused on understanding heart tabolism. They are especially interested in a gene disease and its risk factors. There are high rates of called PGC-1 alpha that works with a gene called diabetes and obesity in our communities; therefore, PPAR that has already been studied in SHS. there is a special emphasis on these two risk fac- They also have discovered two genes called TPD tors. The Institutional Review Boards (“IRB’s”, that and BCL-6 that have effects on how cells grow monitor and control research among hu- and multiply (and sometimes cause man participants) and the tribal councils blockages in our arteries). They found review our study plans before each new one change in the TPD gene that exam; and those of you who are partici- makes people more resistant to their pants are given lots of information about own insulin and also develop high what tests we are going to do when you blood fats. The BCL gene seems to sign the consent form. help control energy metabolism in these athletes. The CNMC investiga- Sometimes we have to cooperate with tors will now work with us to test these other well-known, qualified scientists who same genes in the Strong Heart Study are able to do tests that we are not able samples. Trying to find the really im- to do in our own laboratories and clinics. portant ways that our bodies control For example, scientists that we work with metabolism and energy is a slow proc- at Children’s National Medical Center (CNMC) in ess. Sometimes investigators will find a gene or Washington, DC are able to check for very slight marker in one population, but it doesn’t seem to changes in the DNA. The system they developed be important in another population. If investiga- is able to test hundreds of samples in a very short tors can work together to test their findings in dif- period of time and uses only an extremely small ferent populations, it can advance knowledge amount of DNA, so much more research can be faster and further. This will bring us closer to the done on the SHS samples before they are used up. goal of these genetic studies, which is to find ways The plans for the current exams, which were pre- to predict who will become resistant to insulin and sented to the tribes and the IRB’s, included tests develop diabetes, who will have high blood fat lev- for a number of genes such as PPAR, IL-6, throm- els and who is more likely to become overweight; bospondin, lymphotoxin and TLR-4 genes. These or maybe even lead to medicines or other treat- names are complicated but basically they are ments to prevent these problems. By working with genes that make proteins we think are important in other researchers in this way, the SHS makes bet- understanding what causes diabetes and makes ter use of the data and samples to develop better hardening of the arteries happen. prevention and treatment methods sooner. SHS 1 SHS Newsletter June 2007 Second Exam of Family Study in Full Swing The second examination of the family study co- how these data may be used to improve the hort is going strong. As of March 1st all three health of American Indians. Even the central centers were ahead of schedule in recruitment chemistry laboratory at Penn Medical Labora- for the follow-up examination. The Arizona tory in Washington D.C. and the ECG labora- center had examined 315 participants, Okla- tory at Cornell School of Medicine in New York homa had examined 352 participants, and the had to overcome equipment failures. Penn Dakota center had examined 415 participants. Medical Laboratory has struggled with new As with any large project, there are always diffi- equipment for analyzing blood samples that culties as written study protocol, new equip- has not met the high standards required for the ment, new staff, extensive train- Strong Heart Study samples. This ing, and required certification are has delayed the samples for an put to the test. Arizona had to extended period while the manu- overcome a blown gasket on facturer tries to bring the equip- their new van that carries the ul- ment up to acceptable perform- trasound equipment for imaging ance. Samples remain stored and atherosclerosis in the arteries of safe throughout this delay which your neck and legs. The Dako- now appears to be resolved. Re- tas have had to endure the sea- sults from delayed assays are ex- sonal rain that makes many pected in the next few weeks. roads in the reservation difficult, Malfunctioning ECG equipment if not impossible, to use. Okla- caused some of the first exams of homa has struggled to identify the new cycle to be lost because clinic space for the Strong Heart Study exam the storage mechanism was not working prop- facilities. In spite of these challenges, Strong erly. This problem has also been resolved with Heart Study staff have found ways to overcome minimal loss. As these issues are resolved, the all of these issues and have found the study Strong Heart Study staff looks forward to see- participants eager to be part of this multi-center ing the Strong Heart Family Study participants project that is defining the burden of cardiovas- and updating them on their health. Hope to see cular disease in Indian Country and identifying you soon! SHS Impact of Obesity on Cardiac Geometry and Function in a Population of Adolescents: The Strong Heart Study In adults, obesity causes enlargement of the ments of the U.S. population and in most heart and increase weight of the heart muscle countries around the world, we used measures (called hypertrophy) and negatively affects the of the size and function of the heart obtained ability of heart to increase blood supply to the from echocardiograms - - tests performed us- body in response to stresses. In obese adults, ing high-frequency sound aimed at the heart the heart may also be less able to relax after using a probe positioned on the surface of the pumping blood into the arterial tree. Whether or chest. Participants aged 15-20 years in the 4th not these abnormalities also affect the heart of Strong Heart Study examination, the Strong overweight or obese adolescents had not been Heart Family study, had echocardiograms per- well-documented in population-based samples. formed and the findings related to their body weight in relation to their height. Among 460 To address this question, of particular impor- adolescent participants in the 4th Strong Heart tance in view of rising body weight in all seg- (Continued on page 3) 2 SHS Newsletter June 2007 Impact of Obesity on Cardiac Geometry (Continued from page 2) Study examination, 26% had normal body weight was out of proportion with that needed weight by U.S national guidelines, 25% were to pump blood to the body and was also asso- overweight and 49% were obese. Obese, but ciated with clear abnormalities in both the not overweight, adolescent Strong Heart Study pumping function of the heart and its ability to participants were more likely to have in- relax after each heart beat. creased blood glucose, diabetes, abnormal levels of cholesterol and other fats in the blood This study demonstrated that at an early and high blood pressure. When combined, age - - among individuals aged 15 to 20 these abnormalities lead to diagnosis of a re- years - - obesity, and to a lesser extent over- cently-described condition called the weight may negatively influence both aspects “metabolic syndrome” that has been shown to of body metabolism and the size and function predict cardiovascular events in older SHS of the heart. These findings suggest that early participants and in other populations. interventions during childhood and adoles- cence to reduce the prevalence of overweight Among adolescent participants in the Strong and prevent the transition from overweight to Heart Study, both overweight and obese ado- overt obesity may help to reduce the frequency lescents had greater heart weight than the of diabetes and other severe metabolic altera- group with normal body weight. In overweight tions and to avoid unfavorable changes in car- adolescents the increased cardiac weight was diac structure and function, which have in turn adequate to sustain the increased cardiac been demonstrated to be strong predictors of workload associated with high body weight; in cardiovascular events and death. obese adolescents the increased cardiac SHS Control Your Diabetes by Eating Healthy Evidence from previous studies suggests that and vegetables) is associated with good glyce- glycemic control (maintaining normal or near- mic control in diabetic American Indians. normal blood sugar levels) is fundamental to What does this mean for diabetic American In- the management of diabetes and its impor- dians? This study suggests that if you con- tance in reducing or delaying the complica- sume foods that are lower in total fat, satu- tions of diabetes.
Load more

Recommended publications
  • Arizona 2019 TAL.Pdf
    SHS Logs # SHS MS# Author Title Abst, MS, or cancer related Submission Approval from Pheonix Submitted to Tribe Tacit Approval paper proposal Area IHS/IRB 1 from Tribe 1 100 507 Amina Traore Impact of Stress on Fatal and Non-fatal Cardiovascular Disease among American Indians Abstract and MS 11.5.2018 1.4.2019 11.5.2018 1.4.2019 101 549 Giovanni de Myocardial Mechano‐Energetic Efficiency and Insulin Resistance in non‐diabetic members of the Strong Heart Study cohort Abstract and MS 11.12.2018 1.10.2019 11.12.2018 1.10.2019 Simone 102 559 Martha Powers Pulmonary impairment after history of tuberculosis in an American Indian population” (SHS559 Abstract and MS 11.12.2018 1.10.2019 11.12.2018 1.10.2019 103 565 Pooja Subedi Lay Summary Epigenome‐wide Association Study of Telomere Length: The Strong Heart Study 1.29.2019 2.8.2019 1.29.2019 2.8.2019 500 Astrid Suchy- 104 Urinary arsenic and cadmium associations with findings from cranial MRI in elderly American Indians: the Strong Heart Study Lay Summary & MS 2.15.2019 4.15.2019 2.15.2019 4.15.2019 Dicey 105 581 Ying Zhang Updating the World Health Organization (WHO) cardiovascular disease risk charts: Prediction algorithms to estimate risk in 21 global Lay Summary & MS 2.25.2019 4.25.2019 2.25.2019 4.25.2019 regions 582 Julie Stoner 106 IHS: From Framingham to the Strong Heart Study: Understanding Cardiovascular Disease and its Risk Factors Among American Indians Protocol, Lay Summary, 2.20.2019 4.20.2019 2.20.2019 4.20.2019 CITI certs 107 558 Tiffany Sanchez Identifying novel metal biomarkers
    [Show full text]
  • Strong Heart Study Newsletter Investigating Cardiovascular Disease in American Indians Volume 25, Issue 1 Spring 2016
    Strong Heart Study Newsletter Investigating Cardiovascular Disease in American Indians Volume 25, Issue 1 Spring 2016 STRONG HEART STUDY COMMUNITY MEETING AT WICHITA TRIBAL COMPLEX A Strong Heart Study (SHS) community meeting was held in particular displacements resulting from the Civil War in the the Senior Center of the Wichita and Allied Tribes near west. In 1872, after repeated requests of the Tribes, a Anadarko, OK on October 28, 2015. The community reservation was made available in their ancestral homelands meetings are designed to share information directly with local located along the north shore of the Washita River with an tribal members and to hear concerns and observations by Agency located near where the future town of Anadarko was community members. SHS investigators are committed to established. the doctrine that community based research requires continued face to face discussions with local communities. The Wichita Tribal Complex was chosen as the meeting site in order to focus on members of the Wichita and Affiliated Tribes (Wichita, Keechi, Waco, and Tawakoni), Caddo, and Delaware whose reservation was located along the north bank of the Washita River in what is now southwest Oklahoma. The meeting began with a lunch prepared by the staff of the Wichita Seniors Center. Mrs. Terri Parton, President of the Wichita and Affiliated Tribes presided. Mr. Gary McAdams Dr. Shelley Cole, Chairperson of the SHS Steering Committee, provided an overview of the SHS, with an emphasis on the recently funded Phase VI. The beginning 4549 participants are known as the “original cohort”. The Strong Heart Family Study (SHFS) begun in 2000 permitted the examination of younger individuals as well as permitting the institution of family and genetic studies related to heart diseases.
    [Show full text]
  • Arizona 2015 TAL.Xlsx
    Abst, MS, or cancer related Submission Approval from Pheonix Submitted to Salt Tacit Approval Submitted to Tacit Approval paper proposal Area IHS/IRB Tribe 1 from Tribe 1 Tribe 2 from Tribe 2 SHS Logs # SHS MS# Author Title Journal or Publications 27 441 Gribble, MO Linkage Analysis of Urine Arsenic Species Abstract 1/12/2015 3/12/2015 1.12.2015 3/12/2015 1.12.2015 3.11.2015 Cancer Epidemiology Patterns among Persons without Biomarkers and Diabetes in the Strong Heart Family Prevention Study 28 457 Iyengar, S. K. Gnome wide association & transethnic Abstract 1/12/2015 3/12/2015 1.12.2015 3/12/2015 1.12.2015 3.11.2015 meta analysis for advanced diabetic kidney disease: family Investigation of Neuropathy and Diabetes( FIND). none given 29 440 Carroll, C.R, Neuropsychological Effects of Chronic Abstract 1/12/2015 3/11/2015 1.12.2015 3/11/2015 1.12.2015 3.11.2015 Low‐Level Inorganic Arsenic Exposure in Environmental Health American Indian Elders: The Strong Heart Perspectives Study 30 463 Zhu, Yun Metabolic profiles of obesity in American Abstract 2/9/2015 4/9/2015 2.9.2015 4/9/2015 2.9.2015 4.8.2015 International Journal of Indians Obesity Change‐point proportional hazards 31 468 Deng, Yun model for Cluster event data: an Abstract 4/16/2015 6/16/2015 4.16.2015 6/16/2015 4.16.2015 4.15.2015 application to the Strong Heart Study Statistic in Medicine 32 439 Bang, Casper Validation of a new 4‐group classification Abstract 4/23/2015 6/22/2015 4.23.2015 6/22/2015 4.23.2015 6.22.2015 of left ventricular hypertrophy based on American Society of left geometry in population‐based Echocardiography sample: The Strong Heart Study.
    [Show full text]
  • Oklahoma SHS Newsletter May 2008
    STRONG HEART STUDY I NVESTIGATING C ARDIOVASCULAR D ISEASE IN A MERICAN I NDIANS newsletter strongheart.ouhsc.edu Volume 20, Number 1 May 2008 Young at Heart: Octogenarian Jasper Marrietta The Strong Heart Study (SHS) would like to take that “Mr. Marrietta likes to talk about how much he a moment and recognize an inspirational individual. loves his wife. His health is great. He doesn’t have Jasper Marrietta, an 87 year-old member of the Gila diabetes or anything else.” River Indian tribe is an original cohort member of the Mr. Marietta worked for more than 28 years SHS, beginning his involvement in the for the federal government as a supply SHS in 1989. He currently resides in clerk in White River Arizona before Blackwater, a community on the Gila returning full time to his home, the Gila River Reservation. River Reservation. Upon returning to Bert Lewis has worked on the Gila River, Mr. Marrietta was employed Strong Heart Study for more than 10 as a farmer for approximately 6 years years, and describes Mr. Marrietta as for the Gila River Tribe. He was someone who is “very intellectual, he has responsible for planting groves of citrus a sharp mind and is a fun loving, outgoing fruits and olives. Several people and humorous person.” Bert further describe Mr. Marrietta as someone who states, “he loves to joke around and laugh exercises regularly, gets plenty of sleep, with people, but he is also very interested watches his diet, pays attention to his in helping his community. That is why he health, and just enjoys life.
    [Show full text]
  • Indian Communities: the Strong Heart Study
    TheTStrong SHeart Studyg r uN Barbara VHoward, PhD Blood Pressure in 13 American for the Strong Heart Study Investigators Indian Communities: The Dr. Howard is with the Medlantic Research Institute in Washington, Strong Heart Study DC. SYNOPSIS Using National Heart, Lung, and Blood Institute (NHLBI) protocols, researchers measured blood pressure in 4549 American Indians ages 45 to 74 from 13 communities. The prevalence of hypertension ranged from 27% to 56%. More than 70% were aware of the diagnosis, more than 50% were receiving treatment, and 30% controlled their hypertension with medication. Blood pressure was significantly related to glucose intoler- ance, age, obesity, and alcohol consumption. There was little relation between blood pressure and plasma insulin. T^ he Strong Heart Study is a longitudinal study of cardiovascular disease and its risk factors in American Indians from 13 tribes in Arizona, Oklahoma, and South and North Dakota. This re- port presents prevalence data on blood pressure and the pres- ence of hypertension and relates these to other risk factors. Methods The Phase I examination, which took place between July 1989 and Janu- ary 1992, examined 4549 men and women between the ages of45 and 79 (1). Tribes in Arizona included the Gila River and Salt River Pima-Maricopa and the Ak Chin Pima-Papago. Tribes in Oklahoma included Apache, Caddo, Comanche, Delaware, Fort Sill Apache, Kiowa, and Wichita. Tribes in the Dakotas included the Oglala, Cheyenne River, and Devil's Lake Sioux. Using NHLBI protocols, we measured sitting blood pressure (2), after a 5-minute rest and used the average of the last two of three measures (3).
    [Show full text]
  • Phase III Data Forms (PDF)
    S-1 THE STRONG HEART·STUDY ill r CARDIOVASCULAR DISEASE IN AMERICAN INDIANS PERSONAL INTERVIEW FORM I ID number: 1_1 _I_Dl_ Nl_ 0 j__.__. Community name: _,C"'-'O~MN!o!..!o!..,.._A....,ME.!..!o!='------------- Community Code: I_C_I_C[_j Social Security Number: I_s j_ s j_NI-L_I_j-j_j_j_j_j A. DEMOGRAPIDC INFORMATION: 1. Is this still your full name (Last, First, Middle)? Yes l_j1 No l_j2 (If No, wltat is your current name?)INT13_1 Last: ______________ New Last: _IN.....,_T.._1.... 3<-=<2'---------- ---- First: ______________ New First: ~IN.....,_T.._I.... 3~3 ____________ Middle: _____________ New Middle: --=IN_,_T..._I,_,3'-'-4______ ____ N ickname/Other Name: _______________,_.,_,_T ..... J'-=3'-"'5 ___________ 2. To which IHS 'imd non-illS HospitaVClinic do you usually go? List the one they go to most often first. Give names and 'codes. Do you want your Strong Heart Study report sent to the named hospitals? Hospital Chart number IHS Hospital Code Send Report l=yes, 2=no l=yes, 2=no a. HOSPA IHSNOl THSl INTJ3 6 INT13 10 b. HOSPB IHSN02 IHS2 INT13 -7 INT13 11 c. HOSPC IHSN03 IHS3 INT13 8 1NT13 12 d. HQSPD IHSN04 IHS4 IT13 9 INTI3 13 3. What is your marital status? (Enter up to 3 options with the most recent one in tlte left-most box) I I l_j Current 2nd 3rd I= Never married 4 = Separated 2 = Currently married 5 = Widowed 3 =Divorced 6= Adult roommate/partner/significant other 4. If married, what is your husband's/wife's name? (if not married, skip to Q6) INTI3 15 INTI 3 16 INT13 17 LaS! first Middle Strong Heart Study III- 04/25/97 1 Persona/Interview Form I S-1 Did your husband/wife also participate in the Strong Heart Study examination? Yes l_li No l_l2 INT13 18 6.
    [Show full text]
  • SHS Newsletter 2018 Winter Ncol 011218
    Strong Heart Study Newsletter Investigating Cardiovascular Disease in American Indians Volume 28, Issue 1 Winter 2018 STRONG HEART STUDY PHASE VII PROPOSAL The next phase of the Strong Heart Study is proposed to be funded, with tribal approval, by the National Heart, Lung, and Blood Institute of the National Institutes of Health through contracts with three Field Centers (Arizona, Oklahoma, and North and South Dakota) and one Coordinating Center. Our Coordinating Center proposal includes continuing the Data Center in Oklahoma, the Medstar Health Research Institute Laboratory in Maryland, the Cornell Medical Center Cardiovascular Diagnostic Center in New York, and the Texas Biomedical Research Institute Genetics Center in Texas. The next phase (11/2018 through 11/2026) will fund ongoing follow up of cardiovascular and other health conditions, as approved by tribes, among Strong Heart Study and Strong Heart Family Study participants. It will also provide support for new studies focused on health areas of interest to tribal communities, including heart health, diabetes, nutrition, physical activity, stroke, cancer, disease prevention, environmental health, and other areas. New programs will be funded including community-based pilot projects. There will be a greater emphasis on community education and training in addition to ongoing training of American Indian students, health professionals and researchers. The funding application is due on February 9, 2018. Thank you for Phase VII Proposal your participation and support of the Project period: November 2018 – November 2026 Strong Heart Study! Without your Ongoing participant follow up and clinical exam commitment this study would not be New, approved, health studies possible. We look forward to our continued Community-based pilot projects collaboration and work to improve the Training and education: community members and American health of American Indian communities.
    [Show full text]
  • 2015 Tribal Approval Logs (PDF)
    Abstract, manuscript, or cancer Approval from Inform OKC IHS IRB up front regarding Approval from OKC SHS Logs # SHS MS# Author Title related paper proposal OK tribes cancer related paper proposals IHS/IRB Prolonged QRS duration predicts coronary heart disease events in women 13 Deen, J Abstract 2/3/2015 with type 2 diabetes mellitus: the Strong Heart Study Association of processed meat and unprocessed red meat intake with shor 14 Amanda Fretts Abstract 2/26/2015 leykocyte telomere length: the Strong Heart Family Study Metabolic Profiles of Obesity in American 15 463 Zhu Y, Zhao J Manuscript 3/12/2015 4/15/2015 Indians Early transition to overweight and obesity 16 389 Avery, CL in contemporary, multi-ethnic US Manuscript 3/12/2015 4/15/2015 population Linkage Analysis of Urine Arsenic Species 17 441 Gribble, MO Manuscript 3/12/2015 4/15/2015 Patterns in the Strong Heart Family Study Neuropsychological Effects of Chronic Low-Level Inorganic Arsenic Exposure in 18 440 Carroll, CR Manuscript 3/12/2015 4/15/2015 American Indian Elders: The Strong Heart Study Global and region-specific relationships The Global BMI Mortality of body-mass index and mortality: 19 470 Manuscript 3/12/2015 4/15/2015 Collaboration Angelantonio collaborative analysis of 8.8 million people in 235 prospective studies Access to care and diabetes management 20 423 Nicklett, EJ Manuscript 6/11/2015 7/10/2015 among older American Indians with type 2 diabetes The Natriuretic Peptides N-terminal pro-B-type natriuretic peptide 21 476 Manuscript 6/11/2015 7/10/2015 Studies
    [Show full text]
  • April 1990 Volume 2, Number 2
    STRONG HEART STUDY Cardiovascular Disease in American Indians NEWSLETTER April 1990 Volume 2, Number 2 FLEXIBILITY AND RESOURCEFULNESS REQUIRED OF STRONG HEART STUDY STAFF Conditions for the Strong Heart Study vary The Dakotas have also suffered with personnel from center to center but are always a changes when Arliss Keckler resigned from the challenge. While the Dakota center suffers Eagle Butte clinic to pursue other interests. from the cold weather that makes recruitment We appreciate the contribution of Arliss during difficult, the Arizona center appears to have the early stages of this study. Dr. Welty has picked up the momentum as the weather is hired Mary Clown to replace Arliss. We most accommodating. The Dakota center welcome Mary to the Strong Heart Study staff. waits for the summer when conditions are good enough to reopen the Fort Totten clinic Along with the personnel adjustments and (scheduled for late-May) and boost recruitment weather conditions, two other hurdles confront and response rates while the Arizona center the Strong Heart Study: where is my check? recognizes the heat of summer will slow and where are my result? In response to these progress. In Oklahoma, the weather is not as concerns, all centers have tried to develop ways extreme as in the Dakotas or in Arizona, so of providing payments immediately after the more uniform examination rates are expected. exam, and a review of the process for returning However, weather is not the only challenge. results of the exam to participants in a timely manner will be undertaken. We are pleased to In Arizona, merging the exam with the NIDDK announce that starting this month every center study at Gila River continues to provide an will be handing out cash after the exam.
    [Show full text]
  • Recruitment of American Indians in Epidemiologic Research: the Strong Heart Study
    RECRUITMENT OF AMERICAN INDIANS IN EPIDEMIOLOGIC RESEARCH: THE STRONG HEART STUDY Martha L. Stoddart, M.S., Betty Jarvis, R.N., Beverly Blake, R.N., F.N.P., Richard R. Fabsitz, M.A., Barbara V. Howard, Ph.D., Elisa T. Lee., Ph.D., and Thomas K. Welty, M.D. Abstract: This paper describes the methods used to recruit American Indian (AI) populations for the Strong Heart Study (SHS), a community-based study of cardiovascular disease (CVD) and its risk factors in AI men and women. Recruitment strategies included personal contact by recruiters and drivers/recruiters in remote areas, SHS staff participation in community activities, and mass media. A total of 4,549 participants aged 45-74 years were recruited from 13 American Indian tribes and communities. Overall participation rates were 72%, 55%, and 62%, respectively, for the three study centers (Arizona, the Dakotas, and Oklahoma). Participant feedback and educational material related to risk factor reduction and promoting a healthy lifestyle were emphasized. Participants were likely to be female, young, and nonsmokers. Barriers to recruitment included lack of telephones in a large proportion of households, conflicting beliefs about health/health care/ research, fears, taboos, and occasional rumors about study examination procedures. Participants were referred for follow-up of health problems detected by the study. The strong commitment of the participating communities helped to insure the success of the SHS, which can be considered a model for recruitment in future American Indian population-based
    [Show full text]
  • Data Sharing Issues
    DATA SHARING ISSUES TRIBAL ADVISORY COMMITTEE BETHESDA, MD 9/14/17 YOUR SPEAKER • GREW UP IN WAHPETON, ND • IHS FAMILY DOC, 77-98 • PART TIME, DUNSEITH, ND 99- 2012 • BEGAN WORK WITH STRONG HEART STUDY IN 1998 • TAUGHT GENETICS AT TURTLE MOUNTAIN COMMUNITY COLLEGE, 99- 2012 • INVOLVED IN VARIOUS RESEARCH STUDIES, 1977- PRESENT STRONG HEART STUDY Phase I 1988 4549 Participants ages 45-74 years Arizona: Pima/Maricopa/Papago in the Salt River, and Ak-Chin Indian communities Oklahoma: Apache, Caddo, Comanche, Delaware, Fort Sill Apache, Kiowa, and Wichita Dakotas: Oglala Sioux and Cheyenne River Sioux and the Spirit Lake Nation STRONG HEART STUDY • SIX PHASES: – Phase I (1988 - 1992)….Original Cohort – Phase II (1993 - 1995)….Original Cohort – Phase III (1998 - 1999)....Original Cohort • plus pilot Family Study – Phase IV (2000 - 2005)…Family Study • 3,600 total participants, ages 16 and up • Large families with original cohort members – Phase V (2005 - 2010)…Family Study – Phase VI (2013 - 2018)...Surveillance of all STRONG HEART STUDY • Began in 1988 • Pioneered community- based participatory research – Centers in AZ, OK and Dakotas Drs. Everett Rhoades, Yvette Robideaux et al – Recruited and retained <7,000 over multiple exams – Assisted >50 American Indian young investigators attain advanced degrees – Among first to incorporate genetic Dr Spero Manson Dr Rich Fabsitz, NHLBI analysis STRONG HEART STUDY: Dakota Center STRONG HEART STUDY: Oklahoma Center Dr E Rhoades and Fabsitz at OK community mtg Much younger SHS folks at OK field health office STRONG HEART STUDY: Texas Biomedical Institute John Emhoolah Jr blessing SHS samples, 7/11/17 Visiting the samples and lab facilities during SHS community meeting, 2016 INTO THE FUTURE: • Dr.
    [Show full text]
  • Newsletter Strongheart.Ouhsc.Edu Volume 22, Number 2 December 2010
    STRONG HEART STUDY I NVESTIGATING C ARDIOVASCULAR D ISEASE IN A MERICAN I NDIANS newsletter strongheart.ouhsc.edu Volume 22, Number 2 December 2010 Become a Participant of the Strong Heart Stroke Study Participant enrollment recently began for the exam sometime between 1989 and 1992. The landmark Strong Heart Stroke Study (SHSS) in the SHSS examination includes Magnetic Resonance Arizona, Dakota, and Oklahoma field centers. Strokes Imaging (MRI) of the brain (the MR scanner produces are more common among American Indians compared images of the brain or any other body part without the to the US population. Strokes reduce or cut off the use of radiation), physical function, blood pressure, blood supply to part of the brain and are an important ECG, blood tests, brain functions such as memory, cause of death and disability (e.g., slurred speech, and screening for depression. It takes 3 to 4 hours to confusion, loss of memory, paralysis of one side of the complete the full SHSS examination (not including body, etc.) of American Indians. Some strokes are travel time), and it can be completed in one or two called silent or mini strokes because a person is visits. When the full exam is completed, the participant unaware he or she had a small stroke, but these can receives $200 for time and travel. Participants who also cause problems with mental and physical are unable to complete the MRI part of the exam will functioning of the person. receive $100 for time and travel. If you feel you are Little is known about factors that lead to stroke eligible to participate in the stroke study, please and the resulting reduced quality of physical and contact our study staff.
    [Show full text]