Author Manuscript Published OnlineFirst on July 5, 2012; DOI: 10.1158/1940-6207.CAPR-12-0050 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. 1 Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not 2 affected by genistein or resveratrol 3 4 Serge A.L. Zander1, Ariena Kersbergen1, Wendy Sol1, Maaike Gonggrijp1, Koen van de Wetering1, Jos Jonkers2, 5 Piet Borst1, Sven Rottenberg1 6 7 Authors’ affiliations: 8 Divisions of 1Molecular Oncology and 2Molecular Pathology, The Netherlands Cancer Institute (Antoni van 9 Leeuwenhoek Hospital), Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands 10 11 Running title: 12 ABCG2 loss shortens latency of BRCA1-deficient tumors 13 14 Keywords: resveratrol, genistein, tumor latency, mouse model, ABCG2 15 16 Grant support: 17 This work was supported by grants from the Dutch Cancer Society 2006-3566 (PB, SR, JJ), 2009-4303 (SR, JJ, 18 PB), the European Union FP6 Integrated Project 037665-CHEMORES (PB, SR), CTMM Breast Care (JJ, SR) 19 and ZonMw 40-00812-98-07-028 (KvdW, PB). SR is supported by The Netherlands Organisation for Scientific 20 Research (NWO VIDI-91711302). 21 22 Corresponding author: 23 Sven Rottenberg, Division of Molecular Oncology, The Netherlands Cancer Institute (Antoni van Leeuwenhoek 24 Hospital), Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Phone: +31 20 512 2082; Fax: +31 20 669 25 1383; E-mail:
[email protected] 26 27 Disclosure of Potential Conflicts of Interest: 28 No potential conflicts of interest were disclosed. 29 30 word count: 3984 31 total number of figures and/or tables: 3 1 Downloaded from cancerpreventionresearch.aacrjournals.org on September 24, 2021.