Enabling Microbial Syringol Conversion Through Structure-Guided Protein Engineering
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Report of the Advisory Group to Recommend Priorities for the IARC Monographs During 2020–2024
IARC Monographs on the Identification of Carcinogenic Hazards to Humans Report of the Advisory Group to Recommend Priorities for the IARC Monographs during 2020–2024 Report of the Advisory Group to Recommend Priorities for the IARC Monographs during 2020–2024 CONTENTS Introduction ................................................................................................................................... 1 Acetaldehyde (CAS No. 75-07-0) ................................................................................................. 3 Acrolein (CAS No. 107-02-8) ....................................................................................................... 4 Acrylamide (CAS No. 79-06-1) .................................................................................................... 5 Acrylonitrile (CAS No. 107-13-1) ................................................................................................ 6 Aflatoxins (CAS No. 1402-68-2) .................................................................................................. 8 Air pollutants and underlying mechanisms for breast cancer ....................................................... 9 Airborne gram-negative bacterial endotoxins ............................................................................. 10 Alachlor (chloroacetanilide herbicide) (CAS No. 15972-60-8) .................................................. 10 Aluminium (CAS No. 7429-90-5) .............................................................................................. 11 -
Lavender- and Lavandin-Distilled Straws: an Untapped Feedstock With
Lesage‑Meessen et al. Biotechnol Biofuels (2018) 11:217 https://doi.org/10.1186/s13068-018-1218-5 Biotechnology for Biofuels RESEARCH Open Access Lavender‑ and lavandin‑distilled straws: an untapped feedstock with great potential for the production of high‑added value compounds and fungal enzymes Laurence Lesage‑Meessen1, Marine Bou1, Christian Ginies2, Didier Chevret3, David Navarro1, Elodie Drula1,4, Estelle Bonnin5, José C. del Río6, Elise Odinot1, Alexandra Bisotto1, Jean‑Guy Berrin1, Jean‑Claude Sigoillot1, Craig B. Faulds1 and Anne Lomascolo1* Abstract Background: Lavender (Lavandula angustifolia) and lavandin (a sterile hybrid of L. angustifolia L. latifolia) essential oils are among those most commonly used in the world for various industrial purposes, including× perfumes, phar‑ maceuticals and cosmetics. The solid residues from aromatic plant distillation such as lavender- and lavandin-distilled straws are generally considered as wastes, and consequently either left in the felds or burnt. However, lavender- and lavandin-distilled straws are a potentially renewable plant biomass as they are cheap, non-food materials that can be used as raw feedstocks for green chemistry industry. The objective of this work was to assess diferent pathways of valorization of these straws as bio-based platform chemicals and fungal enzymes of interest in biorefnery. Results: Sugar and lignin composition analyses and saccharifcation potential of the straw fractions revealed that these industrial by-products could be suitable for second-generation bioethanol prospective. The solvent extrac‑ tion processes, developed specifcally for these straws, released terpene derivatives (e.g. τ-cadinol, β-caryophyllene), lactones (e.g. coumarin, herniarin) and phenolic compounds of industrial interest, including rosmarinic acid which contributed to the high antioxidant activity of the straw extracts. -
The Analysis of Grapevine Response to Smoke Exposure
The Analysis of Grapevine Response to Smoke Exposure A thesis presented in fulfilment of the requirements for the degree of Doctor of Philosophy Lieke van der Hulst BSc, MSc The University of Adelaide School of Agriculture, Food and Wine Thesis submitted for examination: November 2017 Thesis accepted and final submission: January 2018 Table of contents Abstract i Declaration iii Publications iv Symposia v Acknowledgements vii Chapter 1 Literature review and introduction • Literature review and introduction 1 • The occurrence of bushfires and prescribed 2 • Economic impact of bushfires 5 • Smoke derived volatile compounds 6 • Volatile compounds in wine 8 • Glycosylation of volatile phenols in grapes 9 • Previous smoke taint research 11 • Glycosyltransferases 14 • Research aims 18 Chapter 2 Detection and mitigation of smoke taint in the vineyard • Authorship statements 20 • Introduction 22 • Paper: Accumulation of volatile phenol glycoconjugates in grapes, 24 following the application of kaolin and/or smoke to grapevines (Vitis vinifera cv Sauvignon Blanc, Chardonnay and Merlot) • Further investigation into methods for the detection and mitigation of 54 smoke taint in the vineyard Material and Methods 55 Results and discussion part A 57 Results and discussion part B 61 Conclusion 68 Chapter 3 Expression of glycosyltransferases in grapevines following smoke exposure • Authorship statements 71 • Introduction 73 • Paper: Expression profiles of glycosyltransferases in 74 Vitis vinifera following smoke exposure Chapter 4 The effect of smoke exposure to apple • Authorship statements 122 • Introduction 124 • Paper: The effect of smoke exposure to apple (Malus domestica 125 Borkh cv ‘Sundowner’) Chapter 5 Conclusions and future directions • Conclusions 139 • Future directions 142 Appendix • Paper: Impact of bottle aging on smoke-tainted wines from 145 different grape cultivars References 152 Abstract Smoke taint is a fault found in wines made from grapes exposed to bushfire smoke. -
Review of Smoke Taint in Wine: Smokederived Volatile Phenols And
Krstic et al. Review of smoke taint in wine 537 Review of smoke taint in wine: smoke-derived volatile phenols and their glycosidic metabolites in grapes and vines as biomarkers for smoke exposure and their role in the sensory perception of smoke taint M.P. KRSTIC1, D.L. JOHNSON2 and M.J. HERDERICH2 1 The Australian Wine Research Institute,Victorian Node, Mooroolbark, Vic. 3138, Australia; 2 The Australian Wine Research Institute, Urrbrae, SA 5064, Australia Corresponding author: Dr Mark Krstic, email [email protected] Abstract In recent years, the exposure of vineyards and grapes to smoke from bushfires and controlled burn events has in some instances resulted in wines described as smoke tainted. Such wines are characterised by undesirable sensory characters described as smoky, burnt, ash, smoky bacon, medicinal and ashtray. This review summarises the knowledge about the composition of smoke from forest and grass fires, describes relationships between smoke exposure of vineyards and smoke taint in wine, and outlines strategies for managing and reducing the risk to producing smoke-affected wines. The sensitivity of grapes and vines at different phenological stages to the uptake of contaminants from smoke, especially smoke-derived volatile phenols, is outlined, and the pathways for entry and metabolic transformation of volatile phenols are discussed. The potential for translocation of phenolic contaminants within the grapevine and the differences in uptake of smoke contaminants of different grape cultivars are also discussed, along with preliminary work on dose/response relationships regarding concentration and duration of exposure and subsequent expression of smoke taint in wine. The chemical basis of smoke taint in wine is described, and the relationship between volatile phenols from combustion of wood/lignin and their glycosides, and sensory panel ratings of smoke attributes in affected wines is discussed. -
Phenolic Components, Antioxidant Activity, and Mineral Analysis of Capparis Spinosa L
Vol. 12(47), pp. 6643-6649, 20 November, 2013 DOI: 10.5897/AJB2013.13241 ISSN 1684-5315 ©2013 Academic Journals African Journal of Biotechnology http://www.academicjournals.org/AJB Full Length Research Paper Phenolic components, antioxidant activity, and mineral analysis of Capparis spinosa L Rezzan Aliyazicioglu1*, Ozan Emre Eyupoglu2, Huseyin Sahin2, Oktay Yildiz3, Nimet Baltas4 1Department of Biochemistry, Faculty of Pharmacy, Karadeniz Technical University, 61080 Trabzon, Turkey. 2Department of Chemistry, Faculty of Science, Karadeniz Technical University, 61080 Trabzon, Turkey. 3Maçka Vocational School, Karadeniz Technical University, 61080 Trabzon, Turkey. 4Department of Chemistry, Faculty of Science, Recep Tayyip Erdoğan University, 53100 Rize, Turkey. Accepted 10 October, 2013 In addition to being consumed as food, caper (Capparis spinosa L.) fruits are also used in folk medicine to treat inflammatory disorders, such as rheumatism. C. spinosa L. is rich in phenolic compounds, making it increasingly popular because of its components’ potential benefits to human health. We analyzed a number of individual phenolic compounds and investigated in vitro biological activities of C. spinosa L. Sixteen phenolic constituents were identified using reverse phase-high performance liquid chromatography (RP-HPLC). Total phenolic compounds (TPCs), ferric reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity were used as determinants of antioxidant capacity. C. spinosa L. exhibited strong antioxidant activity and contained high levels of antioxidant compounds. Gentisic, sinapic and benzoic acid were detected in C. spinosa L. No gallic acid, proto-catechuic acid, proto-catechuic aldehyde, chlorogenic acid, p-OH benzoic acid, vanillic acid, caffeic acid, syringic acid, vanillin, syringaldehyde, p-coumaric acid, ferulic acid or rosmarinic acid were identified. -
CPY Document
3. eHEMieAL eOMPOSITION OF ALeOHOLie BEVERAGES, ADDITIVES AND eONTAMINANTS 3.1 General aspects Ethanol and water are the main components of most alcoholIc beverages, although in some very sweet liqueurs the sugar content can be higher than the ethanol content. Ethanol (CAS Reg. No. 64-17-5) is present in alcoholic beverages as a consequence of the fermentation of carbohydrates with yeast. It can also be manufactured from ethylene obtained from cracked petroleum hydrocarbons. The a1coholic beverage industry has generally agreed not to use synthetic ethanol manufactured from ethylene for the production of alcoholic beverages, due to the presence of impurities. ln order to determine whether synthetic ethanol has been used to fortify products, the low 14C content of synthetic ethanol, as compared to fermentation ethanol produced from carbohydrates, can be used as a marker in control analyses (McWeeny & Bates, 1980). Some physical and chemical characteristics of anhydrous ethanol are as follows (Windholz, 1983): Description: Clear, colourless liquid Boilng-point: 78.5°C M elting-point: -114.1 °C Density: d¡O 0.789 It is widely used in the laboratory and in industry as a solvent for resins, fats and oils. It also finds use in the manufacture of denatured a1cohol, in pharmaceuticals and cosmetics (lotions, perfumes), as a chemica1 intermediate and as a fuel, either alone or in mixtures with gasolIne. Beer, wine and spirits also contain volatile and nonvolatile flavour compounds. Although the term 'volatile compound' is rather diffuse, most of the compounds that occur in alcoholIc beverages can be grouped according to whether they are distiled with a1cohol and steam, or not. -
Metabolomics by UHPLC-Q-TOF Reveals Host Tree-Dependent Phytochemical Variation in Viscum Album L
plants Article Metabolomics by UHPLC-Q-TOF Reveals Host Tree-Dependent Phytochemical Variation in Viscum album L. Tim Jäger 1,2,3,†, Carla Holandino 1,4,* , Michelle Nonato de Oliveira Melo 4,5 , Evelyn Maribel Condori Peñaloza 4,5, Adriana Passos Oliveira 4, Rafael Garrett 5 , Gaétan Glauser 6 , Mirio Grazi 1, Hartmut Ramm 1, Konrad Urech 1 and Stephan Baumgartner 1,3,7,* 1 Society for Cancer Research, Hiscia Institute, Kirschweg 9, 4144 Arlesheim, Switzerland; [email protected] (T.J.); [email protected] (M.G.); [email protected] (H.R.); [email protected] (K.U.) 2 Center for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, University of Freiburg, Breisacher Str. 115b, 79106 Freiburg, Germany 3 Institute of Integrative Medicine, University of Witten/Herdecke, Gerhard-Kienle-Weg 4, 58313 Herdecke, Germany 4 Laboratório Multidisciplinar de Ciências Farmacêuticas, Pharmacy College, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil; [email protected] (M.N.d.O.M.); [email protected] (E.M.C.P.); [email protected] (A.P.O.) 5 Metabolomics Laboratory, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil; [email protected] 6 Neuchatel Platform of Analytical Chemistry, University of Neuchâtel, Avenue de Bellevaux 51, 2000 Neuchâtel, Switzerland; [email protected] 7 Institute of Complementary and Integrative Medicine, University of Bern, Freiburgstrasse 46, 3010 Bern, Switzerland * Correspondence: [email protected] (C.H.); [email protected] (S.B.) † Deceased 1 March 2019. Citation: Jäger, T.; Holandino, C.; Abstract: Viscum album L., commonly known as European mistletoe, is a hemi-parasitic plant of Melo, M.N.d.O.; Peñaloza, E.M.C.; the Santalaceae family. -
The Effects of Combining Guaiacol and Syringol on Their Pyrolysis
Holzforschung, Vol. 66, pp. 323–330, 2012 • Copyright © by Walter de Gruyter • Berlin • Boston. DOI 10.1515/HF.2011.165 The effects of combining guaiacol and syringol on their pyrolysis Mohd Asmadi, Haruo Kawamoto * and Shiro Saka methods, lignin pyrolysis has been studied based on iso- Graduate School of Energy Science , Kyoto University, lated lignins (Martin et al. 1979 ; Obst 1983 ; Evans et al. Kyoto , Japan 1986 ; Saiz -Jimenez and De Leeuw 1986 ; Faix et al. 1987 ; Genuit et al. 1987 ; Meier and Faix 1992 ; Greenwood et al. * Corresponding author. 2002 ; Hosoya et al. 2007, 2008a,b ; Nakamura et al. 2008 ) Graduate School of Energy Science, Kyoto University, and model compounds (Domburg et al. 1974 ; Bre ž n ý et al. Yoshida-honmachi, Sakyo-ku, Kyoto 606-8501, Japan 1983 ; Saiz -Jimenez and De Leeuw 1986 ; Kawamoto et al. Phone/Fax: + 81-75-753-4737 E-mail: [email protected] 2006, 2007, 2008a,b ; Kawamoto and Saka 2007 ; Nakamura et al. 2007, 2008 ; Watanabe et al. 2009 ). Hardwood lignins are known to include both the syringyl (3,5-dimethoxy-4- Abstract hydroxyphenyl)-type (shortly S) and the guaiacyl (4-hydroxy- 3-methoxyphenyl)-type aromatic rings (shortly G), whereas Pyrolysis of guaiacol/syringol mixtures was studied in an softwood lignins contain mainly the G-type units. These dif- ° ferences infl uence the pyrolytic reactivity of hardwoods and ampoule reactor (N 2 /600 C/40 – 600 s) to understand the reactivities of the aromatic nuclei in hardwood lignins. By softwoods (Di Blasi et al. 2001a,b ; Gr ø nli et al. -
Lignin for Sustainable Bioproducts and Biofuels
Demirel, J Biochem Eng Bioprocess Technol 2017, 1:1 Journal of Biochemical Engineering & Bioprocess Technology Editorial a SciTechnol journal and substituted phenols as opposed to methoxy-phenols [7,8]. Type of Lignin for Sustainable particle size of biomass, pyrolysis temperature, reactor type (fluidized bed, ablative, vacuum, and auger), type of condensers (direct and Bioproducts and Biofuels indirect contact) can affect the composition of bio-oil [2,5]. Water Yaşar Demirel* soluble and organic phases are separated as two main streams out of condenser [9]. After condensing the vapor bio-oil is produced with a yield of up to 65 to 75% on a dry basis. Typical bio-oil consists of Keywords (wt% db, except water) acids (3-7), alcohols (1<), aldehydes, ketones, and furans (22-27), sugars (3-6), phenols (2-6), lignin derived fraction Lignin; Bioproducts; Biofuel; Sustainable energy (15-25), and extractives (4-6) [5]. Feedstocks with high extractives content and/or high ash content commonly produce an aqueous Introduction phase, an upper layer, and a decanted heavy oily phase. Bio-oil can be considered a micro emulsion in which the continuous phase is an To meet the goal of replacing 30% of fossil fuel by biofuels around aqueous solution of holocellulose decomposition products and small 2030, approximately 225 million tons of lignin will soon be produced molecules from lignin decomposition. The continuous liquid phase beside the current production of between 40 and 50 million tons per stabilizes a discontinuous phase that contains of pyrolytic lignin year in the paper and pulp industry in the U.S. Yet only about 2% of the macromolecules [2]. -
Accumulation and Secretion of Coumarinolignans and Other Coumarins in Arabidopsis Thaliana Roots in Response to Iron Deficiency
Accumulation and Secretion of Coumarinolignans and other Coumarins in Arabidopsis thaliana Roots in Response to Iron Deficiency at High pH Patricia Siso-Terraza, Adrian Luis-Villarroya, Pierre Fourcroy, Jean-Francois Briat, Anunciacion Abadia, Frederic Gaymard, Javier Abadia, Ana Alvarez-Fernandez To cite this version: Patricia Siso-Terraza, Adrian Luis-Villarroya, Pierre Fourcroy, Jean-Francois Briat, Anunciacion Aba- dia, et al.. Accumulation and Secretion of Coumarinolignans and other Coumarins in Arabidopsis thaliana Roots in Response to Iron Deficiency at High pH. Frontiers in Plant Science, Frontiers, 2016, 7, pp.1711. 10.3389/fpls.2016.01711. hal-01417731 HAL Id: hal-01417731 https://hal.archives-ouvertes.fr/hal-01417731 Submitted on 15 Dec 2016 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. fpls-07-01711 November 21, 2016 Time: 15:23 # 1 ORIGINAL RESEARCH published: 23 November 2016 doi: 10.3389/fpls.2016.01711 Accumulation and Secretion of Coumarinolignans and other Coumarins in Arabidopsis thaliana Roots in Response to Iron Deficiency at -
Survey of Renewable Chemicals Produced from Lignocellulosic Biomass During Ionic Liquid Pretreatment
Lawrence Berkeley National Laboratory Recent Work Title Survey of renewable chemicals produced from lignocellulosic biomass during ionic liquid pretreatment. Permalink https://escholarship.org/uc/item/71d9d3rw Journal Biotechnology for biofuels, 6(1) ISSN 1754-6834 Authors Varanasi, Patanjali Singh, Priyanka Auer, Manfred et al. Publication Date 2013-01-28 DOI 10.1186/1754-6834-6-14 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Varanasi et al. Biotechnology for Biofuels 2013, 6:14 http://www.biotechnologyforbiofuels.com/content/6/1/14 RESEARCH Open Access Survey of renewable chemicals produced from lignocellulosic biomass during ionic liquid pretreatment Patanjali Varanasi1,2, Priyanka Singh1, Manfred Auer1, Paul D Adams1, Blake A Simmons1,2 and Seema Singh1,2* Abstract Background: Lignin is often overlooked in the valorization of lignocellulosic biomass, but lignin-based materials and chemicals represent potential value-added products for biorefineries that could significantly improve the economics of a biorefinery. Fluctuating crude oil prices and changing fuel specifications are some of the driving factors to develop new technologies that could be used to convert polymeric lignin into low molecular weight lignin and or monomeric aromatic feedstocks to assist in the displacement of the current products associated with the conversion of a whole barrel of oil. We present an approach to produce these chemicals based on the selective breakdown of lignin during ionic liquid pretreatment. Results: The lignin breakdown products generated are found to be dependent on the starting biomass, and significant levels were generated on dissolution at 160°C for 6 hrs. Guaiacol was produced on dissolution of biomass and technical lignins. -
Lignin from Bark As a Resource for Aromatics Production by Hydrothermal Liquefaction
Received: 24 April 2018 | Revised: 25 July 2018 | Accepted: 3 August 2018 DOI: 10.1111/gcbb.12562 ORIGINAL RESEARCH Lignin from bark as a resource for aromatics production by hydrothermal liquefaction Julia Schuler1 | Ursel Hornung1 | Nicolaus Dahmen1 | Jörg Sauer1 Institute for Catalysis Research and Technology, Karlsruhe Institute of Abstract Technology (KIT), Eggenstein‐ Biorefineries, which are using mostly unused side streams of other existing pro- Leopoldshafen, Germany cesses like bark or lignin, have a huge potential to open new resources, for exam- Correspondence ple, chemicals. But with new resources new challenges will be met along the Julia Schuler, Institute for Catalysis way. These challenges must be addressed and discussed to build a solid and far‐ Research and Technology, Karlsruhe sighted process. This work focuses on the formation of monocyclic compounds Institute of Technology (KIT), Eggenstein‐ Leopoldshafen, Germany. like catechol as a valuable product during the hydrothermal liquefaction of beech Email: [email protected] wood bark as well as Kraft lignin from pine wood like Indulin AT. The focus is Funding information to get a better knowledge of the behavior of bark during hydrothermal liquefac- Ministry of Science, Research and the tion for depolymerization aiming at the production of aromatic building blocks Arts of Baden‐Württemberg, Grant/Award for chemicals. Therefore, the influence, for example, of temperature and reaction Number: 200007 time, the chemical reaction pathways, and the therefore necessary analytics need to be understood. Several limitations and challenges of common analytical meth- ods are discussed and compared for bark and Kraft lignin, which is relatively well investigated and can act as a reference material to build a common ground and make it possible to build standards for all bioeconomic processes.