Immunoinformatics-Guided Designing of an Epitope-Based Vaccine Against
Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 16 May 2020 doi:10.20944/preprints202005.0271.v1 Immunoinformatics-Guided Designing of an Epitope-Based Vaccine Against Severe Acute Respiratory Syndrome-Coronavirus-2 Spike Glycoprotein Ahmed Rakib1, Saad Ahmed Sami1, Arkajyoti Paul2,3, Asif Shahriar4, Abu Montakim Tareq5, Nazim Uddin Emon5, Nusrat Jahan Mimi1, Md. Mustafiz Chowdhury1, Taslima Akter Eva1, Sajal Chakraborty3, Sagar Shil3, Sabrina Jahan Mily6, Talha Bin Emran2,3* 1Department of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong- 4331, Bangladesh 2Drug Discovery, GUSTO A Research Group, Chittagong-4000, Bangladesh 3Department of Pharmacy, BGC Trust University Bangladesh, Chittagong-4381, Bangladesh 4Department of Microbiology, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka- 1217, Bangladesh 5Department of Pharmacy, International Islamic University Chittagong, Chittagong-4318, Bangladesh 6Department of Gynaecology and Obstetrics, Banshkhali Upazila Health Complex, Jaldi Union, Chittagong-4390, Bangladesh Running title: de novo vaccine design against SARS-CoV-2 *Correspondence: Dr. T.B. Emran talhabmb@bgctub.ac.bd or talhabmb@gmail.com Keywords: COVID-19, SARS-CoV-2, de novo vaccine, epitope, immunity 1 © 2020 by the author(s). Distributed under a Creative Commons CC BY license. Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 16 May 2020 doi:10.20944/preprints202005.0271.v1 Abstract Currently, with a large number of fatality rates, coronavirus disease-2019 (COVID-19) has emerged as a potential threat to human health worldwide. It has been well-known that severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for COVID-19 and World Health Organization (WHO) proclaimed the contagious disease as a global pandemic.
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