Congenital Infection by Trypanosoma Cruzi in an Endemic Area of Chile: a Multidisciplinary Study
Trans R Soc Trop Med Hyg 2013; 107: 98–104 doi:10.1093/trstmh/trs013 Advance Access publication 8 November 2012 Congenital infection by Trypanosoma cruzi in an endemic area of Chile: a multidisciplinary study Werner Apta,*, Ine´s Zulantaya, Marcela Arnelloa, David Oddo´ b, Sandra Gonza´leza, Jorge Rodrı´guezc, ORIGINAL ARTICLE Ulrike Kemmerlingd, Carine Truyense and Yves Carliere aLaboratorio de Parasitologı´aBa´sico-Clı´nico, Programa de Biologı´a Celular y Molecular, Instituto de Ciencias Biome´dicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Chile; bInstituto Nacional del Ca´ncer, Zan˜artu 1010, Santiago, Chile; cEscuela de Salud Pu´blica, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Chile; dPrograma de Anatomı´ay Biologı´a del Desarrollo, Instituto de Ciencias Biome´dicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Downloaded from Chile; eLaboratory of Parasitology, Faculty of Medicine, Free University of Brussels, ULB CP 616, 808, route de Lennik – B1070, Brussels, Belgium *Corresponding author: Present address: P.O. Box 427 - Santiago 3. Santiago, Chile. Tel.: +56 2 9786753; Fax: +56 2 9786122; E-mail address: wapt@med.uchile.cl http://trstmh.oxfordjournals.org/ Received 3 February 2012; revised 27 August 2012; accepted 12 September 2012 Background: This study investigated the prevalence of Chagas disease (ChD) in pregnant women in Choapa Province (IV Region, Chile) and the vertical transmission of Trypanosoma cruzi. Method: ELISA and IFI IgG for ChD was performed for the pregnant women. PCR for T. cruzi was done for all chagasic mothers and their newborns. The congenital infection was confirmed by serial positive PCR and/or ELISA or IFI IgG after age of nine months.
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