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WHO-FWC-IHE-17.3-Eng.Pdf (‎186.6KB) DEVELOPMENT OF A SYSTEMATIC EVIDENCE REVIEW FOR THE WHO GUIDELINE ON PROTECTING WORKERS FROM POTENTIAL RISKS OF MANUFACTURED NANOMATERIALS What training should be provided to workers who are at risk from exposure to the specific nanomaterials or groups of nanomaterials? Yvonne von Mering Christian Schumacher Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) WHO/FWC/IHE/17.3 © World Health Organization 2017 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. Von Mering Y, Schmacher, C. What training should be provided to workers who are at risk from exposure to the specific nanomaterials or groups of nanomaterials? Geneva: World Health Organization; 2017. Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris. Sales, rights and licensing. To purchase WHO publications, see http://apps.who.int/bookorders. To submit requests for commercial use and queries on rights and licensing, see http://www.who.int/about/licensing. Third-party materials. If you wish to reuse material from this work that is attributed to a third party, such as tables, figures or images, it is your responsibility to determine whether permission is needed for that reuse and to obtain permission from the copyright holder. The risk of claims resulting from infringement of any third-party-owned component in the work rests solely with the user. General disclaimers. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of WHO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by WHO in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. All reasonable precautions have been taken by WHO to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall WHO be liable for damages arising from its use. The named authors alone are responsible for the views expressed in this publication. CONTENTS Contents 1 Introduction 1 2 Methods 2 2.1 Inclusion criteria for nanomaterials 2 2.2 Exclusion criteria 3 2.3 Search strategy 3 2.4 Pilot study 3 2.5 Scientific literature study ? search strings 4 2.5.1 Searched databases 4 2.5.2 First search strategy 4 2.5.3 Alternation of the first search strategy 5 2.5.4 Second search strategy 5 2.5.5 Alternation of the second search strategy 6 2.6 PICO inclusion criteria 7 3 Quality criteria for individual studies 8 4 Results 10 4.1 Selection procedure 10 4.2 Description of studies assessed in detail 11 5 Conclusion 13 6 Annex 1 – summary of general training content 15 7 References 18 7.1 Websites and grey literature reviewed 20 iii INTRODUCTION 1. Introduction In 2010, the World Health Organization (WHO) initiated the development of a guideline entitled Protecting workers from potential risks of manufactured nanomaterials (http://www.who.int/ occupational_health/topics/nanotechnologies/en/) using a systematic evidence review process (1). The guideline aims to improve occupational safety and to protect the health of workers handling nanomaterials in all countries, especially those of low- and medium-income. The WHO Guideline Development Group (GDG) identified key questions to be addressed using the Delphi process of consensus seeking (2). For each question, guideline recommendations will be developed. The Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) has undertaken to answer Question (h), which asks: “What training should be provided to workers who are at risk from exposure to the specific nanomaterials or groups of nanomaterials?” It is vitally important to train employees who may be exposed to hazardous chemicals, biological or physical agents. However, assessing the effectiveness of training is not straight forward as a systematic review by the Toronto-based Institute for Work & Health showed (3). The authors found it is of the utmost significance to define the study subject as precisely as possible to get a reliable answer to the question and to avoid inconsistency in the findings. Burke et al. discussed how hazard and safety training influences workers’ learning about safety aspects and safety performance and contributed a whole chapter to The Wiley Blackwell Handbook of the Psychology of Occupational Safety and Workplace Health (4, 5). They found in 2011 that highly-engaging training was considerably more effective than less-engaging training when the hazardous event/exposure severity was high. However, this was not found when the hazardous event/exposure severity was not high or was unknown (6). In 2008 the same group had concluded that to avoid uncertainty may paradoxically lead to greater uncertainty and ineffective safety training as a result (7). This is important in relation to nanomaterials where the risk is still largely unknown. In summary, training is more effective when the hazardous exposure is well-defined and the training methods are highly engaging. For this review, we have defined training as “planned efforts to learn or facilitate the learning of specific competencies for the safe use of nanomaterials at the workplace”. In our review we considered active or passive training, given centrally or individually, with learning-centred or teaching-centred material. Evaluation of the training included timing, format and content of the programme and materials, and also guidance on occupational health and safety measures relating to nanomaterials. This included the use of engineering controls and appropriate personal protective equipment, guidance on dealing with spills and accidental releases, and guidance on appropriate handling of these materials during disposal. We also reviewed enhancements in learning that result from reaction, knowledge, dialogue, behaviour, results and reflections on the training (adopted from Kirkpatrick’s four-level model) (8). 1 WHAT TRAINING SHOULD BE PROVIDED TO WORKERS WHO ARE AT RISK FROM EXPOSURE TO THE SPECIFIC NANOMATERIALS OR GROUPS OF NANOMATERIALS? 2. Methods To answer the question, a literature review was conducted in the year 2015 by searching scientific journal databases via the Internet, to find evidence for effective training regarding the handling of nanomaterials (NM) at the workplace. First, inclusion and exclusion criteria were defined to be able to determine a suitable search strategy. Second, a pilot study was conducted to see if it was possible to find any information about the topic on the Internet before focusing on the scientific literature. The pilot study was also helpful to indicate proper search terms and strings. Third, after the pilot study two researchers from IFA searched the selected databases with a certain set of terms in a certain order (strings) and recorded the results. We also evaluated the references in the papers that we read full-text and we evaluated the grey literature, such as reports not published by commercial or academic distribution channels. Finally, European Union and international research projects (such as Nanodiode, nanoInDex, NanoEIS, NanOpinion and QualityNano) were assessed. The results were evaluated using the PICO approach. Finally, the selected studies were assessed for their methodological quality with a score that ranged from -12 to +12 (1, 9, 10). 2.1 Inclusion criteria for nanomaterials The literature review included synthetically-manufactured nano-objects (nanoparticles, nanofibres and nanoplates) and agglomerates and aggregate forms of these materials, as well as nanostructured materials (Fig. 1) also known as engineered nanomaterials (ENM). The “form” of the ENMs referred to its physical form or the environment (matrix) where the ENM is contained (for instance powder,
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