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Antimicrobial Biomaterials and Biofilm Infection: a stepping stone symposium Tianjin, China 16-18 September, 2018 Organized by State Key Laboratory of Medicinal Chemical Biology, Nankai University, China Institute of polymer chemistry, Nankai University, China AO Foundation, Switzerland Chinese Association for Biomaterials (CAB) Sponsored by State Key Laboratory of Medicinal Chemical Biology, Nankai University, China National Natural Science Foundation of China AO Foundation, Switzerland Sino Swiss Science and Technology Cooperation (SSSTC) as part of the Bilateral Science and Technology Cooperation Programme with Asia by the Swiss State Secretariat for Education, Research and Innovation (SERI) Organization Symposium Chair: Linqi Shi (China) Co-Chair: Fintan Moriarty (Switzerland) Henk Busscher (Netherland) Bingyun Li (USA) Secretary Zhenkun Zhang (China) Registration You can register by sending an email to the symposium secretary at: [email protected] Registration and attendance is free of charge, but you are responsible for payment and making of your own travel and accommodation requirements. Confirmed invited Speakers Henk Busscher (Netherland), Bingyun Li (West Virginia University, USA) ), Weiping Ren (Wayne state University, USA), Jessica Amber Jennings (University of Memphis, USA) (In no particular order) Fintan Moriarty (AO Foundation, Switzerland), Katharina Maniuria (EMPA, St. Gallen, Switzerland), Jens Moeller (ETH Zurich, Switzerland), Cora-Ann Schoenenberger (University of Basel, Group C. Palivan, Switzerland), Qin Ren (EMPA St. Gallen., Switzerland) (In no particular order) Fujin Xu/Shun Duan (Beijing University of Chemical Technology, China), Xin Wang (Beijing University of Chemical Technology, China), Jianzhong Du (Tongji University, China), Lei Zhang (Tianjin University, China), Jian Ji (Zhejiang University), Menghua Xiong (South China University of Technology), Weihui Wu (Nankai University, China), Xinge Zhang (Nankai University, China), Linqi Shi/Zhenkun Zhang (Nankai University, China) (In no particular order) Industry delegates: Jie Xiong (JOHNSON & JOHNSON), Liangliang Wang(JOHNSON & JOHNSON), Josh Yu (Silvan Medical), Ke Yang (Silvan Medical) (In no particular order) Scientific Topics Biofilm infection Nanocarriers of antibiotics targeting biofilm infection Biomaterial related infection Antimicrobial surfaces and polymers Symposium Schedule Date Morning Afternoon Evening Sept. 16, Sun Registration (9:00-20:00, Hall of the Huigao Garden hotel) Sept. 17, Mon Opening Symposium Sessions Reception (8:30~ 9:00) (14:00-16:20) Symposium Sessions Posters Sessions (9:00-12:00) (16:20-17:30) Sept. 18, Tue Symposium Sessions Symposium Sessions Closing Ceremony (9:00-12:00) (14:00-15:15) Panel discussion (15:30-17:30) Sept. 19, Wed Departure Accommodation and Conference location Accommodation The Huigao Garden hotel nearby the old Campus of Nankai University is highly recommended. A limited number of rooms at the Huigao Garden hotel have been reserved for attendees in discounted prices. The price for a standard double room is 380 RMB per night including double breakfast. A bus will be arranged from the Hotel to the conference location. Conference location Mengminwei Building, the old campus of Nankai University (No. 94, Weijing Road, Tianjin) Industry Partner The organization committee would like to acknowledge the following Industry partners for supporting this symposium. INVITED TALK Linqi Shi, Professor Employment Details Director College of Chemistry Institute of polymer Chemistry, Nankai University Key Laboratory of Functional Address: Weijin Rd 94, Polymer Materials of Ministry of 300071 Tianjin Education (MOE), E-mail Address: Nankai University [email protected] Background Prof. Linqi Shi received his B.S. in the Department of Chemistry, Hebei University, China (1984) and his Ph.D. in Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China (1993). He is currently a Professor and the Director of the Institute of Polymer Chemistry at Nankai University and Key Laboratory of Functional Polymer Materials of Ministry of Education (MOE). He is also the vice director of the State Key Laboratory of Medicinal Chemical Biology (SKLMCB). His research focuses on living radical polymerizations, self-assembly of block copolymers, and polymeric nanocarriers for drug delivery. He has over 90 peer-reviewed publications in polymer science and has been awarded the excellent Professor Award by Ministry of Education, China (2002). He is one of the Distinguished Young Scholars financed by the National Natural Science Foundation of China (2006). A primary research theme in his lab is to develop a local antibiotic delivery system to cure biofilm-related infections through deliver sufficiently high local concentrations of antibiotics inside the biofilm in order to kill biofilms, also when consisting of strains currently known to be resistant at concentrations tolerated by the human body. The antibiotic carriers are based on antibiotic loaded polymeric micelles with a surface-adaptive property, targeting in different cases of biofilm-related infections in novel way. Selected Publications 1. Yong Liu, Henk J. Busscher, Bingran Zhao, Yuanfeng Li, Zhenkun Zhang, Henny C. van der Mei*, Yijin Ren, and Linqi Shi* , Surface-Adaptive, Antimicrobially Loaded, Micellar Nanocarriers with Enhanced Penetration and Killing Efficiency in Staphylococcal Biofilms, ACS Nano, 2016, 10 (4), 4779–4789 2. Yong Liu, Henny C. van der Mei*, Bingran Zhao, Yan Zhai, Tangjian Cheng, Yuanfeng Li Zhenkun Zhang, Henk J. Busscher, Yijin Ren, Linqi Shi*, Eradication of Multidrug‐Resistant Staphylococcal Infections by Light‐Activatable Micellar Nanocarriers in a Murine Model. Advanced Functional Materials, 2017,27(44), 1701974. 3. Zhenkun Zhang, Rujiang Ma, Linqi Shi*. Cooperative macromolecular self-assembly toward polymeric assemblies with multiple and bioactive functions. Accounts of Chemical Research, 2014, 47(4): 1426-1437. 4. Fan Huang, Jianzhu Wang, Aoting Qu, Liangliang Shen, Liu J., LiuJ, Zhang Z., An, Y and Shi, L*. Maintenance of Amyloid b-Peptide Homeostasis by Artificial Chaperones Based on Mixed ‐Shell Polymeric Micelles. Angew. Chem. Int. Ed., 53(34): 8985-8990, 2014. 5. Liu Y.; Du J. J.; Yan M.; Lau M. Y.; Hu J.; Han H.; Yang O. O.; Liang S.; Wei W.; Wang H.; Li J. M.; Zhu X. Y.; Shi L. Q.*; Chen W.*; Ji C.*; Lu Y. F.*, Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication, Nature Nanotech., 8(3), 187, 2013. Henk J Busscher PhD Employment Details PhD, Division Head Address: University Medical Center University Medical Center Groningen Groningen Department of Biomedical Department of Biomedical Engineering Engineering Antonius Deusinglaan 1 Antonius Deusinglaan 1 9713 AV Groningen, the Netherlands 9713 AV Groningen, the Netherlands E-mail address: [email protected] Phone: +1-31-50-3636161 Background Henk J. Busscher obtained his MSc degree in Engineering, Physics and Materials Science at the University of Groningen, The Netherlands, where he also obtained his PhD on streptococcal adhesion to surfaces within the Faculty of Dentistry, after which he moved to the Faculty of Medical Sciences. He became full professor in 1998 with as a specialty biomaterials science to prevent and cure biomaterial-associated infections, owns a consulting company “Scientific and Applied Surface Advice” and is editor of “Colloids and Surfaces B: Biointerfaces”. In 1995 he founded the Kolff Institute for Biomedical Engineering and Material Science at the University Medical Center Groningen, The Netherlands. His research interests focus on physico-chemical, microbiological and clinical aspects of biofilm- associated infections, infection prevention and control, especially of infections occurring on biomaterials implants and devices. He has published over six hundred peer reviewed papers (H-factor 71). Content of the presentation Key-players in clearing biomaterial-associated infection Most human infection are due to bacteria growing in a surface-attached, biofilm-mode of growth that provides them with protective, emergent properties, like embedding themselves in extracellular-polymeric-substances. In most human infections, the surfaces involved are surfaces of other bacteria or cells, bone cells or teeth and causative pathogens are inadvertently introduced in the body. Biomaterial-associated infections form a special class of infections. Firstly, because the human immune system is frustrated due to its inability to clear a huge chunk of foreign material out of the body, making it less effective against infecting bacteria. Secondly, infection is frequently caused by per-operative introduction of pathogens to a biomaterial surface, although post-operative introduction through the hematogenous route is also possible. Very few measures are clinically available to treat biofilms on biomaterial implants or devices and often removal and replacement is the sole cure, but also current preventive measures are not always effective due to bacterial resistance against a growing number of strains and species. Key-players determining the success of biomaterials implants and devices are therewith the materials surface, colonizing bacteria, tissue cells trying to integrate the implant and macrophages. Macrophages can either adapt an inflammatory “fighting” M1-phenotype or a tissue stimulating “fix-and- repair” M2-phenotype. In presence of gold-nanoparticle coated surfaces and various dental implant materials,