Hormonal Physiology of Childbearing: Evidence and Implications for Women, Babies, and Maternity Care
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Hormonal Physiology of Childbearing: Evidence and Implications for Women, Babies, and Maternity Care Sarah J. Buckley January 2015 Childbirth Connection A Program of the National Partnership for Women & Families About the National Partnership for Women & Families At the National Partnership for Women & Families, we believe that actions speak louder than words, and for four decades we have fought for every major policy advance that has helped women and families. Today, we promote reproductive and maternal-newborn health and rights, access to quality, affordable health care, fairness in the workplace, and policies that help women and men meet the dual demands of work and family. Our goal is to create a society that is free, fair and just, where nobody has to experi- ence discrimination, all workplaces are family friendly and no family is without quality, affordable health care and real economic security. Founded in 1971 as the Women’s Legal Defense Fund, the National Partnership for Women & Families is a nonprofit, nonpartisan 501(c)3 organization located in Washington, D.C. About Childbirth Connection Programs Founded in 1918 as Maternity Center Association, Childbirth Connection became a core program of the National Partnership for Women & Families in 2014. Throughout its history, Childbirth Connection pioneered strategies to promote safe, effective evidence-based maternity care, improve maternity care policy and quality, and help women navigate the complex health care system and make informed deci- sions about their care. Childbirth Connection Programs serve as a voice for the needs and interests of childbearing women and families, and work to improve the quality and value of maternity care through consumer engagement and health system transformation. © 2015 National Partnership for Women & Families. All rights reserved. This publication may be redistributed electronically or digitally for noncommercial purposes only so long as it remains wholly intact, including this copyright notice and disclaimer. Address all other permission re- quests, except for brief quotations with credit to the source, to Childbirth Connection Programs, National Partnership for Women & Families. Disclaimer: The information provided in this report is not intended as a substitute for the professional guidance of qualified maternity care providers. Suggested citation: Buckley, Sarah J. Hormonal Physiology of Childbearing: Evidence and Implications for Women, Babies, and Maternity Care. Washington, D.C.: Childbirth Connection Programs, National Partnership for Women & Families, January 2015. Available with related documents at: www.ChildbirthConnection.org/HormonalPhysiology 1875 Connecticut Avenue NW, Suite 650, Washington, D.C. 20009 phone: 202-986-2600 • fax: 202-986-2539 • e-mail: [email protected] www.NationalPartnership.org Transform.ChildbirthConnection.org www.ChildbirthConnection.org Abstract Hormonal Physiology of Childbearing: Evidence and Implications for Women, Babies, and Maternity Care This report synthesizes evidence about innate hormonally-mediated physiologic processes in women and fetuses/newborns during childbearing, and possible impacts of common maternity care practices and interventions on these processes, focusing on four hormone systems that are consequential for childbearing. Core hormonal physiology principles reveal profound interconnections between mothers and babies, among hormone systems, and from pregnancy through to the postpartum and newborn pe- riods. Overall, consistent and coherent evidence from physiologic understandings and human and animal studies finds that the innate hormonal physiology of childbearing has significant benefits for mothers and babies. Such hormonally-mediated benefits may extend into the future through optimization of breastfeeding and maternal-infant attachment. A growing body of research finds that common maternity care interventions may disturb hormonal processes, reduce their benefits, and create new challenges. Developmental and epigenetic effects are biologically plausible but poorly studied. The perspective of hormonal physiology adds new considerations for benefit-harm assessments in maternity care, and sug- gests new research priorities, including consistently measuring crucial hormonally-mediated outcomes that are frequently overlooked. Current understanding suggests that safely avoiding unneeded maternity care interventions would be wise, as supported by the Precautionary Principle. Promoting, supporting, and protecting physiologic childbearing, as far as safely possible in each situation, is a low-technology health and wellness approach to the care of childbearing women and their fetuses/newborns that is applicable in almost all maternity care settings. CHILDBIRTH CONNECTION | HORMONAL PHYSIOLOGY OF CHILDBEARING | ABSTRACT i Contents Abstract .......................................................................................................................................................... i Figures and Tables ...................................................................................................................................... iii Message from Debra L. Ness ...................................................................................................................... iv Foreword ....................................................................................................................................................... v Preface ........................................................................................................................................................ vii Acknowledgments ...................................................................................................................................... ix Executive Summary ...................................................................................................................................... x 1 Introduction: Overarching Themes and Scope ............................................................................. 1 1.1 Human Childbearing: Evolution and Safety .......... 2 1.2 Contemporary Childbirth Practices .......... 2 1.3 Current Understandings of the Hormonal Physiology of Childbearing .......... 4 1.4 Alignment with Other Frameworks .......... 7 1.5 Scope of This Report .......... 10 1.6 Introduction: Summary .......... 11 2 Physiologic Onset of Labor and Scheduled Birth ......................................................................... 14 2.1 Physiologic Onset of Labor at Term .......... 15 2.2 Possible Impacts of Scheduled Birth .......... 20 2.3 Physiologic Onset of Labor and Scheduled Birth: Summary .......... 24 3 Oxytocin ............................................................................................................................................ 26 3.1 Oxytocin: Normal Physiology .......... 27 3.2 Common Maternity Care Practices That May Impact Oxytocin Physiology .......... 54 3.3 Oxytocin Physiology: Summary .......... 90 4 Beta-Endorphins ............................................................................................................................. 93 4.1 Beta-Endorphins: Normal Physiology .......... 94 4.2 Common Maternity Care Practices That May Impact Beta-Endorphins Physiology .......... 102 4.3 Beta-Endorphins: Summary .......... 109 5 Epinephrine-Norepinephrine and Related Stress Hormones .................................................. 111 5.1 Epinephrine-Norepinephrine and Related Stress Hormones: Normal Physiology .......... 112 5.2 Common Maternity Care Practices That May Impact Epinephrine-Norepinephrine and Related Stress Hormones .......... 125 5.3 Epinephrine-Norepinephrine and Related Stress Hormones: Summary .......... 138 6 Prolactin ........................................................................................................................................ 140 6.1 Prolactin: Normal Physiology .......... 141 6.2 Common Maternity Care Practices That May Impact Prolactin Physiology .......... 149 6.3 Prolactin: Summary .......... 154 7 Conclusions and Recommendations ........................................................................................... 156 7.1 Conclusions .......... 157 7.2 Recommendations to Promote, Support, and Protect Physiologic Childbearing .......... 163 7.3 Conclusions and Recommendations: Summary .......... 169 Appendix: Resources for Learning More and Improving Practice ...................................................... 171 References ................................................................................................................................................ 175 Abbreviations ........................................................................................................................................... 224 Photo Credits ............................................................................................................................................ 225 CHILDBIRTH CONNECTION | HORMONAL PHYSIOLOGY OF CHILDBEARING | CONTENTS ii Figures and Tables Figures Figure 1: Women’s oxytocin levels in late pregnancy, in early labor, at birth, and after birth .............. 36 Figure 2: Maternal oxytocin levels, with and without epidural analgesia ......................................... 76 Figure 3: Women’s beta-endorphins levels non-pregnant, in labor, and after birth ........................... 99 Figure 4: Maternal beta-endorphins levels, with and without epidural analgesia ...........................