Polymerization of Misfolded Z Alpha-1 Antitrypsin Protein Lowers CX3CR1
SHORT REPORT Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs Srinu Tumpara1, Matthias Ballmaier2, Sabine Wrenger1, Mandy Ko¨ nig3, Matthias Lehmann3, Ralf Lichtinghagen4, Beatriz Martinez-Delgado5, Elena Korenbaum6, David DeLuca1, Nils Jedicke7, Tobias Welte1, Malin Fromme8, Pavel Strnad8, Jan Stolk9, Sabina Janciauskiene1,9* 1Department of Respiratory Medicine, Hannover Medical School, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany; 2Cell Sorting Core Facility Hannover Medical School, Hannover, Germany; 38sens.biognostic GmbH, Berlin, Germany; 4Institute of Clinical Chemistry, Hannover Medical School, Hannover, Germany; 5Department of Molecular Genetics, Institute of Health Carlos III, Center for Biomedical Research in the Network of Rare Diseases (CIBERER), Majadahonda, Spain; 6Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany; 7Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; 8Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany; 9Department of Pulmonology, Leiden University Medical Center, Member of European Reference Network LUNG, section Alpha-1- antitrypsin Deficiency, Leiden, Netherlands Abstract Expression levels of CX3CR1 (C-X3-C motif chemokine receptor 1) on immune cells have significant importance in maintaining tissue
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