VOLUME 43 • ISSUE 4 T XTALKTOXTALK® EDITOR PRESIDENT’S MESSAGE Robert Johnson, Ph.D., F-ABFT ASSOCIATE EDITOR SO-SOFTS and other volunteers who What a wonderful Chris Heartsill, B.S., D-ABFT-FT meeting in San An- gave their valuable time for the cause. tonio! If you were Additionally, I would like to once again thank Kayla Ellefsen for serving as the EDITOR EMERITUS unable to attend, Yale Caplan, Ph.D., F-ABFT you missed a great JAT Special Editor. time of quality sci- TOXTALK The scientific portion of the meeting SECTION EDITORS ence, professional was quite popular, with the workshops Matthew Barnhill, Ph.D., F-ABFT networking, seeing selling out quickly. This underscores Kevin G. Shanks, M.S., D-ABFT-FT old friends, and making new ones. the desire for continuing education On a personal level, I was pleased to among our membership, an item that PRESIDENT get to meet several of my Texas col- SOFT is continuing to address with Dwain Fuller, B.S., F-ABFT, TC-NRCC

leagues, whose names were already BOARD OF DIRECTORS more regional workshop offerings, the familiar to me, but I had never met. Journal of Analytical Toxicology Edi- PRESIDENT ELECT The total meeting attendance was tor’s Choice CE, and hopefully some Sumandeep Rana, Ph.D. 1089 registered attendees, which I am online options in the future. told is the largest attendance ever for a non-joint meeting. That’s fantastic! TREASURER Michelle Peace kicked off the mento- Robert Sears, M.S., F-ABFT Thank you to our hosts, Brad Hall and ring program at the Young Forensic Veronica Hargrove for all your hard Toxicologists (YFT) function on Sunday work. I also want to thank the plan- SECRETARY night. I was fortunate to be able to Amy Miles, B.S. ning committee. Scientific Program attend and make the acquaintance Chairs: Peter Stout and Dayong Lee, of a few of our students and younger PAST PRESIDENT Workshop Chairs: Teresa Gray and Erin members. Round two is planned for Michelle Peace, Ph.D. Karschner, Exhibitor Liaison: Liz Kiely, the American Academy of Forensic Food and Beverage: Ann Marie Gor- Sciences meeting in February. I am DIRECTORS don and Denice Teem, YFT Chair: Kim excited to see where this goes. Samano, Volunteer Coordinators: Kayla Denice Teem, B.S., D-ABFT-FT Ellefsen and MacKenzie Dunn, Mobile At the business meeting the member- Erin Spargo, Ph.D., F-ABFT Application: Rusty Lewis, Roxane M. ship voted for some minor changes to Tate Yeatman, M.S., F-ABFT, F-ABC Ritter, and Sunday Saenz, Audio/Visu- the bylaws, reinstating a “Retired” sta- Chris Heartsill, B.S., D-ABFT-FT al: Frank Wallace, and of course, Beth tus in addition to the recently added Madeline Montgomery, B.S., D-ABFT-FT Olson and CC Watson, and all of the “Emeritus” status. Additionally, a new

President’s Message ...... 1-2 EXECUTIVE DIRECTOR Case Study ...... 2-5 Beth Olson, MBA SOFT 2019 Meeting Recap ...... 6-13 Emerging Drugs: Flualprazolam ...... 14-16 OPERATIONS AND SOCIAL MEDIA MANAGER SOFT 2020 Meeting Update ...... 17-18 CC Watson 2020 JAT Special Issue ...... 19 2020 Call for Workshop Proposals ...... 19 SOFT OFFICE AAFS Annual Meeting Update ...... 20 1955 W. Baseline Rd., Ste 113-442 Tech-IN Tidbit: Better GC/MS Searching ...... 20-21 Mesa, AZ 85202 ICAP 2020 ...... 21 STAFF

INSIDE THIS ISSUE From the Toxicology Literature ...... 22-23 480-839-9106 Share your SOFT Pictures & Messages ...... 24 [email protected] PAGE 1 PRESIDENT’S MESSAGE CONTINUED slate of Officers and Directors were whole and our greater awareness of honor and privilege to serve as your elected. This includes Sumandeep such issues as bias, sexual harassment, President this last year. I will contin- Rana as President, Amy Miles as diversity, etc., I charged the Culture, ue to remain committed to SOFT and President Elect, Erin Spargo as Secre- Values and Diversity Committee with serve the organization in whatever tary and Fiona Couper, Andre Sukta drafting a code of professional con- role is appropriate moving forward. and Phil Kemp as Directors. Incoming duct, which after being approved by Dwain C. Fuller, F-ABFT, TC-NRCC President Rana appointed Mick Smith the Board of Directors, each member SOFT President as Counselor and Luke Rodda as JAT will be asked to be aware of, and to Special Editor. agree to, when paying dues each year. Additionally, as a reflection of the This is my last President’s Message of changing culture of our society as a my presidency. It has been a sincere Case Study: Postmortem Distribution of 3,4-Methylenedioxymethamphet- amine (MDMA) and 3,4-Methylenedioxyamphetamine (MDA) from an Acci- dental Death Due to MDMA Intoxication Danylle Kightlinger, B.S. B.S., Lucas Zarwell, M.S., Victor W. Weedn, M.D.; District of Columbia Office of the Chief Medical Examiner, Washington, DC. Introduction found in the apartment. Approxi- phy-mass spectrometry (GC/MS) mately 18 hours after the decedent methods were conducted. Additional- 3,4-methylenedioxymethamphet- was pronounced dead, a medicolegal ly, electrolytes testing was conducted amine (MDMA), also known as Ec- stasy, is a ring-substituted derivative autopsy was performed and speci- by biosensor analysis. Subsequent to of methamphetamine. It is typically mens were submitted for toxicological the completion of the routine femoral taken in the hydrochloride salt form, analysis. After results from the initial blood testing, the remaining samples ranging in oral doses from 100 – 150 toxicological case analysis were report- previously submitted to toxicology, mg. MDMA undergoes N-demethyl- ed, additional testing was conducted were analyzed by GC/MS to gain infor- ation metabolism, forming the active to collect postmortem distribution mation about the postmortem distri- metabolite 3,4- methylenedioxy- data of MDMA and MDA. bution of MDA and MDMA. amphetamine (MDA). The effects Methods GC/MS System of MDMA often include: dizziness, hyperactivity, anorexia, headache, A medicolegal autopsy was performed An amines analysis (including: amphet- anxiety, disorientation, and insomnia and nine specimens were submitted amine, methamphetamine, ephedrine, (1). Presented is a brief case review for toxicological examination: Femo- pseudoephedrine, MDA, and MDMA) highlighting the postmortem distribu- ral Blood 1, Femoral Blood 2, Heart was performed via liquid-liquid ex- tion of MDMA and MDA in a deceased Blood 1, Heart Blood 2, Urine, Vitreous traction (LLE) with n-butyl chloride intoxication victim. Humor, Liver, Brain, and Gastric Con- followed by heptafluorobutyric an- tent. An expanded postmortem panel hydride (HFBA) derivatization. The Case Background was conducted on Femoral Blood 1 samples were reconstituted in ethyl © A 29-year-old female was found which included: headspace gas chro- acetate and analyzed using an Agilent © kneeling, face-down on her bedroom matography (HS/GC), enzyme-linked GC/MS via Agilent MassHunter data floor approximately two hours after immunosorbent assay (ELISA), basic acquisition software in Selective Ion her last known communication and screen by gas chromatography-mass Monitoring (SIM) mode (Tables 1 and pronounced dead on scene roughly 40 spectrometry- phosphorous 2). The data was then processed using © minutes later. The scene was unre- detection (GC/MS/NPD), and drug Agilent Chemstation (Femoral Blood © markable. Three blister packets of screen by liquid chromatography-time 1) and Agilent MassHunter (all other ZzzQuil® (one empty), a bottle of Robi- of flight-mass spectrometry (LC/TOF/ samples) software over the dynamic tussin®, a pack of oral contraceptives, MS). Based on the screening results, range, 25 - 1000 ng/mL. Upon sam- two prescription bottles (Amoxicillin confirmatory, quantitative analyses pling for extraction, all case specimens and Docusate Sodium), wine and beer by analyte specific liquid chromatog- were diluted to obtain value(s) within were the only reported substances raphy-tandem mass spectrometry the linear range for MDA and MDMA. (LC/MS/MS) and gas chromatogra- Chromatographic separation of amines PAGE 2 Case Study: Postmortem Distribution of 3,4-Methylenedioxymethamphet- amine (MDMA) and 3,4-Methylenedioxyamphetamine (MDA) from an Acci- dental Death Due to MDMA Intoxication Danylle Kightlinger, B.S. B.S., Lucas Zarwell, M.S., Victor W. Weedn, M.D.; District of Columbia Office of the Chief Medical Examiner, Washington, DC. obtained by this method can be seen mal postmortem limits. The extremely heer, A. P. (2002). Distribution Study of in Figure 1. high level of MDMA present in the 3,4-Methylenedioxymethamphetamine gastric content suggested the route and 3,4-Methyldioxyamphetamine in a Results Fatal Overdose. Journal of Analytical Toxi- of administration was oral ingestion. cology, 26, 113-118. However, no tablets were found in the Findings during the medicolegal autop- stomach and the formulation in which sy included: pulmonary edema (1300 the MDMA was ingested – suspected grams combined lung weight), zonal tablet or liquid form – is unknown. necrosis of the liver (Figure 2 and 3), MDMA and its active metabolite, approximately 25 mL of green material MDA, appear to exhibit similar phar- in the stomach (Figure 4), and a contu- macokinetics, showing a seemingly sion on the inner lower lip which is a consistent ratio with respect to the potential indication of agonal seizure MDA/MDMA concentrations (0.01 – activity (Figures 5). 0.02) in all specimens. The liver and During the initial toxicological case brain concentrations were substan- analysis, four other compounds, in tially higher than the femoral blood. addition to MDMA and MDA, were The low MDMA concentration present reported in Femoral Blood 1. Post- in the urine suggests death occurred mortem concentrations of these com- soon after ingestion, as is consistent pounds, excluding MDMA and MDA, with the case history. were: cocaine detected (ELISA, LC/ The MDMA postmortem concen- TOF/MS), 0.03 mg/L benzoylecgonine trations in this case are some of the (ELISA, LC/MS/MS), highest reported, with many reported detected (GC/MS/NPD, LC/TOF/MS), MDMA overdose blood concentrations and 0.005 mg/L (ELISA, LC/ falling below 5 mg/L (1, 2, 3). While MS/MS). Additionally, electrolytes femoral blood remains the preferred analysis was performed on vitreous sample, our data suggests that heart humor, with results presented in blood concentrations are compara- Table 3. After the initial case analysis, ble to femoral blood, indicating heart additional toxicological analysis for blood may be used when necessary. MDMA and MDA was performed for This is supported in literature with a the remaining submitted specimens. reported postmortem distribution, The respective postmortem concen- heart/femoral blood concentration ra- trations, as well as MDMA and MDA tio average of 2.4 (range 1.0 – 3.9) (1). ratios, for all specimens are presented in the Table 4. With the assumption References that the entire gastric contents were submitted to toxicology for analysis, 1. Baselt, R. C. (2017) Disposition of Toxic the amount of unabsorbed MDMA still Drugs and Chemicals in Man (11th edi- present in the stomach calculated to tion). Seal Beach, CA; Biomedical Publica- tions. 19.35 mg (Equation 1). 2. Liu, R. H., Liu, H., Lin, D. (2006). Distri- Discussion bution of Methylenedioxymethamphet- amine (MDMA) and Methylenedioxy- The official cause of death was MDMA amphetamine (MDA) in Postmortem intoxication, with the manner of death and Antemortem Specimens. Journal of being accidental. Other drugs detect- Analytical Toxicology, 30, 545-550. ed were not significant in quantity and all electrolyte levels were within nor- 3. De Letter, E. A., Clauwaert, K. M., Lam- bert, W. E., Van Bocxlaer, J. F., De Leen- PAGE 3 Case Study: Postmortem Distribution of 3,4-Methylenedioxymethamphet- amine (MDMA) and 3,4-Methylenedioxyamphetamine (MDA) from an Acci- dental Death Due to MDMA Intoxication Danylle Kightlinger, B.S. B.S., Lucas Zarwell, M.S., Victor W. Weedn, M.D.; District of Columbia Office of the Chief Medical Examiner, Washington, DC.

PAGE 4 Case Study: Postmortem Distribution of 3,4-Methylenedioxymethamphet- amine (MDMA) and 3,4-Methylenedioxyamphetamine (MDA) from an Acci- dental Death Due to MDMA Intoxication Danylle Kightlinger, B.S. B.S., Lucas Zarwell, M.S., Victor W. Weedn, M.D.; District of Columbia Office of the Chief Medical Examiner, Washington, DC.

PAGE 5 2019 PLANNING COMMITTEE MEMBERS PAGE 6 PAGE Liz Kiely YFT ChairYFT Chair SOFT Staff SOFT Staff CC Watson Beth Olson Beth Denice Teem Laurel Porter Laurel Audio/VisualAudio/Visual Sunday Saenz Sunday Frank Wallace Frank Barbara Garcia Barbara MacKenzie Dunn MacKenzie Exhibitor Liaison Liaison Exhibitor Exhibitor Workshop Chairs Chairs Workshop Workshop Executive Director Executive Ann Marie Gordon Kim Samano, Ph.D. Kim Samano, Mobile Application Mobile Application Food and Beverage and Beverage Food Food 2019 Meeting Hosts Hosts 2019 Meeting 2019 Meeting Kayla Ellefsen, Ph.D. Ellefsen, Kayla Fun Run Coordinators Fun Run Coordinators Brad Hall, Ph.D., F-ABFT Hall, Ph.D., Brad Volunteer Coordinators Coordinators Volunteer Volunteer Peter Stout Ph.D., F-ABFT Ph.D., Stout Peter Scientific Program Chairs Chairs Program Program Scientific Scientific Teresa Gray, Ph.D., F-ABFT Ph.D., Gray, Teresa Dayong Lee, Ph.D., F-ABFT Lee, Ph.D., Dayong Rusty Lewis, Ph.D., F-ABFT Ph.D., Lewis, Rusty Erin Karschner, Ph.D., F-ABFT Ph.D., Erin Karschner, Veronica Hargrove, Ph.D., F-ABFT Veronica Hargrove, Roxane M. Ritter, M.S., D-ABFT-FT M. Ritter, Roxane Operations and Social Media Manager Operations - Brad & Veronica a great meeting happen, we could not we happen, meeting a great to Thanks without them! done it have help and all of their and CC for Beth Finally, the year. support throughout con all those who provided to thanks survey. the feedback through structive in future valuable are responses Your planning. meeting in again see everyone hope to We year! next beautiful San Diego help SOFT make this meeting possible. possible. meeting this SOFT make help to our go should Special recognition for making such committee planning - - -

-

sors and vendors that attended and attended that and vendors sors We would like to thank all of the spon to like would We new friends. friends. new catch up with old friends and made up with old friends and made catch something new but also had time to but also had time new something hopefully everyone left having learned having left everyone hopefully nities, scientific sessions and posters, posters, sessions and nities, scientific workshops, lunch and learn opportu workshops, throughout the year. With all of the the year. throughout us encouraging and supportive words words and supportive us encouraging appreciate all of those who provided of those who provided all appreciate serving as your meeting hosts, and we we and hosts, meeting serving as your one had a blast! We had a great time time great had a We a blast! one had ing in San Antonio, we hope every we Antonio, ing in San

attended and participated in the meet participated and attended Thank you so much to everyone that that everyone to so much you Thank

SAN ANTONIO, TX OCTOBER 13-18, OCTOBER TX 2019 ANTONIO, SAN SOFT 2019 MEETING RECAP MEETING 2019 SOFT BUSINESS MEETING

PAGE 7 NIOSITA

PAGE 8 AWARD WINNERS AWARD BANQUET

PAGE 9 PAGE 10 PAGE 11 POSTER PRESENTATIONS

PAGE 12 PLATFORM PRESENTATIONS

PAGE 13 Emerging Drug: Flualprazolam Donna Papsun¹, MS, D-ABFT-FT, Craig Triebold², F-ABC, D-ABFT-FT ¹NMS Labs, Horsham, PA; ²Sacramento County District Attorney Laboratory of Forensic Services, Sacramento, CA

In recent years, there has been an to be 10-30 min with a duration of limit for the method was 5 ng/mL. increase of misuse related to de- action ranging from 6-14 h (4). The distribution of concentrations for signer (DBZD), a these DUID cases is shown in Figure subcategory of novel psychoactive Flualprazolam was first detected on 2. The detection of flualprazolam has substances (NPS). Benzodiazepines the European drug market in 2018, outpaced the detection of alprazolam are commonly prescribed for their adding to a growing list of designer in this county. , , seda- benzodiazepines being monitored tive-, and anticonvulsant by the European Monitoring Centre In addition to cases from California, properties, but due to their wide- for Drugs and Drug Addiction (EM- NMS Labs in Horsham, Pennsylvania spread availability and relatively low CDDA) (5). More than half of the has confirmed 32 blood cases be- acute toxicity, there is a high po- listed 23 substances of the designer tween June 2019 and early Novem- tential for misuse and dependence. class have emerged ber 2019; testing capabilities were Therefore, in the era of analogs of since 2015, so overall this group of added in June 2019. The range of commonly used substances emerg- substances is increasing in popularity concentrations reported in these cas- ing on the drug market as suitable (6). The Drug Enforcement Agency es ranged from <2.0 – 68 ng/mL. See alternatives, it is not unexpected that (DEA) reported its first chemical iden- Table 2 for reported concentrations designer variants of benzodiazepines tification within the United States in distributed between postmortem and have become available and in de- 2018; there have been an increas- DUID blood concentrations. Flualpra- mand. Compounds of this class may ing number of reports from seized zolam was confirmed in 13 different have either been repurposed from drugs between Q1 and Q2 in 2019 (7, states; PA, SC, NV, LA, TX, OR, CA, IL, pharmaceutical research, chemically 8). The Center for Forensic Science NY, OH, KS, MN, and IN. The highest modified from prescribed benzodi- Research & Education reported its reported concentration of 68 ng/mL azepines, or obtained from diversion first detection of flualprazolam in a flualprazolam was reported in a DUID of pharmaceuticals available in other biological specimen in March 2018 case from TX. In one PA DUID case, countries. through data-mining TOF screening a flualprazolam of 13 ng/mL was the data from authentic specimens, with only positive finding. In a second Flualprazolam, a fluorinated analog 2 additional detections in June 2019 DUID case from PA, a 46 ng/mL of flu- of alprazolam, is an emerging design- (9). In addition, flualprazolam was alprazolam was detected in addition er benzodiazepine with increasing also detected in 1 of 13 postmortem to a 0.029% blood concentra- prevalence, which is an example of bloods collected between 2016-2018 tion (BAC). a modification to a prescribed ben- in NY after re-analysis with an updat- zodiazepine. It was first patented in ed designer benzodiazepine panel Flualprazolam is used as a central the 1970s but never marketed, so it (10). nervous system depressant, including has been repurposed for recreational its /tranquilizer and muscle abuse from pharmaceutical research Sacramento County, California re- relaxant properties. Adverse effects as well (1). Its chemical characteris- ported its first confirmation of flual- of benzodiazepines can include seda- tics and structure are listed in Figure prazolam in biological specimens in tion, reduced anxiety, loss of con- 1. Flualprazolam is a high potency May 2018. Between May 2018 and sciousness, impaired balance, incoor- triazolo-benzodiazepine with sedative August 2019, 124 cases of flualprazol- dination, impaired cognitive abilities, effects similar to other benzodiaze- am were confirmed by the laboratory muscle weakness, confusion, slurred pines (2). It is marketed by internet in submitted blood specimens. Of speech, dizziness, and lethargic companies for “research purposes” the 124 positives, 123 cases were behavior. Misuse of designer ben- as an alternative to alprazolam and submitted from Driving Under the zodiazepines such as flualprazolam discussions on online forums suggest Influence of Drug (DUID) investiga- can produce cognitive and motor that flualprazolam lasts longer and is tions. The concentrations ranged impairment after acute use, poten- stronger than alprazolam, its non-flu- from 5-154 ng/mL, with average and tially contributing to traffic accidents orinated counterpart (3). Onset of median concentrations of 25 and 18 and other poor driving behavior. Like action for flualprazolam is reported ng/mL, respectively; the reporting pharmaceutical benzodiazepines, PAGE 14 Emerging Drug: Flualprazolam Donna Papsun¹, MS, D-ABFT-FT, Craig Triebold², F-ABC, D-ABFT-FT ¹NMS Labs, Horsham, PA; ²Sacramento County District Attorney Laboratory of Forensic Services, Sacramento, CA

designer benzodiazepines can have severe toxicity when concomitant- ly used with other CNS depressant drugs, such as and alcohol, which increases the risk of respirato- ry depression and death. Although cross reactivity of flualpra- zolam has not been formally conduct- ed, anecdotal experience leads the authors to suggest there is cross-re- activity of flualprazolam to com- mercially available immunoassays targeted for benzodiazepines. Many designer benzodiazepines cross-re- act with commercial immunoassay screens; cross-reactivity ranged from 79-107% for , , , , diclaze- pam, and (11). There- fore, it is suggested that an uncon- firmed benzodiazepine immunoassay screen should be scrutinized for the possibility of designer benzodiaze- pines, and additional testing inclusive of flualprazolam may be applicable in certain cases. The GC/MS spectra of flualprazolam is provided in Figure 4. Flualprazolam and many DBZD have never undergone the clinical testing that is required for licensed medi- cines and the increasing availability of these substances may pose serious health risks to drug users. Flualpra- zolam, when sold on the illicit drug market as the counterfeit form of another prescription drug, poses a significant threat to end users due to an increased risk of unintentional overdose and intoxication (4). Flual- prazolam has been reported as the active ingredient in counterfeit alpra- zolam on a harm reduction website in the United States so these users may or may not know the true identity of the substance they are ingesting (12). As an emerging designer benzodiaz- epine, forensic toxicologists, seized PAGE 15 Emerging Drug: Flualprazolam Donna Papsun¹, MS, D-ABFT-FT, Craig Triebold², F-ABC, D-ABFT-FT ¹NMS Labs, Horsham, PA; ²Sacramento County District Attorney Laboratory of Forensic Services, Sacramento, CA

drug and toxicology laboratories, law risk users in Europe. enforcement, hospital personnel, http://www.emcdda.europa. and public health officials should be eu/system/files/publica- aware of the increasing prevalence of tions/2733/Misuse%20of%20 flualprazolam and the threat it poses benzos_POD2015.pdf to public health and safety. Labora- tories should consider adding flual- 7. Emerging Threat Report, first prazolam to their scope of testing in quarter 2019, order to truly understand the preva- lence of this NPS in the United States. https://ndews.umd.edu/ sites/ndews.umd.edu/files/ References DEA-Emerging-Threat-Report- 2019-Quarter-1.pdf 1. Hester, JB. (1976) 6-Phe- nyl-4H-s-triazolo[4,3-a][1,4] 8. Emerging Threat Report, sec- benzodiazepines. Patent US ond quarter 2019, 3987052. https://ndews.umd.edu/ 2. Garzone, PD., Krobeth, PD. sites/ndews.umd.edu/files/ (1989) Pharmacokinetics of Emerging-Threat-Report- the newer benzodiazepines. 2019-Quarter-2.pdf Clin Pharmacokinet, 16 (6), 337-64. 9. Krotulski, A; Logan, BK. 2019. Flualprazolam. Center for 3. World Health Organization. Forensic Science Research & (2019) Critical Review Report: Education and Temple Univer- Flualprazolam. 42nd Expert sity. NPSdiscovery.org. Committee on Drug Depen- dence. 10. Mei, V., Concheiro, M., Pardi, J., Cooper, G. (2019). Valida- 4. Zawilska, JB., Wojcieszak, J. tion of an LC-MS/MS Method (2019) An expanding world of for the Quantification of 13 new psychoactive substanc- Designer Benzodiazepines in es—designer benzodiaze- Blood. J Anal Toxicol. pines. Neurotoxicology, 73, 8-16. 11. O’Conner LC., Torrance HJ., McKeown DA. ELISA Detec- 5. Moosman B., Auwärter V. tion of phenazepam, etizolam, (2018) Designer Benzodiaze- pryazolam, flubromazepam, pines: another class of new , and delorazepam psychoactive substances. in blood using Immunalysis® Handb Exp Pharmacol, 252, Benzodiazepine Kit. J Anal 383-410. Toxicol, 2016, 40, 159-161. 6. European Monitoring Centre 12. DrugsData. 2019. “S903 Coun- for Drugs and Drugs Addic- terfeit Alprazolam: SampleID tion. 2018a. Perspective on 7343”. https://drugsdata. drugs: the misuse of ben- org/7343 zodiazepines among high- PAGE 16 2020 PLANNING COMMITTEE MEMBERS PAGE 17 PAGE Dani Mata Dani Mata Liz Kiely Eucen Fu Carl Wolf YFT ChairYFT Chair Jay Vargas Jay SOFT Staff SOFT Staff CC Watson Beth Olson Beth Luke Rodda Luke Rusty Lewis Rusty Bill Johnson Andre Sukta Andre Sue Pearring Denice Teem Kevin Shanks Kevin Phyllis Mallet Phyllis Audio/VisualAudio/Visual Sunday Saenz Sunday Javier Velasco Javier Frank Wallace Frank Delisa Downey Delissa Downey Roxane M. Ritter Roxane Jennifer Limoges Jennifer Exhibitor Liaison Liaison Exhibitor Exhibitor Workshop Chairs Chairs Workshop Workshop Bruce Goldberger Vanessa Meneses Vanessa Laureen Marinetti Laureen Executive Director Executive Ann Marie Gordon Mobile Application Mobile Application Food and Beverage and Beverage Food Food 2020 Meeting Hosts Hosts Meeting Meeting 2020 2020 Alanna de Korompay Fun Run Coordinators Fun Run Coordinators JAT Special Issue Editor Special Issue Editor JAT JAT Volunteer Coordinators Coordinators Volunteer Volunteer Scientific Program Chairs Chairs Program Program Scientific Scientific Social Event Coordinators Coordinators Social Event Social Event Denice Teem Denice Teem Opening Ceremony Coordinators Coordinators Opening Ceremony Opening Ceremony Operations and Social Media Manager Operations - -

reached non-stop from more than 60 more from non-stop reached Estimat U.S. and abroad. the cities in USD. is $18 fare taxi ed one-way at the Marriott will be $245.00 per $245.00 will be the Marriott at is close This property plus taxes. night Inter Diego San 5 miles) to (less than can be which (SAN), Airport national

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https://www.mar

http://soft-tox.org/meeting

CA 92101. The conference room rate rate room CA 92101. The conference ed at 333 W. Harbor Drive, San Diego, San Diego, Harbor Drive, 333 W. ed at ott-marquis-san-diego-marina/ riott.com/hotels/travel/sandt-marri San Diego Marina, San Diego der one roof at the Marriott Marquis Marriott Marquis the at der one roof and the exhibit hall will be entirely un hall will be entirely and the exhibit The meeting hotel, scientific program, program, scientific hotel, The meeting

local activities information. information. activities local hotel room block, sight-seeing, and block, sight-seeing, room hotel tion dates, abstract submission dates, submission dates, abstract tion dates, updates to our meeting page, registra page, our meeting to updates at continue to check the SOFT website website to check the SOFT continue sharing in the year to come. Please Please come. to sharing in the year features that we’re looking forward to to looking forward we’re that features an exciting program with several new new with several program an exciting hard for several months now creating creating now months several for hard History Committee have been working been have Committee History committee and the newly formed and the newly committee tion in the future. Both our planning Both our planning tion in the future. how we plan to grow as an organiza grow plan to we how

history of our organization as well as as of our organization history meeting, with the focus being on the focus meeting, the with planned to make this a very special this a very make planned to Diego in 2020. We have several things several have 2020. We in Diego anniversary of that meeting in San meeting of that anniversary to serve as your hosts for the 50th for hosts your as serve to are extremely honored and privileged and privileged honored extremely are held on Long Island, New York. We We York. New held on Long Island, of Forensic Toxicologists (SOFT) was (SOFT) was Toxicologists of Forensic of what we now know as the Society as the Society know now we of what In 1970, the first informal meeting meeting informal the first In 1970,

Diego, California. California. Diego, held September 21-25, 2020 in San 21-25, held September

ciety of Forensic Toxicologists will be Toxicologists of Forensic ciety The 50th Annual Meeting of the So of the Meeting 50th Annual The

SAN DIEGO, CA September 21–25, 2020 2020 21–25, 21–25, September September CA CA DIEGO, DIEGO, SAN SAN

SOFT 2020 MEETING UPDATE UPDATE MEETING MEETING 2020 2020 SOFT SOFT 2020 PLANNING COMMITTEE MEMBERS PAGE 18 PAGE Dani Mata Dani Mata Liz Kiely Eucen Fu Carl Wolf YFT ChairYFT Chair Jay Vargas Jay SOFT Staff SOFT Staff CC Watson Beth Olson Beth Luke Rodda Luke Rusty Lewis Rusty Bill Johnson Andre Sukta Andre Sue Pearring Denice Teem Kevin Shanks Kevin Phyllis Mallet Phyllis Audio/VisualAudio/Visual Sunday Saenz Sunday Javier Velasco Javier Frank Wallace Frank Delisa Downey Delissa Downey Roxane M. Ritter Roxane Jennifer Limoges Jennifer Exhibitor Liaison Liaison Exhibitor Exhibitor Workshop Chairs Chairs Workshop Workshop Bruce Goldberger Vanessa Meneses Vanessa Laureen Marinetti Laureen Executive Director Executive Ann Marie Gordon Mobile Application Mobile Application Food and Beverage and Beverage Food Food 2020 Meeting Hosts Hosts Meeting Meeting 2020 2020 Alanna de Korompay Fun Run Coordinators Fun Run Coordinators JAT Special Issue Editor Special Issue Editor JAT JAT Volunteer Coordinators Coordinators Volunteer Volunteer Scientific Program Chairs Chairs Program Program Scientific Scientific Social Event Coordinators Coordinators Social Event Social Event Denice Teem Denice Teem Opening Ceremony Coordinators Coordinators Opening Ceremony Opening Ceremony Operations and Social Media Manager Operations - - hosts, Your Dani & Denice We will have dinner on the flight on the flight dinner will have We ship, along impressive deck of this the inside. explore able to with being SOFT join us at to you invite We and look honor our past 2020 as we Please come. to the years to forward September for calendars mark your on collaborating 21 – 25, 2020, start propos abstract and those workshop cele join us as we als, and plan to of SOFT! 50 years brate This decommissioned aircraft carrier carrier aircraft decommissioned This less than located a museum is now hotel. our meeting from a mile walk . - - - -

https://www.mid

way.org/about-us/midway-history/ the USS Midway the USS Midway Wednesday evening event aboard aboard event evening Wednesday SOFT has arranged for a special for SOFT has arranged

September is expected to be 77/66 F. be 77/66 F. to is expected September ocean beaches! Typical weather in weather Typical ocean beaches! do, Old Town, golf, and spectacular spectacular and golf, Old Town, do, Little Italy, Seaport Village, Corona Seaport Village, Little Italy, Whale Watching, Casinos, Hotel Spa, Casinos, Hotel Whale Watching, Hang Gliding, Balboa Park, Kayaking, Kayaking, Hang Gliding, Balboa Park, Legoland, Surfing, Beer/Wine Tasting, Surfing,Legoland, Beer/Wine San Diego Padres baseball, SeaWorld, baseball, SeaWorld, Padres San Diego ego Zoo, San Diego Wild Animal Park, Wild Animal Park, San Diego Zoo, ego activities nearby such as the San Di activities nearby Quater. There are also many other also many are There Quater. ing distance to the famous Gaslamp Gaslamp famous the to ing distance meeting. The hotel is within walk within is hotel The meeting. and come early or stay after the the after early or stay and come

families, so plan to bring them along bring them along so plan to families, San Diego is a great destination for destination is a great Diego San

SAN DIEGO, CA September 21–25, 2020 2020 21–25, 21–25, September September CA CA DIEGO, DIEGO, SAN SAN

SOFT 2020 MEETING UPDATE UPDATE MEETING MEETING 2020 2020 SOFT SOFT 2020 Journal of Analytical Toxicology Special Issue Submitted By: Luke N. Rodda, Ph.D. Chief Forensic Toxicologist and Director, Forensic Laboratory Division, San Francisco OCME Assistant Adjunct Professor, UCSF [email protected]

Both JAT and SOFT have grown from (EDIT) Award that all first authors of national origins, to truly international accepted manuscripts are eligible for. entities that forensic toxicologists rely on to disseminate and receive The success of the Special Issues pivotal information in our industry. is reliant on you, the authors and The ever-increasing impact factor and reviewers. I therefore also invite you meeting attendance, respectively, are to serve as a reviewer, performing demonstrations of such. comprehensive and timely reviews of submitted manuscript in the peer-re- Participation and sharing of your view process. It is a great hono(u)r to be invited as important research fuels further Guest Editor for the Journal of Ana- knowledge in our field, and provides With this year being a 50th anni- lytical Toxicology’s Special issue, and key information for medicolegal case- versary SOFT meeting, an increased I do promise to maintain the use of work in court deliberations. Manu- amount of submissions are expected, American English. This issue is par- script completion and submission in thus I encourage all to submit punc- ticularly special being that 2020 will peer-reviewed literature is often a tually since the deadlines are not far be the 50th anniversary of SOFT, so challenging exercise. In acknowledge- away! I thank our incoming SOFT President ment, submission to this JAT Special Dr. Suman Rana for entrusting me in Issue provides the opportunity to be I look forward to your submissions this challenging yet rewarding role. recognized as the 2020 Experimen- and see you in San Diego! tal Design and Impact on Toxicology DEADLINES! January 31st, 2020: Title and abstract submissions due to Special Editor [email protected]

February 14th, 2020: Completed manuscripts due to JAT via Manuscript Central https://mc.manuscriptcentral.com/jat 2020 CALL FOR WORKSHOP PROPOSALS

Workshop Proposals for SOFT 2020 workshop idea you’re planning to if you’re not quite sure – look for- are due by April 1, 2020. Look for submit. This includes ideas from SOFT ward to all of your SOFT 2020 Work- the proposal submission form on the committees! This helps avoid dupli- shop Proposals. SOFT website in January 2020! cation of topics and aids in soliciting ideas if an area of interest has not yet 2020 Workshop Chairs Please contact the Workshop Pro- been met. Sue Pearring and Jen Limoges gram Chairs, Sue Pearring and Jen [email protected] Limoges, in advance if you have a We’re happy to brainstorm with you [email protected] PAGE 19 AAFS Annual Meeting News

Biology Section. This year’s Annual Desrosiers (Irving Sunshine Award), and Toxicology Lectureship features Re- Haley Mulder (June K. Jones Scholar- search Psychologist Dr. Dary Fiorentino ship). speaking on “The Effects of Low Blood • Hotel accommodations are available Alcohol Concentrations on Human now at the Anaheim Hilton via the AAFS Performance and Behavior” Thursday, website and the Advance Program is set February 20, 2020. for release on November 1, 2019.

Please double check your calendars • The Academy Cup returns on Finally, we extend our gratitude to and make arrangements to attend Wednesday, February 19, 2020 at 8:00 those generous vendors who have com- the 72nd Annual AAFS Meeting, Feb- AM. Come early for what is always a mitted financial sponsorship towards ruary 17-22, 2020 at the Anaheim fun and exciting start to the day and the Toxicology Section: Shimadzu Scien- Convention Center in Anaheim, CA, you can help your team on to victory in tific Instruments; Thomson Instrument USA. Dedicated to this year’s theme of 2020. Company; Lemos Toxicology Services, “Crossing Borders”, we have another • The annual Toxicology Section Lun- LLC; RTI International; Waters Corpo- science-filled program in store for all cheon will take place immediately prior ration; UTAK Laboratories, Inc; and attendees. Thanks again to the Toxicol- to the Toxicology Section Business Lipomed, Inc. If your organization would ogy Section officers, chairs, co-chairs, Meeting on Wednesday, February 19, like to offer support to the Toxicolo- moderators, abstract reviewers, and 2020. Members choosing to attend gy Section, please contact Madeleine volunteers for your tremendous efforts the Toxicology Section Luncheon must Swortwood, [email protected] for towards another successful meeting. register and pay for it during pre-regis- more details. Attendees can expect a wide array tration as this luncheon is not included of quality workshops, posters and in the regular registration and on-site Thanks and see you all in Anaheim! scientific sessions, breakfasts, and registration is unavailable. luncheons in 2020. The Toxicology • During our Toxicology Section Busi- Section will continue the traditional ness Meeting we will acknowledge special sessions on Drugs and Driving, the following award winners: Christine Postmortem Pediatric Toxicology and Moore (Rolla N. Harger Award); Eric our joint session with the Pathology/ Lavins (Ray Abernethy Award), Natalie Tech-IN Tidbit: Better GC/MS Searching Submitted By: Dan Baker, Franklin County Coroner’s Office, Columbus, OH Agilent’s Chemstation DrugQuant total, the toxicologist can work-around er, make a copy of the library file to software is a common GC/MS data the three library search software limita- C:\Database, and rename to some- analysis platform used in many foren- tion. thing like MERGED2019.L. sic toxicology laboratories. Full-scan 2. Now open Chemstation DrugQuant untargeted searching is a basic strategy As an example, some of the following Data Analysis and go into the Inter- of systematic toxicological analysis. common GC/MS libraries can be com- active Library Search view. Unfortunately, Chemstation DrugQuant bined, so that not to exceed 3 total: 3. Select the dropdown Library and software only permits up to three GC/ 1. AAFS2012 click Parametric Retrieval. Click MS libraries to be searched for the 2. SWGDRUG Cancel. generation of automated library search 3. Cayman 4. Select the dropdown Library and summary reports. This is a major 4. Designer Drugs (Rosner) click Subset Library. limitation for our laboratory which 5. NIST 5. Type the library/destination you commonly uses several commercial would like to add to your existing and open-source libraries. However, The above libraries 1-3 may be com- MERGED2019.L (it already contains the Chemstation DrugQuant software bined for improved automated search- AAFS2012). i.e. C:/SWGDRUG.L and enables users to subset and append ing. click Search. multiple libraries into a single library 6. Select Append To Library and click source allowing more effective and -ef 1. Start by locating an open source OK. ficient automated library searches. By library such as C:\Database\ 7. Select MERGED2019.L from the combining libraries to not exceed three AAFS2012.L in Microsoft File Explor- browse list (the library you want to PAGE 20 Tech-IN Tidbit: Better GC/MS Searching Submitted By: Dan Baker, Franklin County Coroner’s Office, Columbus, OH

add to) and click OK. created MERGED2019.L library, psychoactive substances. Lastly, bear 8. Once started, a counter in the bot- then next DesignerDrug.L, then next in mind, the subset/append utility is tom left of the window will show NIST.L. When you run the automat- most useful for combining multiple how many GC/MS spectra entries ed library search report, you will smaller libraries, because there are file have been added. In this example, be searching now up to 5 libraries size limits that can be reached. Happy the message read “Finished add- even with the 3 library Chemstation searching! ing 1660 entries to C:\Database\ DrugQuant selection limit. MERGED2019.L.” Repeat steps 4-7 I would like to thank Dr. Graham Jones to add more GC/MS libraries to Keep records of what libraries and their for originally sharing this knowledge your merged library (just type the release dates have been combined. on how to subset/append libraries a new additional library/destination You will want to periodically re-create few years ago. We have found it of to be added in step 5). Now you your combined library to reflect new great benefit performing effective and may set up your Library Search releases, maintaining the ability to efficient automated GC/MS general Parameters to search your newly detect a broad range of drugs and new unknown searches.

ICAP 2020 Call for Presentations

The call for presentations for the 2020 alcohol-impaired driving. driving focus IACP Drugs, Alcohol, and Impaired • Toxicology topics related to im- Driving (DAID) Conference is now open. Submitters are encouraged to submit paired driving The conference will be held August 6-8, innovative and engaging workshops on • Traffic safety and enforcement 2020 in San Antonio, Texas. a variety of topics. IACP is looking for • Submissions will be accepted topics focusing on: through the online system now The DAID Conference is the largest • Alcohol-impaired driving and alco- through December 31, 2019. Infor- training conference for drug recog- hol in combination with drugs mation regarding conference regis- nition experts and provides law en- • Drug-impaired driving issues, drug tration and hotel accommodations forcement, physicians, toxicologists, trends, and drug effects will be released Winter 2020. For prosecutors, and other traffic safety • Law enforcement executives and more information about the DAID professionals with a forum to share impaired driving enforcement Conference, please visit: https:// best practices for reducing drug- and • Prosecutor topics with an impaired www.theiacp.org/DAIDconference.

SUBMIT A PROPSAL PAGE 21 From the Toxicology Literature Submitted by: Kevin G. Shanks, M.S., D-ABFT-FT Axis Forensic Toxicology [email protected]

Clinical Toxicology (Philadelphia) effect while mice treated with XLR-11 only Fentanyl, sufentanil, buprenorphine, nor- did not show this effect. When treated buprenorphine, naloxone, carfentanil, and Volume 57 with AM-251, the effects of the XLR-11 norcarfentanil were detected in the plas- DOI: 10.1080/15563650.2019.1580371 degradant were suppressed. Extracellu- ma sample. She was discharged after eight Fatal Intoxication with New Synthet- lar dopamine and glutamate showed no days. In case 3, a 57 year old man became ic Cannabinoids AMB-FUBINACA and involvement in this reported hyperreflexia, dizzy and faint and suffered a heart attack EMB-FUBINACA but did suppress the locomo- while at a music festival. He was admitted tor activity. The authors conclude that to the hospital and died after six days in Adamowicz et al. describe the case of a 27 the XLR-11 pyrolytic degradant causes a the intensive care unit. Plasma and urine year old man who was found deceased in hyperreflexic effect via mediation of the samples were taken for toxicological anal- bed. He was last seen living about 6 hours CB1 receptor and potentially by GABAergic yses. The urine was positive for , prior. Pathological findings at autopsy activity. codeine, , laudanosine, lidocaine, included congestion of the internal organs, remifentanil, and norcarfentanil. Remifen- pulmonary edema, and left-sided pleural Forensic Toxicology tanil and norcarfentanil were the only sub- adhesions. Samples were drawn at autop- Volume 37 stances detected in the plasma samples. sy for toxicological analyses. Postmortem The authors conclude that norcarfentanil blood was positive for (6 ng/ DOI: 10.1007/s11419-019-00481-2 is a shared metabolite of both carfentanil mL), haloperidol (11 ng/mL), lidocaine (29 Norcarfentanil: Carfentanil Misuse or and remifentanil. ng/mL), and caffeine (5.8 mcg/mL). Urine Remifentanil Treatment? was positive for lorazepam, haloperidol, Clinical Toxicology (Philadelphia) lidocaine, caffeine, and the synthetic can- In this case report, Allibe et al. discuss the nabinoids AMB-FUBINACA and EMB-FU- Volume 57 detection of norcarfentanil, a shared me- DOI: 10.1080/15563650.2018.1534241 BINACA. Both synthetic cannabinoids were tabolite of carfentanil and remifentanil, in also detected at varying concentrations three human intoxication cases. Detection A Novel Synthetic Cannabinoid (CUMYL- 4-Cyano-BINACA) Resulting in Hyperther- in kidney, liver, intestine, lung, and brain, of carfentanil, remifentanil, and norcarfen- mia, Rhabdomyolysis, and Renal Failure in along with gastric contents. The authors tanil was completed by liquid chroma- a 29-Year-Old Patient: It’s Not Meningitis conclude that this case report shows that tography with triple quadrupole mass synthetic cannabinoids can be undetect- spectrometry after solid phase extraction. In this letter, El Zahran et al. report a case able in postmortem blood, even if the case In case 1, a 41 year old man insufflated a of a 29 year old man who was admitted to was specifically an acute/fatal intoxication white powder purported to be cocaine. the hospital after a fall at his home. Wit- with the substances. After a few minutes he became unrespon- ness reports stated he had been tired and physically weak for three days prior to the Forensic Toxicology sive and exhibited myosis and bradypnea and was admitted to the hospital inten- incident and had vomited. At admission, Volume 37 sive care unit. Plasma and urine samples he was altered, combative, and hyperther- DOI: 10.1007/s11419-019-00476-z were drawn for toxicological analyses. The mic (39°C). The man was given lorazepam urine was positive for benzoylecgonine, for agitation and antibiotics for presumed Hyperreflexia Induced by XLR-11 Smoke Is ecgonine methyl ester, anhydroecgonine sepsis and meningitis. Over the next three Caused by the Pyrolytic Degradant methyl ester, lidocaine, levamisole, mid- days, he was confused and renal failure azolam, carfentanil, and norcarfentan- progressed into day four of the admission. Hataoka et al. report a study in which mice il. Carfentanil and norcarfentanil were The man underwent dialysis on days five were exposed to the synthetic cannabi- detected in the plasma sample. He was and six and his mental status improved noid, XLR-11, and locomotor activity and discharged in good health a few days later. significantly, at which time he admitted body temperature were monitored, along In case 2, a 48 year old woman was found to smoking “synthetic marijuana” that he with intensity of catalepsy. Extracellular unconscious at home. She was admitted had purchased over the internet. He was dopamine was measured in the regions to the hospital intensive care unit and ad- discharged against medical advice on day of the nucleus accumbens and glutamate ministered naloxone – which had no effect. ten with intact mental status. Serum from was measured in the hippocampus. Mice Later she was intubated, ventilated, and the hospital admission was analyzed by exposed to the XLR-11 smoke (which con- treated via various medications. Plasma liquid chromatography-quadrupole time tained both XLR11 and the XLR-11 pyrolyt- and urine samples were taken for toxico- of flight mass spectrometry. The synthetic ic degradant) exhibited hyperreflexia early logical analyses. The urine was positive for cannabinoid CUMYL-4-Cyano-BINACA was and was followed by hypothermia and THC metabolite, lidocaine, buprenorphine, detected (35.5 ng/mL). Sepsis, meningitis, catalepsy. Mice treated with the XLR-11 norbuprenorphine, naloxone, fentanyl, serotonin syndrome, and cyclobenzaprine degradant only showed a hyperreflexic sufentanil, carfentanil, and norcarfentanil. overdose were ruled out as causative fac- PAGE 22 From the Toxicology Literature Submitted by: Kevin G. Shanks, M.S., D-ABFT-FT Axis Forensic Toxicology [email protected]

tors by various other analyses. The authors lites in hair samples. Sample preparation conclude that intoxication with CUMYL-4- included washes with Cyano-BINACA can result in acute kidney and , drying under nitrogen injury, altered mental status, rhabdomy- gas flow, ball mill grinding, addition of olysis, and hyperthermia, which can mimic internal standards, addition of methanol, other neurological conditions. and incubation at 55°C for fifteen hours. Instrumental analysis was performed on Forensic Science International a Shimadzu LC-30A Series system liquid Volume 304 chromatograph coupled to a Sciex 5500 tri- DOI: 10.1016/j.forsciint.2019.109915 ple quadrupole mass spectrometer. During method validation, selectivity, specificity, A Case Report on Potential Postmortem linearity (including limits of detection and Redistribution of Furanyl Fentanyl and quantitation), precision and accuracy, 4-ANPP carryover, recovery, and matrix effects Freni et al. report the potential postmor- were assessed. The method was applied tem redistribution of furanyl fentanyl to authentic hair specimens (taken from and 4-ANPP via the case of a 53 year old people aged 18-40 who were attending a man who was found unresponsive at him party in New York City). The study honed while sitting at his desk with a needle still its focus on individuals who reported any inserted in his hand. The individual was in past-year non-medical opioid or heroin full rigor mortis and declared deceased at use. A total of thirty four samples were the scene. Pathological findings at autopsy analyzed; each hair sample was analyzed included recent puncture wounds on the in full length. Seventeen of the samples hands, needle marks on the arms, petechi- tested positive for at least one opioid ae on the lower limbs, multi-visceral con- analyte. Results included oxycodone (n=9, gestion, pulmonary edema, and cerebral 13-780 pg/mg), tramadol (n=8, 2.0-3700 edema. Heart blood, femoral blood, urine, pg/mg), hydrocodone (n=4, 13-71 pg/mg), gastric contents, bile, and cerebrospinal fentanyl (n=2, 3-6 pg/mg), furanylfentanyl fluid were collected at autopsy for toxi- (n=1, 44 pg/mg), and 4-ANPP (n=2, 1-2 pg/ cology testing. Analyses revealed positive mg). Any positive quantitative results refer results for furanylfentanyl and 4-ANPP in to the average value across the full length each of the specimen matrices. Cardiac of hair. blood was positive for furanylfentanyl (11.8±0.7 ng/mL) and 4-ANPP (93.5±7.6 ng/mL), while femoral blood was positive for furanylfentanyl (2.7±0.1 ng/mL) and 4-ANPP (50.4±2.9 ng/mL). The authors demonstrate in this case report that both furanylfentanyl and 4-ANPP can undergo extensive postmortem redistribution.

Journal of Analytical Toxicology Volume 43 DOI: 10.1093/jat/bky093 Detection of Fentanyl Analogs and Syn- thetic Opioids in Real Hair Samples

Salomone et al. describe a rapid analyti- cal method using liquid chromatography with triple quadrupole mass spectrometry for the detection of thirteen synthetic opioids, fentanyl analogs, and metabo- PAGE 23 Share your SOFT Pictures & Messages FUTURE SOFT MEETINGS 2020 Marriott Marquis San Diego Marina, San Diego, CA September 21–25, 2020 Denice Teem and Dani Mata

2021 Gaylord Opryland, Nashville, TN September 26–October 1, 2021 TOXTALK Jennifer Colby and Erin Karschner TOXTALK® is the official publication of the Society of Forensic Toxicologists 2022 and is published quarterly. Huntington Convention Center, Cleveland, OH October 30-November 4, 2022 To submit articles please email Doug Rohde and Michele Merves Crosby CC Watson at [email protected] 2023 For advertsing opportunites please Gaylord Rockies, Denver, CO email Beth Olson at [email protected] October 29–November 3, 2023 TBD

Deadlines for Contributions: February 1 for March Issue May 1 for June Issue August 1 for September Issue November 1 for December Issue SOFT 2019 COMMITTEE CHAIRS FIND SOFT ONLINE! Awards Erin Spargo, Ph.D., F-ABFT Visit the SOFT website Culture, Values and Diversity Samantha Tolliver, Ph.D., Gail Cooper, Ph.D. SOFT-TOX.ORG ConEd Workshops Robert D. Johnson, Ph.D., F-ABFT Designer Drugs Dani Mata, D-ABFT-FT Follow and Like SOFT on Facebook @SOCIETYOFFORENSICTOXICOLOGISTS Drugs & Driving Curt E. Harper, Ph.D., F-ABFT Drug Facilitated Crimes Laureen Marinetti, Ph.D., M.S., F-ABFT CONTACT SOFT Ethics Jennifer Limoges, M.S., DABC Finance Robert Sears, M.S., F-ABFT SOFT OFFICE 1955 W. Baseline Rd., Ste 113-442 IT Matthew Juhascik, Ph.D., F-ABFT Mesa, AZ 85202 JAT Special Issue Kayla N. Ellefsen, Ph.D. Meeting Resource Sumandeep Rana, Ph.D. GENERAL INFORMATION: Membership Amy Miles, B.S. PH: 480-839-9106 Nominating Michelle Peace, Ph.D. E: [email protected] Policy & Procedures Amy Miles, B.S. EXHIBITOR/SPONSORSHIP: Publications Matt Slawson, Ph.D. [email protected] YFT Kim Samano, Ph.D.

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