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Infertility in the Male Dog - a Diagnostic Approach [Infertilidade No Cão - Abordagem Clínica]

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Infertility in the Male Dog - a Diagnostic Approach [Infertilidade No Cão - Abordagem Clínica] Congresso de Ciências Veterinárias [Proceedings of the Veterinary Sciences Congress, 2002], SPCV, Oeiras, 10-12 Out., pp. 171-176 Animais de Companhia Infertility in the male dog - A diagnostic approach [Infertilidade no cão - Abordagem clínica] Stefano Romagnoli Introduction Infertility in the male dog can which has a normal libido and is able to mount can be due to lack of or incomplete ejaculation or to poor semen quality. Infertility due to inability to mount or to low libido may or may not be a reproductive issue (it is often an orthopedic or a behavioral problem) and will not be discussed here. Ejaculation problems Failure of or incomplete ejaculation may occur if the coital lock is not adequate because of fright or discomfort during mating or at semen collection. Ejaculation may sometimes occur retrogradely into the bladder if there is an incompetence of the internal urethral sphincter muscle Retrograde ejaculation - The ejaculatory process is coordinated by sympathetic and parasympathetic nervous activity, and is divided into seminal emission (the deposition of semen from the vasa deferentia and accessory sex glands into the prostatic urethra) and ejaculation (passage of semen through the uretra and outside through the external urethral orifice). During ejaculation the bladder neck contracts, thus playing an important role in preventing a retrograde flux of spermatozoa into the bladder. Vasa deferentia and bladder neck are primarily under the control of the sympathetic nervous system. Alfa-adrenoceptor stimulation causes contraction of the vas deferens, while beta- adrenoceptor stimulation mediates relaxation of the vas deferens. The use of alfa-adrenergic agonists increases seminal emission: for example, administration of xylazine (alfa-2 adrenoceptor agonist) in the dog causes increased contraction of vasa deferentia and decreased urethral pressure, thereby facilitating passage of spermatozoa into the bladder (not associated to ejaculation). The bladder neck has a rich cholinergic and adrenergic innervation. Stimulation of the adrenergic component causes contraction of the bladder neck and relaxation of the bladder body. Administration of fentolamine (an alfa-adrenergic antagonist) in the dog 5-10 minutes prior to semen collection increases the (physiologic) retrograde flux of sperm into the bladder. Diagnosis of retrograde ejaculation requires confirmation of aspermia = lack of ejaculate or presence of minimal amounts (< 0.2 cc) following normal erection and urethral contractions, followed by observation of presence of high numbers (5-50 millions) of spermatozoa in the bladder. Treatment consists of oral administration of 5 mg/kg pseudoephedrine 3 and 1 hour prior to semen collection. Retrograde ejaculation in the dog is considered a rare event. However, aspermia will obviously go unnoticed at natural matings, and presence of spermatozoa in the urine after ejaculation is not regularly assessed. Three cases of canine retrograde ejaculation have been diagnosed at the Department of Veterinary Clinical Sciences of the University of Pisa during the 1991-2000 period. Poor semen quality From the classification standpoint, poor semen quality can be defined as azoospermia (absence of spermatozoa in the ejaculate), oligozoospermia (low number of spermatozoa in the ejaculate), asthenozoospermia (presence of a high percentage of spermatozoa which do not show a normal progressive motility) or teratozoospermia (presence of a high percentage of spermatozoa with morphological defects). Congresso de Ciências Veterinárias [Proceedings of the Veterinary Sciences Congress, 2002], SPCV, Oeiras, 10-12 Out., pp. 171-176 Poor semen quality can be due to poor quality of spermatozoa or may reflect abnormal seminal plasma. Poor quality of spermatozoa can be due to congenital defects such as testicular hypoplasia, the immotile cilia syndrome, chromosomal abnormalities (XXY syndrome, XX males), mono- or bilateral cyrptorchidism, anomalies of the duct system (cysts or other developmental anomalies of the epididymis, the vas deferens or the rete testis). Hypogonadism is a poorly characterized disease in the dog. A recent survey showed >70% of 314 cases of canine hypogonadism as being of idiopathic etiology. A familial tendency is suspected in some breeds (Bull Mastiff, Bernese mountain dog, Beagle, Welsh Corgi, Cocker Spaniel). Abnormal seminal plasma may be due to prostatic disease or to inflammation of the testis or of the epididymis. Prostatic hyperplasia A complete discussion of prostatic diseases is beyond the scope of this paper. However, benign prostatic hyperplasia can predispose the dog to infertility, especially if it evolves into prostatitis. Therefore, prostatic hyperplasia will be briefly outlined. Canine prostatic hyperplasia is the most common canine prostatic disorder, with almost 100% of intact dogs developing histologic evidence of prostatic hyperplasia with aging. It is characterized by an increase in epithelial cell numbers (hyperplasia) as well as an increase in epithelial cell size (hypertrophy), but the increase in cell number is more marked. It begins as glandular hyperplasia in dogs as young as 2.5 years of age. Intraparenchymal fluid cysts may develop in association with hyperplasia. Such cysts are variable in size and contour, contain a thin, clear to amber fluid and, if intraprenchymal, may communicate with the urethra thus leading to intermittent haemorrhagic or clear, light yellow urethral discharge. Hyperplasia is associated with an altered androgen:estrogen ratio, and requires the presence of the testes. Dihydrotestosterone (DHT) within the prostate gland probably serves as the main hormonal mediator for hyperplasia. The hyperplastic prostate is highly vascularized and therefore the gland bleeds easily, which explains the common clinical sign of blood from the tip of the penis or blood in the urine. Blood loss in the prostatic urethra can be so intense that the ejaculate may appear completely red. Although presence of blood in the semen is typically considered to be a cause for infertility, dogs with some blood in their ejaculates may sometimes be fertile. However, prostatitis or abscessation are likely consequences of presence of blood in the prostate. A clinical approach to the infertile dog If infertility must be ruled out, the following steps need to be carefully followed: a) collect a thorough history; b) perform an accurate clinical exam of the external genitalia; c) evaluate one or more semen samples. Information needed in order to collect a meaningful reproductive history - The first and most important information to be collected is a complete list of all bitches mated, starting from when the dog was still fertile, so as to be sure to understaqnd when the problem began. Furthermore, clinicians should try to put together the following information: a) If and how was fertility assessed for mated bitches b) If and how was ovulation determined in previous breedings c) If some of the bitches bred did whelp, it is very important to calculate the exact duration of pregnancy. Gestations of 57-59 days mean that the bitch had already ovulated when she was mated, while gestations of 67-72 days mean that the bitch ovulated 2-9 days following mating. Gestations whose lengths is shorter or longer than the intervfal 60-66 days may be characterized by a small litter size, but this is more likely due to wrong timing of breeding rather than to poor male fertility. d) If, how and when (after breeding) was pregnancy diagnosis carried out on mated bitches Congresso de Ciências Veterinárias [Proceedings of the Veterinary Sciences Congress, 2002], SPCV, Oeiras, 10-12 Out., pp. 171-176 e) Whether any drugs were used which could depress testosterone production (such as androgens, glucocorticoids, oestrongens, progestogens, cimetidine or ketoconazole) or act on the ejaculatory process (such as xylazine or fentolamine) f) Whether the dog has suffered from any disease, accidents or injuries which can be relevant to reproduction. The clinical exam - Following a complete physical exam (to rule out systemic disease directly or indirectly affecting reproduction), scrotum, prostate and penis should be carefully inspected and palpated. Normal testicles are freely movable within the scrotal sac, have the same shape and consistency and their size must be average for the breed. Epididymides are palpated on the dorso-lateral aspect of the testicle to check for the presence of nodules, keeping in mind that palpation can only exclude the presence of macroscopic lesions. The prostate is examined using the index finger of one hand per rectum to locate the symmetrically bilobed spongy structure, whose caudal half can be felt with the fingertip cranial to the pelvis; the other hand should locate the prostate abdominally and push it backward towards the rectally located index finger. Finally, penis and prepuce are examined to rule out presence of lesions as well as to make sure that the penis can be normally extruded from the prepuce. Semen Evaluation - Sperm motility, concentration and morphology, presence of white blood cells in the sperm sediment, seminal plasma pH and alkaline phosphatase should be assessed. Sperm concentration can be measured loading a haemocytometer with the right amount of semen and the right dilution rate according to manufacturer’s instruction for the haemocytometer being used. The number of cells in the central square millimetre x 106 x semen volume gives the total number of spermatozoa/ejaculate (normal is 200-2000
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