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Lithium Diisopropylamide, 2M Solution in THF/N-Heptane/Ethylbenzene

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Lithium Diisopropylamide, 2M Solution in THF/N-Heptane/Ethylbenzene Material Safety Data Sheet Creation Date 01-Apr-2009 Revision Date 01-Apr-2009 Revision Number 1 1. PRODUCT AND COMPANY IDENTIFICATION Product Name Lithium diisopropylamide, 2M solution in THF/n-heptane/ethylbenzene Cat No. AC268830000, AC268831000, AC268838000 Synonyms LDA.THF complex Recommended Use Laboratory chemicals Company Entity / Business Name Emergency Telephone Number Fisher Scientific Acros Organics For information in the US, call: 800-ACROS-01 One Reagent Lane One Reagent Lane For information in Europe, call: +32 14 57 52 Fair Lawn, NJ 07410 Fair Lawn, NJ 07410 11 Tel: (201) 796-7100 Emergency Number, Europe: +32 14 57 52 99 Emergency Number, US: 201-796-7100 CHEMTREC Phone Number, US: 800-424- 9300 CHEMTREC Phone Number, Europe: 703- 527-3887 2. HAZARDS IDENTIFICATION DANGER! Emergency Overview Flammable liquid and vapor. May form explosive peroxides. Water reactive. Causes burns by all exposure routes. Vapors may cause drowsiness and dizziness. Aspiration hazard if swallowed - can enter lungs and cause damage. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Appearance Orange. Physical State Liquid. Odor pungent. Target Organs Skin, Respiratory system, Eyes, Gastrointestinal tract (GI), Central nervous system (CNS), Liver, Kidney, spleen, Blood Potential Health Effects Acute Effects _____________________________________________________________________________________________ Page 1 / 11 Thermo Fisher Scientific - Lithium diisopropylamide, Revision Date 01-Apr-2009 2M solution in THF/n-heptane/ethylbenzene _____________________________________________________________________________________________ Principle Routes of Exposure Eyes Causes burns. Skin Causes burns. May be harmful in contact with skin. Inhalation Causes burns. May be harmful if inhaled. Inhalation may cause central nervous system effects. Ingestion Causes burns. Aspiration hazard if swallowed - can enter lungs and cause damage. Chronic Effects Experiments have shown reproductive toxicity effects on laboratory animals. Tumorigenic effects have been reported in experimental animals.. May cause adverse liver effects. May cause adverse kidney effects. See Section 11 for additional Toxicological information. Aggravated Medical Conditions Central nervous system disorders. Preexisting eye disorders. Skin disorders. 3. COMPOSITION/INFORMATION ON INGREDIENTS Haz/Non-haz Component CAS-No Weight % Heptane (n-) 142-82-5 25-30 2-Propanamine, N-(1-methylethyl)-, lithium salt 4111-54-0 20-30 Tetrahydrofuran 109-99-9 20-30 Ethyl benzene 100-41-4 10-15 Diisopropylamine 108-18-9 0-4 4. FIRST AID MEASURES Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required. Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with a respiratory medical device.. Immediate medical attention is required. Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately. Notes to Physician Treat symptomatically. 5. FIRE-FIGHTING MEASURES Flash Point 2°C / 35.6°F Method No information available. Autoignition Temperature No information available. Explosion Limits Upper No data available Lower No data available Suitable Extinguishing Media CO2, dry chemical, dry sand, alcohol-resistant foam. Cool closed containers exposed to fire with water spray. _____________________________________________________________________________________________ Page 2 / 11 Thermo Fisher Scientific - Lithium diisopropylamide, Revision Date 01-Apr-2009 2M solution in THF/n-heptane/ethylbenzene _____________________________________________________________________________________________ Unsuitable Extinguishing Media DO NOT USE WATER!. Hazardous Combustion Products No information available. Sensitivity to mechanical impact No information available. Sensitivity to static discharge No information available. Specific Hazards Arising from the Chemical Flammable. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Reacts violently with water. May form explosive peroxides. Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors. NFPA Health 3 Flammability 3 Instability 1 Physical hazards N/A 6. ACCIDENTAL RELEASE MEASURES Personal Precautions Use personal protective equipment. Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas. Remove all sources of ignition. Take precautionary measures against static discharges. Environmental Precautions Should not be released into the environment. Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable and closed containers for disposal. Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Do not expose spill to water. 7. HANDLING AND STORAGE Handling Use only under a chemical fume hood. Wear personal protective equipment. Do not get in eyes, on skin, or on clothing. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. Use explosion-proof equipment. Do not breathe vapors/dust. Do not ingest. Take precautionary measures against static discharges. Do not allow contact with water. Do not get water inside containers. If peroxide formation is suspected, do not open or move container. Storage Keep containers tightly closed in a dry, cool and well-ventilated place. Corrosives area. Keep away from heat and sources of ignition. Refrigerator/flammables. Keep under nitrogen. May form explosive peroxides on prolonged storage. Containers should be dated when opened and tested periodically for the presence of peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals. _____________________________________________________________________________________________ Page 3 / 11 Thermo Fisher Scientific - Lithium diisopropylamide, Revision Date 01-Apr-2009 2M solution in THF/n-heptane/ethylbenzene _____________________________________________________________________________________________ 8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering Measures Use only under a chemical fume hood. Use explosion-proof electrical/ventilating/lighting/equipment. Ensure that eyewash stations and safety showers are close to the workstation location. Exposure Guidelines Component ACGIH TLV OSHA PEL NIOSH IDLH Heptane (n-) TWA: 400 ppm (Vacated) TWA: 1600 mg/m3 IDLH: 750 ppm STEL: 500 ppm (Vacated) TWA: 400 ppm TWA: 350 mg/m3 (Vacated) STEL: 2000 mg/m3 TWA: 85 ppm (Vacated) STEL: 500 ppm Ceiling: 1800 mg/m3 TWA: 2000 mg/m3 Ceiling: 440 ppm TWA: 500 ppm Tetrahydrofuran TWA: 50 ppm (Vacated) TWA: 200 ppm IDLH: 2000 ppm STEL: 100 ppm (Vacated) TWA: 590 mg/m3 TWA: 590 mg/m3 Skin (Vacated) STEL: 250 ppm TWA: 200 ppm (Vacated) STEL: 735 mg/m3 STEL: 250 ppm TWA: 200 ppm STEL: 735 mg/m3 TWA: 590 mg/m3 Ethyl benzene TWA: 100 ppm (Vacated) TWA: 100 ppm IDLH: 800 ppm STEL: 125 ppm (Vacated) TWA: 435 mg/m3 TWA: 435 mg/m3 (Vacated) STEL: 125 ppm TWA: 100 ppm (Vacated) STEL: 545 mg/m3 STEL: 545 mg/m3 TWA: 100 ppm STEL: 125 ppm TWA: 435 mg/m3 Diisopropylamine TWA: 5 ppm (Vacated) TWA: 20 mg/m3 IDLH: 200 ppm Skin (Vacated) TWA: 5 ppm TWA: 20 mg/m3 Skin TWA: 5 ppm TWA: 20 mg/m3 TWA: 5 ppm Component Quebec Mexico OEL (TWA) Ontario TWAEV Heptane (n-) TWA: 1640 mg/m3 TWA: 1600 mg/m3 TWA: 1635 mg/m3 TWA: 400 ppm TWA: 400 ppm TWA: 400 ppm STEL: 2050 mg/m3 STEL: 2000 mg/m3 STEL: 2045 mg/m3 STEL: 500 ppm STEL: 500 ppm STEL: 500 ppm Tetrahydrofuran TWA: 100 ppm TWA: 590 mg/m3 TWA: 200 ppm TWA: 300 mg/m3 TWA: 200 ppm TWA: 590 mg/m3 STEL: 735 mg/m3 STEL: 250 ppm STEL: 250 ppm STEL: 735 mg/m3 Ethyl benzene TWA: 100 ppm TWA: 435 mg/m3 TWA: 100 ppm TWA: 434 mg/m3 TWA: 100 ppm TWA: 435 mg/m3 STEL: 125 ppm STEL: 125 ppm STEL: 125 ppm STEL: 543 mg/m3 STEL: 545 mg/m3 STEL: 540 mg/m3 Diisopropylamine TWA: 21 mg/m3 TWA: 20 mg/m3 TWA: 20 mg/m3 TWA: 5 ppm TWA: 5 ppm TWA: 5 ppm Skin Skin NIOSH IDLH: Immediately Dangerous to Life or Health Personal Protective Equipment Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure. Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. _____________________________________________________________________________________________ Page 4 / 11 Thermo Fisher Scientific - Lithium diisopropylamide, Revision Date 01-Apr-2009 2M solution in THF/n-heptane/ethylbenzene _____________________________________________________________________________________________ 9. PHYSICAL AND CHEMICAL PROPERTIES
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