Material Safety Data Sheet Creation Date 01-Apr-2009 Revision Date 01-Apr-2009 Revision Number 1
1. PRODUCT AND COMPANY IDENTIFICATION
Product Name Lithium diisopropylamide, 2M solution in THF/n-heptane/ethylbenzene
Cat No. AC268830000, AC268831000, AC268838000
Synonyms LDA.THF complex
Recommended Use Laboratory chemicals
Company Entity / Business Name Emergency Telephone Number Fisher Scientific Acros Organics For information in the US, call: 800-ACROS-01 One Reagent Lane One Reagent Lane For information in Europe, call: +32 14 57 52 Fair Lawn, NJ 07410 Fair Lawn, NJ 07410 11 Tel: (201) 796-7100 Emergency Number, Europe: +32 14 57 52 99 Emergency Number, US: 201-796-7100
CHEMTREC Phone Number, US: 800-424- 9300 CHEMTREC Phone Number, Europe: 703- 527-3887
2. HAZARDS IDENTIFICATION
DANGER! Emergency Overview Flammable liquid and vapor. May form explosive peroxides. Water reactive. Causes burns by all exposure routes. Vapors may cause drowsiness and dizziness. Aspiration hazard if swallowed - can enter lungs and cause damage. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Appearance Orange. Physical State Liquid. Odor pungent.
Target Organs Skin, Respiratory system, Eyes, Gastrointestinal tract (GI), Central nervous system (CNS), Liver, Kidney, spleen, Blood
Potential Health Effects
Acute Effects
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Principle Routes of Exposure
Eyes Causes burns. Skin Causes burns. May be harmful in contact with skin. Inhalation Causes burns. May be harmful if inhaled. Inhalation may cause central nervous system effects. Ingestion Causes burns. Aspiration hazard if swallowed - can enter lungs and cause damage.
Chronic Effects Experiments have shown reproductive toxicity effects on laboratory animals. Tumorigenic effects have been reported in experimental animals.. May cause adverse liver effects. May cause adverse kidney effects.
See Section 11 for additional Toxicological information.
Aggravated Medical Conditions Central nervous system disorders. Preexisting eye disorders. Skin disorders.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Haz/Non-haz Component CAS-No Weight % Heptane (n-) 142-82-5 25-30 2-Propanamine, N-(1-methylethyl)-, lithium salt 4111-54-0 20-30 Tetrahydrofuran 109-99-9 20-30 Ethyl benzene 100-41-4 10-15 Diisopropylamine 108-18-9 0-4
4. FIRST AID MEASURES
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required.
Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.
Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with a respiratory medical device.. Immediate medical attention is required.
Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.
Notes to Physician Treat symptomatically.
5. FIRE-FIGHTING MEASURES
Flash Point 2°C / 35.6°F
Method No information available.
Autoignition Temperature No information available. Explosion Limits Upper No data available Lower No data available
Suitable Extinguishing Media CO2, dry chemical, dry sand, alcohol-resistant foam. Cool closed containers exposed to fire with water spray.
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Unsuitable Extinguishing Media DO NOT USE WATER!.
Hazardous Combustion Products No information available.
Sensitivity to mechanical impact No information available. Sensitivity to static discharge No information available.
Specific Hazards Arising from the Chemical Flammable. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Reacts violently with water. May form explosive peroxides.
Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.
NFPA Health 3 Flammability 3 Instability 1 Physical hazards N/A
6. ACCIDENTAL RELEASE MEASURES
Personal Precautions Use personal protective equipment. Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas. Remove all sources of ignition. Take precautionary measures against static discharges.
Environmental Precautions Should not be released into the environment.
Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable and closed containers for disposal. Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Do not expose spill to water.
7. HANDLING AND STORAGE
Handling Use only under a chemical fume hood. Wear personal protective equipment. Do not get in eyes, on skin, or on clothing. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. Use explosion-proof equipment. Do not breathe vapors/dust. Do not ingest. Take precautionary measures against static discharges. Do not allow contact with water. Do not get water inside containers. If peroxide formation is suspected, do not open or move container.
Storage Keep containers tightly closed in a dry, cool and well-ventilated place. Corrosives area. Keep away from heat and sources of ignition. Refrigerator/flammables. Keep under nitrogen. May form explosive peroxides on prolonged storage. Containers should be dated when opened and tested periodically for the presence of peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals.
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8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Measures Use only under a chemical fume hood. Use explosion-proof electrical/ventilating/lighting/equipment. Ensure that eyewash stations and safety showers are close to the workstation location.
Exposure Guidelines
Component ACGIH TLV OSHA PEL NIOSH IDLH Heptane (n-) TWA: 400 ppm (Vacated) TWA: 1600 mg/m3 IDLH: 750 ppm STEL: 500 ppm (Vacated) TWA: 400 ppm TWA: 350 mg/m3 (Vacated) STEL: 2000 mg/m3 TWA: 85 ppm (Vacated) STEL: 500 ppm Ceiling: 1800 mg/m3 TWA: 2000 mg/m3 Ceiling: 440 ppm TWA: 500 ppm Tetrahydrofuran TWA: 50 ppm (Vacated) TWA: 200 ppm IDLH: 2000 ppm STEL: 100 ppm (Vacated) TWA: 590 mg/m3 TWA: 590 mg/m3 Skin (Vacated) STEL: 250 ppm TWA: 200 ppm (Vacated) STEL: 735 mg/m3 STEL: 250 ppm TWA: 200 ppm STEL: 735 mg/m3 TWA: 590 mg/m3 Ethyl benzene TWA: 100 ppm (Vacated) TWA: 100 ppm IDLH: 800 ppm STEL: 125 ppm (Vacated) TWA: 435 mg/m3 TWA: 435 mg/m3 (Vacated) STEL: 125 ppm TWA: 100 ppm (Vacated) STEL: 545 mg/m3 STEL: 545 mg/m3 TWA: 100 ppm STEL: 125 ppm TWA: 435 mg/m3 Diisopropylamine TWA: 5 ppm (Vacated) TWA: 20 mg/m3 IDLH: 200 ppm Skin (Vacated) TWA: 5 ppm TWA: 20 mg/m3 Skin TWA: 5 ppm TWA: 20 mg/m3 TWA: 5 ppm
Component Quebec Mexico OEL (TWA) Ontario TWAEV Heptane (n-) TWA: 1640 mg/m3 TWA: 1600 mg/m3 TWA: 1635 mg/m3 TWA: 400 ppm TWA: 400 ppm TWA: 400 ppm STEL: 2050 mg/m3 STEL: 2000 mg/m3 STEL: 2045 mg/m3 STEL: 500 ppm STEL: 500 ppm STEL: 500 ppm Tetrahydrofuran TWA: 100 ppm TWA: 590 mg/m3 TWA: 200 ppm TWA: 300 mg/m3 TWA: 200 ppm TWA: 590 mg/m3 STEL: 735 mg/m3 STEL: 250 ppm STEL: 250 ppm STEL: 735 mg/m3 Ethyl benzene TWA: 100 ppm TWA: 435 mg/m3 TWA: 100 ppm TWA: 434 mg/m3 TWA: 100 ppm TWA: 435 mg/m3 STEL: 125 ppm STEL: 125 ppm STEL: 125 ppm STEL: 543 mg/m3 STEL: 545 mg/m3 STEL: 540 mg/m3 Diisopropylamine TWA: 21 mg/m3 TWA: 20 mg/m3 TWA: 20 mg/m3 TWA: 5 ppm TWA: 5 ppm TWA: 5 ppm Skin Skin
NIOSH IDLH: Immediately Dangerous to Life or Health
Personal Protective Equipment Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure. Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
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9. PHYSICAL AND CHEMICAL PROPERTIES
Physical State Liquid Appearance Orange Odor pungent Odor Threshold No information available. pH No information available. Vapor Pressure No information available. Vapor Density No information available. Viscosity No information available. Boiling Point/Range 60 - 136°C / 140 - 276.8°F@ 760 mmHg Melting Point/Range No information available. Decomposition temperature °C No information available. Flash Point 2°C / 35.6°F Evaporation Rate >1.0 (Butyl Acetate = 1.0) Specific Gravity 0.81 Solubility Decomposes in contact with water log Pow No data available Molecular Weight 107.12 Molecular Formula C6 H14 Li N
10. STABILITY AND REACTIVITY
Stability Moisture sensitive.. Air sensitive. Water reactive. May form explosive peroxides.
Conditions to Avoid Incompatible products. Excess heat. Keep away from open flames, hot surfaces and sources of ignition. Exposure to moist air or water. Exposure to air. Temperatures above 40°C.
Incompatible Materials Strong oxidizing agents
Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), Nitrogen oxides (NOx)
Hazardous Polymerization Hazardous polymerization does not occur.
Hazardous Reactions . None under normal processing..
11. TOXICOLOGICAL INFORMATION
Acute Toxicity
Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Heptane (n-) 5000 mg/kg ( Mouse ) 3000 mg/kg ( Rabbit ) 103 g/m3 ( Rat ) 4 h Tetrahydrofuran 1650 mg/kg ( Rat ) Not listed 180 mg/L ( Rat ) 1 h 53.9 mg/L ( Rat ) 4 h Ethyl benzene 3500 mg/kg ( Rat ) 15354 mg/kg ( Rabbit ) 17.2 mg/L ( Rat ) 4 h Diisopropylamine Not listed 10000 mg/kg ( Rabbit ) 5.3 mg/L ( Rat ) 4 h
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Irritation Causes burns by all exposure routes
Toxicologically Synergistic No information available. Products
Chronic Toxicity
Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.
Component ACGIH IARC NTP OSHA Mexico Tetrahydrofuran A3 Not listed Not listed Not listed Not listed Ethyl benzene A3 Group 2B Not listed X Not listed
ACGIH: (American Conference of Governmental Industrial Hygienists) A1 - Known Human Carcinogen A2 - Suspected Human Carcinogen A3 - Animal Carcinogen ACGIH: (American Conference of Governmental Industrial Hygienists) IARC: (International Agency for Research on Cancer) IARC: (International Agency for Research on Cancer) Group 1 - Carcinogenic to Humans Group 2A - Probably Carcinogenic to Humans Group 2B - Possibly Carcinogenic to Humans
Sensitization No information available.
Mutagenic Effects Mutatagenic effects have occured in microorganisms.
Reproductive Effects Experiments have shown reproductive toxicity effects on laboratory animals.
Developmental Effects Developmental effects have occurred in experimental animals.
Teratogenicity Teratogenic effects have occurred in experimental animals..
Other Adverse Effects Tumorigenic effects have been reported in experimental animals.. The toxicological properties have not been fully investigated.. See actual entry in RTECS for complete information..
Endocrine Disruptor Information No information available
12. ECOLOGICAL INFORMATION
Ecotoxicity Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Component Freshwater Algae Freshwater Fish Microtox Water Flea Heptane (n-) Not listed LC50= 375.0 mg/L Cichlid fish Not listed EC50 > 10 mg/L 24 h 96 h Tetrahydrofuran Not listed LC50 2700 - 3600 mg/L Not listed EC50 > 10000 mg/L 24 h Pimephales promelas 96 h LC50= 2160 mg/L Pimephales promelas 96 h
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Component Freshwater Algae Freshwater Fish Microtox Water Flea Ethyl benzene EC50 = 4.6 mg/L 72 h LC50= 14.0 mg/L EC50 = 9.68 mg/L 30 min EC50 1.8 - 2.4 mg/L 48 h EC50 > 438 mg/L 96 h Oncorhynchus mykiss 96 h EC50 = 96 mg/L 24 h LC50= 150.0 mg/L Lepomis macrochirus 96 h LC50= 32 mg/L Lepomis macrochirus 96 h LC50= 4.2 mg/L Oncorhynchus mykiss 96 h LC50= 48.5 mg/L Pimephales promelas 96 h LC50= 9.09 mg/L Pimephales promelas 96 h LC50= 9.6 mg/L Poecilia reticulata 96 h Diisopropylamine EC50 = 20 mg/L 96 h LC50 150 - 223 mg/L Not listed EC50 = 25.8 mg/L 24 h Brachydanio rerio 96 h EC50 = 53 mg/L 24 h LC50 420 - 560 mg/L Oryzias latipes 96 h
Persistence and Degradability No information available
Bioaccumulation/ Accumulation No information available
Mobility .
Component log Pow Heptane (n-) 4.66 Tetrahydrofuran 0.45 Ethyl benzene 3.118
13. DISPOSAL CONSIDERATIONS
Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.
Component RCRA - U Series Wastes RCRA - P Series Wastes Tetrahydrofuran - 109-99-9 waste number U213 (Ignitable waste) -
14. TRANSPORT INFORMATION
DOT UN-No UN2924 Proper Shipping Name FLAMMABLE LIQUID, CORROSIVE, N.O.S. Proper technical name Heptane (n-),2-Propanamine, N-(1-methylethyl)-, lithium salt Hazard Class 3 Packing Group II
TDG UN-No UN2924 Proper Shipping Name FLAMMABLE LIQUID, CORROSIVE, N.O.S. Hazard Class 3
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14. TRANSPORT INFORMATION Packing Group II
IATA UN-No UN2924 Proper Shipping Name Flammable liquid, corrosive, n.o.s Hazard Class 3 Subsidiary Hazard Class 8 Packing Group II
IMDG/IMO UN-No UN2924 Proper Shipping Name Flammable liquid, corrosive, n.o.s Hazard Class 3 Subsidiary Hazard Class 8 Packing Group II
15. REGULATORY INFORMATION
All of the components in the product are on the following Inventory lists: All of the components in the product are on the following Inventory lists:
International Inventories Component TSCA DSL NDSL EINECSELINCS NLP PICCS ENCS AICS CHINA KECL Heptane (n-) T X - 205-563- - XXXXKE- 8 18271 X 2-Propanamine, N-(1- P X - 223-893- -X-XX- methylethyl)-, lithium salt 0 Tetrahydrofuran T X - 203-726- - XXXXKE- 8 33454 X Ethyl benzene T X - 202-849- - XXXXKE- 4 13532 X Diisopropylamine Present X - 203-558- - XXXXKE- 5 24105 X
Legend: X - Listed E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA. F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA. N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. P - Indicates a commenced PMN substance R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA. S - Indicates a substance that is identified in a proposed or final Significant New Use Rule T - Indicates a substance that is the subject of a Section 4 test rule under TSCA.
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XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B). Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater. Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants that comprises one of the eligibility criteria for the exemption rule.
U.S. Federal Regulations
TSCA 12(b)
Component TSCA 12(b) Heptane (n-) Section 4, 1 % de minimus concentration Tetrahydrofuran Section 4, 1 % de minimus concentration
SARA 313
Component CAS-No Weight % SARA 313 - Threshold Values % Ethyl benzene 100-41-4 10-15 0.1
SARA 311/312 Hazardous Categorization Acute Health Hazard No Chronic Health Hazard No Fire Hazard Yes Sudden Release of Pressure Hazard No Reactive Hazard No
Clean Water Act
Component CWA - Hazardous CWA - Reportable CWA - Toxic Pollutants CWA - Priority Pollutants Substances Quantities Ethyl benzene X 1000 lb X X
Clean Air Act
Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors Ethyl benzene X-
OSHA Not applicable
CERCLA This material, as supplied, contains one or more substances regulated as a hazardous substance under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302)
Component Hazardous Substances RQs CERCLA EHS RQs Tetrahydrofuran 1000 lb - Ethyl benzene 1000 lb -
California Proposition 65 This product contains the following Proposition 65 chemicals: Component CAS-No California Prop. 65 Prop 65 NSRL Ethyl benzene 100-41-4 Carcinogen -
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State Right-to-Know
Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island Heptane (n-) X X X - X Tetrahydrofuran X X X - X Ethyl benzene XXXXX Diisopropylamine X X X - X
U.S. Department of Transportation Reportable Quantity (RQ): Y DOT Marine Pollutant N DOT Severe Marine Pollutant N
U.S. Department of Homeland Security This product does not contain any DHS chemicals.
Other International Regulations
Mexico - Grade Serious risk, Grade 3
Canada
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPR.
WHMIS Hazard Class B2 Flammable liquid E Corrosive material F Dangerously reactive material
16. OTHER INFORMATION
Prepared By Regulatory Affairs
Creation Date 01-Apr-2009
Print Date 01-Apr-2009
Revision Summary "***", and red text indicates revision
Disclaimer The information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text.
End of MSDS
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