Vulvar Verruciform Xanthoma Ten Cases Associated with Lichen Sclerosus, Lichen Planus, Or Other Conditions
OBSERVATION ONLINE FIRST Vulvar Verruciform Xanthoma Ten Cases Associated With Lichen Sclerosus, Lichen Planus, or Other Conditions Charlotte Fite, MD; Franc¸oise Plantier, MD; Nicolas Dupin, MD, PhD; Marie-Franc¸oise Avril, MD; Micheline Moyal-Barracco, MD Background: Verruciform xanthoma (VX) is a rare be- acanthosis without atypia, and elongated rete ridges. nign tumor that usually involves the oral cavity. Since Xanthomatous cells were aggregated in the papillary the first report of this tumor in 1971, only 9 cases have dermis. been reported on the vulva, and 3 of these were associ- ated with another vulvar condition. We describe the clini- Conclusions: Vulvar VX is a benign tumor with mis- copathologic features of 10 patients with vulvar VX and leading clinical features. All 10 cases were associated with focus on their associated conditions. a vulvar condition, mainly a lichen sclerosus. There- fore, VX might represent a reaction pattern induced by Observation: The mean age of the patients was 68 years different conditions, mainly characterized by damage to (range, 51-80 years). The VX lesions were asymptom- the dermoepidermal junction. When confronted with the atic, yellowish-orange verrucous plaques. The diagno- diagnosis of vulvar VX, clinicians may look for an asso- sis was clinically suspected in 2 cases; other suggested ciated vulvar condition. diagnoses were condyloma or squamous cell carci- noma. All of the patients had an associated vulvar con- dition: lichen sclerosus (6 patients), lichen planus (2 Arch Dermatol. 2011;147(9):1087-1092. patients), Paget disease, or radiodermatitis. Under mi- Published online May 16, 2011. croscopy, the VX lesions displayed parakeratosis, doi:10.1001/archdermatol.2011.113 ERRUCIFORM XANTHOMA location, histologic findings, history of dyslip- (VX) is a rare benign tu- idemia, treatment, follow-up, and associated mor which was first vulvar conditions.
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